Conserved Protein Domain Family
V-ATPase_V1_B

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TIGR01040: V-ATPase_V1_B 
V-type (H+)-ATPase V1, B subunit
This models eukaryotic vacuolar (H+)-ATPase that is responsible for acidifying cellular compartments. This enzyme shares extensive sequence similarity with archaeal ATP synthase. [Transport and binding proteins, Cations and iron carrying compounds]
Statistics
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PSSM-Id: 273410
Aligned: 18 rows
Threshold Bit Score: 922.197
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P11574    18 EYRTVSGVAGPLVILDKVKGPKYQEIVNIRLGDGSTRRGQVLEVDGEKAVVQVFEGTSGIDNKFTTVQFTGEVLKTPVSL 97  thale cress
Q38681    25 EYRTVGGVSGPLVVVELVKRPKFAEIVNIRLGNGTSRRGQVLEVDGNRAVVQVFEGTSGIDNRNTTLQFTGEVLSTPVSK 104 Acetabularia acetab...
P48413    22 EYRTVSAVNGPLIILQNVKSPRFAEIVNVTLGDGSVRRGQVLEINQDKAVVQIFEGTTGIDNKKTVCQFTGEILKTPVSL 101 Cyanidium caldarium
Q26976    26 EYTTIRAVNGPLVILGDVRLPTFAEIVNIELSDGTMRRGQVLEVDGDKAVVQVFEGTSGIDVMRSKCEFTGKVMELGVSE 105 Trypanosoma congolense
P31409    25 TYKTVSGVNGPLVILDEVKFPKFAEIVQLRLADGTVRSGQVLEVSGSKAVVQVFEGTSGIDAKNTLCEFTGDILRTPVSE 104 fruit fly
AAF67183  24 CYKTVTGVNGPLVILDDVKFPKFAEIVNLHLADGTERKGQVLEVSGSKAVVQVFEGTSGVDAKYTVCEFTGDILRTPVSE 103 green crab
P16140    27 NYNTVSGVNGPLVILEKVKFPRYNEIVNLTLPDGTVRQGQVLEIRGDRAIVQVFEGTSGIDVKKTTVEFTGESLRIPVSE 106 Saccharomyces cerev...
P22550    27 NYTPVGGVNGPLVILDNVKFPRYNEIVNLTLPDGTVRQGQVLEVRGTKAIVQVFEGTSGIDVKKTRVEFTGENLKIPVSE 106 Candida tropicalis
P11593    17 RYNTVGGVNGPLVILDNVKFPRYNEIVTLTLPDGTQRSGQVLEARGNRAVVQVFEGTSGIDVKKTKVEFTGESLKLGVSE 96  Neurospora crassa O...
P31411    23 SYNTVNSITGPLVILDNIRRPQYNEIVNLNLPDGSVRSGQVLEVAGHKAIVQVFEGTSGVDVRKTTIDFTGHSMRIPVSE 102 Schizosaccharomyces...
P11574    98 DMLGRIFNGSGKPIDNGPPILPEAYLDISGSSINPSERTYPEEMIQTGISTIDVMNSIARGQKIPLFSAAGLPHNEIAAQ 177 thale cress
Q38681   105 DMLGRVFNGSGKPIDGGPPVLAEAYLDIQGSSINPSERTYPEEMIQTGVSTIDVMNSIARGQKIPLFSAAGLPHNDIAAQ 184 Acetabularia acetab...
P48413   102 DMLGRVFNGSGKPIDGGPPILPEAYLDIQGQPINPQSRTYPEEMFETGISSIDVMNSIARGQKIPLFSGAGLPHNEVAAQ 181 Cyanidium caldarium
Q26976   106 DMLGRVFNGSGIPIDDGPPVLAEQYRDIQGIPINPRARVYPEEMIQTGISSIDVMTSISRGQKIPLFSGAGLPHNEIAAQ 185 Trypanosoma congolense
P31409   105 DMLGRVFNGSGKPIDKGPPILAEDFLDIQGQPINPWSRIYPEEMIQTGISAIDVMNSIARGQKIPIFSAAGLPHNEIAAQ 184 fruit fly
AAF67183 104 DMLGRVFNGSGKPIDQGPSVLAEDFLDIQGQPINPWSRTYPEEMIQTGISSIDVMNSIARGQKIPIFSAAGLPHNEIAAQ 183 green crab
P16140   107 DMLGRIFDGSGRPIDNGPKVFAEDYLDINGSPINPYARIYPEEMISTGVSAIDTMNSIARGQKIPIFSASGLPHNEIAAQ 186 Saccharomyces cerev...
