Conserved Protein Domain Family
Tmemb_cc2

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pfam10267: Tmemb_cc2 
Predicted transmembrane and coiled-coil 2 protein
This family of transmembrane coiled-coil containing proteins is conserved from worms to humans. Its function is unknown.
Statistics
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PSSM-Id: 463036
Aligned: 28 rows
Threshold Bit Score: 362.042
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015782805         49 IKAAIEHYQAKIMRTKEAIKAEQTSRDENVNEYLKLAANA--------DKVQTQRIKSMFEKKNQKSAHTIAQLQKKLDS 120
XP_014347179        238 SRAAQRHLQQKILRLVEQIRVEETERDQNLSEYLQMANNV--------EKRQAFRIKQTFEHRNQKSAAAIAQLQHRLEH 309
CRZ25036             40 GLDDRTRIERKIEQIKERLSRISLAREADVDDFLSMTSSMeg----grENPQLARVRQHFEKKNKKSSQEIEHLKKKLEQ 115
Q18025               20 DEREKAKIVQKLIEIKDKLRALNEKREADVEKFLSITRQSeisrgvgaDNPQRARIRNNFERQNRKHAHETEMLQKKLID 99  Caenorha...
EKC40365            111 TKAAIEHYQRKLNKTMELIKAEQAAKEENVNEYLRLAASAs------eDKQQLARIKAVFEKKNQKSTQSISTLQKKLEG 184
XP_009019798         87 ARSAIEQLQVKIGKTQQRIKLEQNAKEDNVNEYLKLSTDA--------DKQQLQRIKAVFEKKNIKSAQAIAHLQKKLEE 158
WGS:AAPP:GF16655-PA 253 SVQAIDRLNTKIQCTKESIRQEQTARDDNVNEYLKLAASA--------DKQQLQRIKAVFEKKNQKSAHNISQLQKKLDN 324
EDS32659            117 SSLAHNRIITKIACTKESIKKEQTTRDANVNEYLKLAASA--------DKQQLQRIKAVFEKKNQKSAHNISQLQKKLES 188
EEB11565            148 RSAAIEHIQSKISKTMDQIRAEQTTRDDNVNEFIKLATNA--------DKQQIQRIKSVFEKKNQKSAQIISQLQKKLET 219
XP_001949074        120 TRAAMDHVRSKIVRTKDLIRSEQTARDDNVNEYLKLASNA--------DKQQLARIKSIFEKKNQKSAVGISQLQKKLEG 191
XP_015782805        121 YLKR---IRDIEny-----gIQALHq-------hSRSKAMLTNVGHGLKGVGTNIKEG----ISGLSE------------ 169
XP_014347179        310 YHHKvmeLKELElklranpeQESKG---------RSPR--LSNVTR----------------ESSLSMiqsmqsvaprkp 362
CRZ25036            116 LQSK---LVDLNmgivsevsPKSSVln-----niRKTGPLLR-------------------------------------- 149
Q18025              100 YEER---LKLVDsg----eyEPSPTksrvfptgiRKAKGMTE-------------------------------------- 134 Caenorha...
EKC40365            185 YSKR---IEEIQ--------TSGVTs-------hKKAKEVLSDMGHGLKGVGANIVDG----ITGFSGgvvgni------ 236
XP_009019798        159 YDRK---LREISl-------QGTTAi-------hKGSKGVLKDVGQGLRVLF--VRDPtrsrDASPSTs----------- 208
WGS:AAPP:GF16655-PA 325 YTKR---AKDLQnh-----qYQTKSq-------hRQPREVLRDVGQGLRNVGGNIRDG----ITGFSG------------ 373
EDS32659            189 YSKR---YKDLQyh----qsQKQQQs-------hRQPREMLRDVGQGLRNVGGNIRDG----VSGLSA------------ 238
EEB11565            220 YNKR---IRDIEs-------QKLHTs-------hRQPREVLRDMGQGLKNVGGNIRDG----ISGLSG------------ 266
XP_001949074        192 YNKR---LKDLEt-------HGLTTsh-----hlKQPKEMLRDVGHGLRHVGGNIRDG----ISGLSG------------ 240
XP_015782805        170 -----------------GVIGSIKSFSspntHhssgdnfnskpkdSF--KNKIGSADNINSADnsindsst--------- 221
XP_014347179        363 atwprngrvsssepvedTMSLRPPDFA------------------MGtlKTTVPAADSRDMAG----------------- 407
CRZ25036            150 -----------------EVIAAPRGIA----H-------------II--KSTFGSADNIPDSI----------------- 176
Q18025              135 -----------------TMVNAPIEFA----Q-------------RV--KSAF-SADNVNSTQ----------------- 160 Caenorha...
