Conserved Protein Domain Family
Strabismus

?
pfam06638: Strabismus 
Strabismus protein
This family consists of several strabismus (STB) or Van Gogh-like (VANGL) proteins 1 and 2. The exact function of this family is unknown. It is thought, however that STB1 gene and STB2 may be potent tumour suppressor gene candidates.
Statistics
?
PSSM-Id: 461971
Aligned: 17 rows
Threshold Bit Score: 750.341
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q7Q072        40 HRTRHSH-------------------------------------RSsSNNHSRsGSNNKrpdm-------apfQTSVNL- 74  Anopheles gambi...
XP_005476776  24 RDRRDRH-------------------------------------RS-KSRDSS-SRGDK--------------SVTIQTp 50 
XP_002613474  26 RDRKRRS-------------------------------------RGdHNHSSSlLKADR--------------SVTIQTp 54 
EEC08043      20 snSRHHHqgnnihhqshqqhqqqnhtpnqhqhqnhdgqqsyrasRRhSHRSTRsc----------------ptQVKV--- 80 
NP_477177     45 ERDRSRH----------------------------------------SHRSTHsSKSAKgfqrg----dmapyQTSVNMt 80 
OWR51627      14 SRRSSRH-------------------------------------RQhTHRSTRsSKSQRkesdn----mmapfQTSVNIn 52 
XP_011269502  29 hsskqhH-------------------------------------RQhSHRTPRsTRSQRkerqnldtnemapfQTTVNVr 71 
EEZ99288      28 HRDRNNY-------------------------------------RQhSHRSTRsSKSRKndem-------apfQTAVTLt 63 
XP_009858318  28 KRHRSHE-------------------------------------RGsRRHR---NRGEK--------------TVTIRTp 53  vase tunicate
XP_029696607  24 RERRDRY-------------------------------------RQ-KSRDAS-IRGEK--------------PGSIRVp 50  torafugu
Q7Q072        75 GDDGRD-GQEIIEVSIl---PQDETWGDNTTAITGnTSEQS-ISMEDVSY-FQM-----ADDRGVGFACQRYLERGLAVM 143 Anopheles gambi...
XP_005476776  51 G-EPLL-DAESTRGDD-----RDDNWGETTTVVTG-TSEHS-ISNEDLTR-VTK-----DLEESTPLECKRFVGPALGGC 115
XP_002613474  55 PHSTTG-GGDGEDGEE------DDNWGDNTTAITG-TSEQT--SMEDISR-MAK-----DMEDSIGLGSIQHLGVVIATM 118
EEC08043      81 GGDRRD---EVIEVQIl---PQDDNWGDNTTAITGnTSERS-VSAEDVSR-LGRgpgdqDTPGGL-FRCHMWAGTVLTGV 151
NP_477177     81 GDGSHD-GQEVIEVQIl---PQDENWGENTTAVTGnTSEQS-ISMEDINNmWHR-----ESDKGFSFACRRYVESSFYFL 150
OWR51627      53 PETGRD-GQEVIEVQIl---PQDENWGENTTAVTGnTSEGS-QSMEDVSN-WPI-----EADSGLGFVCSRYFSTTIALG 121
XP_011269502  72 GDSVDNmGQEVIEVQIl---PQDENWGENTTAVTGnTSDRS-ESTEDVSH-WPN-----ETDGSFGSSCSRYVGPVVAMI 141
EEZ99288      64 PDN-RD-GQEVIEVQIl---PQDDNWGENTTAITGnTSEQS-QSTEDVSN-WPG-----EPDTGLSFVCQRYMGTVLTYI 131
XP_009858318  54 PMDGRH-DSRATEGTIsvniPEDDNWGETNTFISG-TTDVTqLSHESLAK-LTK-----DIEASIGFRDCGYVGTII--- 122 vase tunicate
XP_029696607  51 P-ESLL-DEESTRGDD-----RDDNWGETTTVVTG-TSVDS-VSNEDLTK-IRK-----DLDDSLQPECRRYLSPALGAS 115 torafugu
Q7Q072       144 LCAVAFVSPLAMVVLPRVgffpaafesldlsqNERLRLL-A-CNAECKGMLVSLAARLLLLAIGLWALFLRQPAAIMPRI 221 Anopheles gambi...
