Conserved Protein Domain Family
mena_SCO4494

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TIGR03700: mena_SCO4494 
putative menaquinone biosynthesis radical SAM enzyme, SCO4494 family
Members of this protein family appear to be involved in menaquinone biosynthesis by an alternate pathway via futalosine, based on close phylogenetic correlation with known markers of the futalosine pathway, gene clustering in many organisms, and paralogy with the SCO4550 protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Statistics
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PSSM-Id: 213851
Aligned: 9 rows
Threshold Bit Score: 594.735
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_003956176   9 LEAKVTAGERLSREDGIALYA-SDDLAWLGGLAHEVRTRKNGDVVHFNVNRHLNMTNVCTASCAYCSFQRKPGEKDAYTM 87  Streptomyces cl...
WP_010941110   8 ISGRVHAGERISDEEALFLFE-SRDPLAVGELAAAVNRRRNGDRVFFNVNRHINHTNICVNRCSFCAFYRAADEPGAYLY 86  Geobacter sulfu...
WP_005997632  11 VCDKVARGERISDQDALDLFN-SDDLFGIGQLAAEINEKKNGNRVFFNVNRHLNYTNFCVNQCRFCAFCHEPGQPGGYAY 89  Desulfuromonas ...
WP_011172898  12 IAEKVMEGKRLSFEDGLVLYQ-TKDLPTLMRLANLVRERKHGHKTYFVHSIRVSQTNICYVGCTFCAFQRRFGEEGAWDW 90  Thermus thermop...
WP_007339462  13 IRDKVESEQRLSMEDGLFLYEpEVSIQQVGELANFVRERKNGNVGYYNINTHLNPTNVCVYRCRFCAFRKDLRDENGYAM 92  Rhodopirellula ...
WP_010887011  12 IVEKVEAGQRLTFDEGMQLFH-TRDLNTLMRLADLQKRQLHGDKVFFVHSMRLEFTNICYVGCTFCAFAARKGEERAWDY 90  Deinococcus rad...
WP_010940022  15 IRDKVMAGHRLSYDDGLRLFA-CPDITAIGALAHHVRTRLHGDRTYYVVNRQVNYTNICVNGCLFCAFQRERGQQGAFAL 93  Desulfovibrio v...
WP_011339991   7 IAAKVEAGHRLSEAEAVFLLQ-SSDLLAVGELAALANRRLHGDKVYFNVNRHINYTNICVNNCAFCAFRRDDGAAGGYTL 85  Pelobacter carb...
WP_000346642   3 FLEKVLDNQVTESKELVRLYD--YDLYTLGEVADRMRQNMHQKIVYFNVNRHLNPSNICADACKFCAFSAHRKNPNPYEM 80  Helicobacter py...
WP_003956176  88 RIEEAVRLAKAMESDNLTELHIVNGLHPNLPWRYYPRSLSELKKALPDVSLKAFTATEIHHFETISGLSASDILDELIEA 167 Streptomyces cl...
WP_010941110  87 DLEEIRNRAAEAHAQGATEIHIVGGLHPDLPFDFYLAMLRTVKEVSPDLHVKAFTAVEIEYLSRLAGLSTAETLTVLKEA 166 Geobacter sulfu...
WP_005997632  90 HLSEILEKAAEASAAGATELHMVGGLHPELPFEFYLRMITTIKANNPNLKIKAFTAVEVDYFSKISKLPVETVISEMKRL 169 Desulfuromonas ...
WP_011172898  91 DVDEVVAWVKERYQPGLTEIHLTAGHHPKRPFAYYLDLVRALKENFPGVQVKAWTAAEIHHFSKIARLPYREVLKALKEA 170 Thermus thermop...
WP_007339462  93 SDEQILHRGAEATANGCTEMHIVGGLHHQRKYEWYRDIISMLKENYPKIHLKAWTAVEIDWFRFQTKKSFEWVLDDMRSA 172 Rhodopirellula ...
WP_010887011  91 DPDEVVAQVGRRYLPGITELHMSSGHHPNHKWEYYPAMVQKLREAYPDLQVKAFTAAEIEHLSKISKKPTREVLAELQAA 170 Deinococcus rad...
WP_010940022  94 TPDEMVARVMDDGGVPFSEVHIVGGCHPDLPLEWFEDVIRRIHAARPSIVVKAFTAVEIAHFAKLAGIDTEEVLRRLKAA 173 Desulfovibrio v...
WP_011339991  86 SLEQVAARAKQAAAAGATEVHVVGGLHPHLPLAFYEQILRTIRESGPDLHIKAFTAVELAHFSAISGRPLEEVIGRLQAA 165 Pelobacter carb...
WP_000346642  81 SLEEILEKVKNSYNKGIKEVHIVSAHNPNYSYEWYLKVFETIKQEMPNLHLKAMTAAEVHFLSVKFNKPFELVLEDMLKA 160 Helicobacter py...
WP_003956176 168 GLESLTGGGAEIFDWEVRQHIVDHRTHWEDWSRIHRLAHSKGLKTPSTMLYGHIEEPRHRVDHVLRLRELQ-------DE 240 Streptomyces cl...
WP_010941110 167 GLGSLPGGGAEIFAPAVRNRLCPEKISGDKWLAIMEEVHRAGLKSNATMLYGHIESYADRVDHMRRLRELQ-------DR 239 Geobacter sulfu...