P22550   107 DMLGRIFDGSGRPIDKGPKIFAEDYLDINGSPINPYARIYPEEMISTGVSAIDTMNSIARGQKIPIFSASGLPHNEIAAQ 186 Candida tropicalis
P11593    97 DMLGRIFDGSGRAIDKGPKVLAEEYLDINGSPINPYAREYPQEMISTGISAIDTMNSIARGQKIPIFSAAGLPHNEIAAQ 176 Neurospora crassa O...
P31411   103 DMLGRVFNGSGLPIDKGPNLLAEDYLDINGSPINPYARIYPEEMIQTGISSIDGLNSIARGQKIPIFSAAGLPHNEIAAQ 182 Schizosaccharomyces...
P11574   178 ICRQAGLVKRl-eKTVDLLEDHgEDNFAIVFAAMGVNMETAQFFKRDFEENGSMERVTLFLNLANDPTIERIITPRIALT 256 thale cress
Q38681   185 ICRQAGLVKRg-nQDSMIDAGHeEEEFAIVFAAMGVNMETAHYFKQDFEENGSMEKTVLFLNLANDPTIERIITPRIALT 263 Acetabularia acetab...
P48413   182 ICRQVCLVSt---CTLVKRSGKdEEDFAIVFAAMGVNMETARFFRQDFEENGAMERVTLFLNLANDPTIERIITPRLALT 258 Cyanidium caldarium
Q26976   186 IVRQAGLVR---------KEGK-QEDFCIVFAAMGVNQETARFFRTEFEENGSMEKTVLFMNLANDPTIERIVTPRLALT 255 Trypanosoma congolense
P31409   185 ICRQAGLVKL---PGKSVLDDH-TDNFAIVFAAMGVNMETARFFKQDFEENGSMENVCLFLNLANDPTIERIITPRLALT 260 fruit fly
AAF67183 184 ICRQAGLVKL---PSKGVHDDH-KDNFAIVFAAMGVNMETARFFKQDFEENGSMENVCLFLNLANDPTIERIITPRLALT 259 green crab
P16140   187 ICRQAGLVR----PTKDVHDGH-EENFSIVFAAMGVNLETARFFKQDFEENGSLERTSLFLNLANDPTIERIITPRLALT 261 Saccharomyces cerev...
P22550   187 ICRQAGLVR----PTKDVHDGH-EENFSIVFAAMGVNLETSRFFKQDFEENGSLERTTLFLNLANDPTIERIITPRLALT 261 Candida tropicalis
P11593   177 ICRQAGLVQRqgiTNKGVHDGH-EENFSIVFGAMGVNLETARFFTRDFEENGSLGRTTLFLNLANDPTIERIITPRLALT 255 Neurospora crassa O...
P31411   183 ICRQAGLVKR---PTKDVHDGH-EDNFSIVFAAMGVNLETARFFQRDFEENGSFERVTLFLNLANDPTIERIITPRLALS 258 Schizosaccharomyces...
P11574   257 TAEYLAYECGKHVLVILTDMSSYADALREVSAAREEVPGRRGYPGYMYTDLATIYERAGRIEGRKGSITQIPILTMPNDD 336 thale cress
Q38681   264 TAEYLAYECGKHVLVILTDMSSYADALREVSAAREEVPGRRGYPGYMYTDLATIYERAGRIEGRKGSITQLPILTMPNDD 343 Acetabularia acetab...
P48413   259 FAEYLAYEKGKHVLVILTDMSAYADALREVSAAREEVPGRRGYPGYMYTDLATIYERAGRVEGRPGSITQLPILTMPNDD 338 Cyanidium caldarium
Q26976   256 TAEYLAYDCGKHVLVILTDMSSYADALREVSAAREEVPGRRGFPGYMYTDLACIYERAGRVLGRAGSITQIPILTMPNDD 335 Trypanosoma congolense
P31409   261 AAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDD 340 fruit fly
AAF67183 260 TAEYLAYQCEKHVLIILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRQGSITQIPILTMPNDD 339 green crab
P16140   262 TAEYLAYQTERHVLTILTDMSSYADALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVEGRNGSITQIPILTMPNDD 341 Saccharomyces cerev...
P22550   262 TAEFLAYQTERHVLTILTDMSSYADALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVEGRNGSITQVPILTMPNDD 341 Candida tropicalis
P11593   256 TAEYYAYQLEKHVLVILTDLSSYCDALREVSAAREEVPGRRGFPGYMYTDLSTIYERAGRVAGRNGSITQIPILTMPNDD 335 Neurospora crassa O...