XP_005476776 116 LSFFALVTPLAFLILPQV--------------LWRDALE-P-CGTPCEGLYVSLAFKLLVLLISSWALFLRPPRATLPRF 179
XP_002613474 119 LSFFAFLTPIAFVVLPLV--------------LWKETLD-P-CNTVCHGLFISFAFKLLILLIGAWALFFRRPRVVMPRV 182
EEC08043     152 LSLTAFLSPVVMVALPRVem-----------fEWKVQ---K-CGPECDGLLISFAFKLLILAVASWALFLRKPRATMPRI 216
NP_477177    151 LGCGAFFSPVAMVVMPYVgffpsafdhpeitqTVRTQLL-A-CSEQCKGQLVSLAARLLLLAIGLWAVFMRRTSATMPRI 228
OWR51627     122 LSLVSFVSPLAMVVLPKLgffpgltdnlalqpSQRIQLL-S-CTAECKGILLSLAFKLVLLAIGVWAVFLRPRNAVLPRI 199
XP_011269502 142 LGISAFLSPIAMVILPKLgffpds--ttvltmQQKLQLL-S-CNAECKGQLLGLAFKLVLLGIGSWAVFLRPRIATMPRI 217
EEZ99288     132 LSIVAFLSPLAMVVLPKLgffpalssrlgladSAK--LL-A-CGAECKGQLVSLAFKMAILAVGAWAVFLRKPNATLPRF 207
XP_009858318 123 FALISYLSPIAFVVMPKF--------------LWDNSSPlSaCGTSCKGTLISMSFKLLILLVASWAIFFRRQRTSMPKV 188 vase tunicate
XP_029696607 116 LGLLALITPLAFLLLPQL--------------LWRDALE-P-CGTPCEGLYISLAFKLLILLISTWALFLRPARAGLPRF 179 torafugu
Q7Q072       222 FLFRSCALLL-VLISSFAYWLFYIVQVTEGAraiv-sgssVVDYRTLVAYATSFCDTLLFVHYVAVVLLEIRHLQPLYHV 299 Anopheles gambi...
XP_005476776 180 FVFRCLLMVL-VFLFVASYWLFYGVRVLEPR---------ERDYRGIVEYAASLVDALLFIQYLALVLLEVRHLQPAFCL 249
XP_002613474 183 FVFRSMIMAL-VFVYTLSYWLFYGVRVLDER---------PSNYQDIVQYAVSLVDALLFIHYLAVILIELRHLRPQFIV 252
EEC08043     217 FILRAVVLAM-VFVFTFSYWLFFSVRVFEKRhq-----dyELTYLSIVQFALSLVDALLFIHYLAVILVEVRQLQPQFYV 290
NP_477177    229 FLYRALVLLL-VTICTFAYWLFYIVQVTNGAkivvetggdAVDYKSLVGYATNFVDTLLFIHYVAVVLLELRHQQPCYYI 307
OWR51627     200 FVFRAMMLVI-LAVCAFSYWLFYFVQITEASkala-vgeeAMDYTSLVSYSSSFSDTLLFIHYAAVVLMEIRHLEPVYYV 277
XP_011269502 218 FLFRAGVLLL-TMLCICTYWLFYVVQITESAktaa--ngeISEYKSLVNYAGTLADTLLFIHYVAVLLIEVRHLQPTFYL 294
EEZ99288     208 FLFRAAVLAF-VLVCIFAYWLFYIVQVTETAraat-tpeeTVDYEALVAYALSLTDTLLFIHYLAVVLMEIRHQQPMYYI 285
XP_009858318 189 FMFRSLIMVFvLLI-TLTYWLFYGIWILEQK---------EKDFQSIIEFSDSMTNCLLFVHYLSLVLLELRHLQTTFVL 258 vase tunicate
XP_029696607 180 FLFRCLLLAL-VFLFVASYWLFYGVRVLEPK---------ETDYRGIVGYAVSLVDALLFIQYLALVLLEVRHLRPAFSL 249 torafugu
Q7Q072       300 KVIRSPDGESHSYSIGQLSIQRAAVWVLQRYYTEFSIYNPYLERLPv--SKAQ--RKAAAvsSFKYYDV---DGATPAQ- 371 Anopheles gambi...
