5ZX5


Conserved Protein Domain Family
LSDAT_euk

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pfam18139: LSDAT_euk 
SLOG in TRPM
Family in the SLOG superfamily, found in several eukaryotic channels including diverse ciliate channels and the TRPM class of animal ion channels. Positioned near the N-terminus of all TRPM channels, it is predicted to play a regulatory role for the channel in potentially recognizing a universal nucleotide or nucleotide-derived ligand.
Statistics
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PSSM-Id: 465665
Aligned: 29 rows
Threshold Bit Score: 313.746
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5ZX5_A        105 AKYVRLSYDTKPEIILQLLLKEW-------QMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNT 177 
EYB91093      220 AQFVRASFDTDPAALSYLFHKIW-------KLPPPKLVITIHGGLTNFDLQPKLARIFRKGILKAARSTDAWIITSGLNT 292 
EFO93718      207 AQYARVSFDSDPRDIVHLMMKVW-------KLKPPKLIITINGGLTKFDLQPKLARTFRKGIMKIAKSTDAWIITSGLDE 279 
CEF65614      158 AYYCRVGFDSNPKDILYLMENIW-------KLETPNLVITIHGGMTNFEVQQKLGKVFREGLLKAAQTTGAWIITSGIDS 230 
EYC46003      171 AQYIRLGYDSDPENVMYLMEKVW-------GLQPPKLVITVHGGMTNFEVQEKLGRMFRDGLLKAAQTTGAWIITGGLDS 243 
EDO47658       34 AKYIRLAHDTDPELVLRLLCGEW-------ALDLPKLLISVTGGAKNFILSPKIKRVLREGLLKAAQTTGAWVITGGTNT 106 
XP_001749743   91 APYVRVSLKDDAQDVLKFVQANLyrhfgnrNYPAPSLILSVTGGAQSFDLPPRLRDAIKRGLTKAVASTDAWVVTGGTHS 170 
XP_004996225   74 APFLCLSKDDSPTDALEFVEAMMnag-aqhRFVKPNLVLSVTGGATSFALSRHLEEALTKGISNVVRRTNAWVVTGGTHT 152 
EGD73753       84 APYLRLSVNDNPEDALLFVKGMLtqk-ygeTYDRPSLILSVTGGARNFTLPPRLETAIAKGLRLAAQRTNAWVVTGGTNT 162 
XP_004993318  108 APYLRLSVNDDPEDALLFVKAMLaqk-ygeTYDRPSLILSVTGGARNFTLPPRLETAIAKGLRLAAQRTNAWVVTGGTNT 186 
5ZX5_A        178 GVAKHVGDALKEH-----AS-R--SSRKICTIGIAPWGVIENRNDLV---GRDV-VAPYQTLL-NPLSKL-NVLNNLHSH 243 
EYB91093      293 GVVPHVASALEDL-----GS-TsrSRTRVVSIGVAPWGMLKRRNRFI---GTDI-SVHYAPNQ-FNKSRL-AELNDRHSY 360 
EFO93718      280 GVVRHLDSALHDQ-----GThH--AAKKHVAIGIASWGMLKQRNRFV---GKDS-TVTYATNV-FNNTRL-KELNDNHSY 346 
CEF65614      231 GVVRHVARALDDA-----GI-SarMRSKIILLGIAPYGLLSNREKFI---GKNI-VIPLDHQPySVRNNY-TMLNDRHSY 299 
EYC46003      244 GVVKHVAQALDDA-----GI-SarMRSKIVTIGIAPWGVIKRKERLI---AKDA-QIQYDPHAfGSSTGL-GVLNDHHSY 312 
EDO47658      107 GVMRHVGEAVKGHtvmsrGEqLknTAHQVHLIGIASWGIVDHKEMLV---NPKVeVVPYQMTS-SMQSRG-ACLDNNHSH 181 
