1HO8


Conserved Protein Domain Family
VATPase_H
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cd00256: VATPase_H 
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VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The topology is that of a superhelical spiral, in part the geometry is similar to superhelices composed of armadillo repeat motifs, as found in importins for example.
Links
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Statistics
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PSSM-Id: 238159
Aligned: 7 rows
Threshold Bit Score: 499.62
Created: 4-Sep-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide binding site
Evidence:
  • Comment:hydrophobic residues form a shallow groove
  • Structure:1HO8_A; autoinhibitory when N-terminal residues are bound
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1HO8_A     13 THFNEIRSIIRSRSVAWDALARSEELSEIDASTAKALESI----LVKKNIGDglsssnnahsgfkvngkTLIPLIHLLST 88  Saccharomyces cere...
AAF53555   19 SVLQQQAADIRTRTINWASYMQSQMISEEDYKAISALDKS----RASFLAQNss--------------qVVKTLLNLVSH 80  fruit fly
AAF17192   17 NIIAAKAAEVRANKVNWQSYLQGQMISAEDCEFIQRFEMK----RSPEEKQEmlqt---------egsqCAKTFINLMTH 83  human
12585473    2 DQAELSIEQVLKRDIPWETYMNTKLVSAKGLQLLRRYDKKp--eSARAQLLDedg------------paYVHLFVSILRD 67  thale cress
12585452   12 THFQKEADKVRAMKTNWGLFTRTRMIAQSDYDFIVTYQQAen-eAERSTVLSvfk------------ekAVYAFVHLMSQ 78  Caenorhabditis ele...
12585453   19 SRLQLEAQELRNNKPNWGSYFRSQMIQEDDYNFITSFENA----KSKEERDQvlaan-------nangqAAKTMANLITQ 87  Caenorhabditis ele...
12585394   22 SQVDEIINNVRCVAIPWQGYQRSGSLEENELQEIENLTGKplsaYVKTAEEDtt--------------aYSNLFLKLLSM 87  fission yeast

Feature 1                       #                                            #                
1HO8_A     89 SDN-EDCKKSVQNLIAELLSSdkyGDDTVKFFQEd-----pKQLEQLFDvSLKGDFQTVLISGFNVVSLLVQNGl----h 158 Saccharomyces cere...
AAF53555   81 LSK-DSTIQYILVLLDDLLQE---DRSRVDLFHDtagklkqCIWGPFLN-LLNRQDGFIVNMSSRILAKFACWGh----e 151 fruit fly
AAF17192   84 ICK-EQTVQYILTMVDDMLQE---NHQRVSIFFDyar-cskNTAWPYFLpMLNRQDPFTVHMAARIIAKLAAWGk----e 154 human
12585473   68 IFK-EETVEYVLALIYEMLSA---NPTRARLFHDesl-aneDTYEPFLR-LLWKGNWFIQEKSCKILAWIISARpkagna 141 thale cress
12585452   79 ISK-DDYVRYTLTLIDDMLRE---DVTRTIIFEDvav-llkRSPFSFFMgLLHRQDQYIVHITFSILTKMAVFGn----i 149 Caenorhabditis ele...
12585453   88 VAK-DQNVRYVLTLFDDMLQE---DKSRVELFHSaaarqkrTVWSQYLG-ILQRQDNFIVNQMSSIIAKLACFGt----t 158 Caenorhabditis ele...
12585394   88 KDTpDVVNFALVKLADTLLNSnkfLSAFGPAFYDf-----lEKDESYIN-YLDDDSKLLFARVFALCSSSSPCSv----a 157 fission yeast

Feature 1                                                     #   #                           
1HO8_A    159 NVKLVEKLLKn---nNLINILqni-----------------eqMDTCYVCIRLLQELAVIPEYRDVIWLHEkkFMPTLFK 218 Saccharomyces cere...
AAF53555  152 TMPKSDLNFYl---qFLKDQLas------------------nnNEYIQSVARCLQMMLRVDEYRFAFVGVD--GISTLIR 208 fruit fly
AAF17192  155 LMEGSDLNYYf---nWIKTQLssqklrgsgvavetgtvsssdsSQYVQCVAGCLQLMLRVNEYRFAWVEAD--GVNCIMG 229 human
12585473  142 VIGNGIDDVLkglveWLCAQLkqp----------------shpTRGVPIAISCLSSLLKEPVVRSSFVQAD--GVKLLVP 203 thale cress
12585452  150 KLSGDELDYCm---gSLKEAMnrg-----------------tnNDYIVTAVRCMQTLFRFDPYRVSFVNIN--GYDSLTH 207 Caenorhabditis ele...
12585453  159 RMEGQDLQYYf---sFLKEQLkns-----------------ttNDYMNTTARCLQMMLRHDEYRHEFVDSD--GVQTLVT 216 Caenorhabditis ele...
12585394  158 KAFTLFLEYLg----KLMQSLn---------------------PLTRLFAVQCLNGVLTLKAHRYALWAENt-CSFRLAE 211 fission yeast