XP_005476776 250 KVVRSTDGASKFYNVGHLSIQRAAVWVLDRYYSDFPVYNPALLNLP---KSIL--SKKMT--GFKVYSLd--ENTTNN-- 318
XP_002613474 253 KVVRNTDGENRFYHVGQFSIQRAAVWLLEQYYRDFPPYNPALMHIP----TRA--PKQLT--GFKFYDV---DGNPGNA- 320
EEC08043     291 KIVRSPDGQSRSYAVGQLSIQRAAVWMLHKYYQDFPIYNPYLDTLPsrhRKQQqqLQQQS--AFKVYDV---DGGAMDEd 365
NP_477177    308 KIIRSPDGVSRSYMLGQLSIQRAAVWVLQHYYVDFPIFNPYLERIPisvSKSQ--RNKISn-SFKYYEV---DGVSNSQ- 380
OWR51627     278 KVVRSPDGESRSYAIGQLSIQRAAVWVLQKYYTEFPIYNPYLEKIPi--SKSQ--RKGQG--SIKFYEV---DSNTNA-- 346
XP_011269502 295 KVVRSPDGESRSYAIGQLSIQRAAVWVLERYYTEFPIYNPYLERLPv--SKSG--RKQSS---FKFYEV---DGGVTGGm 364
EEZ99288     286 KVVRSPDGASRAYAIGQLSIQRAAVWVLEKYYTEFPIYNPYLERIPv--SKS---RKNSS--SFKFYEV---DGVNNSSl 355
XP_009858318 259 EVIRTTDGERRFYNIGDLSIQRCSVWVLEKYYCDFPVYNPALMRIP----SRSarMKHINn-TFKVYDV---DGKPGND- 329 vase tunicate
XP_029696607 250 KVVRSTDGASRFYNVGYLSIQRAAVWVLDQYYSDFPVYNPALLNLP---KSIL--SKKMS--AFKIYNLgeaENGTDN-- 320 torafugu
Q7Q072       372 ----QQSQSRAVLAAHARRRDSSHNERFYEEHEYERRVKKRRARLVTAAEEAFTHIKRMQQpsspQQQHdqqgdgsgaAP 447 Anopheles gambi...
XP_005476776 319 ----STGQSRAMIAAAARRRDNSHNEYYYEEAEMDRRIRKRKARLVVAVEEAFTHIKRLQE----EEAAss------pKH 384
XP_002613474 321 ----SASQTRAMIAAAGRRHESIHKERYYEEQEYERRVKKRRVRFVCATEEAFTHIKRLSE----E------------RG 380
EEC08043     366 gdipPRNQTTVLPA-----RRSGHNDRFYEEHEYERRVRKRKARLVSAAEDAFTHIKRMHD----ENGq--------gTR 428
NP_477177    381 ----QQSQSRAVLAANARRRDSSHNERFYEEHEYERRVKKRRARLITAAEEAFTHIKRIHN----EPA------------ 440
OWR51627     347 ----PSGQTRSASGSVSGRRNS-HNERYYEEAERARRVRKRRARLHSAAEDAFAHVRRVRL----TAA------------ 405
XP_011269502 365 q-srGGSGDRAVLAAQARRRDSSHNERFYEEHDYERRVRKRRARLITAAEEAFAHIKRLHS----EVEs---------TP 430
EEZ99288     356 ----QQSQSRAMLAAHARRRDSSHNERFYEEHEYERRVKKRRARLITAAEEAFTHIKRLHN----DQV------------ 415
XP_009858318 330 ----TQGQNRAILAAVARRRDAGHNERYYEEAEYERRVRKRRARLVAATEDAFTHIRKASE----HEINtk------gKS 395 vase tunicate
XP_029696607 321 ----TTGQSRTTLSAASRRRDNSHNEFYYEEAEMERRVRKRKARLVVAVEEAFTHIKRHHA----EEAAss------pKH 386 torafugu
Q7Q072       448 PAIPLDPQEAAQAIFPSMARALQKYLRVTRQQPRHTVESILKHLAHCLKHDMSPRAFLEPYLVEAPVLQNDKER-RTNHN 526 Anopheles gambi...
