4FDJ,1P49,1E3C


Conserved Protein Domain Family
GALNS_like
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cd16026: GALNS_like 
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galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS)
Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Links
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Statistics
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PSSM-Id: 293750
Aligned: 50 rows
Threshold Bit Score: 495.545
Created: 10-Sep-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:4FDJ; human GALNS binds N-Acetyl-D-Galactosamine and Ca++ at active site, defined by 4A distance.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 ##                                      #                              
4FDJ_A         4 PPNILLLLMDDMGWGDLGVYGEPsRETPNLDRMAAEGLLFPNFYSaNPLXSPSRAALLTGRLPIRNGFyttnaharnayt 83  human
EEF57355      24 KPNIIFILADDMGYGDIGPFGSTlNRTPNLDRMAKEGMKLTSFYA-APLCTPSRAQILTGCYAKRVSLpkvls------- 95  Pedosphaera par...
WP_040422018   7 LPNFVVIYVDDMGYADISCFGAPlTRTPVLDGMAARGMRLTSFYAgNPVCTPSRASMMTGMWAPRVNLpdvlgp------ 80  Actinopolymorph...
NP_868076     28 QSNFIIVYCDNLGYGDIEPFGSTlHRTPNLNRMAREGRTFTHFCVtAGVCTPSRASIMTGCYAQRVGMhlndrdga--vl 105 Rhodopirellula ...
NP_869252     46 KPNVIVIFTDDQGYNDLGCYGSPnIKTPNLDRLASEGRRYTSFYSaCSVCSPSRAALLTGCYPKRVGLhqhvlf------ 119 Rhodopirellula ...
WP_035214891  28 QRNFIVILVDDMGYGDVQPLGGS-IPTPAINRMAEQGILATSYYSpANLCTPSRAGLLTGRYPIRTGLayevi------- 99  Acidobacteriace...
EJU11930      31 KPNFIVILCDDLGYGDIEPTGGTaIPTPNLNRMAREGMVLTDYYApQNICTPSRAGLLTGRYPIRTGLawgail------ 104 Sphingomonas sp...
WP_042367652  26 HPNIIHILMDDVGYDDLSCFGSQdIKTPNIDAIASQGMKFTEFYApHGTSTPSRAALLTGRYAPRVNNgtglsvl----f 101 Bacteroidaceae ...
WP_015884458   4 RPNIVLINADDLGYGDLGCYGSMrNDTPHLDRLAAEGVRLTDFYMaSPVCSPSRGGMLTGCYPPRIGFgefvgrpv---l 80  Beutenbergia ca...
EDM25411      22 MPNFIFIMTDDQGYGDLGCYGHPiIKTPNIDKMADRGVRFTDFYA-RHKCSPARASLMTGAFNFRVGVgsivy------- 93  Lentisphaera ar...

Feature 1                                      # #                       #                       
4FDJ_A        84 pqeivgGIPDSEQLLPELLKKAGYVSKIVGKWHLGhr-pqFHPLKHGFDEWFGSPNCHFgpydnkarpnipvyrdwe--- 159 human
EEF57355      96 -prsevGLNTNEQTVAKLLKRQGYATMAIGKWHVGda-peNLPTRHGFDHYLGLPYSNDmggeepgkdqpakrgarpp-- 171 Pedosphaera par...
WP_040422018  81 -dasdgLSYTQETLIPAYLKEAGYTSGIFGKWHLGtp-ntYHPFQYGFDRWYGIPWSNDqwpvpiyddeei--------- 149 Actinopolymorph...
NP_868076    106 rpvspyGLHPDEITIAEVLKQQNYATALVGKWHLGdq-peFLPTHQGFDWFFGVPYSDDmteriwkqdgshwppl----- 179 Rhodopirellula ...
NP_869252    120 -pqstyGLHPDEVTIADHLKSAGYATACVGKWHLGhh-keTLPTSNGFDSYYGIPYSNDmnhpdnkrlgkmssddrwtdq 197 Rhodopirellula ...
WP_035214891 100 -qpgddRGLPLSEKTIPDALKPTYVSGLFGKWHLGqtgpdWLPTHHGFDTYYGIPYSHDmlplavyeadak--------- 169 Acidobacteriace...
EJU11930     105 -qpdkrILPLDEVTIPKALQPAGYRSGLFGKWHLGhlgpdWQPTRHGFDRFYGIPYSHDmkplqiftdtsp--------- 174 Sphingomonas sp...
WP_042367652 102 phtpngLEDEDEVCITELLKKQGYTTGLIGKWHLGhl-pqYLPVVHGFDRFVGIPYPNDhgperlggtgvrpsgisdp-- 178 Bacteroidaceae ...
WP_015884458  81 fpgdpvGLDPAERTMARVLGDAGYATAAIGKWHCGdq-peFLPTRHGFDSYFGIPFSNDmgrqrehedwpplp------- 152 Beutenbergia ca...
EDM25411      94 -pnsttGLIKEVVTIPEMLKEKGYTTALIGKWHLGht-agYLPRDQGFDYYFGVPGTNHgdakthklpvaegfkpsgeft 171 Lentisphaera ar...