Feature 1                                                                                     
1HO8_A    219 ILQRAtdsqlatrivatnsnhlGIQLQYHSLLLIWLLTFNPvfaNELVQKYLSDFLDLLKLVKITIKEKVSRLCISIILQ 298 Saccharomyces cere...
AAF53555  209 ILSTRv----------------NFQVQYQLIFCLWVLTFNPl--LAAKMNKFSVIPILADILSDCAKEKVTRIILAVFRN 270 fruit fly
AAF17192  230 VLSNKc----------------GFQLQYQMIFSIWLLAFSPq--MCEHLRRYNIIPVLSDILQESVKEKVTRIILAAFRN 291 human
12585473  204 LISPAst-------------qqSIQLLYETCLCIWLLSYYEp--AIEYLATSRTMQRLTEVVKHSTKEKVVRVVILTFRN 268 thale cress
12585452  208 ALYSTrk--------------cGFQIQYQIIFCMWLLTFNGh--AAEVALSGNLIQTISGILGNCQKEKVIRIVVSTLRN 271 Caenorhabditis ele...
12585453  217 ALNGKt----------------NFQLQYQLIFAVWCLTFNAd--IARKAPSLGLIQALGDILSESTKEKVIRIILASFVN 278 Caenorhabditis ele...
12585394  212 LLRNSi---------------gDTQLQYYSLFCFWQLTFESh-iAQDINKRFDLIKLLVQIIRSDTKTKVYRLVLAILVN 275 fission yeast

Feature 1                                                                                     
1HO8_A    299 CCstrvkqhkKVIKQLLLLG-NALPTVQSLSERKYSDEELRQDISNLKEILENEYQELTSFDEYVAELDSKLLCWSPPHV 377 Saccharomyces cere...
AAF53555  271 LIekpedssvAKDHCIAMVQcKVLKQLSILEQRRFDDEDITADVEYLSEKLQNSVQDLSSFDEYATEVRSGRLEWSPVHK 350 fruit fly
AAF17192  292 FLeksteretRQEYALAMIQcKVLKQLENLEQQKYDDEDISEDIKFLLEKLGESVQDLSSFDEYSSELKSGRLEWSPVHK 371 human
12585473  269 LLp-------KGTFGAQMVDlGLPHIIHSLKTQAWSDEDLLDALNQLEEGLKDKIKKLSSFDKYKQEVLLGHLDWNPMHK 341 thale cress
12585452  272 LItsnqdvymKKQAALQMIQnRIPTKLDHLENRKFTDVDLVEDMVYLQTELKKVVQVLTSFDEYENELRQGSLHWSPAHK 351 Caenorhabditis ele...
12585453  279 ILskvderevKREAALQMVQcKTLKTLELMDAKKYDDPDLEDDVKFLTEELTLSVHDLSSYDEYYSEVRSGRLQWSPVHK 358 Caenorhabditis ele...
12585394  276 LIdk----apKDTISTMLLE-HVDKAVQLLQKRKWADEDITNYLDFITSTLDESSKHLSTFDMYKSELDTGILHWSPSHR 350 fission yeast

Feature 1                                                                                     
1HO8_A    378 DNGFWSDNIDEFKKDNYKIFRQLIELLQAKvrngdvnakqEKIIIQVALNDITHVVELLPESIDVLDKTGGKADIMELLN 457 Saccharomyces cere...
AAF53555  351 SAKFWRENAQRLNEKNYELLRILVHLLETSk---------DAIILSVACFDIGEYVRHYPRGKHVLEQLGGKQIVMQHLG 421 fruit fly
AAF17192  372 SEKFWRENAVRLNEKNYELLKILTKLLEVSd---------DPQVLAVAAHDVGEYVRHYPRGKRVIEQLGGKQLVMNHMH 442 human
12585473  342 ETNFWRENVTCFEENDFQILRVLLTILDTSs---------DPRSLAVACFDISQFIQYHAAGRVIVADLKAKERVMKLIN 412 thale cress
12585452  352 CEVFWNENAHRLNDNRQELLKLLVAMLEKSn---------DPLVLCVAAHDIGEFVRYYPRGKLKVEQLGGKEAMMRLLT 422 Caenorhabditis ele...
12585453  359 SEKFWRENASKFNDKQFEVVKILIKLLESSh---------DPLILCVASHDIGEYVRHYPRGKTVVEQYQGKAAVMRLLT 429 Caenorhabditis ele...
12585394  351 SEDFWHQNAKRLNEDNYALLKKLFHIVQYNe---------DNTSLAVACHDLGAYIRSYPEGRSLIIKYGAKQRIMDLMS 421 fission yeast

Feature 1                            
1HO8_A    458 HSDSRVKYEALKATQAIIGYTFK 480 Saccharomyces cerevisiae
AAF53555  422 HEDPNVRYEALLAVQKLMVHNWE 444 fruit fly
AAF17192  443 HEDQQVRYNALLAVQKLMVHNWE 465 human
12585473  413 HENAEVTKNAILCIQRLLLGAKY 435 thale cress
12585452  423 VKDPNVRYHALLAAQKLMINNWK 445 Caenorhabditis elegans
12585453  430 AEDPNVRYHALLAVQKLMVHNWE 452 Caenorhabditis elegans
12585394  422 HPDPEVRFEALSTVQLLMTEVCF 444 fission yeast

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