Conserved Protein Domain Family
LMF1

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pfam06762: LMF1 
Lipase maturation factor
This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.
Statistics
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PSSM-Id: 462004
Aligned: 78 rows
Threshold Bit Score: 206.804
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4N0L2       107 PKTVSDLLLLEVGFLAIFIfSPFKFFDKH-----LSL--------------DLPSLVKWSFRLLSYRVVLLSGLYKIFL- 166 Theileria parva
EDS35875      85 FRQQSDEMLLEAGFLCILL-APAKLSDPR-----G----------------PIEGLAMLLMKWLLFRYVFASGSVKLASg 142
ETN68032     137 FRQQADHLLLEAGFLCILL-APTRLTDGR-----N----------------PMEDIALLLLKWLVFRFMFASGSVKLASg 194
XP_001950772 123 LSDLADELLLEVGLLCILI-APIPFQKLR-----VPSkkrnlrlqtslaslPHDSIPFWLVRWLLFRVAFSAGVAKMSSk 196
CDS42250     117 ADWKWTSLLIEAGFLCFLL-SIKLRKYSR----------------------SASMIVAWLIKWLLFREAVSTGFARLANd 173
EGT43258     122 MHYQWDAFLLESTVAVALL-AWFCDG-------------------------PPDSIALYGIVLVFLRAIFMNGVTKLQSk 175
Q21435         1 MYYQWDALLLESTVYVAIL-AWFDNG-------------------------PADSIALFGIVSLLLRVVFMNGATKLLSk 54  Caenorhabditis ...
XP_003118157 122 MYYQWDAFLLESTVYVAVL-AWFDDG-------------------------PADSVALFSIVALLVRVIFMNGASKLLSk 175
CAP30168     122 MYYQWDAFLLESTVYVAIL-AFFRDG-------------------------PADIVAIFGIVVLIVRVTFMTGATKLLSk 175
XP_022170379 123 LSDLADELLLEVGLLCILI-APLPFQKLRipskkRNLrlqts-----laslPHDSIPFWLVRWLLFRVAFSAGVAKMSSk 196 green peach aphid
Q4N0L2       167 -----KLN-FQHILTSIPLPTFFAHFLTRAVAKYSFLNTLLTvglLFYEVVLSVFIVTPHRSCRLFGGMALMVYGSVFTL 240 Theileria parva
EDS35875     143 cpmwwDLTgLKKHFETMPLPTSYSWYTFQQPDGIHKLSTIYV---YVSELVCSWLFFAPNQRVRMFSLWWQVFLHLNIIG 219
ETN68032     195 cplwwSLDgLRRHYETMPLPTSYSWYTYQLPEAFHRLSTIYV---YLSELVVPWLFFAPNRVVRRFALVWHVFLHANIIG 271
XP_001950772 197 ssiwyDLTaLSKYFESMPLPNAISWYAHYFPLWFLKTITVFA---EINDLFVPLMFLVPIRSVKKLAFYIQVFMQVGILA 273
CDS42250     174 nyfwwDLSaMEHYFSTQISPTPAAYYLSLAPSLVLRIISLFF---IVMEIFIPFLFLIPVRELQIFSFFAKVMFHADLIV 250
EGT43258     176 cpaywSLTaLDYYFESQPLPTVFAWHAHQLPPYIKQVASLVM---HYCEIILPAFFLIPLKHVRYVAFFGQVLLMSANIL 252
Q21435        55 cptwwNLTaLNYHFESQPLPTPFAWYAHYFPQFFKQLATLQM---NFIEILLPPLFLIPLIHVRYFVFFCQVLLTTLTLF 131 Caenorhabditis ...
