1JFF,1TUB,4UY0,2BTO,2BTQ,4FFB,1FFX,3DU7,3RYC,4F61,4LNU,4I4T,4DRX,1Z2B,2XRP


Conserved Protein Domain Family
beta_tubulin

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cd02187: beta_tubulin 
Click on image for an interactive view with Cn3D
The beta-tubulin family
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.
Statistics
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PSSM-Id: 276956
Aligned: 94 rows
Threshold Bit Score: 404.256
Created: 5-Feb-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotide binding site [chemical binding site]
Evidence:
  • Comment:In beta-tubulin, E-site (exchangeable) exposed on surface of dimer
  • Structure:1JFF_B: Bos taurus alpha-beta tubulin binds GDP (defined using 4.0 A contacts)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ###  #                                                                  
1JFF_B         2 REIVHIQAGQCGNQIGAKFWEVISDEHG-IDPt-------GSYHGdsdlq----leriNVYYne----aaGNKYVPRAIL 65  cow
EER20448       7 REIITLQLGRCGNNMAHEFWRDLCEEHL-IEYr-------DGSGTytgevdgirrdhiSVFFne----gsKGRYVPRTVL 74  Perkinsus marin...
CDW90712       2 KEIINIGIGNYGIQIANEFLEELCIDHD-IGLd-------GVKKPlsekdq--qldypNIYFee----lsSGKFISRSLL 67  Stylonychia lemnae
EJY86382       2 KEILTLGIGGFGINSLDLINQDLSEDHN-IGLd-------GQVLKedsyg----nhypETYFqe----msNGKYCARSLL 65  Oxytricha trifa...
XP_001027475   2 SSIVSIAIGQCGISIQEKQWITLLQEYG-IDEc-------GIINKlend------kklDSYFye----vkENVYKPRALF 63  Tetrahymena the...
CAI38962       2 REILVIQLGGFGNKVGVKFWEEMLKDSD-FGN--------QNEQGlq---------sqDPLLns----inNNKPLPRCVQ 59  Paramecium tetr...
ELR21982     104 SPLIQISSGIIGEALLASYVEQVALEHDlLVPsaaatsgpGGLTLnhkipp-ralyglGSHFresdpgrsDQSVVARAVF 182 Acanthamoeba ca...
XP_001009182   1 MSVISIATGKCGISIQEKAWITLLKEQG-INEe-------GFIECqnth------qgiNVYFee----vkQDVYKPRSII 62  Tetrahymena the...
XP_001444054   2 GEIIQLSFGDIANNIGHQYLEKLIDDHC-LDDk-------NNSTKdqyr------qkiHVSFee----lkTQQYQFRGIF 63  Paramecium tetr...
CAI38951       2 REILVLQLGGFGNKMGVKFWEEMYIDSE-FES--------DIDLQeqnknn--llnssNILFyn----lsEKTPLPRTVQ 66  Paramecium tetr...
Feature 1                                                                                  # ####
1JFF_B        66 VDLEPGTMDSVRsgp--fgqIFRPDNFVFGQSGAGNNWAKGHYteGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGT 143 cow
EER20448      75 VDLNLSDLQQVIgssdglgsLYRPEGIIANDEGSGNCYARAFHteGPDLAEHVLETVRKEAESCDCLQGVQFVQSLCGGT 154 Perkinsus marin...
CDW90712      68 IDTDSTKIENVRsgk--mrqLQSIDNYSCLKSGGSGNYAKARNayEDGLIDSFQDKLRKLVEGCDKFQAFQVQYATGGGT 145 Stylonychia lemnae
EJY86382      66 IDGDDMAIDNIRsgd--sanMYMLDNYSYSNIQSGGLFSKGCYsvDSDFIESVKEKVRKSLEMTNQCLSVEFHFAFGGGI 143 Oxytricha trifa...
XP_001027475  64 TDLDDHRINSLQsas--lkqLFQGVPTVYSIDGSHNLFARGMYsvGSELKDEIQNQITYLLEQCDSVDSIQIQNSLYGGT 141 Tetrahymena the...
CAI38962      60 VDLGQDLPCTNI--------DFNPCSQFSFNYSSGNNYGFVKNhcANEIMDIIVDSIRQETEKCDQLQGIQLFSSIIGGT 131 Paramecium tetr...
ELR21982     183 ADLEYLGMRTSKhps--svlFDRSNCFHTTDNTLHGYWSQGHYleGAESLDDVLDLVRREAERADTLQAFQLFHDVAGAC 260 Acanthamoeba ca...
XP_001009182  63 ADLDDQEINRVQngf--lkrLFQSNTSFSKQESSQNIFPRGYYshGAELKEEIEYEIQKQVEVCDKVDSIQVQRSLCGGA 140 Tetrahymena the...
XP_001444054  64 VNSSDQSIHKLLispe-seyINNDLILENGNRNKSGTFSNSQLnfRDQIKDKLFEKLRHQIEKCDKFFGCQFAHSTYDYS 142 Paramecium tetr...
