Conserved Protein Domain Family
EH_Signature

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pfam15611: EH_Signature 
EH_Signature domain
This domain with a strongly conserved glutamate at the N-terminus and a histidine at the C-terminus, is found in a SWI2/SNF2 four gene operon. Its strict-neighbourhood association with SWI2/SNF2 ATPase strongly suggests a function in conjunction with it. The other genes in the operon are a OmpA protein and a TM protein. This has a DNA related function along with the TerY-P triad.
Statistics
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PSSM-Id: 434811
Aligned: 21 rows
Threshold Bit Score: 141.934
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_013838040    23 WQRVAAEA-------KHIARNAGSGRRA-----EALHGPVRRLLEERRtdelltrmgdrvfarvvVALWAEEPRLAQRSM 90  Isoptericola ...
jgi:AciX9_2577  32 LRPLDAAV-------TKMKAQAASTRPPdpariEKLIARFHAEKQNLD-----------------RFEPREIRLLAWNNQ 87 
WP_014428003    35 EKPVREA--------ERIFQGYAKAQPRqedsyAAARAFLRGQRLDAW-------------------------------- 74  Rubrivivax ge...
jgi:Galf_1108   27 slQMQHEL-------SMMKDWVKGASRReevplATIEAALLFYQKNSY------------------------------LK 69 
CAP40554         3 eggLDKHL-------ATLQQHVKAGSSPyepedLQAKAVRRFWE-------------------------------TTRLD 44 
jgi:Pnap_4265   25 sDDIDKVL-------LALEKQVKSGGRNdepkdLQIEAVRRFWK-------------------------------TGHVE 66 
ABM05095        16 VAMMEAAFsidncsnESIFENLVLPQVPprdvkQLIQLVMSSQSEKISllewfs-----ifdnenYFKQLSGEALINTQK 90 
WP_006198867    14 PKCIPNQL-------IQLTSNLPEPKIStpsvdKVLAAIEQGKADQVSqldwiy-----cihakaQWDKQNTDRSHKTSA 81  Nodularia spu...
WP_014395903    25 QQQVEEGM-------QQLFLRVETAQQRaddrePDRLARMRQTLDVAA-------------------------------- 65  Corallococcus...
jgi:Acfer_1261  29 PVELEKWL-------KKTVSDSGRRPALdpvtmEELYTKVKVQERGKK----------------------------VQLD 73 
WP_013838040    91 TPELVRAVVe--------------------------------RPEGRPVGHPTAITLASLflehydrlddwhaglfeava 138 Isoptericola ...
jgi:AciX9_2577  88 MLLNARFRS---------------------------------QLAERVRSRAVKPNLLILsqvyfgswgthaehelfeqm 134
WP_014428003    75 ---QRDLVAsavaqpireagdet------algsqrfdtllgeYQAEAERGDLWRLTWHGLlysyfqydisaaggtaaqtg 145 Rubrivivax ge...
jgi:Galf_1108   70 GLRQARLICygctqrlnsycli--------eerdafnklltyVDGYKSRRRTFRKLYRGLlssyfsydpdsadmrggvsr 141
CAP40554        45 TLKEARLVSfgmclpshpngpcll---edskrfdaalssdtgVDQWVKKPQWFRRCYQGLvrsyfsyddrkgkvapdegr 121
jgi:Pnap_4265   67 TLREARLVAfglavtpwddrrsl------medkrlfgsaldaVDAWQGAPRQYRKCFQGLvrsyfdydgmgrstpdvgkv 140
ABM05095        91 ALWKCILEIpkvtnialwrmclyfdkqyhmmpllimdafqkhDRQIRLLDKQRGLVLKALseqkaskiayfslqignkpe 170
WP_006198867    82 AIWKVAISNswlqhqll-----------------wrlalyshHQQEQVLAKSLADSFDIFansnlvshllpvqivralcs 144 Nodularia spu...
WP_014395903    66 -----------------------------------------------VLKKLHARDFASLtrrerravpglwrevgpkdm 98  Corallococcus...
jgi:Acfer_1261  74 LRREVPFLPvlltrekkekpr----------fyevllqdilkVIQEGIPRSARRNTFRNLvfayftvygqpykgermqkc 143
WP_013838040   139 stvdvaahrthprah--------------------------rdlvevlrdlrryvverdgprafarhlitsgatpeKDRD 192 Isoptericola ...
jgi:AciX9_2577 135 lriladqqagft---------------------------------pllqrykekatsifsasadvflsrqisveqaSLTE 181
WP_014428003   146 weklraflertwplidrq--------------------vgaglvpdwvhvlrkegavlsrspvdkyargylrgdsaAVDQ 205 Rubrivivax ge...
jgi:Galf_1108  142 dalslflsdhlatfvi------------------------gdftpdwlaalakypdllgenpgqavessllqgdysMLEE 197
CAP40554       122 knwkklreylhdrssnii--------------------dperinpdwaitavenkglfsenpclpyaktalsgdmsSINR 181
jgi:Pnap_4265  141 nwrqlrdylnsnaasir----------------------daslnpdwvsctlsntglfteepcaaygpdllagnsdLVGD 198
ABM05095       171 dflacl---------------------------------------------------------------glpnqislvvk 187
WP_006198867   145 qqpgrelakiadeqrvn----------------------------------------qtelvniilrdlpvwipsfsqfi 184 Nodularia spu...