XP_003118157 176 cpawwNLTaLDYHFESQPLPTPFSWYAHHFPPFFKQLATIAI---YYFEIILPPLFLIPVIHVRYVVFFCQILLMILTML 252
CAP30168     176 cpewwSLNaLDYHFESQPMPTPLSFYAHHFPSFLKQAATLAT---FCFEIALPCMYMIPVIHVRYVMFFGQFLLTTLTIL 252
XP_022170379 197 spiwyDLTaLSKYFESMPLPNAISWYAHYFPLWFLKTITVFA---EINDLFVPLMFLVPIRSVKKLAFYIQVFMQVGILA 273 green peach aphid
Q4N0L2       241 LGNFGPFYILLLLTSLFCLDDQFLHPFtqwkfnpfaksdtlmkkvsidliesltnsgdsvesvenvenedpvdtvesvDn 320 Theileria parva
EDS35875     220 SGNYGFLSLIVMTLLLTLVDD-----R---------------------------------------------------El 243
ETN68032     272 CGNYGFLSPLVLTLMVTLLDD-----Ddklllkllr---------------------------------dnpgttnsgNs 313
XP_001950772 274 SGNYSYYNLLYIVLCLSLLDDHTFYRE---------------------------------------------------L- 301
CDS42250     251 IGNHGIYNLLSIVLSFALLPE-----P---------------------------------------------------K- 273
EGT43258     253 TGNGGYLYYNILVLLISLLG----------------------------------------------------------S- 273
Q21435       132 TGNNGFFNYNILVLMVSLLQ----------------------------------------------------------T- 152 Caenorhabditis ...
XP_003118157 253 TGNNGFFNYNVIILLVSLLE----------------------------------------------------------T- 273
CAP30168     253 TTNNGFMNYNVLVLLVSMLE----------------------------------------------------------I- 273
XP_022170379 274 SGNYSYYNLLYIVLCLSLLDDHTFYKE---------------------------------------------------L- 301 green peach aphid
Q4N0L2       321 vdnVLecntvrseecteetFGSVYIERILSNLSYnrhrEYL-RDFMNLDNLSVSeLFKK-----------------IITD 382 Theileria parva
EDS35875     244 ---VQp-------------VKEESKEDKTGAMTVkaiaVLMtLGTWLVFGVGYKnGENGv-------------------- 287
ETN68032     314 gveRRtrggv-----vrnqAEPNNDSDRIGNRIVkvigVLMvVGSWIIFGIGFSsSEDGyltfktnf--skdqylsVMPV 386
XP_001950772 302 ---ALa-------------RTRQWCSTVFTRLMTinviTVLiAVFPMLYNFRISpANTPdftiaft----hqqfnvILGK 361
CDS42250     274 ---RY--------------KGSSVSHRFVSVATTvavlTVLfYGVWVFFGFQEGieamritilrkefidqaktvnyYTIL 336
EGT43258     274 ---PN---------------LNISIAPFLSGLVF----GKMiYDVLHGSPIEIIiGESKhivltit----qnvfqkFVAW 327
Q21435       153 ---PR---------------VPIG-ASFLAAIVF----AKIgFEVVYRLPYKILfEDDRlpsfaltl--thesfrkFMIY 207 Caenorhabditis ...
XP_003118157 274 ---PR---------------VPVG-APLLSALVF----GKLgYDLAHRMPVKLVtTEGSlpsfvlnl--sydtfqkLAIY 328
CAP30168     274 ---PR---------------VPQG-EPFLSMLIF----ARIaYDVIYKGRFKIItEVGSwptftldm--nyesfqkLVRY 328
XP_022170379 302 ---ALa-------------RTRLWCSTVFTRLMTinviTILiAVFPMLYNFRISpANTPdftiaft----qqqfnvILGK 361 green peach aphid
Q4N0L2       383 LLfllyltvilvlllllllfphykgVKSLILFLVCVLLKSHCEAVRTkisllqgeytlfllqsilifemvkngpntwsfl 462 Theileria parva
EDS35875     288 -----------------------------------------QAVVPPdrrypehdaddgsacsaagdgtd---------- 316
ETN68032     387 ML-----------------------LAAPLLVFGLLVRKFLKLLSFQdtvgs---------------------------- 415
XP_001950772 362 SL-----------------------PFIAYFALGSFVFECLKALYSSlplk----------------------------- 389
CDS42250     337 IV-----------------------SSFFVLNLLAAMFRSLSTRGCM--------------------------------- 360
EGT43258     328 SV-----------------------EIMTVLMFFMLSLIGVT-------------------------------------- 346
Q21435       208 YI-----------------------DVIVATMAIIFTIVNCYSMLKVgss------------------------------ 234 Caenorhabditis ...