Feature 1                                                                          #             
4FDJ_A       160 ---------------mvgryyeefpinlktgeANLTQIYLQEALDFIKRQa-rHHPFFLYWAVDATHAPVYASKPFlgt- 222 human
EEF57355     172 --------------lplvrdeqvievvkpadqDRLTERYTDEAVKFIRANd--KQPFFLYLAHTAVHAPIHPGHNFrgk- 234 Pedosphaera par...
WP_040422018 150 ---------------------vrtiegpsdnqDSLTREFTEKAVEFIDMHa--NEPFFLYLATSQPHGPIASEFHGrs-- 204 Actinopolymorph...
NP_868076    180 -----------------plmenetvieapcnrDGLTKRYTERAMQWIAEHk--DEPFFLYFPQAMPGSTKTPFSSDafrg 240 Rhodopirellula ...
NP_869252    198 ss--------avtlwntplvqdeeiielpvdqRTVTRRYTDRAIEFVEANq--DKPFFLYLPHSMPHIPLYVPEDVydp- 266 Rhodopirellula ...
WP_035214891 170 ---------------------nsdvktsppdyPNLQQQFYAHAEQFIEQNr--DHPFFVELALSAPHLPEYPNSRFkgt- 225 Acidobacteriace...
EJU11930     175 ---------------------drraseeepvmAELQQRFYEEAVNFIEANk--DQPFFVELALSAPHLANYPNPRHrdd- 230 Sphingomonas sp...
WP_042367652 179 -------------aiplirqaqvvkecdnndlAELPALFQREACKFLYDAvqsKKPFYLQYANIETHTPYFIPRGFegr- 244 Bacteroidaceae ...
WP_015884458 153 ------------------lmsgesvvqeqpdqRSLTERYTVAATRFIEENa--HQPFFLYLAHMYVHVPLFVPAPFlaa- 211 Beutenbergia ca...
EDM25411     172 iedywadkgkgvhgnstilmkndnviewptdiTQLTKRYTHDAVRYIKENk--DKPFFLYFAHGTPHHPYTVDAAFrgk- 248 Lentisphaera ar...

Feature 1                                                ##                                ##    
4FDJ_A       223 -sqRGRYGDAVREIDDSIGKILELLQDlHVADNTFVFFTSDNGAAlisa------------peqGGSNGPFLCGKQTTFE 289 human
EEF57355     235 -srNGLYGDWVEEVDWSVGKVLDTLRElGLSENTLVLFSSDNGPWlaq-------------ktnGGTAGPLRGGKGGTFE 300 Pedosphaera par...
WP_040422018 205 --aGGAYGDSVEEIDFHVGRLLAALDRnGLRDNTCVIFTSDNGPSwq----------------dSGDSGPFLGRKFETYE 266 Actinopolymorph...
NP_868076    241 ksrNGPWGDAVEELDWSIGQMLDQLVKlGIAEKTFVIWTSDNGAPinrdp----------ddlsRGSNLPLHGRGYTTSE 310 Rhodopirellula ...
NP_869252    267 -dpQNAYKCVIEHIDTEVGRLVQTVRDlGLSEKTLIVYTSDNGPWlqf-------------knhGGSAGPLRAGKGTTFE 332 Rhodopirellula ...
WP_035214891 226 sktAGPYGDVISEIDSIVGRLLDKLKAlSLDQNTVVILTSDNGPWf-----------------eGSSGPLRDRKGGMAYD 288 Acidobacteriace...
EJU11930     231 -kmASAYGEVVEEIDAIVGALMVKLRTlGLDRDTLVLFTSDNGPWy-----------------eGSSGPLRDRKGGAGYD 292 Sphingomonas sp...
WP_042367652 245 -skAGAFGDAVEYLDNTVGVIMDMVKRlKIEDNTWIIITSDNGPLihkdkelencygrfgetdpSRKHLLRGGKYQEKYD 323 Bacteroidaceae ...
WP_015884458 212 -srNGGYGGAVAALDWSTGVVMDTLRRlGLEENTIVVFTSDNGSRar---------------geGGSNDPLRGHKAQTWE 275 Beutenbergia ca...
EDM25411     249 -sdHGLYGDMIEEIDWSVGEVIKALQEnGIEKKTIIAFTSDNGADskpnk----------ehaeKGSNLPLKGWKGSSEE 317 Lentisphaera ar...

