Conserved Protein Domain Family
Fdhalpha-like

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TIGR01701: Fdhalpha-like 
oxidoreductase alpha (molybdopterin) subunit
This model represents a well-defined clade of oxidoreductase alpha subunits most closely related to a group of formate dehydrogenases including the E. coli FdhH protein (TIGR01591). These alpha subunits contain a molybdopterin cofactor and generally associate with two other subunits which contain iron-sulfur clusters and cytochromes. The particular subunits with which this enzyme interacts and the substrate which is reduced is unknown at this time. In Ralstonia, the gene is associated with the cbb operon, but is not essential for CO2 fixation.
Statistics
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PSSM-Id: 273765
Aligned: 5 rows
Threshold Bit Score: 1125.67
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P77561        11 AAGGWGAVKSVANAVRKQMDIRQDVIAMFDMNKPEGF--------DCPGCAWPD--------PKHSASFDICENGAKAIA 74  Escherichia col...
Q10821        34 EAAGVRAVMVSLQRGMQQMGALRTAAALARLNQRNGF--------DCPGCAWPEe-------PGGRKLAEFCENGAKAVA 98  Mycobacterium t...
BAB73018      13 agGGLPVIQYWVEQTLSP----QGLQLWQTLNHKS----------ACLSCAWGTggqkggfvNEAGEYLQRCAKSVEAIA 78  Nostoc sp. PCC ...
WP_010898681  17 DPSLWAGKVPLGLGKVKPKHIRDTLKVALENRDNLGYayriltqgVCDGCALGVsg----lqDQTLAGPHLCTTRLNVLR 92  Bacillus halodu...
WP_010916153  16 PAGGWGSAKSVAAIIAREHVLLRDPKLLSTQNKPEGY--------MCVSCAWAK--------PAQPHPLEFCENGAKATA 79  Mesorhizobium loti
P77561        75 WEVTDKQVNASFFAENTVQSLLTWGDHELEAAGRLTQPLKYDAVSDCYKPLSWQQAFDEIGARLQSYSdPNQVEFYTSGR 154 Escherichia col...
Q10821        99 EEATKRTVTAEFFARHSVAELSAKPEYWLSQQGRLAHPMVLRPGDDHYRPISWDAAYQLIAEQLNGLDsPDRAVFYTSGR 178 Mycobacterium t...
BAB73018      79 AELQPG-IKQEFFQEHSISELQNLTSQECDRLGRLSYPLILrSGSSHYQRISWEEVYQIATQAFNFP--PARVASYSSGR 155 Nostoc sp. PCC ...
WP_010898681  93 LNTMPA-IDPKWLDD--VEELRKLDSTELRKLGRIPYPLSRKPGEKRFTRISWDDALNRIAAKIKAID-PKQLAFYLTAR 168 Bacillus halodu...
WP_010916153  80 WETTSRRAGPAFFANHTLSELETWSDHDLEEQGRLTHPMRWDAASDKYIPVAWSDAFDEIGRELRSLD-PHQVDLYTSGR 158 Mesorhizobium loti
P77561       155 -TSNEAAFLYQLFAREYGSNNFPDCSNMCHEPTSVGLAASIGVGKGTVLLEDFEKCDLVICIGHNPGTNHPRMLTSLRAL 233 Escherichia col...
Q10821       179 -TSNEAAFCYQLLVRSFGTNNLPDCSNMCHESSGAALTDSIGIGKGSVTIGDVEHADLIVIAGQNPGTNHPRMLSVLGKA 257 Mycobacterium t...
BAB73018     156 -SSNEAAYLLQLFMRSLGSNNLADCSDLCHAPSTVGLKKVFGSGTSMVSLESLKHSDCLVLIGSNAPANHPRLMNELIKL 234 Nostoc sp. PCC ...
WP_010898681 169 gITNEVYYTAAKVARFLGTNNIDNASRICHSPSKTALKRSLGIGASSCNYQDWIGTDVLVFWGSVAANNQPVSTKYMYAA 248 Bacillus halodu...
WP_010916153 159 -ASLETSYMYQLFARMYGSNNLPDSSNMCHEGSSVALPESIGSSVGTAILSDFENTDCIFYIAQNVGTSSPRMLHDLQDA 237 Mesorhizobium loti
P77561       234 VKRGAKMIAINPLQERGLERFTAPQNpFEMLTNSETQLASAYYNVRIGGDMALLKGMMRLLIERDDAASaagrP------ 307 Escherichia col...
