Conserved Protein Domain Family
hlyIII
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TIGR01065: hlyIII 
channel protein, hemolysin III family
This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.
Links
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Statistics
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PSSM-Id: 273425
Aligned: 12 rows
Threshold Bit Score: 190.228
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
BAA89436           33 RPVMRGWGHLIAAILSLISSTVLITYAWMTLg----WVAALGVTIYGNGLVGLFAVSALYHRWPwPtAR----------- 97  Corynebact...
P54176             14 EEIANAITHGIGAILSIPALIILIIHASKHGt----ASAVVAFTVYGVSMFLLYLFSTLLHSIH-H-PK----------- 76  Bacillus c...
P54175              6 EEIANAITHGIGVLLSIPALVFLIIFAANYGs----AWDIVSFTIFGVSMLLLYLSSTLLHSIT-H-KK----------- 68  Bacillus s...
O84000             35 EEIANAVTHGIGVGLSIVALVLLVVRAVHYTpadltARYVVGFSVFGSSLIVLYLCSTLYHALP-R-G------------ 100 Treponema ...
Q46827             15 EEIANSVSHGIGLVFGIVGLVLLLVQAVDLNa---sATAITSYSLYGGSMILLFLASTLYHAIP-H-QR----------- 78  Escherichi...
O51144             23 NELFSSISHLFGIILSIIGTTILVTISTLKKk----DLHVVVFLIYGFSMTLLYVMSTLYHIFP-KgSK----------- 86  Borrelia b...
O53433             33 KPRFRGWIHVYSAGTAVLAGASLVAVSWAVGs----AKAGLTTLAYTAATITMFTVSATYHRVNwKsAT----------- 97  Mycobacter...
Q15546             27 EHAANCYTHAFLIVPAIVGSALLHRLSDDCW-------EKITAWIYGMGLCALFIVSTVFHIVSwKkSHlr--------- 90  human
FlyBase:CG4615-PA  85 EQVANVITHGIWILPAVFAAIKLFERSSSAS-------QYLVAWVYGGALCMLFTVSTFFHCSCyCaEHkppknvkawpc 157 fruit fly
WP_001097986       15 EEIANSVTHAVGAVIMLILLPISSIYSYEAHg----FLSSIGVSIFVISLFLMFLSSTIYHSMA-YgST----------- 78  Streptococ...
WP_010888515        9 REPVNAWTHWAGAVAGALLLWPLLAWAGTHG------VARWPFVVFDLSLVALYAASASYHSFS-PgGN----------- 70  Deinococcu...
WP_002216724        4 GERFNTYSHLSGLILAAAGLALMLLKTIGHGd----GYRIFSVSVYGISLLLLYLSSSLYHGIAa--GK----------- 66  Neisseria ...

BAA89436           98 --------AVQWWRRADHATISVFIAATYTPLCIIA--FDTRTTAWMLGIAWTGALCAVILNLVWINHp--RWLDVIVYL 165 Corynebact...
P54176             77 --------VEKLFTILDHSAIYLLIAGTYTPFLLIT--LRGPLGWTLLAIIWTLAIGGIIFKIFFVRRf--IKASTLCYI 144 Bacillus c...
P54175             69 --------TKDILEIIDHSAIYVLIAGTYTPFLLGP--LKGTLGFTLLVIVWSLALGGIVFKIFFVKRf--ILLSTFVYL 136 Bacillus s...
O84000            101 --------AKYVFGVIDHCCIYVLIAGTYTASCLTT--LYGAIGWTVFGVIWGLACSGSVIYSVFGHRv--RWLSLVMYI 168 Treponema ...
Q46827             79 --------AKMWLKKFDHCAIYLLIAGTYTPFLLVG--LDSPLARGLMIVIWSLALLGILFKLTIAHRf--KILSLVTYL 146 Escherichi...
O51144             87 --------IKKIFRKFDHISIFILIAGTYTPACAIL--VPNKSGLIILCIVWSLAIIGIIFKIIFTNSp--GWFNGSIFI 154 Borrelia b...
O53433             98 --------ARNWMKRADHSMIFVFIAGSYTPFALLA--LPAHDGRVVLSIVWGGAIAGILLKMCWPAAp--RSVGVPLYL 165 Mycobacter...
Q15546             91 -------tVEHCFHMCDRMVIYFFIAASYAPWLNLR--ELGPLASHMRWFIWLMAAGGTIYVFLYHEKy--KVVELFFYL 159 human
FlyBase:CG4615-PA 158 lgwqtyqgLKNVLHRCDRAMIYVFIAGSYFPWLTLEntDHSAILFCMEWVIWLMAGIGIAYQQVFHERy--KCLETFFYL 235 fruit fly
WP_001097986       79 --------HKYVLRIIDHSMIYVAIAGSYTPVVLTL--MNNWFGYLIIVIQWGTTIFGILYKIFAKKVn--EKFSLALYL 146 Streptococ...
WP_010888515       71 --------GALWLRKLDHAAIFLLIAGTYTPVAFLG--LAEPQRSRVLALIWGIALLGIGLKLFTLKVp--RWLSTALYV 138 Deinococcu...
WP_002216724       67 --------LKSILKKTDHCMIYVLIAGSYTPFALVS--LRNGPGWTVFSLSWLLAAAGIAQELTIGRKsekRLLSIVIYV 136 Neisseria ...