WP_014395903    99 awfltlspdslprlvrqrlrdwsssedaasqrewaklvgqrpleksavrwalpmsveealgpdgpgtlakhwlahplvdv 178 Corallococcus...
jgi:Acfer_1261 144 islflqkdpe------------------------------------llksvlylrnrkqllkpnghklltreiqkqRSFR 187
WP_013838040   193 ARALCGDNSGRYAQVLRNTFYLELIAGADhSAEGHSFLADATARATALRRD--------------EDDRRFGIAVLSALC 258 Isoptericola ...
jgi:AciX9_2577 182 TLALWGVPTTTPLASAVLTAYVNHILTEI-SSGRVGQLDDLLATLQLPLVQm------------sTFQAGAGTLILSPHA 248
WP_014428003   206 LAEDLGIPPSSWFWHALVLGAVKRATADS-DAEFQRLVPQLIQLIKTR-----------------PGFRDEALEYILVRY 267 Rubrivivax ge...
jgi:Galf_1108  198 IRERLGVDGGSWLVRRLVMSPFVAIGRMP-DAEFKDHLASLLLLLNDY-----------------PLYASAALPLLLERY 259
CAP40554       182 IREQLGITDDSWFTNELVLSQVRHAVASP-YEEFKVQVPNLLTMLASLARHg-------------TKVRNRGLSLILDAY 247
jgi:Pnap_4265  199 IRKLLGISDGSWFTRELIIAQIRQATQLG-DQAFHAAVSGLLRLLGGN-----------------EVLRDRGLQILLDRY 260
ABM05095       188 aqeelenvlvevwkPELCDNYVKIIKQYS-YLQADTAVTKLLSLN----------------------------------- 231
WP_006198867   185 eeitpyfvkmispnQQQVTWLLSCLNEMS-NTQQINAVDYLLTRV----------------------------------- 228 Nodularia spu...
WP_014395903   179 vemlknsglkpgnsyaghviarylLRRLQsRQDVAEGLKFLVDEPLGRSWMphnntddvavsaplEARVAVVAATLACWG 258 Corallococcus...
jgi:Acfer_1261 188 KALEEFCWPVNLWYGSFSQWAVKDFFQLE-EEDDWDELFGVLKEICEDKAC--------------GNMVPYAAEKMIYLT 252
WP_013838040   259 DKSdTAVPST---EWVDAVLA---IGGDPRHEQSstwRDWWAHVD---EPLRARAVRWMSGADLRAFLRAVRVYgdetq- 328 Isoptericola ...
jgi:AciX9_2577 249 DK--NDSFRK---RIEAFVLDs-pRLGDPRLPHN---LPKWNGVD---AAALRKFRTWRATKDLVFFFRSVLPE------ 310
WP_014428003   268 HACrAAPQDE---LLRDFVCAp-aVWRNPKLKAAg-yATAWNRVP---EPVWQMVLGWVNERNLKDFFDILAAR------ 333 Rubrivivax ge...
jgi:Galf_1108  260 VQCkDRPMHA---QMRDYAVG---LWGNPWRAQQ-----QWLCS----DKARVMLAHWLKRQLLSEFFSLLSND------ 318
CAP40554       248 AQGsTPAIFE---QLRDVSVD---WWGNPWLPST---AAQWGGVS---PQAREMVSEWLRGEFIETFFTKLAQD------ 309
jgi:Pnap_4265  261 ALIpQPPQHP---SLRDYAVT---CWGNPWLPSN---QDRWGGVQ---TAARQMVSNWLKLEFIELFFTKLAQD------ 322
ABM05095       232 ----KEKALNespVLLDHLKE---KYG-PSSASS-----RWGMLS---LQAQHQLRAVIGAGWFAEFKLFIFQLtsqela 295
WP_006198867   229 ----YNDVVKnysFLVDWLRN------NYRNGEN------WYKLS---EPARRRLRQWIGGINYGDFQRLVDVIlsria- 288 Nodularia spu...
