Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing
This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Feature 1:ATP binding site [chemical binding site]
Evidence:
Comment:based on structures of the HATPase domain of human Hsp90, Escherichia coli DNA gyrase B, and other related proteins, bound with ATP, ADP or their analogs; contacts at 4A
Jiyao W et al.(2023). "The conserved domain database in 2023.",