BAA89436          166 TLGWLVVPLIPTLWTNLGPTVVWLLAAGGLFYTVGAVVYGLKwPGRnA-------Kyy---gyHEHFHTATIAAAVVHLV 235 Corynebact...
P54176            145 IMGWLIIVAIKPLYENLTGHGFSLLLAGGILYSVGAIFFLWE-KLP-F-------N-------HAIWHLFVLGGSAMMFF 208 Bacillus c...
P54175            137 VMGWLMIIAVKPLYASLSGAGFSLLFLGGILYSVGTIFYIWK-KIP-F-------H-------HAIWHSFVLGGSAAMFF 200 Bacillus s...
O84000            169 AMGWLVVFVAKPLRERLPEISFLFLVLGGVLYTVGCVFYALK-RIK-W-------T-------HTIWHMFVIGGSVMHFF 232 Treponema ...
Q46827            147 AMGWLSLVVIYEMAVKLAAGSVTLLAVGGVVYSLGVIFYVCK-RIP-Y-------N-------HAIWHGFVLGGSVCHFL 210 Escherichi...
O51144            155 IMGWIIIFKIKPIYKALSGKGFFWLVFGGIVYTIGGIVYILS-KK--F-------NptinmkmHDVFHILIIIASASHFW 224 Borrelia b...
O53433            166 LLGWVAVWYTATILHNAGVTALVLLFVGGALYSIGGILYAVRwPDPwP-------Ttf---gyHEFFHACTAVAAICHYI 235 Mycobacter...
Q15546            160 TMGFSPALVVT-SMNNTDG--LQELACGGLIYCLGVVFFKSDgIIPf---------------aHAIWHLFVATAAAVHYY 221 human
FlyBase:CG4615-PA 236 VMGLGPALVVVFTGHHFHG--MMQLKFGGGFYILGIVFFKADgTIPm---------------aHAIWHLFVVLAAGCHYY 298 fruit fly
WP_001097986      147 IMGWLVLAIIPAIISQTTPVFWSLMVTGGLCYTVGAGFYAKKkPy-----------------fHMIWHLFILAASALQYI 209 Streptococ...
WP_010888515      139 GMGWLAVGFLPQLSRQLPHAAIVWLALGGVLYTLGAFGYATKrPRT-PrrlgglgTwg----fHELWHLFVLGGSAAHVV 213 Deinococcu...
WP_002216724      137 VMGWMVLAVMKSLTASLPSAGLAWLAAGGMLYSVGIYWFVNDeKIR-Hg--------------HGIWHLFVLGGSITQFV 201 Neisseria ...

BAA89436          236 AVWMAV 241 Corynebacterium stationis
P54176            209 CVLFYV 214 Bacillus cereus
P54175            201 CVLFYC 206 Bacillus subtilis subsp. subtilis str. 168
O84000            233 SLYLSF 238 Treponema pallidum subsp. pallidum str. Nichols
Q46827            211 AIYLYI 216 Escherichia coli
O51144            225 LMLKYI 230 Borrelia burgdorferi B31
O53433            236 AMWFVV 241 Mycobacterium tuberculosis
Q15546            222 AIWKYL 227 human
FlyBase:CG4615-PA 299 AILVNL 304 fruit fly
WP_001097986      210 AIVYYM 215 Streptococcus pneumoniae
WP_010888515      214 MMFNLR 219 Deinococcus radiodurans
WP_002216724      202 SVYGYV 207 Neisseria meningitidis
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