WP_014395903   259 NGQvASDVRG---RIEERLIArdsVFGDPRLTTL---SKAWQAVRvlgEAAFDEFLAALIQQDLEFFFERAMHE------ 326 Corallococcus...
jgi:Acfer_1261 253 DRFgDGNREK---EVRILLFQ---ALGDPRDPGA---SLNWVDVE---ERAREIFLSWLKKNDLNLFFTIISKTvrqv-- 318
WP_013838040   329 -----neslQRMFPRRERFLMGLYEtgRVQATRLILGNDVRRTMRRvTNINLVDAPRFDD---------MNTDTAIVFVD 394 Isoptericola ...
jgi:AciX9_2577 311 ---------GRDPHGRKDFWLRYVD--QVVDSVVALCPTDLQRLHT-SLSLERVHHCRIQ---------ENQSISCFLMR 369
WP_014428003   334 ---------NQADEGRLAFWSQYLK--QITWTRLVFG-ADTMALQR-RSPEVRNLIAREEgaya--rldGKSEVDAFMMQ 398 Rubrivivax ge...
jgi:Galf_1108  319 ---------DKALSRRFNFWDLYSE--DLTGMYFALG---KDAYVQ-GNMRLYKFRHLAKglia-klteEKHGVHTCIMQ 382
CAP40554       310 ---------GIGDRRRANFWLRYVK--SMTNVQFALG---PRALNS-PSRDFAVLLEKMKglyt-elkdSGSANNAFIMT 373
jgi:Pnap_4265  323 ---------GLSDTRRVKFWAKYVP--AIEEIHFALG---PHAMYS-RERDFVELRDKLKgliv-plqdNIAANNAFIMT 386
ABM05095       296 kalslspkdINQLQKRVTFWSNYQS--RFHSFRVFLPLKTATIIKN-SSLSLPEHTLIESg-------wDLKETELCFLE 365
WP_006198867   289 ----lesfeSNRLRSRREFWANYSN--RFERLRILLPSTSQIAIGY-----------QIQgdvdllkddGSDPTEVCIFD 351 Nodularia spu...
WP_014395903   327 -------------QDRRKFWLNYLG--AIRRTTCWLDSVTYDVLHS-KFATLPVEQQAAFrra---krlPQGDVSAFELS 387 Corallococcus...
jgi:Acfer_1261 319 ------atsENMWKYRKNFWEKYLD--AMYYTRVFLGPDAERIAWRmELAKQGMGFGRLNg-------sGDSMRSLLMFS 383
WP_013838040   395 CG----DFHLVEGSH-KFK-LHLYlgrpgpkltdprrraytrdeliHVIPDAHKRRHPLGERAHDAWT------------ 456 Isoptericola ...
jgi:AciX9_2577 370 FKganeDFIVAEFSN-VGKaRIFY-----------------------YGRFLERIGDINRSEFRLRELkseegl------ 419
WP_014428003   399 IG----SYLIVEFSK-KPNaCYAYkvdelpfep----yakhydggtTDLAYGYRGEK--AARIV---------------- 451 Rubrivivax ge...
jgi:Galf_1108  383 FS----HHHVVEFNR-EKNiAYFYdv------------------rqGTPSFYFAKGWVDIGAISVTAIekgadia---rt 436
CAP40554       374 LG----NLVAVEFSA-TGHaLYGY-------------------------QKGVLPFVFDSSEPLRLSGravntlkdrnqt 423
jgi:Pnap_4265  387 MG----DLVAVEFSG-ASNaFYGY--------------------------NVKNRMPFDLTQPVRTPVngqnslkn-ssr 434
ABM05095       366 FD----NHIVVEYLRgNASgLKLYdk------------------seISISKLLTNEKLKVSKLAEIEFkk---------- 413
WP_006198867   352 FG----DLFVVEFFRgRGSeTRLF---------------------------------PNNSQTQQILFgesrlsvkqirc 394 Nodularia spu...
WP_014395903   388 FE----RYVVVEFSR-TGNaTYIY------------------------------EHGESTQVLKRAVVehashfkh--rg 430 Corallococcus...
jgi:Acfer_1261 384 IG----DYVFIEASH-NGK-LRIWkrgkeplpf----yqakytykgFSYSDVTQASNVEKDFV----------------- 436
WP_013838040   457 -----HDq----gGAWLRKALDF 470 Isoptericola variabilis
jgi:AciX9_2577 420 aisfsHM------NNWQSKVRST 436
WP_014428003   452 -----HT------PGWQARAAEE 463 Rubrivivax gelatinosus
jgi:Galf_1108  437 skplrHEdt--klSTWEACFAAE 457
CAP40554       424 viwllHKdnihgwNRWEDMYEAT 446
jgi:Pnap_4265  435 alylrHQdnvlgfNGWEGRFQDE 457
ABM05095       414 ----eHDh----lFCWQNSCENM 428
WP_006198867   395 lggdkHDh----vFLWQVFSPIW 413 Nodularia spumigena
WP_014395903   431 atrliHT------PGWQLRFEQA 447 Corallococcus coralloides
jgi:Acfer_1261 437 -----HSss--etGSWQRKVNEW 452
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