Conserved Protein Domain Family
NERD

?
pfam08378: NERD 
Nuclease-related domain
The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins. It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing.
Statistics
?
PSSM-Id: 462454
Aligned: 352 rows
Threshold Bit Score: 32.0375
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_011778295    63 ASMNAE-EAVET-ALR------KAGwKHVFLRRRVFVPR----------LQhNREIDVVAVGPV-VLVVEVKHWRG---- 119
jgi:Nther_0442  84 KGVAGE-KLVRE-HLKe----qLSD-SYYLINNFYFFNNs------------PCEIDHIIVGPAgFVIVETKHLGG---- 140
Q144J1          41 PGEEGE-REVSA-ELRwhltrlCGE-NWEVLDGLVLIHApg-------sTFpTAEIDHLAITPFgVFVVETKHWAGv--- 107 Paraburkholde...
WP_013094393    37 SGDEGE-ALVQA-ELR------SAL-QWLCGENFYLHPGalllnhapgtKFpTAELDHLAITPFgIFVIETKNWAG---- 103 Paraburkholde...
mbdal:THA_862   62 KGDDGE-TDVSF-FLWi----cLSR-KAIIVNDVVLEVA----------KGeFIQIDHLIFHQKgIFVIETKNWNG---- 120
Q8RBY3          62 QGSSGE-NSVGW-ALHl----wLPS-SAVVINDLVLEVE----------PDeFIQIDHLVLNTNgIFVLETKSWDG---- 120 Caldanaerobac...
WP_006667874    56 KGSLGE-NLIALlLMT------FPD-NWVLFKNALIPAT----------AGsLTEIDLLLIGNRgIFLIEVKTWKG---- 113 Limnospira ma...
EAZ94129        56 KGEIGE-NLVSMlAIS------LPE-HWIMLKNALIPTT----------KGkLTEIDLLLIGEPgVFLIEVKTWKGs--- 114
jgi:Rcas_1002   63 KGATGE-HLVLH-AIAr----fLPH-SWVIAQGAILEPY----------PNwFTQIDHVLIGPPgIFLVETKAWSGs--- 122
jgi:Daud_0711   65 KGEGGEdSAFLNlWLM------LPR-DWIVLNDVVLEPK----------PDeFIQLDHVLIGPPgIYLVETKAWDGafla 127
XP_011778295   120 ----SVWCN------GQRWFQQVhktaralefedirednvvkaaalrrHIENdk--rVPLPDFNLLSDCLQESEg--dGT 185
jgi:Nther_0442 141 ----KLFVHp----cHYKWLRAPln----------------------nPDAIkkpmkNPLKQLERNVAEFKSLLs---EA 187
Q144J1         108 ----VTHGEtd---dTLTLTTVD-------------------------GQRCvr--tSPMKQNAAKVRFLRKLL------ 147 Paraburkholde...
WP_013094393   104 ----SILPGp----dAQTVVRIG-------------------------ADGQretrrSPLRQNRSKVGFLRGVL------ 144 Paraburkholde...
mbdal:THA_862  121 ----ALICD------KDIWRLK--------------------------VGNTwqevsSPSKQNQRHVRLL-LKW----FE 159
Q8RBY3         121 ----AFLGT------KDKWRMK--------------------------QGNKwvevqSPTKQNERHVKLFKKWL------ 158 Caldanaerobac...
WP_006667874   114 ----SLAGN------QDNWKRRE-------------------------GSQWvpvsnSPTSQSLYHQQMF-QRWifseIP 157 Limnospira ma...
EAZ94129       115 ----WTAYR-------DNWKRRE-------------------------GTKWipienSPTQQSLYHQKMFQQWLny-sLS 157
jgi:Rcas_1002  123 ---yFVQGDkwkrkdGHCWVNCS----------------------------------SPTRQADYHRNMW-LLW----MQ 160
jgi:Daud_0711  128 hkdnWKRKQ------GNRWVRCE----------------------------------SPTRQSLRHLLADVRTIy----- 162
XP_011778295   186 WYEDRrlhkqcgtVIIPVVVFT 207
jgi:Nther_0442 188 EMGEL--------PVQGVLVFP 201
Q144J1         148 PPRLW--------IVEGLGVFS 161 Paraburkholderia xenovorans LB400
WP_013094393   145 -PGTW--------PVEGLGVFA 157 Paraburkholderia atlantica
mbdal:THA_862  160 NNLPErlyekikdYVFPVVVFP 181
Q8RBY3         159 EENLPdlherikdHIHPIVIFK 180 Caldanaerobacter subterraneus subsp. tengcongensis
WP_006667874   158 SLPTD--------CITAPVVFP 171 Limnospira maxima
EAZ94129       158 GFNRD--------LVVAPVIFP 171
jgi:Rcas_1002  161 QHVSGdfyrkiipLIHSVIVLT 182
jgi:Daud_0711  163 ------------pDFFGKHALS 172
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap