Conserved Protein Domain Family
Rxyl_3153

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TIGR03989: Rxyl_3153 
NDMA-dependent alcohol dehydrogenase, Rxyl_3153 family
This model describes a clade within the family pfam00107 of zinc-binding dehydrogenases. The family pfam00107 contains class III alcohol dehydrogenases, including enzymes designated S-(hydroxymethyl)glutathione dehydrogenase and NAD/mycothiol-dependent formaldehyde dehydrogenase. Members of the current family occur only in species that contain the very small protein mycofactocin (TIGR03969), a possible cofactor precursor, and radical SAM protein TIGR03962. We name this family for Rxyl_3153, where the lone member of the family co-clusters with these markers in Rubrobacter xylanophilus. [Unknown function, Enzymes of unknown specificity]
Statistics
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PSSM-Id: 274905
Aligned: 14 rows
Threshold Bit Score: 600.072
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEI31700       4 NTRGAILRSAPGKYEVVDLVADDPRQGELQVKLAASGMCHSDDHIATGDMPV----------GHYPFLGGHEGAGVVTAV 73  Geodermatophilu...
EEN88616       2 KTKGAILWGLNEKWSVEEIEIGEPVAGEVQIRMEAAGMCHSDHHIVTGATPM----------PSFPVMGGHEGSGVITKL 71  Rhodococcus ery...
EEJ97607       2 QTRAAILWEPHTEWSVEDIELDDPKAGEVKIKLTASGLCHSDEHMVTGDMAMdpevaklmqvEQYPIIGGHEGAGEVVEV 81  Thermomonospora...
EEN88612       2 KVKAAVVKAPGQAWEIEEVELGDPVSGEVQVRLAASGLCHSDEHLRTGASPL----------PFYPALGGHEGAGVVTKV 71  Rhodococcus ery...
EEI38142      26 KTKGAILRGPGQPWQIEEFELGDPVAGEVQVKLVSSGLCHSDHHLRTGDSPA----------PM-PVLGGHEGAGVVQKV 94  Gordonia bronch...
EEI40886       4 TTKAAVLTAPGKPFEIVELALDEPREGEVLIKYTAAGLCHSDLHLTDGDLP-----------PRYPIVGGHEGSGIIEAV 72  Gordonia bronch...
EEN89625       2 RTRGAVIRQAPGTYEVVDLELDSPRSGELTVKMVASGLCHSDDHIASGDHGV----------GRYPICGGHEGAGIVVEV 71  Rhodococcus ery...
WP_011892490   2 KTKGALIWEFNQPWSIEEIEIGDPVKDEVKIQMEASGMCHSDHHLVTGDIPM----------AGFPVLGGHEGAGIVTEV 71  Mycobacterium g...
WP_012296772  11 KTKGALIRELNKPIVVEEITFGDPAEGEVQVQLHAAGMCHSDYHVLTGATPM----------E-LPVLPGHEGAGVVTKV 79  Mycobacterium a...
WP_012642824   2 KTKAAVLHGPTKVFSIEELELDEPKAGEVLVKMVATGICHSDWHFATGDHPA-----------RYPIVPGHEGAGIVEQV 70  Thermomicrobium...
EEI31700      74 GPGTPGFKEGDHVVFSFLPGCGRCRYCANGQQYICDSGANLLIGSRWDDaESFRFSTt-DGTPVGQMCGLGTFAEVTTVD 152 Geodermatophilu...
EEN88616      72 GPEVKGLEVGDHVVLSFIPACGTCPACSAGHQNLCDLGMGLLSGQAISD-GTYRIQA--RGENVIPMCLLGTFSPYMVVN 148 Rhodococcus ery...
EEJ97607      82 GPGVTTLKEGDHVVLSFIPACGRCPSCAQGRQHICDLGAVLLAGRQISD-MTARHHAkkNGADLGIMCCTGTFAPYTVVN 160 Thermomonospora...
EEN88612      72 GPGVASVEEGDHVVLAFIPACGRCPSCAKGLQNICDEGAGLLTGQAISD-KTYRVTL--DDEPVIQMCLLGTFSPYVTVN 148 Rhodococcus ery...