XP_005476776 385 PREVMDPREAAQAIFAPMARAMQKYLRTTRQQAFHSMESILTHLQFCITHNMTPKAFLERYLTAGPTMQYQQQN-GRGRQ 463
XP_002613474 381 PAVPMDPHEAAQAIFPAFARPMQKYLRVTKQQPYHTMDSILKHLAFCIVHDCTPKAFLERYLTPGPSIQNESEI-HKKQK 459
EEC08043     429 PAIPMDPTEAAQAIFPSMARALQKYLRITRQQPRHTMQGILDHLAECLHYDLSPRAFLEKYLVSAPVLQDDREV-RPVQT 507
NP_477177    441 PALPLDPQEAASAVFPSMARALQKYLRVTRQQPRHTFESILKHLAHCLKHDLSPRAFLEPYLTESPVMQSEKER-RWVQS 519
OWR51627     406 GGGALGPREAAQAVFPSLARALQKYLRATRQQPRHSAESVLAHLARCLSQDASPRAFLEPFLVEGPVLSAEQES-RTLQR 484
XP_011269502 431 NSGPMDPMEAAQAVFPSMARALQKYLRITRQQPRHSVESILNRLARCLAQDAAPRAFLEPFFVTSPVLSNEKERqKRSHH 510
EEZ99288     416 PAIPMDPHEAAQAIFPSMARALQKYLRVTRQQPRHSVESILTHLANCLSNDLTPKAFLEQYLVSEPVLQNDKEV-KDVQT 494
XP_009858318 396 SNSVMECDAASEAIFPALARSLQKYLRTTRQHQHYQVEDIHKHLAFCIKNEMTPKAFLQRYINPGSYLTYDPR--HDSSQ 473 vase tunicate
XP_029696607 387 PREAMDPREAAQAIFAPLARAMQKYLRATRQQSYHTMESIINHLQFCITHNMTPKAFLEHYLGPGPTIQYLEPS--RGRQ 464 torafugu
Q7Q072       527 WALICD-ELLSRPLSDGCTFQLIQNDVSLTVSIHRIPHFTVSEEVVDPKSNKFVLKLNSETSV 588 Anopheles gambiae str. PEST
XP_005476776 464 WTLVSE-EPVTSALRQGLVFSLRRLDFSLVVTVTPLPFLRLGEEFIDPKSHKFVMRLQSETSV 525
XP_002613474 460 WTLVSD-LPLHNSLEPGMSFALREQSFSLLVTVMRIPTIKLKEDYQDPKSNKFVLRLQSETSV 521
EEC08043     508 WALVCD-VLLSRPLKPGVSFLLRQGEISLLVSVHALPHFNVTEEIVDPKSNRFVLRLNSETSV 569
NP_477177    520 WSLICD-EIVSRPIGNECTFQLIQNDVSLMVTVHKLPHFNLAEEVVDPKSNKFVLKLNSETSV 581
OWR51627     485 WALVSD-DLLARPLADGVEFQLRQGDVSLICTIKSLPRFSLSEEVVDPKSNRFVLRLNSETSV 546
XP_011269502 511 WALVCEgELPSRPIANGCEFQLRQGEVALLCTAHRLPHFNLTEQLAHPKSNKFLLRLNSETSV 573
EEZ99288     495 WALICE-ELLTRPIGDNTSFQLRQNDVSLLCTIKKIPHFNITEEVVDPKSNKFVLRLNSETSV 556
XP_009858318 474 WDLVSD-EPLVNMLKDGTVFRLNQPEYSLVVTVRKSPRIGLQEVFIDPDSYRYVMHMQSETSV 535 vase tunicate
XP_029696607 465 WTLVSE-EPVTAAIHQGQVFSLRRTDFSLIVTVTSLPFLHLAEEFVDPKSHKFVMKLQSETSV 526 torafugu
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap