1PMR,1GJX,1K8O,1QJO,1LAB,2PNR


Conserved Protein Domain Family
lipoyl_domain
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cd06849: lipoyl_domain 
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Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid dehydrogenase (BCDH), contain at least three different enzymes, 2-oxo acid dehydrogenase (E1), dihydrolipoyl acyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) and play a key role in redox regulation. E2, the central component of the complex, catalyzes the transfer of the acyl group of CoA from E1 to E3 via reductive acetylation of a lipoyl group covalently attached to a lysine residue.
Links
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Statistics
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PSSM-Id: 133458
Aligned: 407 rows
Threshold Bit Score: 43.9323
Created: 29-Sep-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:lipoyl attachment site [posttranslational modification site]
Evidence:
  • Structure:2PNR; Lipoamide-containing lipoyl domain 2 (L2) of human pyruvate dehydrogenase kinase 3
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                             #                                  
1PMR_A      3 VDILVPdlpesvaDATVAtWHKKpGDAVVRDEVLVEIETDKVVLEVPASADGILdaVLEDEGTTvt-sRQILGRL 76  Escherichia coli
2PNR_G     28 MQVLLPalsptmtMGTVQrWEKKvGEKLSEGDLLAEIETDKATIGFEVQEEGYLakILVPEGTRdvplGTPLCII 102 human
P47514      3 NEFKFTdvgeglhEGKVTeILKQvGDQIKIDEALFVVETDKVTTELPSPFAGTIsaINVKVGDVvs-iGQVMAVI 76  Mycoplasma genitalium
NP_975266   2 FKVKFAdigegltEGIVAeVLVKvGDVVKEGQSLYFVETDKVNSEIPAPVAGKIavINIKAGQEik-vGDVVMEI 75  Mycoplasma mycoides sub...
CAK98642    2 VKFKFAdigegltEGKVAkIMIEvGDKIKDGVEMFAVETDKVNTEIYAPCDGIVskINMAVGDTiy-vGDVVVEI 75  Spiroplasma citri
ABO43796    3 YIFRLPemgegltEGDVAsWLVKeGEAIKADDPLIEIQTDKSTTQLVSPVDGTVkkLFVKEDDHve-kGDKLAEI 76  Lactobacillus reuteri
NP_757896   2 YIFKFAdigegihEGKVSdILVKeGDSVKDGTDLFSVETDKITTEVSSPVNGVIskILIKVGDTih-vGDPIFEI 75  Mycoplasma penetrans HF-2
NP_853265   2 FEYKFTdvgeglhEGVVAqIYVKvGDTIKEGDPMFSVETDKVTTDLPAPEGGKVtaILASVGQTvh-vGEVMLVL 75  Mycoplasma gallisepticum R
AAT58044    4 YTFKFAdigeglhEGVVAeIYVKvGQQVKEGDNLFSVETDKVTSDIPSPVSGTVtaIKMAQGDTih-vGQDIFVF 77  Mycoplasma synoviae
P35489      2 YEFKFAdigegihEGTVLqWNFKvGDKVKEGETLVIVETDKVNAELPSPVDGTIvsLGAKEGEEih-vGQIIVTI 75  Acholeplasma laidlawii

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