EEI38142      95 GPGVTRLKEGDHVVTAFIPACGVCDPCSRGDQNFCDEGARLLTGLAISD-DTHRCHTs-DGEGLTQMCLLGTFAPYITVN 172 Gordonia bronch...
EEI40886      73 GPGVTKVKPGDHVVCSFIPNCGTCRYCSTGRQNLCDMGATILEGSMP-D-GTFRFHS--GSDDFGAMCMLGTFAERATIS 148 Gordonia bronch...
EEN89625      72 GPNTEGWSEGDHVVFSFLAACGRCRWCASGIQNLCDNGAAIMTGSRPGEtSSYRMSL--DGQPVAQTCGLSTFSEYTTVS 149 Rhodococcus ery...
WP_011892490  72 GPGVEGLEPGDHVVLSFIPSCGACPSCQAGLRNLCDLGAMLLQGTAVSD-NTHRIHAa-DGTPVIPMTLLGTFSPYMVVH 149 Mycobacterium g...
WP_012296772  80 GKGVTSVQEGDHVIFAFIPACGKCPPCMRGYRSLCDRGAILLGGKAIAD-GTNRIHA--GNTPVSAMNLLGTFSPYAVVH 156 Mycobacterium a...
WP_012642824  71 GPGVTEVQPGDHVLLTFIPPCGKCRWCLTGIPVLCDRGAQATIGAQL-D-GTFRLRTt-DGQEVGQFAMIGCFSQYTVAP 147 Thermomicrobium...
EEI31700     153 VRSTVKIPDDIPLDVACLVGCGVGTGWGTAVQAGEVKAGDTVIVMGIGGIGINAVQGAAHAGASHVIAVDPVAFKREKAM 232 Geodermatophilu...
EEN88616     149 QSSVVKIDKDIPFEVAALVGCGVPTGWGSATHIADVKPGEDVVIMGVGGVGISALQGAVASGARYIFAIDPVPWKREQAL 228 Rhodococcus ery...
EEJ97607     161 EATCIKIDPSIPLDKAALVGCGVTTGWGSAVYAADVQPGETVVVIGLGGIGMNAVQGAAFAGARYVVAVDPVEWKRQKAL 240 Thermomonospora...
EEN88612     149 EASVIKIEKDIPLDKAALLGCGVATGWGSATAIGGAKVGDTVVVVGVGGVGINSVQGAASAGARFVIAIDPVEFKRDKAK 228 Rhodococcus ery...
EEI38142     173 EASLVKIEDDIPLKEAALLGCGVATGWGSAVEIGGTHAGDIVVVVGVGGVGINSVQGAAAAGARIVAAVDPVPFKRQMAE 252 Gordonia bronch...
EEI40886     149 QHSVVKVDDWLPLEKAVLVGCGVPSGWGTSVYAGGVRAGDTVVIYGIGGLGINAVQGAVSAGAKHVVVVDPVAFKRDTAL 228 Gordonia bronch...
EEN89625     150 TLSAVKVDKHLPLDALCLLGCGVGTGWGAAVNSAQVYPGQTVIVMGVGGIGINAVQGASHAGAAHVIAVDPVAFKRDSAL 229 Rhodococcus ery...
WP_011892490 150 KSSVVKIDPSIPFEVACLVGCGVTTGYGSAVRSADVRPGDDVVIAGIGGVGMGALQGALNAGARNIFAIDPVEWKRDQAL 229 Mycobacterium g...
WP_012296772 157 EDSVVKIDDDVPFESAALLGCAVPTGFGSSTNIAEVKPGEDVIIVGIGGIGMSALQGAVVSGARRVIAIDPVPWKREQAL 236 Mycobacterium a...
WP_012642824 148 VDAIVKIDPDIPLDKACLVSCCVPTGVGAAAKRGEVRAGEVVAVFGLGGVGMNAVQGAALAGASKVIAVDVVDWKLEAAQ 227 Thermomicrobium...
EEI31700     233 E-LGATHAF-ESIEEAAEFSRSVTNGQGADKALVTVGILKGEHVAQAFEAIGKGGRVVITGLGDLTDVGIPINPSMLALF 310 Geodermatophilu...
EEN88616     229 K-FGATHAF-ESAAAAIQPIIDATYGRMAQKTIITVGEMKGEYVEEAMILTAKAGRCVVTAMGHLTDMDVKLNLFLMAML 306 Rhodococcus ery...