XP_003118157 329 YI-----------------------DMIIILTALMFSIINAYTVLKGlg------------------------------- 354
CAP30168     329 YI-----------------------DLLVIIIIIMLAVTILRAILQScl------------------------------- 354
XP_022170379 362 SL-----------------------PFIAYFALGSFVFECLKALYSSlplk----------------------------- 389 green peach aphid
Q4N0L2       463 lwigltelqlnlskkmdnmhhltKMIIQSFLFIHLIVFSVRVfqhsVTEILTPQSnnirsvnintmsnintmsNINTMSN 542 Theileria parva
EDS35875     317 -gaevpsrsvpkqtgttnvadgiRKLTENWQLFLPTLAAFIV----LFTSIVPHFqltq----------staiSSSIFTK 381
ETN68032     416 ------------------laegaRQFTKNLGLLISTIVAFTV----FFMSIVPHSrllp----------staiSSPVMTR 463
XP_001950772 390 -------------------sktdGSLSALITSTLYVSICLGI----FSLSSVNFSalhqs---------vnntVPKDLKL 437
CDS42250     361 -----------------------NRMLDFTGVALVGLMGGGL----FAASLAPFSslvd-----------sssVVPLPSF 402
EGT43258     347 ---------------------------AV--------------------------------------------------- 348
Q21435       235 ---------------------qnGRMKKWVHLAFVLCSVLFL----GVYGNIPLLrmdekla-------qrtyepPVVMT 282 Caenorhabditis ...
XP_003118157 355 ---------------------sqARVSKIVHVAFVAACVLLL----NIYGSVPLLrmdekla-------qrtnenPMIMS 402
CAP30168     355 ---------------------stDKFSKMFHVAFVASTVVIL----SVYGFIPLLrldekla-------tktnenPIIMT 402
XP_022170379 390 -------------------sktdGSFSALITSTLYVSICLGI----FSLSSVNFSalhks---------vnntVPKDLKI 437 green peach aphid
Q4N0L2       543 intISSGMNNFYSVSNYRNVFRVGR--------DR---YELVIEGTNESVvttrTHWEEYYFKRKPSKLDQFPH--LTPf 609 Theileria parva
EDS35875     382 ---PYNGLHNMFVVNQYG--QHLIK--------MRpkrVEIILEYSDDLS----GPWKEYGFQYKPW--NEAGSmpYAWv 442
ETN68032     464 ---AYGGLHSLYVVNQYG--RHLTK--------MRpvrREIILEYADDLN----GTWQEYGFDYKPWTVERTSSlpYAGl 526
XP_001950772 438 ---FYNKLAPYKISNSYLPPKEFINl------eNR---KEIVIQGASDIK----GPWYEYQFLYKPGNVNVTPPi-IAP- 499
CDS42250     403 ayeLTAALKPFHLANDYRFFHQKEKdvllkvdrQR---TVLVLEGAMNEN----GPWKELSFHHVPSTPEKMPS--VIPg 473
EGT43258     349 ---------------------KMTGi------yGR---PEIVIEGATNIE----GPWKEISFSSKPGNVSRRPDy-PRP- 392
Q21435       283 ---MYKTVNSWSVANSYGSYRQMTGt------hGR---PEIVIEGSHHIE----GPWREIEFTSKPGKVSKRPRf-ISP- 344 Caenorhabditis ...
