4DLF,2FFI,4I6K,4MUP


Conserved Protein Domain Family
COG3618

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COG3618: COG3618 
Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only]
Statistics
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PSSM-Id: 442836
Aligned: 564 rows
Threshold Bit Score: 73.3237
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4DLF_A         5 RIDSHQHFWRYRAadYPWIgA--G-MGv--L-AR---------------DY----LPDALHPLMHAQALGASIAVQAr-- 57 
WP_015792535   3 VIDTHCHVISPDLdaYPHA-PigGkQSewaA-SR---------------PI----TAEGMVAAMDEVGIRQSVLVQAtt- 60 
WP_043720614   5 LADAHLHLFANG---YPGRyg--------rSpAG---------------AE----ELAAYQDIRRVHGIDRALVVGYege 54 
WP_068025048   2 IIDTHTHVIATDTkkYPLA-PlfGkQSdwsQ-AH---------------PI----DYPDMVKAEAEAGVDKAVLVQAss- 59 
WP_046966589   3 IFDTHTHVIAPDTtlYPTD-PigGhQSewsQ-KR---------------PA----DAAGLLAAIDGAGIAKAVVVQAst- 60 
WP_086088741   4 VIDIHTHVISSDSerYPFA-PlgGkQSdwsR-AR---------------PT----SAAALLAAMDEAGVAKSAVVQAst- 61 
WP_083216122  17 LYDTHAHLVSDDEirYPRSyPfeN-TSlrmP--RipgtigtpggmhgpePInekpTAELMHKWMAEENVVGIAAVQKgm- 92 
WP_122824008   4 RADAHVHLATTGr--FSTAv------------DE---------------GH----EVETYDRARvRAAITDALVVGYqgw 50 
WP_124688000   5 VVDIHPHVISTDTraYPRD-PlwGrPSawsQ-ER---------------PA----STEQLLQAMDEAGVAKAAIVQAst- 62 
WP_124691225   9 IIDLHTHVIASDQqaYPLA-PlsGrQSdwsR-ER---------------PV----TREAMLAAMDEAGIAQVALVQAst- 66 
4DLF_A        58 -AGRDETAFLLELACD-EA-RIAAVvGWEDLRAP--QLAERVAEWRGT-KLRGFRHQLQDEADv--rA-FVDD-ADFA-R 126
WP_015792535  61 -nYGYDNSYVVDSRRR-YPeRFIAV-GTFDPLAP--DAGSRLKALTADgGLSGVRLFTSGSTVptqgE-WFAA-PETH-E 132
WP_043720614  55 eHFAGNNDYLAS-LVGsHP-WIAPV-AYVSPDGPa-D--GQLARWWAA-GFVGVSAYLADTEQ----AdRFA---AWLtT 120
WP_068025048  60 -aYAFDNSYVADSVAA-HPeRFTGV-FSIDVVAP--DAPAKMKHWMSK-GLTGMRIFTSGSTHaaqeT-FFAE-EKAY-P 130
WP_046966589  61 -vYGHDNRYVVDTVRA-HPsRFVGV-YSIDALAP--DAVQRIDHWQSE-GLSGFRLFTTGSTMpgqsD-WLGH-KDSF-P 131
WP_086088741  62 -aYGFDNSYLADCVAA-HPeRFTGV-FCIDMFAP--DAGAEFKRWTQA-GLTGMRLFTTGSTSpgqaD-WLAD-ERTF-P 132
WP_083216122  93 -iYGTDNSYIVDAADA-FPdEMRAI-IIVDPQAP--ETPDMIRECASR-GIVGIRFFGVGVVDk---GaWLSS-PASL-K 161
WP_122824008  51 pGLEANNADVLAIARE-RS-WVHPL-AYLDVRHPpaD--DLLTGAAAR-GFRGFSVY--DDPD----GaHLADwPv---A 115
WP_124688000  63 -cYGYDNSYAADAVAA-HPdRFTGV-FSVDMLAP--DAPARMRHWVDR-GLTGLRLFTAGSTVegqvP-GLDD-PRSF-G 133
WP_124691225  67 -cYGHDSSYVADSVAA-RPdRFIGV-YSIGLAEP--GAAERIAYWHGR-GLQGMRVFIAGHTAadhaA-RLDD-PLGF-P 137
4DLF_A       127 GVAWLQANDYVYDVLVF-ER----QLPDV-QAFCARHDAHWLVLDHAGKP---ALAEF--DrddtalARWRAALRELAAL 195