CAI38951      67 VDLGQDLPYSNT--------DFNPCNQFSFNYSSGNNFGFVKNncCNQIVDIIFDRIRQEIEQCDSLQGFQIFASIIGAG 138 Paramecium tetr...
Feature 1        #                                           #                       #           
1JFF_B       144 GSGMGTLLISKIREEYPd-----RIMNTFSVVPSPkv--sdTVVEPYNATLSVHQLVEN-TDETYCIDNEALYDICFRTL 215 cow
EER20448     155 GAGLGGLCMKTISDFLDsgvgvkCIMQSFATVPSPdv--gdRVLEYYNAALGVQDLMDY-CHQAFLFDNMALSAICQKTL 231 Perkinsus marin...
CDW90712     146 GSGLGSKITEHLSAEYPg-----ELVQTFNLLSNGkl--qeRSLETYNTVLGFNSLVQN-VQSTVLFDNHSLFNLCQRQF 217 Stylonychia lemnae
EJY86382     144 GSGLGSKLLQEINENFKg-----FSYVGSNLLSNLkf--sqHTLEPYNTCLSMNNLVEF-LDGVTLFDNYALNNVCQRQF 215 Oxytricha trifa...
XP_001027475 142 GSGLGGLIYDILNEVAPq-----YITNNLVQYPDLstq-sqMTLEIYNNILGQNKQAHLtLILPFCNQNIQFLNDGSYKI 215 Tetrahymena the...
CAI38962     132 GSGLIAALDDKLGYDPLl-----QYNLLIPSIKQDd----vCVVSPYNSILALSQIMNQ-REQIVCFDNQGLKQNLSRLG 201 Paramecium tetr...
ELR21982     261 GGGFTTLLLSRLREEYPd-----TMMSTLSVIPAPdm---pLAVGPYNIVLTLHQLIEY-ADLCFYVSEKRARSLCGPST 331 Acanthamoeba ca...
XP_001009182 141 GSGLGNVISDIIMDNYFs----qIIHNTLVQLPDIkdenswNTLEIYNTILSLHSLVIS-DIVIPFCNSNISNMNQNSFQ 215 Tetrahymena the...
XP_001444054 143 SGSSSVAIDSYKEGYPYs-----PFCSSFSILPNIvs---sNTIEIYNTCFSMHKLIEY-CDVVMLFDYGALENQLTKLR 213 Paramecium tetr...
CAI38951     139 SGLSAVLSQMLNDEYSNa-----ITQCNLLVPSVKln--dnCVVSPYNSALAFNQLIDS-AEQLIFFDNEGLKQNLSRLG 210 Paramecium tetr...
Feature 1              #   #                                                                     
1JFF_B       216 klttpTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLavNMVPFPRLHFFMPGFAPLTsrgsq--qyralTVPELTQQM 293 cow
EER20448     232 nmevpRFSNMNNIVALAMSGITSSLRFPGTLDADLRKMhtNLVPFKNAHFLMTGFAPLTafsct--eyrkvSILDLMQQM 309 Perkinsus marin...
CDW90712     218 klpkpNIEDVNYLMTQYMTTITSAIRFPSKQINDFRKMatSTVPFPRMHFFIPSMANLApryteeyekddmRTKDVCYRL 297 Stylonychia lemnae
EJY86382     216 kipqpSFEDFNTLISQYNCTLTSTLRHPSTQMKSYRQIltSTIPFPRIHFMSPSLGNLTpmfne--ekekqDEDKIIEDL 293 Oxytricha trifa...
XP_001027475 216 qk-qkGFDNINNVISQIHPLITSGSRYHGSINASTRKIctNIIPFPRLKHMSMICLPLNyykq-----kqqTQLDYIEMI 289 Tetrahymena the...
CAI38962     202 ie--fNYDDANHHIAQTICCNSSPFRNNGDINSSLKKLsaNLIPFPQQNFLTCSQSNNQfsdyfk-eylkmDETQIFREL 278 Paramecium tetr...
ELR21982     332 k----PIDLIARAFAGVTHPLRFPARQGNYAPSSLRSLahTLVPYPRLHLLSLNHVPSWqpa------aamTPRALVDAL 401 Acanthamoeba ca...
XP_001009182 216 lqkqfNFDTINNVVSQIQPNFTCGIRYPGSINASSRKIctNLVPFARVKMMTATFLPFNyfrq-----nqiSQLELTDMI 290 Tetrahymena the...
XP_001444054 214 ql--sTLENCNNVIAECLLQMNCSQRFPGYQNGDQKKLstNLIPFPRLHFLTCAFTPIEiv--------sdLNQKLINLC 283 Paramecium tetr...
CAI38951     211 iq--fDYQDANLHVAQTICCNSSPFRNPGDINSSLRKLstNLSPFAFYKLFTCNMTNNLysdyyk-eylkmDEYQIFKEL 287 Paramecium tetr...
Feature 1                                                                                        
1JFF_B       294 FDAKNMMAa----------CDPRHGRYLTVAAVFRG------RMSMKEVDEQMLNVQNKNssy----------------- 340 cow
EER20448     310 MSKDNATLscdplnpgdprNGIPRSRFLASFAAFRG------ECPSGEVDEICHALQRDGsrytaiw------------- 370 Perkinsus marin...