EKC40365            237 ------------kgakdTMMAKPKEFA----H-------------LI--KNKFGSADNINQIK----------------- 268
XP_009019798        209 -----------------TMQLKSRNAAtlpgvwk-----tkdshhAF--KNRYGSADNITSSLi---------------- 248
WGS:AAPP:GF16655-PA 374 -----------------SVMSKPREFA----H-------------LI--KNKFGSADNINQMT----------------- 400
EDS32659            239 -----------------TVMSKPREFA----H-------------LI--KNKFGSADNINQLAanhnviemnrdltasni 282
EEB11565            267 -----------------TVMSKPREFA----H-------------LL--KNKFGSADNINSLSr---------------- 294
XP_001949074        241 -----------------SVMSKPREFA----H-------------LI--RNKFGSADNINSISrss-------------- 270
XP_015782805        222 ---mnesesneGKEAQSkssgvHNQGGSVFYTHSHTHSHSTK--------------------------HTSDESSSISSv 272
XP_014347179        408 ---------------------------------------------------------------------TSPDEAASSRv 418
CRZ25036            177 ------------------------ASGASNVGHSTFYSDTQT-----------------------------NDRIHKLDf 203
Q18025              161 ----------------------NGTTGAPKTGQSTFFTTRKSadtdev---------------esnavHKNRGAKRNSSt 203 Caenorha...
EKC40365            269 ------------SLEEAggtegDKQHGGTLPASFk---------------------------------YPSEDDNS---- 299
XP_009019798        249 -----------PTQSSVnpsnpNNLQSSSSANNSPIVNLTSQqqrlqlqq----------rlqqqqhqQLQDDSLNDEQq 307
WGS:AAPP:GF16655-PA 401 -----------DAELQG-----MQSSNADVLAANERLQQTPGvgtstgsggggqnnntgggagsgtgkFNSDNGSECSSv 464
EDS32659            283 ddsvsfhydnlSSSNVGihgvcLDPADTRVISNTRIVEDASG--------------------------KYSEHESECSSv 336
EEB11565            295 -----------NGENGStgeedKTHHGSATLPGNCTLTTTTTttattvttq--------gstpgntkkFASDEGSPCSSv 355
XP_001949074        271 --------eadLTEDNSdkqsgRNHHGSATLPGGVGLHASTAgaa---------------------asRSEDGASECSSv 321
XP_015782805        273 sd------------------------niGAIAGLVTSGASSASPAkqlyrtfdsqlVSQSGSSHNIHDLETILSQLRDRE 328
XP_014347179        419 ---------------------------------------------------------eLIAEHLNPNTYTSILQQLADLK 441
CRZ25036            204 enrdvapspakrghkrnetlpsmafdldNLVISSLPEMLPHDE---------------PEVKFTAANTVIELHNDIQELK 268
Q18025              204 lppnlsltspdplsaykeedssdpesrpGSAADETSNVPYHTADNslylp--pnhpYHSAHAAPSEEGFNAIHEHLNSIL 281 Caenorha...
EKC40365            300 ----------------------------SILSGSNFEIQSSPLSNsq--------nTSQQFPGLTQAALEPILQEMEQIK 343
XP_009019798        308 ---------------------------------------------------------qQQLAIMQAKDLATIITNLTEFQ 330
WGS:AAPP:GF16655-PA 465 ---------------------------tSESIPAGSGKSQSGA-------------------SQYHIVLKTLLTELAERK 498
EDS32659            337 tsd---------------------siplSSGKHRRLRSQHCTN-----------------------------YKAMGDIR 366
EEB11565            356 tse---------------------slhlGQVTHHHTSPRHNRTSY------------N----------LDPLFRELQERR 392
XP_001949074        322 tse-----------------------sipPRTGPGAPPPPASATT------------S----------LEPVWAEL---- 352
XP_015782805        329 GDC-------QRLAEEIEAVKTSLHAEYSLINQSLQEERYKSERLEEQMNDLIELHQNEIENLKQNIGDMEEKVQYQSEE 401
XP_014347179        442 EEQ-------VNLEASFEKLRENYQHENKFLMNSIQEEKHKYRDLEAQVNDLMDIQQTELMNIKQDLSSMEEKLVYQSYD 514
CRZ25036            269 AQN-------QALFEQLNKLQTQNKSEFNYFNSALHEERIKTQRLEEMLNETIELHQAEMIALKSDLNTIATRMDYQYSD 341
Q18025              282 QHL-------MLIDRKYDRLEDDIKKEIKFYAEALEEERFKTTKLEEILNEAVELQQAEIATLKEQ-NLMATRVDYQHND 353 Caenorha...