XP_001749743  171 GVMQLTGSIMSDL--------L--RDRFVPVVGVITWGILKDRKEME---QPQYrAKPYVVQD----QMF-KCPDHNHNM 232 
XP_004996225  153 GVMRLTGSIMDSL-----YKsQ--KNIASPTIGIATLGVLAQQEALL----KGA-TVNHDLAG---KSKG-VNLDPNHTC 216 
EGD73753      163 GVMKLTGQIMEAL-----SKtQ--SHFIPPTIGIATFGVIVGGADLSa-tGSNEpPKRDHLFDiTKKDGFkAPLDPNHNL 234 
XP_004993318  187 GVMKLTGQIMEAL-----SKtQ--SHFIPPTIGIATYGVIIGGDDMTrgePPKI-GLEYEMHK-KDPPKT-TPLDDNHNL 256 
5ZX5_A        244 FILVDDGTVGKYGAEVRLRRELEKTINQQRIHarIGQGVPVVALIFEGGPNVILTVLEYLQEspPVPVVVCEGTGRAADL 323 
EYB91093      361 FVFADNGTVGRYGSEIILRKRLETYLAQH-----NSCSIPVVCVVLEGGAFTIKVVHDYITTipRIPVVVCDGSGRAADL 435 
EFO93718      347 FLFSDNGTVNRYGAEIILRKRLEAYLAQGDK---KRSAIPLICVVLEGGAFTIKMVHDYVMTvpRIPVIICDGSGRASDI 423 
CEF65614      300 FLLVDNGTVGRYGADMVLRKRFENYLSLPNNLfyPAKRIPIICVILEGGICTLESALQYVTSkpPCPVIVCDGSGRISDL 379 
EYC46003      313 FLLADNGTSSRYGADLHLRQNFEEFLAKGDDN--GLRKVPVVCAVLEGGTSTLKAIHQYLTKepNIPVIVCDGSGRASDL 390 
EDO47658      182 FILVDNGTDGEYGGEISFRASLENLIASKKMAq-kFHGVPVVLLVLEGGPNTIRTVLESVSRcpAVPVVIAEGSGRAADI 260 
XP_001749743  233 FVFVDSG-IDDFGGEIEVRAQFEQAAR-------VEYNAPTITIVIQGGPGTMKTAMESVRA--GNPIVVVDGSGLAADV 302 
XP_004996225  217 FLLVDDGSRGKFGVEIPFRAKLEKAIF-------DKCQASIISIVIQGGVGTLDTAFNAVKE--RTPLVVVNHSGGAADV 287 
EGD73753      235 FMLVDDGTT-EFGREITFRAAFEKAAA-------TAFGAPVITIVVQGGPGTLNTALQAVRQ--GTPIVVVDGSGLAADV 304 
XP_004993318  257 FLLVDDGSTNKFGKEIKFRAAFENAAG-------QAFAAPVVTIVVQGGPGTLGTALQAVRQ--GTPIVVVDGSGLAADV 327 
5ZX5_A        324 LAYIHKQTEEGGN-LPDAAEP-----DIISTIKKTF-NFGQSEAV--HLFQTMMEC 370 
EYB91093      436 LAFTHHAIGDDGK-LSDSVRN-----QLMSLVEVVF-NYDEKNAG--RTVRQLIEC 482 
EFO93718      424 LAFAHQTVSQNGF-LSDNIRN-----QLVNIVRRIF-GYDPKTAQ--KLIKQIVEC 470 
CEF65614      380 LSFAQKNLLQNGL-LSPPVRN-----DLEILIKKIF-NADSNTAH--QILNTIMKC 426 
EYC46003      391 VAFASRYLDVDGV-FPVEVKE-----ELLSLISTVF-SETPKTPQ--QILDVIVEC 437 
EDO47658      261 LAFAHRFIAPSNG-EMSGVADvvehrQLLHKIEKSFaECSPEDRL--SIYQNVLKC 313 
XP_001749743  303 LAYAYQFLHSGNSrHRSHTVQ-----ELKAIIATQFaHLPGDKQV--DLMHQAFEC 351 
XP_004996225  288 IAYAYYLFHGEGS-EHSSLSGk----ALVGLVKKAFkPKTQADLN--KILQRVFDC 336 
EGD73753      305 LAYAYNFMHNPRSrFTSYTIE-----DLKTMVKNTF-NTGDDDAKltQLLDKALEC 354 
XP_004993318  328 LAYAYNFMHNPLTrFKSYTID-----DLRQKVAQTFnPKSSQQLT--NLLDSALEC 376 
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