CDW90712     298 FDARNTLLd----------VDFSKGRFYGYTAIFRGi-----NYSTVDLIQALRKNQDSNssy----------------- 345 Stylonychia lemnae
EJY86382     294 FDCRNFLLd----------VNPKQGRYYTYASIFRGk-----KYSDIDIKYKLRKNQSTNssy----------------- 341 Oxytricha trifa...
XP_001027475 290 HDSVNQEYs---------fFSKDTFRILCSHHMIRGv-----DIHQEEIESEYNKLYRSNnif----------------- 338 Tetrahymena the...
CAI38962     279 MSTNHNQAs----------NDYTQGRFLTAALSLRG------NISNKEVDKSCSLFQHYLdkqtyyr------------- 329 Paramecium tetr...
ELR21982     402 YYYGNLLAp---------rEQWVSGRLLASHAHFQLephtssAGVVSNIEEPLAQMHDITttvaakgqggeaeppptttd 472 Acanthamoeba ca...
XP_001009182 291 PQTLNEKNf---------fFGYGNPSIITSRHIFRSs-----NIFEEELELQLVKLYQKQei------------------ 338 Tetrahymena the...
XP_001444054 284 LPTNSYFSf----------QNATRNLYLSQAFITRC------NSYYLDFQYALSKLQNNIe------------------- 328 Paramecium tetr...
CAI38951     288 ISSDHNQTs----------AVYTQGKFVSAALSVRG------KVSNKEFDKQCSCFDYYLehqryrt------------- 338 Paramecium tetr...
Feature 1                                                                                        
1JFF_B       341 ---------fveWIPNNVKTAVCD-----------------------------IPPRGLKMSATFIGNSTAIQELFKRIS 382 cow
EER20448     371 ------diffpdWIPNSISASICT-----------------------------VGHCEAGDSATMVSNNTSMYEVMDRLG 415 Perkinsus marin...
CDW90712     346 ---------faeWLPDHHAVGVISr----------------------------DLKYLPKNQGILLGNSTCISQTLEKLV 388 Stylonychia lemnae
EJY86382     342 ---------fveWLPDHNATSVISr----------------------------DFESNPTNQAVLYGNNSAVKECFTAIG 384 Oxytricha trifa...
XP_001027475 339 ---------atnWIPNSCSISYCN-----------------------------VPCQYNSKLIFSIISNYNICRHFEKYT 380 Tetrahymena the...
CAI38962     330 -----rqeakkiKYIDMFLTNICK-----------------------------KPFQNFEYFGSCLINSTSITQSLESLI 375 Paramecium tetr...
ELR21982     473 rrdevvvpwyvpWVADNAKHSFGRwhprpslsfgsreadvagttaatatttgeQGSRLPRGSCTLVSNSTSVRHSLETSW 552 Acanthamoeba ca...
XP_001009182 339 ----------paWLPNSYSFQYCK-----------------------------VSSALNKNQILTLILNRNIYIQLQIYK 379 Tetrahymena the...
XP_001444054 329 ------------WIPDAVFHINCK-----------------------------IENRNLGKTAMHVGNHRDLGHSFKQHC 367 Paramecium tetr...
CAI38951     339 ------gvkkkfEGINMFFTNICQ-----------------------------KKYQNYEFFGSSIIHSSSITQSLKSLS 383 Paramecium tetr...
Feature 1                                                    
1JFF_B       383 EQFTAMFRRKAFLHWYTgegMDEMEFTEAESNMNDLVSEYQQYQ 426 cow
EER20448     416 ACWDSMYKAKSHLYVYQqdgLSTDDMLESRNVLQYISDQYCEFA 459 Perkinsus marinus ATCC 50983
CDW90712     389 EDFTKLLRRKAYLTHFTeqgLDEMEFTEAESNLNDLISEFKPCN 432 Stylonychia lemnae
EJY86382     385 DQFTKLFRRKCYLHKYLedgMDEMEFTESESALNDLISEYQPFN 428 Oxytricha trifallax
XP_001027475 381 QQYSQLFRRKAYLHYYLqegMDEMEFTEAESNINDVICDYQASG 424 Tetrahymena thermophila
CAI38962     376 EKFNKMYVRKSYLYKYTqegIDEDNFIDAKTRLEEICDSYKNTY 419 Paramecium tetraurelia
ELR21982     553 EIFNVMFRRKAYLYYERg--CDEMEYAEASSNVRDLADEYQEVA 594 Acanthamoeba castellanii str. Neff
XP_001009182 380 KKFDEMLKKRAFIHHYLqegMDEMEFQEAKYNTADLITEYQILS 423 Tetrahymena thermophila
XP_001444054 368 EIFTANFRRKAFIHYYLqdgMDEMEFTEAESNMNDFISEYQDYC 411 Paramecium tetraurelia strain d4-2
CAI38951     384 EKFKKMYPKKSYVHKYIqegIEESEFVGAQSRLDDTIFLYQDTL 427 Paramecium tetraurelia

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