Feature 1                                                                                        
4FDJ_A       290 GGMREPALAWWPGHVTa-GQVSHQLGSIMDLFTTSLALAGLTPPsd--rAIDGLNLLPTLLQGrlm---drPIFYYrgd- 362 human
EEF57355     301 GGMREPTLAWWPGKVPa-QSVCDTVAGNIDLLPTFVKLAGGTLPkd--kKIDGRDISNLLLGQtke--aqrEAHYYfag- 374 Pedosphaera par...
WP_040422018 267 GGMRAPCIVEWPEMMRrkGLAYEHPASVVDLLPTFCEAANVPINtq--rTYDGTSILQALQSGrpv--etkPVAYYrin- 341 Actinopolymorph...
NP_868076    311 GAFRVPTIAWHPGKVPa-GTQCDELATTMDLLPTFANLAGCKLPtn--rKLDGHDIAPILFGApnaktpheAFYYYhqd- 386 Rhodopirellula ...
NP_869252    333 GGQRVPCIMWAPGRIPa-GTSSNAFATNMDLLPTIASFTGVALEnd--rKIDGIDLTSTFTSDesa---rdEFVFYsah- 405 Rhodopirellula ...
WP_035214891 289 GASRVPFIAWAPSLIQp-GTKTNSIISGIDLLPTFCHLSGLPLPqg--vELDGRDISQVLTSGaas--phdEIVLFnne- 362 Acidobacteriace...
EJU11930     293 GGYRVPCIAWQPGTVPa-GLRCDSIAMGIDFLPTFCAMAGTPVPag--pVIDGKDISQILLRGaes--pheSLLLFdde- 366 Sphingomonas sp...
WP_042367652 324 GGIRVSCVFSWPGVIPa-GTVCNELATSMDLFTTMALVSGATVPtd--rPIDGKNILPLLKKEknassphkAVFGFrpr- 399 Bacteroidaceae ...
WP_015884458 276 GGQRVACVVRWPAAIPa-GGVCDAVTRSIDLLPTFAAVAGAADWadparPVDGVDLTALLTGAgpa--pneTFAYYymd- 351 Beutenbergia ca...
EDM25411     318 GGVRVPFVLSWPGTLPe-GKKTNEIASLMDIFPTYAALAGIEPEvp--qKIDGNNIFPIMMCEpdvk-spnKYIFYagnt 393 Lentisphaera ar...

Feature 1                                                                            
4FDJ_A       363 -tlMAATLGqHKAHfwtwtnswenfrqgidfcpgqnvsgvtthnledhtklPLIFHLGRDPGERFPLS 429 human
EEF57355     375 talQAVRSGpWKLAivpqyegmgkfs--------------enaveggkpfaPRLYNLDEDIGEKTDVV 428 Pedosphaera parvula Ellin514
WP_040422018 342 -slNAMRFGrWKVHvrrvlnpptpg----------------rvgwsataemPQLFDLSVDEGECYDLS 392 Actinopolymorpha alba
NP_868076    387 -qlQAVRSGpWKMFlpvdaspghp------------------hfnatqeptTLLFNVVDDIACQHNVA 435 Rhodopirellula baltica SH 1
NP_869252    406 gvlEGIRMGdWKYLrqvarrgpn-------------------akgpkpepkVFLFDLSQDIGEKNNLV 454 Rhodopirellula baltica SH 1
WP_035214891 363 -dvVGIRTQqWKFVdenywrggi--------------------tnfsnrkyKQLFDATTDISESYSLA 409 Acidobacteriaceae bacterium...
EJU11930     367 -evTGIRTQrWKYVaqtyyhgh---------------------lmsvttryPQLYEVAKDPGENYSVN 412 Sphingomonas sp. LH128
WP_042367652 400 ggiESVRFKhWKLImpqtdk-------------------------qgkeqpAQLYNLQEDEGEQTNVA 442 Bacteroidaceae bacterium MS4
WP_015884458 352 -dlEAVRVGdWKLHlskr-----------------------------rdpmRELYDLRTDAAETHDVA 389 Beutenbergia cavernae
EDM25411     394 pkiTGVRNHrFKYStk----------------------------------tSGLYDMHADIGETTNVA 427 Lentisphaera araneosa HTCC2155

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