Conserved Protein Domain Family
MRC1

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pfam09444: MRC1 
MRC1-like domain
This putative domain is found to be the most conserved region in mediator of replication checkpoint protein 1.
Statistics
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PSSM-Id: 430616
Aligned: 77 rows
Threshold Bit Score: 61.4267
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
GAC71561     1436 DKKRKSAFIEGEAEESEDedlgeqkrgDGGGLKGVfadengsdsgKDEDEDDEEdeDAeDLQELVDNERdIDE--AQKDE 1513
EGO01600     1119 KKLEKSEFVEAEAEESDEe--------RTFGFGGRk--------kGDDDEEEDEd-QDkILEGLVDDGEvDVQ-----EK 1176
XP_001837399  882 RKLDKSEFVEDEADESDDd----------AGFWGRpk------kdDDEEMENDEd-LDkTLETLVDDQEmDDQ--TLAEE 942 
EDR14758     1004 KRHEALEFFEDEAQESDEd--------DAFGFGTKhh------ieRGEEEDEDEd-LDkTLETLVDDQEmGEE--VVAAE 1066
XP_007329579 1075 gkmvRKEWLAEEAEESDEd--------EAVGFGFIkr------ksREDDEEGENgdLDaTLTELVDDEKmDED--TAGAD 1138
XP_007846948 1086 kplQRSEFVEAEAQESDE---------ETFGFVKS----------RDDDENGGEd-LDkTLETLVDDKEmDEN--TIAVE 1143
EPT02727     1060 gKTKRSEFIEGEAEESDDd--------EMRGFGLRk--------rVEDEDEDDEa-QDqTLQELVDDQDmDEN--TLAED 1120
XP_002475465 1079 rRLQKSEFIEGEAEESDDd--------AMMGFGPRn--------kVDEDEEDDEs-QDqTLTELVDDAAmDAE--TLAEH 1139
EMD40666       63 kalRKSEFIEGEAEESDDd--------ALAGFGIRkq-------pEDDEESGGEd-QDqLLAELVDDTAlDEK--ALAAD 124 
XP_009265877  746 krpidpRYFEAQAEISDEd--------NLVGLI------------SDDEEDDER--NNrQLDELVNDDRvAREtrDKQDK 803 
GAC71561     1514 VARARFREDMEARDREDLEIHQKAIQGGYRnRRGrg-agLNGIeGFLddDADEEElqrrAaLGLHMSSSAWKKRKLLDGT 1592
EGO01600     1177 LVLEKVREHREQDDRDLEKLHRDAVEGKFRtKRrnr------dfGLNddSEDEDEd-----ERARRIRNNMYKKR--KID 1243
XP_001837399  943 RVREKFKEQEQQEDEKLEKIAHNVVEGEFRkRKkdg------gfNLSdeSDDDDEd-----ENRKARRRLRRQQK----N 1007
EDR14758     1067 KILEKFHEQAEEDDQALERLHQAAVRGELRrKKrhh------gvGMd-dSEDESDd-----EDQRARRARHSMKR-ARVD 1133
XP_007329579 1139 RVMEKHQELLEQDDEAALKFHQGVVQGELRkKRKnrf---------gleDSDDEEe-----EDDRARRIRRKMKE--KVE 1202
XP_007846948 1144 KVLEKYKEHAEIDDKEVEALHMRAAQGELRkKRTrgv---------gvdDSDDEEd-----DEERARRIRRRMDRGARID 1209
EPT02727     1121 AVLEKHREQLEQDDQEVEKLHQDAIQGKLRmARrnr------gvGFEddDSDEEDd-----DAARARRRMQRQKR--NVQ 1187
XP_002475465 1140 AVIEKHREHQQIDDEANEKLQKDVVAGNWKtKRrdr------giGFEdsDSEDDDd-----DDAKARRRKMSKKR--RIE 1206
EMD40666      125 AVLEKVREHEEEDDRQLEKLHRDAVEGKLRlRRrdh------gvGFEdeDSDEDEd-----DRIR-RQRAMRKKR--KLD 190 
XP_009265877  804 LATEKYQEQLKEDDELDKKVAQNAADGRYRyRRRhrnedGLEMsS------DDDDiefmKaQEQLATRLAKRRRK--QAG 875 
GAC71561     1593 QdGMDALAAHDEAKAFVH 1610
EGO01600     1244 GdHLEALGQKEETRAFYE 1261
XP_001837399 1008 ReDVLALTLNPETHAFAQ 1025
EDR14758     1134 RdDVKALEANPETKAFAE 1151
XP_007329579 1203 RgDIQELAANEKTAAFAn 1220
XP_007846948 1210 RqNIKELGDHPETRAFYN 1227
EPT02727     1188 GdSLDEIAKDPASAPFVK 1205
XP_002475465 1207 DdSLEQLAKNPETLAFVQ 1224
EMD40666      191 DdRLEELAKHQDTLPFVQ 208 
XP_009265877  876 EePMERYARNPRTAAFVA 893 
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