Conserved Protein Domain Family
DnaJ-like_C11_C

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pfam11875: DnaJ-like_C11_C 
DnaJ-like protein C11, C-terminal
This is the C-terminal domain found in DnaJ-like proteins, including DnaJ homolog subfamily C member 11 (DNAJC11) from mammals and Chaperone protein dnaJ 13 from Arabidopsis. DNAJC11 is a mitochondrial outer membrane protein involved in mitochondrial biogenesis and in the response to microenvironment changes and requirements. The J-domain is mediated its mitochondrial localization, while this domain is critical for protein-protein interactions.
Statistics
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PSSM-Id: 463378
Aligned: 92 rows
Threshold Bit Score: 90.7261
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q57VU5           570 PYQ--SARMAALYRQNRLDHRTEMDVARVRATHEQKALQSSSLRSRMAEEQI---GGLVIINARYGV------------- 631 Trypanosoma...
XP_001419313     415 PIM--NRYIRKRQLAAREKNKRTILVAMREAHSATKMIAETADKKARAARER---GGLVIESAVFGAp------------ 477
EEH54910         387 vepiaTRKVEAKQRALRAKYAERVRESKAEAANTAALLFDQAEARTAREREN---GGLVIECAAYGH------------- 450
jgi:MICPUN_67204 389 vspavAKKEATAKAKLRERHRERVAAAKAEAAEAAEMLRRDTEKRTEKERSV---NGLVVEEAVFGN------------- 452
EFJ44045         392 vrplarWHRQRRERQQQQQHADAIRESLQKAFSERSLIEPVARRKARSEAAKrpaAGLVVLDAVYGKveaylaeggqqqg 471
A0D406           390 PWNdlQNKKRQLYLHKIEEYQKFNEETRRNIEQG-----DNFQKALQFETDL---NGLIITLAYAGE------------- 448 Paramecium ...
XP_002261467     144 gyI--HESTIEECRRQLQMEAEVIYRNK------INEVKSIYLEKLQKEERK---NGLIIEKALFGNltlkeeh------ 206
XP_001023515     338 gikyfkkSSQKSENEKEAQYQKALEEKIKKRKGQLSLIEFQSQENNQYQINR---NGLIIIEGYYGNsqhikel------ 408
3_pfamImport       1 --R--ERQRRLELERRHDMLVQYLAAARQNALEQQKLMLRCAKEKMEQERQRrdgRGLVIMLGRYGK------------- 63 
2_pfamImport       1 PYR--KQEKERQSEESEESLTNETKRRKEEAEATIKMMKQSSQRKIDAEERK---LGLVITEAWYGR------------- 62 
Q57VU5           632 --------------------------LQPRYpeslvlppkqpnaagnrsevsgrqrqtwwrfwragrgtptpsesvtvng 685 Trypanosoma...
XP_001419313         --------------------------------------------------------------------------------    
EEH54910         451 --------------------------FPERG------------------------------------------------- 455
jgi:MICPUN_67204 453 --------------------------FPERGgvprr-------------------------------------------- 462
EFJ44045         472 aavgamavassadgsgdvaaamaaavAGATTpanaagptdpdledrsgshat---------------asasgrdtaaast 536
A0D406               --------------------------------------------------------------------------------     Paramecium ...
XP_002261467         --------------------------------------------------------------------------------    
XP_001023515         --------------------------------------------------------------------------------    
3_pfamImport      64 --------------------------DPTSPdplesqendldtvlqaieds----------------emdfedgveaesg 101
2_pfamImport      63 --------------------------FVSED------------------------------------------------- 67 
Q57VU5           686 kkkdegeETEGDSSSSVLVLDVTVPLQNFV--R--------DS-QLVL-PEG-SKSKLVGFTDPDP------Ft------ 740 Trypanosoma...
XP_001419313     478 -------DAPKPAASPPPYVDVTRALQFMV-----------DNdTLDL-YENvAMCDLLGFCDPCP------G------- 525
EEH54910         456 -------PPRSLDEPPTPWLDVTTATRFMV--F--------DS-ALDV-LEGtHKASLLGYCDPCP------G------- 503
jgi:MICPUN_67204 463 --gepivSGWGSGGDDDAWVDVTTALRFQV--F--------DS-SLDM-IEGlDKAGMLGFCDPCP------G------- 515
EFJ44045         537 pgngatgAATQPPALPPPWLSVTSALQYQV--S--------DS-KLTL-HPGlSKKNQMGFADPTP------G------- 591
A0D406           449 ------------LGDINQYIQNKVPNQYLSniKeqlqaeilDS-GLFIpPNClDK--LDGFFKVSS-------------- 499 Paramecium ...
XP_002261467     207 innclnmDVITENDLEGPFLDLTTILQARI--E--------NS-SFMF-NDEfSFAHFCGIPKPLIkipcrkDvsyadil 274
XP_001023515     409 kesinraNYLHQNKARAEVIDVTIPLRFFQ-----------SKrGLNI--QTlSKENLIGFFNPCR-------------- 461
3_pfamImport     102 tgeritqQEVDGDVLVQKWIDVSVPLQFFV--K--------DG-ELAL--SCaSKAGLLGFYNPCI------G------- 155
2_pfamImport      68 ------------SSRTSKLIDVRIPLQNLV--E--------NS-KLQL-PAGiTKSGLPGFYDPCP------G------- 110
Q57VU5           741 --rER---K---------------QLKIVYRFQRRRHVVILDDEDIVRLP 770 Trypanosoma brucei
XP_001419313     526 ---ED---K---------------HLRVRYRYRRALHEVTVKADAMVSLP 554
EEH54910         504 ---ED---A---------------FLRVRYLYREKLHEVTVGEDDELTLP 532
jgi:MICPUN_67204 516 ---EE---K---------------FLRVRYRYRGAMCEVTVGENDALALP 544
EFJ44045         592 ---SAd-sR---------------LLYVAYLYGDKVYEVTVDDMDGLQLP 622
A0D406           500 --------Kkns---------shyWGYVEYIYKGKAGNKKWNWAEPLSIG 532 Paramecium tetraurelia
XP_002261467     275 qstEM-------------------YLYIKYKFLNTDHELIVVDRSRFTLP 305
XP_001023515     462 ---ENdcsK---------------SLLIRYSLYGQIFEQIYMDNKDVEIs 493
3_pfamImport     156 ---VD---QtiadarspsisgvtpSLYVRYAYDGQVFEASFDDDQAVNLP 199
2_pfamImport     111 ---SE---I---------------KLKVVYKFRGGVHKASFDDRDAVRIP 139
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