Conserved Protein Domain Family
Peptidase_S26
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pfam10502: Peptidase_S26 
Signal peptidase, peptidase S26
This is a family of membrane signal serine endopeptidases which function in the processing of newly-synthesized secreted proteins. Peptidase S26 removes the hydrophobic, N-terminal, signal peptides as proteins are translocated across membranes. The active site residues take the form of a catalytic dyad that is Ser, Lys in subfamily S26A; the Ser is the nucleophile in catalysis, and the Lys is the general base.
Links
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Statistics
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PSSM-Id: 431321
Aligned: 71 rows
Threshold Bit Score: 94.1943
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q89AM6         51 VVQTFASFFPILIIV--FIIRTFICEPFQIPSESMMPTLLPGDFILVKKfsygiknpfsnnvivfINTPKRGDIVVFKHP 128 Buchnera aphid...
WP_011806074   26 RARIVLSGLAACGLA--ALAWAYFVHPLPRLIYNPSDSVAVGWYRVDPLhhrp---------cslPRPLSVDTIVLTTLP 94  Acidovorax sp....
jgi:Ajs_2658   22 RARLVLAGFAAVGLA--ALAWAAFVQPLPRLIYNPSDSVPVGWYRVDPIqhra---------gslARSLSVGSIVLTQLP 90 
Q11L03          3 RAGYLLTATGAALLL--ITLAMVHVAPRLV--WNASASVPVGLYEIGS-----------------ATPLEVTDLVAVNAP 61  Chelativorans ...
jgi:Pden_1510   3 RARYIM-VTVAALAA--VIVGSIPTAPRLV--WNASASVPIGFYTIAP-----------------VDRLAVPDLVAVMPP 60 
WP_011749450    6 RTTYLAATAAAVMVI--GAVSVTDITPRLI--WNASASLPIGLYRVEP-----------------PTTLTLGDLVAVDPP 64  Paracoccus
jgi:Pden_0136   6 RTAYLAATGLAVLVI--GAVSVTEIAPRLI--WNASASVPLGLYAVQP-----------------VGNLTLGDLVAVTLP 64 
Q20ZK4          1 MKARKVTFLTTLSAAaiLLVSMGEQTP-KLFIWNASESVPVGLYRLRP-----------------IRKLAVTELVAVQPP 62  Rhodopseudomon...
Q11FV4          1 MTPFGYVMVTYFATM--GVAVAPLIPTSVKLIWNASASAPIGLYTVEA-----------------ADRLAVPDLVAVDPP 61  Chelativorans ...
Q89YA7          1 MTRFGYLMLTYLAAL--VAGALALVHPAPRLIWNATASTPIGLYALHP-----------------LGELRDLELVAVRLP 61  Bradyrhizobium...

Q89AM6        129 N------------NNAINYVKRIVGLPGDKINYNilTKRLTITpnninEQHTKnisinykyikpndftkhfklnNIILNN 196 Buchnera aphid...
WP_011806074   95 PdaaalaaqrgylPARIPLLKRVGAIAPQHVCVF--DALVWIE-----GVPVA---------------------TVRPAD 146 Acidovorax sp....
jgi:Ajs_2658   91 AdgaalaaqrgylPAHVPLLKRVGAVAPQHVCIV--AGQVRID-----GVPVA---------------------AALPAD 142
Q11L03         62 EplaafladrgylPRGVPLLKRVAALPGQTVCRS--EGDISVD-----GITVG---------------------NALDRD 113 Chelativorans ...
jgi:Pden_1510  61 EpfagfmvargyvGRDVPILKHVIGLPGQRICRD--GAAITID-----GRHLG---------------------EARERD 112
WP_011749450   65 EplaqfvtargyvGPGVPLLKRVAALPGTRVCRT--GATITVQ-----GEAIG---------------------EARERD 116 Paracoccus
jgi:Pden_0136  65 EplaqfivargyvGPGVPLLKRVAALPGTRVCRR--GSTITGD-----GQVLG---------------------EARERD 116
Q20ZK4         63 EplakflseggylPRGIPMLKRVLALPGQTVCRN--HLLISVD-----DIALG---------------------EALERD 114 Rhodopseudomon...
Q11FV4         62 EplarfmvergylARGVPLLKRVLGLPGQRVCRS--GRTITVD-----AVEMG---------------------EALERD 113 Chelativorans ...
Q89YA7         62 EpiasfladggflPKGLPLLKRVMALPGQTVCRS--GDAITVD-----AVDVG---------------------AAHEHD 113 Bradyrhizobium...

Q89AM6        197 VHSLEssnnnllqlemyqekiekiayniffkkklidqkdlyfkqFSQKQGtwiVPKHKYFVLGDNRDNSLDSRYWGFVPE 276 Buchnera aphid...
WP_011806074  147 RLGRP---------------------------------------LPSWPQcrqLRPGELFLLSSTNPASFDSRYFGPVSA 187 Acidovorax sp....
jgi:Ajs_2658  143 RLGRP---------------------------------------LPSLQLcrcLEPGELFLLSVTNPASFDSRYFGPVSA 183
Q11L03        114 RLGRT---------------------------------------LPIWRGchrIGASELFLMNIGVRDSLDGRYFGPLAV 154 Chelativorans ...
jgi:Pden_1510 113 SQGRD---------------------------------------LPVWQGcrtIAEGEVFLMNPAVADSFDGRYFGPFPT 153
WP_011749450  117 RIGRP---------------------------------------LPTWQGcqvVGTDEVFLMNREVGDSLDGRYFGPLPL 157 Paracoccus
jgi:Pden_0136 117 RFGRP---------------------------------------LPTWQGcrlIAEGEVFLMNQDAEDSLDGRYFGPLPL 157
Q20ZK4        115 RRDRS---------------------------------------LPVWQGchvVAEGEVFLMNLQSADSLDGRYFGVTPA 155 Rhodopseudomon...
Q11FV4        114 RFGRK---------------------------------------LPVWLGcrvIADGEIFLMNWEVRDSHDGRYFGPIPA 154 Chelativorans ...
Q89YA7        114 HRGRP---------------------------------------LPRWSGchtLEPGEVFLMNPTVPDSLDGRYFGALPV 154 Bradyrhizobium...

Q89AM6        277 KNLIGKVVfIWmhL 290 Buchnera aphidicola str. Bp (Baizongia pistaciae)
WP_011806074  188 SAVIGVAR-PI--W 198 Acidovorax sp. JS42
jgi:Ajs_2658  184 SAVIGIAH-PV--W 194
Q11L03        155 TTVIGRAT-PL--Y 165 Chelativorans sp. BNC1
jgi:Pden_1510 154 SAVIGRAS-PL--F 164
WP_011749450  158 ASVTARIV-PL--W 168 Paracoccus
jgi:Pden_0136 158 GSVTARIV-PL--W 168
Q20ZK4        156 TAILGRAE-PL--W 166 Rhodopseudomonas palustris BisB18
Q11FV4        155 SSVIGRAT-PL--W 165 Chelativorans sp. BNC1
Q89YA7        155 SSIVARAV-PL--W 165 Bradyrhizobium japonicum
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