Q10821       258 KANGAKIIAVNPLPEAGLIRFKDPQK-VNGVVGHGIPIADEFVQIRLGGDMALFAGLGRLLLEAEERVP----G------ 326 Mycobacterium t...
BAB73018     235 RERGGKVIIINPQVEIGLVKFASPAFpIKSLLTGGSDISSLYLQPIPGSDVALFVGLQKSLIEQN--------------- 299 Nostoc sp. PCC ...
WP_010898681 249 KKAGTKIIMINPYREPAMENYWIPSIpESALFG--TQIVDDVFQVNIGGDIAFMNGVMKHWFEMEKEQP----G------ 316 Bacillus halodu...
WP_010916153 238 VNRGVKIVTFNLLRERGLERFVNPQS-PQMLTGKETKISSEYYQVRSGGDIAALFGVCKALIEADDALKasgaSrvagqd 316 Mesorhizobium loti
P77561       308 ------------------------SLLDDEFIQTHTVGFDELRRDVLNSEWKDIERISGLSQTQIAELADAYAAAERTII 363 Escherichia col...
Q10821       327 ------------------------SVVDRSFVDNHCAGFDGYRRRTLQVGLDTVMDATGIELAQLQRVAAMLMASQRTVI 382 Mycobacterium t...
BAB73018     300 -------------------------LIQTEYLNAYTQNWQKVVDYANHISWNDITNTCGISQEEITATAYIIGKSARVVF 354 Nostoc sp. PCC ...
WP_010898681 317 ------------------------SAIDHAFIANHTNGFAELKEHVEQLNWNDIVKSAGLSKERILEFAKLLANSRSGVF 372 Bacillus halodu...
WP_010916153 317 gkpkdqdnaamvafaasmasadnkHVLDHDFIHEHTTGFEEFAQAARAHQWDELERVSGLSRAEMMQAATTYANASAVMM 396 Mesorhizobium loti
P77561       364 CYGMGITQHEHGTQNVQQLVNLLLMKGNIGKPGAGICPLRGHSNVQGDRTVGIT------EKPSAEFLARLGERYGFTPP 437 Escherichia col...
Q10821       383 CWAMGLTQHAHAVATIGEVTNVLLLRGMIGKPGAGVCPVRGHSNVQGDRTMGIW------EKMPEQFLAALDREFGITSP 456 Mycobacterium t...
BAB73018     355 AWAMGVTQQANGVDNIFSIANTALITGNAGKIGAGTMPIRGHSNVQGFGSMGVT------VNLREEIKQALSQVLGKTLN 428 Nostoc sp. PCC ...
WP_010898681 373 IWSMGLTQHRFATDNISQVANLALLQGFIGRKHCGVMPIRGHSGVQGSGEMGADpfvlpgGDFEPEHKKRIEAIWGFHIP 452 Bacillus halodu...
WP_010916153 397 VYGMGLTQHLMGVENVHMVCNLALLRGNIGKPGANICAVRGHSNVQGQRTVGIT------EKPGLAPLDKLSQLYGFEPP 470 Mesorhizobium loti
P77561       438 HAPGHAAIASMQAICT-----GQARALICMGGNFALAMPDREASAVPLTQLDLAVHVATK--LNRSHLLTARHSYILPVL 510 Escherichia col...
Q10821       457 RAHGFDTVAAIRAMRD-----GRVSVFMGMGGNFASATPDTAVTEAALRRCALTVQVSTK--LNRSHLVHGATALILPTL 529 Mycobacterium t...
BAB73018     429 ETPGYHTRDLIEAAET-----GKIDTLFCLGGNLYAANPDLEQAKQALSQIDTIFYVATKpnLGHFHGLAKQQTLILPVF 503 Nostoc sp. PCC ...
WP_010898681 453 DWQGDTVGQMLENVLLpddheRKVRLFYTSGGNFLETMPDPAFIQRVLENVELRVHQDIIf-NTSTLVDAKEEVIVLPAM 531 Bacillus halodu...
