Conserved Protein Domain Family
nicotinamidase_related

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cd01014: nicotinamidase_related 
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.
Statistics
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PSSM-Id: 238496
Aligned: 39 rows
Threshold Bit Score: 144.271
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
catalytic triadconserved
Feature 1:catalytic triad [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #                                                                          
NP_627545     8 ALVVVDVQKGFEEvdfwgt--rnnpaaDDNIAALIDAWQSAgrPVVFVRHdsvqagsplregyegngFKEYVEQRrgkgg 85  Streptomyces coe...
ZP_00037727   7 AIVVIDLQKGVCFdsspih---eletvTALVNKRIKTYETIgkPVIFVQHedaql-------vpqtkPWELLSELsi--p 74  Enterococcus fae...
NP_658289     6 ILIVIDLQNGVCYseehlf---dlknlLTKVNKRISSYRKLnkPIIFVQHcdddl-------vpekeLWAIHSDLdv--q 73  Bacillus anthrac...
NP_785243     4 VLIIIDMQVGVCRgsqpvt---nlatvIAGIQQRITSYRAQnkPIVFVQHhdadl-------vtgsaDWQMIPELpi--e 71  Lactobacillus pl...
NP_268211    18 ALIVIDMQNEVCAgiyr------reelIEQINQRILTYRKAkkPIIFIQHnddel-------ikesfGWQMIPELlt--a 82  Lactococcus lact...
NP_816701     5 ALLLIDFQKGIESptqqly---rlpavLDKVNQRIAVYRQHhaPIIFVQHeetel-------pfgsdSWQLFEKLdt--q 72  Enterococcus fae...
NP_691200    21 LLLIIDVQQDLVDgndteqpvflkeelISTINDVIEKARNEnmPVVFVRDldvag--------gsgeGFDVHRNIhv--p 90  Oceanobacillus i...
NP_655497     4 ALLIIDAQQELMDgneqehevfrktdlLATLNTAVQKAIDAnaLIVFVRDidvas--------gsgeGFEVHNQIqv--p 73  Bacillus anthrac...
ZP_00086318   4 ALLIIDVQRALCTgeyech---dikrvIDTINGLSARARQSgvPVVLIQHnekdsp-----fahgaeGWQLADGLat--a 73  Pseudomonas fluo...
ZP_00026483   4 ALLVIDVQQGLCEgdevpl---ahheiIDRINDVAGKARTArvPVIFIQHesaddy-----lpygsaRWHLADGLta--l 73  Ralstonia metall...
Feature 1              #                                 #                                      
NP_627545    86 GAELLVTKSVNSAFLGApDLGAWLRaaGIRQLVLAGIQTNMCVETTARMGGNLGYEVVVPLDATYTFGlegpfgWRQSAD 165 Streptomyces coe...
ZP_00037727  75 EHSYFVRKTHANSFYKT-NLSVLLTelDCHSIELCGAQAEYCIDTTVKFAHGLGYQLMMCRGATTTYDn-----PFMKAK 148 Enterococcus fae...
NP_658289    74 EQDFFIRKTHANSFFKT-NLIEILDqlSVQRIEFCGAQTEYCMDATIKFAHGLGYENFMVQKATSTLNn-----PFMSAK 147 Bacillus anthrac...
NP_785243    72 ATDIVVQKTHANAFYHT-DLQAQLTaiGCQTLEICGAQVEFCVDTTVKMAHGLGYHLEMVRGLTTTTAn-----SMMSAQ 145 Lactobacillus pl...
NP_268211    83 STDKYVEKTHANGFYQT-ELQKLLTdlSVKLIEFCGAQTEFCVNTTLVFAHGLGYQNWMQRGASSTFDs-----KWLSAK 156 Lactococcus lact...
NP_816701    73 PTDFFIRKTHANAFYQT-NLNDLLTeqAVQTLEIAGVQTEFCVDTTIRMAHGLGYTCLMTPKTTSTLDn-----GHLTAA 146 Enterococcus fae...
NP_691200    91 ENARFFNKSATNAFYGT-GLLEYVKgeKFNHLIIMGCETQHCIDSAVRTATINGMDVTLVGDGHSTKGn-----EVLSGE 164 Oceanobacillus i...
NP_655497    74 QSAILINKAATNSFYGT-SLLELLKeeKINHIVIGGCKTEHCIDTAVRTATVEGFDVTLIKNGHSTTDs-----TVLSAE 147 Bacillus anthrac...
ZP_00086318  74 PGDLRVDKTANDSFYQT-NLQKLIPreDFDRLVICGLQTDYCVNATVRQAHQLGYDVELAADAHSTVDn-----GNMSAE 147 Pseudomonas fluo...
ZP_00026483  74 DSDLRVRKTTPDSFFGT-TLEATLKehGVTHLVICGMHTEYCVDTTTRRALALGYPVRLIADGHTTVSn----aALSAGQ 148 Ralstonia metall...
Feature 1             
NP_627545   166 ELARAS 171 Streptomyces coelicolor A3(2)
ZP_00037727 149 ETIAFY 154 Enterococcus faecium
NP_658289   148 ETIDFL 153 Bacillus anthracis str. A2012
NP_785243   146 QTIDFY 151 Lactobacillus plantarum WCFS1
NP_268211   157 EIVDFY 162 Lactococcus lactis subsp. lactis
NP_816701   147 QIIQHH 152 Enterococcus faecalis V583
NP_691200   165 QIIRHH 170 Oceanobacillus iheyensis HTE831
NP_655497   148 QIIDHH 153 Bacillus anthracis str. A2012
ZP_00086318 148 DIIAEH 153 Pseudomonas fluorescens PfO-1
ZP_00026483 149 IIHHHN 154 Ralstonia metallidurans

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