EEJ97607     241 EtFGATHAA-ASIEEAIFLVNEITWGANAEKVILTTGVATGDLIAPMMSMVAKGGRGVVTAVAPMSQEDVKLNLFELAMT 319 Thermomonospora...
EEN88612     229 E-FGATHTF-ASLEEALPVIGEITWGKMADVTVITVGEIHGDIIQPALSATGKGGQVVVVGMGHYADSQVTLSLFELTLL 306 Rhodococcus ery...
EEI38142     253 K-LGATHTF-ESMEDALPVLGEISWGKMANTTILTVGEIDGSMIAPALALTGKGGQVIVTGMGNFASMDAQMNLFELTLL 330 Gordonia bronch...
EEI40886     229 K-FGATHAF-ADAAEAAEKVNELTWGQGADQALILVGTVDEEVVQNATAVVGKGGVVVITGLADPTKLTVHVSGTDLTLN 306 Gordonia bronch...
EEN89625     230 K-LGATHAV-ATMEEATDIARSFTNGQGADSAIVTVGVTTGEHVAQAFSSIRKAGTCVVTGLGKMTDVGIPVSLMELTLY 307 Rhodococcus ery...
WP_011892490 230 K-FGATHAY-PDIFSAMAGVAELTQGRMAAKTIITTGELHGEEIDNYLNITSKGGTCVVTAVANMAKSDVTLNLSMLTLL 307 Mycobacterium g...
WP_012296772 237 K-FGATHAF-PTMAEALLPVMDLTWGIMAQKTIITVGEMRGEMIEEAMLLTAKTGTCVVTGMGAMVDVDVKFNLFLFTML 314 Mycobacterium a...
WP_012642824 228 E-FGATHTInAKYDDPVQRILDLTNGVGADKTIVTIGHVEPEHIGIAYRATRKAGRCVVVGLAPIATDSMKVPPADLVLL 306 Thermomicrobium...
EEI31700     311 TKEIRGALFGDQNPSADMLKMLRLYQEGKIKLDELITKRYKLDDIQQGYEDMHAGKNIRGVIVY 374 Geodermatophilus obscurus DSM 4...
EEN88616     307 QKDLQGNIFGGGNARQDVPNLLAMYKAGKLNLDDMVTRTYTLEGVNDGYQDMLDGKNIRGVIRY 370 Rhodococcus erythropolis SK121
EEJ97607     320 RKELVGCIFGNANPRRDIPRLLHLYQDGKLKLDELVTRTYTLDEINQGYQDMRDGKNIRGMIKY 383 Thermomonospora curvata DSM 43183
EEN88612     307 QKRLQGAIFGGVGPRSQIPKLLDHYRSGALKLDELVTKTYKLEEINEGYADMLEGKNLRGMIVY 370 Rhodococcus erythropolis SK121
EEI38142     331 QKRVQGAIFGGASPRTQVPNLLNEYRAGKLNLGDLVTNTYRLDQINEAYDDMLAGNNIRGMIVY 394 Gordonia bronchialis DSM 43247
EEI40886     307 QKTIKGTLFGSANPQYDIVRLLRLYDAGQLKLDELITQTYTLDQVNEGYQDLRDGKNIRGVIIH 370 Gordonia bronchialis DSM 43247
EEN89625     308 QKRIQGSLFGASNPTADIPWMIDLYTSGKLELDGLITNRYTLDQINDGFADMHAGRNLRGIITF 371 Rhodococcus erythropolis SK121
WP_011892490 308 QKNLQGTIFGGGNPHHDIPQLLSMYKAGRLNLDDMVTRQYKLEQINDGYKDMLEGKNIRGVIRY 371 Mycobacterium gilvum
WP_012296772 315 QKTLKGNIFGGGTTHTETPRLVGLYKQGLLKIDEMITSTYSLEQINEGYQDMLDGKNIRGVIKY 378 Mycobacterium abscessus
WP_012642824 307 GKEVVGTLYGHVNPRVDFPYLLQLYRAGRLKLDELVTQTYSLDQINQGYQDLLEGRVIRGVVLF 370 Thermomicrobium roseum
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