P31411   259 ASEFLAYQTEKHVLTILTDMTSYADALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVEGRNGSITQIPILTMPNDD 338 Schizosaccharomyces...
P11574   337 ITHPTPDLTGYITEGQIYIDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHSDVSNQLYANYAIGKDVQAMKAVVG 416 thale cress
Q38681   344 ITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHSEVSNQLYANYAIGKDVAAMKAVVG 423 Acetabularia acetab...
P48413   339 ITHPIPDLTGYITEEQIYLDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHSDVSNQLYAAYAMGKDALAMRAVVG 418 Cyanidium caldarium
Q26976   336 ITHPIPDLTGYITEGQIYVDRQLHNRQLYPPINILPSLSRLMKNAIGEGMTRRDHSGVSNQMYARMRL-DDILAMKAVVG 414 Trypanosoma congolense
P31409   341 ITHPIPDLTGYITEGQIYVDRQLHNRQIYPPVNVLPSLSRLMKSAIGEGMTRKDHSDVSNQLYACYAIGKDVQAMKAVVG 420 fruit fly
AAF67183 340 ITHPIPDLTGYITEGQIYVERQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHSDVCNQLYACYAIAKDLQAMKAVVG 419 green crab
P16140   342 ITHPIPDLTGYITEGQIFVDRQLHNKGIYPPINVLPSLSRLMKSAIGEGMTRKDHGDVSNQLYAKYAIGKDAAAMKAVVG 421 Saccharomyces cerev...
P22550   342 ITHPIPDLTGYITEGQIFIDRQLHNRGIYPPINVLPSLSRLMKSAIGEGMTRKDHGDVSNQLYAKYAIGKDAAAMKAVVG 421 Candida tropicalis
P11593   336 ITHPIPDLTGYITEGQIFVDRGLHNRGIYPPINVLPSLSRLMKSAIGEGMTRKDHGDVSNQLYAKYAIGRDAAAMKAVVG 415 Neurospora crassa O...
P31411   339 ITHPIPDLTGYITEGQIFVDRQLHNNAIYPPINVLPSLSRLMKSAIGEGMTRNDHGDVSNQLYAMYAIGRDAASMKSVVG 418 Schizosaccharomyces...
P11574   417 EEALSSEDLLYLEFLDKFERKFVMQGAYDTRNIFQSLDLAWTLLRIFPRELLHRIPAKTLDQFY--SRDST 485 thale cress
Q38681   424 EEALSSEDLLYLEFLDKFERKFVNQGHYEARTIFDSLDLAWTLLRLFPKELLRRITAKTLEKMY--ERSES 492 Acetabularia acetabulum
P48413   419 VEALSQEDLLYLEFHDKFERRFVNQGAYERRDIYTSLDMAWDLLRIFPVQMLRRIPEKILQEYY--HRTSN 487 Cyanidium caldarium
Q26976   415 EETLSSEDLLHLEFLEKFEKKFICQGFHESRDVFQSLDLCWQLLRIFPKVLLNKIDVKTRNEFY--DGQPM 483 Trypanosoma congolense
P31409   421 EEALTPDDLLYLEFLTKFEKNFISQGNYENRTVFESLDIGWQLLRIFPKEMLKRIPASILAEFY--PRDSr 489 fruit fly
AAF67183 420 EEALTADDLLYLEFLAKFEKSFISQGSYMKRTIFESLDIGWQLLRIFPKEMLKRIPASTLAEFY--PRDRP 488 green crab
P16140   422 EEALSIEDKLSLEFLEKFEKTFITQGAYEDRTVFESLDQAWSLLRIYPKEMLNRISPKILDEFY--DRARD 490 Saccharomyces cerevisiae S288c
P22550   422 EEALSTEDKLSLEFLEKFEKNFISQGAYENRTIFESLDLAWSLLRIYPKEMLNRISPKILEEFYgrDREQD 492 Candida tropicalis
P11593   416 EEALSNEDKLSLEFLDKFERSFIAQGPYESRTIFESLDLAWSLLRIYRKDMLNRIPKKIIDEFY--SRSAA 484 Neurospora crassa OR74A
P31411   419 EEALSQEDRLALEFLGKFEKTFISQGAYENRTIFETLDLAWSLLRIFPREMLTRIPKKILDQYY--SRSSA 487 Schizosaccharomyces pombe 972h-
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