WP_015792535 133 FWRTAEQTGVPVCLQMRlGP----ATTQL-VDVLGRFPEAKVLLDHFGYP---DIA-As-P------LRAGQEVAKLAKH 196
WP_043720614 121 AVPQLTAARALLSLNAT-PA----ATARL-GTALAGLDACPVLFSHLGLPgsrPTPPTpqQa-----AETLAPLLDLARL 189
WP_068025048 131 AWQFANDNDLSVCMQMR-VV----GLPLLeEKIIKRFPKVRILLDHFARA---EAADGi-P------FPSAAPLWALSKY 195
WP_046966589 132 AWAHAEKRGIPVCLQMT-ME----GLPAL-RALLERFPTVRVLLDHCARP---DLSDGa-P------FAAARALFDIATF 195
WP_086088741 133 VWELAEAASLPVCLQMR-PE----GVPDL-LKLLARFRKVPIVLDHMARP---ALSDGp-P------YRAAQWLFDLAAH 196
WP_083216122 162 VWELADSLGLLVDIEAP-ATgsevLIPVI-EQMADHLPELRIVLDHVFLP---DCTQp--Ny------GIDERFDGFARR 228
WP_122824008 116 TRRRLAAGGDVLSLNLR-PA----ALARL-AAVAGDLAGTTVLVSHLGLPgplPATAGraEv-----RDRLRPLLDLARF 184
WP_124688000 134 AWDCAADLDLPVCVQMR-IA----GVPQL-RVLLARYPRVPIVLDHFFAL---PLDEGp-P------YASAQELFRLAAH 197
WP_124691225 138 AWEQAQELDIPVCVQLR-AD----GLPQL-ENILRRFPRVRVLLDHFARP---RLDDGp-P------YAAAASLFALADH 201
4DLF_A       196 PHVVCKLSGLVTEAdwrrglR---ASDLRHIEQCLDAALDAFGPQRLMFGSDWPVCLLAASYDEVAS-LVERW--AeSRL 269
WP_015792535 197 PGLYLKLTHRNLERl-----Q---D-VGDKAVEFLQRVVEAFGSERIAWGSNCPAAEQS--LPELLG-LAEGV--L-AVL 261
WP_043720614 190 PQVGVKVSGLYAVSep---aH---AWPHSAARPFVDLLLERFGSRRLYWGSDFPPSLDHVSFSQTLE-PV--G--L-AQL 257
WP_068025048 196 PNVYLKLTHRPIEQs-----V---K-GKSTPEAFLGKVVSEFGAGRICWGSNFPAAKEP--LPELIE-MARKA--L-SFL 260
WP_046966589 196 PGVYLKLTNRTLAAa-----T---V-GKSTPRAFLERTIETFGAGRIAWGSNFPAAEGS--LPTLVA-TAHDA--L-ASL 260
WP_086088741 197 PNVFLKLTSRTIEQa-----G---T-GSSTPEAFFPKLVATFGADRIAWGSNFPAHAGP--MSHLLE-DAQKS--L-SSL 261
WP_083216122 229 ENISVKFTSLSMDVi----rEkgvA-P----ERVLRRTVDFYGADRTMWGSDIGTSSGT--YKMMVA-RAIAateL---L 293
WP_122824008 185 EHVSVKLSGLYAIDp--------vP-PHAGALAVTEEVLGAFGPGRLLWGSDFSPALDVVGLDDALTlPA--W--L-PEL 250
WP_124688000 198 PNIHLKLTPVILAKa-----Y---L-GQASPQSFFGRALAEFGASRIAWGSNFPATAGS--LKTLLD-EAQQA--L-AWA 262
WP_124691225 202 PNLFFKFTTHNVREa-----R---E-GAATQASFLRRAIDVFGVRRIAWGSNFPASAGS--LASLLG-EALEA--T-ASL 266
4DLF_A       270 S-AAERSALWGGTAARCY-AL 288
WP_015792535 262 S-DEARADIFAGTARQLYpGL 281
WP_043720614 258 S-RTEQADIFGANLRRALdGV 277
WP_068025048 261 S-QADQNQIFHKTALALYpAL 280
WP_046966589 261 S-PQDRALIFSGTAAAIYpVL 280
WP_086088741 262 S-EADRAHIFSGTARRLYpAL 281
WP_083216122 294 T-DEERRKVLHDTGRRIMlGW 313
WP_122824008 251 AtPAEIDDIGGATLRRLL-AA 270
WP_124688000 263 G-DDDLNWIFHRTAERLYpAL 282
WP_124691225 267 S-GEEREWIFHRTARALYpAL 286
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