WP_005997632 170 GLDSTPGGGAEILGAEVRQQICPEKISGERWLEVTQKIHEGGLKSNATMLFGHVEGYADRVDHMAKLRELQ-------DR 242 Desulfuromonas ...
WP_011172898 171 GLDAMPGGGAEIFAERVRRKIARAKVSAEGWLEIHRTAHELGIPTNATMLYGHIETLEERLDHMDRLRRLQ-------DE 243 Thermus thermop...
WP_007339462 173 GLGSMPGGGAEIFHPEVRDQLCEHKANTPAWLEIHRTAHQIGLKTNCTMLYGHVEKAYHRIDHLMRLRELQ-------DK 245 Rhodopirellula ...
WP_010887011 171 GLSAMPGGGAEIFADRVRKQVAKNKVKAEKWLQIHREAHELGMRTNATMLYGHIETLEERLDHMHRLRELQ-------DQ 243 Deinococcus rad...
WP_010940022 174 GLSQLPGGGAEIFAPDVRQRICPRKIDAEAWLRVAGEAHRLGIGTNCTMLFGHLESEADRVDHLCRLRAQQ-------DE 246 Desulfovibrio v...
WP_011339991 166 GLQSLPGGGAEVFAERARAHLCPEKISGTRWLEVMRTVHQAGLRSNATMLFGHLETPVERIEHLARLRALQ-------DE 238 Pelobacter carb...
WP_000346642 161 GVDSMPGGGAEIFDEEIRRKICNGKVGSSRWLEIHAYWHKLGKMSNATMLFGHIENKIHRIDHMLRIKKIQspknqveNK 240 Helicobacter py...
WP_003956176 241 TGGFQVFIPLRYQhdfvdmKDGKVRNRLQARttMATGAEALKTFAVSRLLFDNVPHVKVFWVMHGLQTAQLALQHGADDM 320 Streptomyces cl...
WP_010941110 240 TGGFQVFIPLAFQ------KDNNPLGHLKRP--GPGGVDALLTLAVARIYLDNFANIKAYWVMLGVKIAQTSLAFGVNDL 311 Geobacter sulfu...
WP_005997632 243 TGGFQSFIPLAFQ------PDNTRIPN--AK--GPDGIDCLKTLAISRIYLDNFQHIKAYWVMLGLKIAQVALAFGVNDL 312 Desulfuromonas ...
WP_011172898 244 TGGFMSFIPLAFQ------PDGNQLARELGKkeFTTGLDDLRNLAVARLYLDNFPHIKGYWATLTPELAQVSLDWGVTDV 317 Thermus thermop...
WP_007339462 246 TNGFQVFIPLAFH------PDNTKLSDL--K--KPSGLMDLRTMAISRLMLDNIQHIKAYWIMLGIETAQTALAYGADDI 315 Rhodopirellula ...
WP_010887011 244 TGGFHAFIPLAFQ------PLGNTLAQNLGKteYTTGLDDLRNLAVARIYLDNFPHIKGYWVMIGSELTQVSLDWGVSDI 317 Deinococcus rad...
WP_010940022 247 TGGFTCFIPLPFL------TENSLLKLPPERvgQHVGLDRLRTVAVSRLMLDNIAHIKAYWVMMGVKLAQVALHYGANDL 320 Desulfovibrio v...
WP_011339991 239 TGGFQAFVALPFQ------DVGTRLDGV--R--GPGGVEILKTLAVARLFLDNISHIKAYWVMLGVKLAQVALAFGVNDL 308 Pelobacter carb...
WP_000346642 241 EGGFNAFIPLLYQ------KENNYLNVE--K--SPSAIEILKTIAISRILLNNIPHIKAYWATLGLNLALVAQEFGANDL 310 Helicobacter py...
WP_003956176 321 DGSVVEYKITHDADNyGTPNKLTRDDLLELIRDAGFRPVERNTRYEII 368 Streptomyces clavuligerus
WP_010941110 312 DGTVVEEKIGHDAGA-ASPQTMGRDEIVSLIRTAGRVPVERDTLYNEL 358 Geobacter sulfurreducens
WP_005997632 313 DGTVIEEKIGHDAGA-DSPQELSKAELLRQIRGAGKLPVERDTLYQQV 359 Desulfuromonas acetoxidans
WP_011172898 318 DGTLIEERIVHMAGS-PTPQGLTKRELARIILMAGRIPVERDALYREV 364 Thermus thermophilus
WP_007339462 316 DGTVRHELIYHDAGA-KTPEFMSVDQIKDLIREAGRDPIERDTTYNRV 362 Rhodopirellula baltica
WP_010887011 318 DGTIQEEHIAHAAGA-TSPMALSQAGMVKMIQSAGRVPVLRDAYYNEL 364 Deinococcus radiodurans
WP_010940022 321 DGTIVEEKIGHMAGS-DAVQAMTIAQLEDMIRRSGFTPVRRDTHFNPV 367 Desulfovibrio vulgaris
WP_011339991 309 DGTVVEEQIGHQAGA-ASPQALSREGLVRMILRAGRTPVERDSLYQDL 355 Pelobacter carbinolicus
WP_000346642 311 DGTIEIESIQSAAGA-KSRHGLEKEDLIFKIKDAGFVAVERDSLYNFI 357 Helicobacter pylori
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