1C4Z


Conserved Protein Domain Family
HECTc

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cd00078: HECTc 
Click on image for an interactive view with Cn3D
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.
Statistics
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PSSM-Id: 238033
Aligned: 48 rows
Threshold Bit Score: 302.562
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
E2 interactioncatalytic cleft
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:E2 interaction site
Evidence:
  • Structure:1C4Z; E6AP(E3)-UbcH7(E2) complex
  • Comment:A conserved Phenylalanine (Phe 63) of E2 is the primary determinant of specificity

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
1C4Z_A       6 LRLKVRRdhIIDDALVRLEMIamenpaDLKK-QLYVEFEGEQGVDeGGVSKEFFQLVVEEIFNPDIGMFTYDes---tkL 81   human
CAB92704  3708 LQLQVRRehVFHDSFRSLYYKka---dELKFgKLNIRFQGEEGVDaGGVTREWFQVLSRQMFDPNYVLFVPVssd--rtT 3782 Neurospora crassa
2224565   1549 MAVHVRRdhVFEDSYRELHRKsp---eEMKN-RLYIVFEGEEGQDaGGLLREWYMIISREMFNPMYALFRTSpgdrvtyT 1624 human
10039443  1229 IKLIIRRdhLLEGTFNQVMAYsr---kELQRnKLYVTFVGEEGLDySGPSREFFFLLSQELFNPYYGLFEYSand-tytV 1304 human
BAA92558   211 DILLVHRdsIFRSSCEVVSKAnc---aKLKQ-GIAVRFHGEEGMG-QGVVREWFDILSNEIVNPDYALFTQSad---gtT 282  human
T37900     317 LQLKVSRatTFEDAYDIISKLsv---sDMKK-KLLIRFRNEDGLDyGGVSREFFYILSHAIFNPGYSLFEYAtdd--nyG 390  fission yeast
7662052    462 VTLKVSRhaLLESSLKATRNFsi---sDWSK-NFEVVFQDEEALDwGGPRREWFELICKALFDTTNQLFTRFsdn-nqaL 536  human
AAF51314   607 MALKVQRekILESSMKAVKGFsv---sDWCG-NFEVTFQGEQGIDwGGLRREWFELVCSALFDARGGLFCTFhdk-hqaL 681  fruit fly
7503507    520 LCWKVSRdrLLDDAFRIILNVdp---fVLKKsRLHIRFEGELALDyGGLSREFFILLSRELFHPKNGYFEYEgn---dyH 593  Caenorhabditis e...
NP_192994  511 HEMLIDRsnLLSESFEYIVGAsp---eALHG-GLFMEFKNEEATG-PGVLREWFYLVCQEIFNPKNTLFLRSadd--frR 583  thale cress
Feature 1                                                                           #  ## ##  #
1C4Z_A      82 FWFNPSSfe---tEGQFTLIGIVLGLAIYN-------NCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY 151  human
CAB92704  3783 FHPNKLSpindehLPFFKFIGRIIGKALYE-------GRLLECYFSRAVYKRILGKPVSVKDMESFDPDYYKSLVWMLEN 3855 Neurospora crassa
2224565   1625 INPSSHCnp--nhLSYFKFVGRIVAKAVYD-------NRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN 1695 human
10039443  1305 QISPMSAfve-nhLEWFRFSGRILGLALIH-------QYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN 1376 human
BAA92558   283 FQPNSNSyvnpdhLNYFRFAGQILGLALNH-------RQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN 355  human
T37900     391 LQISPLSsvnpdfRSYFRFVGRVMGLAIYH-------RRYLDVQFVLPFYKRILQKPLCLEDVKDVDEVYYESLKWIKNN 463  fission yeast
7662052    537 VHPNPNRpah-lrLKMYEFAGRLVGKCLYEsslggayKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILN 615  human
AAF51314   682 VHPNPTRpah-lkLKHFEFAGKMVGKCLFEsalggtyRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILD 760  fruit fly
7503507    594 LQLRPRGcetekeKKWLILCGRVLALAVIH-------RCYIDVFFTNVFYKSLQKRPVTLMDFKESDAEFYKSMNWLLEN 666  Caenorhabditis e...
NP_192994  584 FSPNPASkvdplhPDFFEFTGRVIALALMH-------KVQVGVLFDRVFFLQLAGLKISLEDIKDTDRIMYNSCKQILEM 656  thale cress
Feature 1                # #   ## #                 #    #                #   #                
1C4Z_A     152 egn---vedDMMITFQISQTDl------------FGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILnkSVEKQFKAF 216  human
CAB92704  3856 di-----tdIITETFSVEDDV-------------FGEVKVVDLIENGRNIPVTEENKHEYVRLIVEHKLitSVKDQMKAF 3917 Neurospora crassa
2224565   1696 dvs----tlGYDLTFSTEVQE-------------FGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMtgAIRKQLAAF 1758 human
10039443  1377 ni-----tdILDLTFTVNEEV-------------FGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVerGVVQQTEAL 1438 human
BAA92558   356 dis----dlGLELTFSVETDV-------------FGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMtrAIQPQINAF 418  human
T37900     464 dv-----deSLCLNFSVEENR-------------FGESVTVDLIPNGRNIAVNNQNKMNYLKALTEHKLvtSTEEQFNAL 525  fission yeast
7662052    616 nd-----msEMELVFAEEKYNk-----------sGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLasQVKEEVEHF 679  human
AAF51314   761 tdld--atdTLELYFVEEMYDss----------sGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLcnNVKDEVDSF 828  fruit fly
7503507    667 dvv----dlEMSFVYSSMVNGkvsdltlssivsvALQLAEQELVPGGESQMVTEANKAEFIDLMCQKKAirGVEKPLEIL 742  Caenorhabditis e...
NP_192994  657 dpeffdsnaGLGLTFVLETEE-------------LGKRDTIELCPDGKLKAVNSKNRKQYVDLLIERRFatPILEQVKQF 723  thale cress
Feature 1                                                                                      
1C4Z_A     217 RRGFHMVTNESPLKy----LFRPEEIELLICGs-rNLDFQALEETTEYDGGyt-rdSVLIREFWEIVHSFTDEQKRLFLQ 290  human
CAB92704  3918 LTGFHEIIPEELIA-----IFNEQELELLISGl-pDIDIDDWKANTEYHNYsa--gAPQIQWFWRAVRSFDKEELAKLLQ 3989 Neurospora crassa
2224565   1759 LEGFYEIIPKRLIS-----IFTEQELELLISGl-pTIDIDDLKSNTEYHKYqs--nSIQIQWFWRALRSFDQADRAKFLQ 1830 human
10039443  1439 VRGFYEVVDSRLVS-----VFDARELELVIAGt-aEIDLNDWRNNTEYRGGyh-dgHLVIRWFWAAVERFNNEQRLRLLQ 1511 human
BAA92558   419 LQGFHMFIPPSLIQ-----LFDEYELELLLSGm-pEIDVSDWIKNTEYTSGye-reDPVIQWFWEVVEDITQEERVLLLQ 491  human
T37900     526 KGGLNELIPDSVLQ-----IFNENELDTLLNGk-rDIDVQDWKRFTDYRSYte--tDDIVIWFWELLSEWSPEKKAKLLQ 597  fission yeast
7662052    680 LKGLNELVPENLLA-----IFDENELELLMCGt-gDISVSDFKAHAVVVGGswhfrEKVMRWFWTVVSSLTQEELARLLQ 753  human
AAF51314   829 LKGLNSIIPDNLLS-----IFDENELELLMCGt-gEYSISDFKAHHIANGNsa-efRRVLAWFWAGVSNFSQTEMARLLQ 901  fruit fly
7503507    743 LTSFNQILNDNLLN-----SLESSDLKRILSGs-lELDLNDWRTNTIYKGGys-dcHIVVEWFWEVIETMTNQERFDLLL 815  Caenorhabditis e...
NP_192994  724 SRGFTDMLSHSVPPrsffkRLYLEDLDGMLRGgenPISIDDWKAHTEYNGFke--tDRQIDWFWKILKKMTEEEQRSILF 801  thale cress
Feature 1                                                                                 
1C4Z_A     291 FTTGTDRAPvGGLGKL-------KMIIAKNgpdtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAk--GFG 356  human
CAB92704  3990 FVTGTSKVPlNGFKELegmngvsRFNIHRDygskDRLPSSHTCFNQLDLPEYENYETLRSQLLKAITAGs-dYFG 4063 Neurospora crassa
2224565   1831 FVTGTSKVPlQGFAALegmngiqKFQIHRDdrstDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECs-eGFG 1904 human
10039443  1512 FVTGTSSVPyEGFAALrgsnglrRFCIEKWgk-iTSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETs--TFG 1583 human
BAA92558   492 FVTGSSRVPhGGFANImggsglqNFTIAAVpytpNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCG---SYG 563  human
T37900     598 FATGTSRLPlSGFKDMhgsdgprKFTIEKVgh-iSQLPKAHTCFNRLDIPPYNSKEELEQKLTIAIQETa--GFG 669  fission yeast
7662052    754 FTTGSSQLPpGGFAALc-----pSFQIIAApt-hSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGc-eGFG 821  human
AAF51314   902 FTTGCSQLPpGGFQELn-----pQFQITAApt-fGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGs-eGFG 969  fruit fly
7503507    816 FVTGSSSVPfEGFSALrgneeisKFCIEKWgd-aTSFPRAHTCFNRLQLPSYNTKQQLKSKLQQAIVNGm--SYS 887  Caenorhabditis elegans
NP_192994  802 FWTSNKFVPvEGFRGLs-----sKLYIYRLyeanDRLPLSHTCFYRLCIPRYPTITLMEQRLRLIAQDHvssSFG 871  thale cress

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