XP_003118157 403 ---YYKIANSWSVANPYGTYRHMTGq------hGR---PEIVIEGAPNFD----GPWKEIEFKAKPGSISRRPDf-VSP- 464
CAP30168     403 ---YYAAANKWGVANSYGSYRQTTGk------fGR---PEIVIEGSHQVE----GPWKEIGFKVKPGLLSKRPQf-VSP- 464
XP_022170379 438 ---FYNKLAPYKISNSYLPPKEFISl------eTR---KEIVIQGASDIK----GPWYEYQFLYKPGNVNVTPPi-IAP- 499 green peach aphid
Q4N0L2       610 YQYFLDDILvqsfnlqynnsnsnsnsssnrnnrnsvrkkkyvvttgdtgdtgdtvegtgdsvdrvngdelpyAVTEK--- 686 Theileria parva
EDS35875     443 YFPRFDFKF---------------------------------------------------------------YDASAtkp 459
ETN68032     527 YFPRFDFKF---------------------------------------------------------------YDAAAskl 543
XP_001950772 500 YKPLLDRQL---------------------------------------------------------------FFAAHslp 516
CDS42250     474 HLPVVDFEA---------------------------------------------------------------ALSGertf 490
EGT43258     393 GYHRLDMQM---------------------------------------------------------------HYAAEgty 409
Q21435       345 HHPRLDMQM---------------------------------------------------------------YYAAEgty 361 Caenorhabditis ...
XP_003118157 465 HHPRLDAQM---------------------------------------------------------------YYAAEgty 481
CAP30168     465 GHPRLDVQM---------------------------------------------------------------HYAAHgty 481
XP_022170379 500 YKPLLDRQL---------------------------------------------------------------FFAAHslp 516 green peach aphid
Q4N0L2       687 ----FIFDLLRMLLMGSGEVKNLM---YNPFeGT--KPKYTRVLLYKYYFsNLhsGNSNTRsKNWYYRNLVTEL-IP 753 Theileria parva
EDS35875     460 tsqkWLYPMVQRLLQNNQAVTKLFdqsHIPPg----PPKFIRASLYEFRFtS----WFHGNsTTFWTRERLNDY-FP 527
ETN68032     544 daqkWFYPMVLRLLQHQLPVLDLFdghHVPFk----APRFIRASLYQFSYtTS--PTKDTVdGAFWERNRLGDY-FS 613
XP_001950772 517 aqnpWLMSVLYRLLNNQKEVLSLLntnQIPF-GKn-PPKFVKVSLYKYQFsS---KLQRER-GVWWNRQILNSEfIA 587
CDS42250     491 enspIVATLVYRILTKEKEVLALLe--PSGFp---iGPKFVQIRKYTYEIsR------SINgPQWWKRKLQNIY-LP 555
EGT43258     410 qqnpFFLSLIYHLMQNNSEVVGLLd--HHPFqNRsePMNFARAKLYMYHFtKE--G----E-TDWWRRDFQEEY-MP 476
Q21435       362 qqnpFFLSLVYHLMQNTTEVVNLIe--DYPFkNRsePMRFARAKLYMYHFtDI--G----D-KNWWTRSFQEEY-MP 428 Caenorhabditis ele...
XP_003118157 482 qqnpFFLSLVYHLMQNTTEVVSLIe--NYPFkNRsePMQFVRAKLYMYHFtDI--G----D-KNWWRRDFQEEY-MP 548
CAP30168     482 qqnpFFLSLVYHLMQNTTEVVGLIe--DYPFkNRsePMKFVRAKLYMYHYaKM--D----D-KNWWTRDFQEEY-MP 548
XP_022170379 517 aqnpWLMSVVYRLLNNQKEVLSLLntnQIPF-GKn-PPKFVKVALYKYQFsS---KLQRER-GVWWNRQILNSEfIA 587 green peach aphid
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