EKC40365            344 ESNkllsetvTRLTEELDQCKRWYSTELAALKQVFDEERFKYERLEEQMNDMTELNQNEFSNLRQDITSMDEKIQYRLDE 423
XP_009019798        331 EMQ-------YKLHCSVSTLKTQLDEEGIFCRQALEEEHDRCERLEEQINDLTELHQNEMYNIKQEMVGMQEKMEYQLEE 403
WGS:AAPP:GF16655-PA 499 AEN-------EKLKERIERLET-GQKEFNNLTATLESERYRAEGLEEQINDLTELHQNEIENLKQTIADMEEKVQYQSDE 570
EDS32659            367 DGY-------DRMKTKLERLEL-MHKDVTDLAIALETERYRTERLEEQVNDLTELHQNEIENLKQAIADLEEKVQYQSDE 438
EEB11565            393 EEI-------EILKEKLENLKG-VHQEIQYLTMAIQEEKFRSERLEEQINDLTELHQNEVENLKQALTDMEEKVQYQSEE 464
XP_001949074        353 ----------DHLRSKMEHIKQLVSKDIASLNHSLQEERFRTERLEEQINDLTELHQNEVENLKQTITDMEEKVQYQSEE 422
XP_015782805        402 RLRDIYEMLESCQTRISRMEHQQHQHlQqLVNLDSLENSNARALVLKLINVLLTILQVVLLLVATVANIVTPFLKTRIRF 481
XP_014347179        515 RARDLWEVIESFQTRIGKLELQQQ-----AAQLEVLENPSTRAFFAKFMSLVLASITVILVFVSAMTSITIPLVKTRLRT 589
CRZ25036            342 RFRSIEENIESTQNKMIRMEVNVKEW------TESRPQTTFNSVMLSGTNILVEFIKLVLLIVSFALDFVKPFTGTRTRA 415
Q18025              354 RFRNVEENMESLQNHLVRIENALMDVrQvKLTSNVW-----QRVALNAGNIVVELLKIALFVVASILDLVRPLTGSRNRS 428 Caenorha...
EKC40365            424 RTTDLQDNVENCQTRITKMELQQQQQ-Q-IISMEMVDNVTFRTLLTKLINVVLAIVAVVLVVVSTAANLVAPFLTTRARI 501
XP_009019798        404 RTRDIQELLLTCQTRINKMELQQQQ--QqLISMEGIENTSFRGLATKLINIVLAVLAVVLVLVSEVANLIGPFLQTRLRI 481
WGS:AAPP:GF16655-PA 571 RLRDVNEVLENCQTRISKMEHMSQQQ---YVTVEGIDNSNARALVVKLINVVLTILQVVLLLVATAAGIIMPFLKTRVRV 647
EDS32659            439 RLRDVYEIMENCQTRVSKMEHLSQQQ---YVTIEGIDNSNARAVVVKLINVVLTVLQVILLLVATAAGITMPFLRTRIRV 515
EEB11565            465 RIRDLHEMLENCQTKISKMEHQQAQH-QqYVTLEGIDNSNARAVVVKLINVLLTVLQVVLLLVATAAGILMPFLKTRLRI 543
XP_001949074        423 RLRDIHEMLEACQTKMSKMEHQQAQH-QqYVTLEGLDNSNARALVVKLINVLLTVLQVVLLLVATFAGILMPFLRTRLRI 501
XP_015782805        482 LTTIFILVIVMMFVRQK 498
XP_014347179        590 LTTIFLLLLGTSYWWHQ 606
CRZ25036            416 GFVIFFWLALMILTHFI 432
Q18025              429 AMAFGLVFLAIFFGHHL 445 Caenorhabditis elegans
EKC40365            502 LSSALLVVAIILVGRNW 518
XP_009019798        482 VGTALLASLLAILWNRR 498
WGS:AAPP:GF16655-PA 648 LTTFLSICFVIFVIRQW 664
EDS32659            516 LTTVVCIVMLAFMVRQW 532
EEB11565            544 LSTLVLIAATVFVLKQW 560
XP_001949074        502 ITTTAVVAGLFIAVKQW 518
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