Conserved Protein Domain Family
PIP49_C

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pfam12260: PIP49_C 
Protein-kinase domain of FAM69
This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.
Statistics
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PSSM-Id: 463512
Aligned: 29 rows
Threshold Bit Score: 133.568
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002604567 242 FLKLLQktfdDNgNKRlnrLEQAIPRKKl-PIPAFLGACGNLVATETAG--KPlsm-----yleVKGPWQVRANLSLQLL 313
XP_697696    194 LYTLAV----NQ-QPL---ILQMFPGTEgwPFLRYHGSCGRLMVWAASRalRTl----------FSSPLERRADLAYQLL 255
XP_416761    208 LYTLSV----NS-HPI---LLQIFPDVEgwPFPRYLGSCGRLVVSASTRplr----------dfFRAAPEVAADLALQLL 269
EDL97684      13 LYTLAV----NA-HPI---ILQIFPGAEgwPMPKYLGSCGRFLVSTSTRplq----------efYDAPPEQAADIAYQLL 74 
XP_002593078 195 LSTLKF----NP-EPL---MLQTFPITEgwPFPFYFGACGRLTVVQKCDktl---------asyYSAPWLKRVELSLQMM 257
VFV43512      49 LLTLAF----NP-EPL---VLQSFPSDEgwPFAKYLGACGRMVAVNYVGe-ELws--------yFNAPWEKRVDLAWQLM 111
XP_001637923 193 LITGLHl---NP-ELL---LLQIFRQEEgwPFPRFYGVCGRIMVVEDSG--PPis-------sfLEESWDVRAQIAVNLI 256
XP_002434016 195 AYTASV----NP-EPL---ILQAFPRRDgwPFPEFCGSCGRL-VVESYEgtPLsq--------fELFDWSVRAHLANRLL 257
XP_001841876 188 SWNLVQ----NH-EYV---MLNLFDEKD--LFPYIAENCGEMFVTEYLNavEFdeehr-ygshiDLDRWRYHIKIAVLIL 256
Q176Y7       184 SWNLIQ----NH-EFV---MAVMFNEND--LFPYVEGNCAEMFASEKLNavEFdenrsyfgshiTLDRWRYHIKMAVLIL 253 yellow fever mo...
XP_002604567 314 QMLDDFQNKDPDWlLMFVEVNIENFSVS-SDGRLILTDLGNMTIINKhdldKNS-TKKRSsvcN--------EACFK-RF 382
XP_697696    256 HITQSLSANSLRFrLFYTRIPEDMFGIL-EDNKVFIVDTSTIGIIDL----QEG-HPPDK---Dll-----pEELDV-FS 320
XP_416761    270 AVLHSMGTNDLNYfFYFTRVDVGTFGVF-SNGHLFIRDASTLGIIDKeegsQPI-DGQQE---Y--------KD--I-FS 333
EDL97684      75 GVLESLRSNDLNYfFYFTHVDAGMFGIF-DNGHLFIRDASALGIIDKqeasQAA-DRTGE---N--------ED--I-FS 138
XP_002593078 258 KIAEYLTNNEADFgLYLTDISYENFGVT-SDGNLFVIDVENVIVVDKq--kIKA-DKPRN---WearyqshfDECPGmSN 330
VFV43512     112 EIAEQLTNNDFEFaLYLLDVSFDNFAVGpRDGKVIIVDAENVLVADKr--lIRQ-NKPEN---WdvwyeskfDDCDK-EA 184
XP_001637923 257 TLAHQLSSALDDWaLYIADPAPGNFGVS-DSGKVTLLDLEHLVVVDLsevqMEEaNDKPK---P--------SDCSQ-PD 323
XP_002434016 258 DLAQLLTENPTEFaLYLTDVSMDNFAVD-AMGQVTVVDAENVIVVDQr--eVREgQKPGW---Dkry--ehlEE-AC-HD 327
XP_001841876 257 DYVSELEQ---HE-LQMCHVDLRRFGIN-NN-RLKYDDVRYLFPEYTinrkISSgTQCAS---D--------DDCRF-MF 318
Q176Y7       254 DYMDELDQ---HG-IQMCHVDLSRFGIN-NN-RLKYDDLRFVFTDYTinrkISSgSYCAR---D--------EHCNF-MH 315 yellow fever mo...
XP_002604567 383 TR-N-LSHRPETSCRQAGRYSQlmYARACQR-I------LGCWqtersgegrvvlssskdascaygrglLFGP----PRE 449
XP_697696    321 CL-S-GSCVRPPPCETVREAQS--FILLCKY-I------LNNL--------------------------LTSNd--kQSG 361
XP_416761    334 CL-TvDCQSAFVSCNSIREKQS--LVMVCQE-L------LPKL--------------------------LRGKf---LPP 374
EDL97684     139 CLvS-GCQVQMSSCDTVPEKQN--LVLVCQQ-L------LPQL--------------------------LRGKf---PSP 179
XP_002593078 331 CL-S-FD--VSALCRYLHTDHN--YYAVCRNmL------SEYAsemgk-----------------pgglLHDP----PET 377
VFV43512     185 CL-S-FSK--EILCARATVDHN--YYAVCQN-L------LSRHatwrg----------------tsgglLHDP----PSE 231
XP_001637923 324 CL-S-FSP--SDMCSGGSRDHN--YYAICQG-VlagssrRQGL--------------------------LHNP----PVA 366
XP_002434016 328 CL-S-FSS--EDLCSHQLADHN--YFAVCSG-Ll-----APRAfyss------------------vgglLHSV----PPD 373
XP_001841876 319 CQ-S-ECNREKHRCESTVLNNN--VQIVCEK-I------FLGTs------------------------gYPGIl--iTHK 361
Q176Y7       316 CK-S-ECNVEKNRCESTVMNNN--VQIVCDK-I------FLGS--------------------------KRYPgiliTQK 358 yellow fever mo...
XP_002604567 450 AKQE--LEDLLTECVEE 464
XP_697696    362 LPRA--AVDELLVCADP 376
XP_416761    375 VQEK--IDSFLQHCAEG 389
EDL97684     180 VQQE--IDSALSLCSKD 194
XP_002593078 378 VVRDgtLQRLLAECAKP 394
VFV43512     232 IAKDgrLEALLDECANP 248
XP_001637923 367 LKAS--LNQLLQDCTAQ 381
XP_002434016 374 VEKQhgLSALLAACDRP 390
XP_001841876 362 TPDR--LKELLERCARP 376
Q176Y7       359 TPDR--LHMLLERCANP 373 yellow fever mosquito
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