WP_010916153 471 TWTGRSTVETCEAIVN-----GQCRAFISLGGNFLKAIPDTAAMEEGWRKLHLSVQIATK--LNRSHVLHGEVAYLLPCL 543 Mesorhizobium loti
P77561       511 GRSEIDMQKNGAQAVTVEDSMSMIHASRGVLKPAGVMLKSECAVVAGIAQAALP-QSVVAWEYLVEDYDRIRNDIEAVLP 589 Escherichia col...
Q10821       530 GRTDRDTRNGRKQLVSVEDSMSMVHLSRGSLHPPSDQVRSEVQIICQLARALFGpGHPVPWERFADDYDTIRDAIAAVVP 609 Mycobacterium t...
BAB73018     504 NRFENPHKTTT---ESGNNFVRLNDEGKSHLQPRNADLISEIELITEIAHRLHS-ETPINWRKLQDT-TYIRELIAKTIP 578 Nostoc sp. PCC ...
WP_010898681 532 TRYEQPGGGTS------TSTERMVYFSPEIKGPRIEEARAEWDIYVELAKRVDP-E--RAHLIDFQTAQQIRDEIAVANP 602 Bacillus halodu...
WP_010916153 544 GRIEVDQQASGPQAVSIESSIAHFHGSRGKAKPAGAELLSEPAIVAGIAKATLG-ETKVPWDAWVGNYAQIRDAIERTYP 622 Mesorhizobium loti
P77561       590 -EFADYNQRIRHPGGFHLINAAA-E-RRWMTPSGKANFITSKGLLEDPSSAFns---------kLVMATVRSHDQYNTTI 657 Escherichia col...
Q10821       610 -GCDDYNHKVRVPDGFQLPHPPRdA-REFRTSTGKANFAVNPLQWVPVPPGR------------LVLQTLRSHDQYNTTI 675 Mycobacterium t...
BAB73018     579 -GYEKIATIDQTKQEFVIERRILeE-PKFTTSDGKAQMFVTPLPQLSVPTKAefgvsenqpgivLILGTGRSYGQHNTVV 656 Nostoc sp. PCC ...
WP_010898681 603 -NYDGIQHLKNRGDVFQWGGAWLcEgGVCPTPDGRGNLLPIDLPEFRRTEGH-------------FYVTSRRGKQFNSMV 668 Bacillus halodu...
WP_010916153 623 eTFKDFNKRLFQPGGFARPVPAR-E-RKWVTKTGKANFITPHRLFPEFSTSGra--------dvLHLSTLRSNDQFNTTI 692 Mesorhizobium loti
P77561       658 YGMDDRYRGVFGQRDVVFMSAKQAKICRVKNGERVNLIALTPDGk--rSSRRMDRLKVVIYPMADRSLVTYFPESNHMLT 735 Escherichia col...
Q10821       676 YGLDDRYRGVKGGRRVVFINPADIETFGLTAGDRVDLVSEWTDGqgglQERRAKDFLVVAYSTPVGNAAAYYPETNPLVP 755 Mycobacterium t...
BAB73018     657 YRSEDKYRGMP-HRLCILMNYFDVKKAGLQEHQRVTVKGD---------KGKLDNIEIICGAILEGVAFMFYPEANVLFK 726 Nostoc sp. PCC ...
WP_010898681 669 YSETDPFNGAD--RYDVIMNETDGKKLNIRNGESIVVYNQYG---------TFQG-RACFGDTQTGNIAVYWPEGNMLLP 736 Bacillus halodu...
WP_010916153 693 YGYSDRFRGVEGTRRVVFMNGEDISRLGFVDGEHIDVTTAIDDN----NIRKVTNLRIVQYNIPKGCCAAYYPEANPLFP 768 Mesorhizobium loti
P77561       736 LDNHDPLSGIPGYKSIPVELEPS 758 Escherichia coli K-12
Q10821       756 LDHTAAQSNTPVSKAIIVRLEPT 778 Mycobacterium tuberculosis
BAB73018     727 AK-IDPQSGTPAYKRVPVCILAP 748 Nostoc sp. PCC 7120
WP_010898681 737 KGVYETHAKIPEYNTTVIVEKAE 759 Bacillus halodurans
WP_010916153 769 FAHHDPKAKTPSYKLLPVRLTRS 791 Mesorhizobium loti
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