Conserved Protein Domain Family
Knl1_RWD_C

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pfam18210: Knl1_RWD_C 
Knl1 RWD C-terminal domain
This domain is found in Knl1, a sub-unit of the KMN network, present in Homo sapiens. The KMN network is the core of the outer kinetochore which is responsible for microtubule binding/stabilization and controls the spindle assembly checkpoint. This domain is the second of two RING finger, WD repeat, DEAD-like helicase (RWD) domains. The tandem RWD domains mediate kinetochore targeting of the microtubule-binding subunits by interacting with the Mis12 complex. The Mis12 complex is a KMN sub-complex that tethers directly onto the underlying chromatin layer.
Statistics
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PSSM-Id: 465680
Aligned: 239 rows
Threshold Bit Score: 35.8918
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KFP19470       147 KLQSRIEK---VDELLKEAESCLvdletvwaffaALFSHSFfPFlleLESLqaqEEELqsvlhlmwlaYLCRELADLetq 223 
ESQ37036       806 EITEEIEV---LDSKIKNLIKCF-----------PTCDKMA-GEpayADTI-----------------TIAEDKLKK--- 850 
XP_006299822   988 EITQEIKE---LDSKIKNLVQCF-----------TTFDTMT-EEpayADII-----------------MIAEDTLKK--- 1032
NP_001324637   958 EITQEIKE---IDSKIKNLIQCF-----------TACDTMTgPQpayADTI-----------------MIAEETLKK--- 1003
10_pfamImport    1 EKMHALDM---IKQKMERSRSSL-----------ESFSNTK-GDiscDEFT-----------------RADTQQLET--- 45  
28_pfamImport    1 EKKLALDM---IKKKVERSRSSL-----------EYFCTTK-GDiscDDFI-----------------VAAEQQLEM--- 45  
XP_004965919   787 EKRLELNN---IQQKVENLRNSL------------ECFRNI-EGdvsCESV---MRRA-------------EEQLKM--- 831 
ELA46738       550 ILKQRIQS---ERKEEQTLRVTI-----------REMEENA------RTKT-----------------VDEQECEQM--- 589 
EAZ01623       630 LITEKMHAldmIKKKVERARSSL-----------ESFCNTK-GDiscDDFI-----------------KAAEQQLEM--- 677  long-grained...
XP_020173424   763 EKKLALSM---IQQKVENLKISL-----------EHFCNIK-GDi--sEVL-----------------RVAEEQLKM--- 805  Aegilops tau...
KFP19470       224 neqmcaqmsqlkEeeKHCqELLESydFTEW-EIT---EW---Sg--Q--QAVFNFlYDsIELTVVFGppidgdvfgedps 292 
ESQ37036       851 ------------K--MNCrFIRQE--ILAW-KVE---SLgekNd--Cq-SIVLNY-RGlINQRLTLKp------------ 894 
XP_006299822  1033 ------------R--TSCrSIRQD--ILVW-KVD---SLgewNd--Cq-SIVLNY-SGlFNQRLTLKp------------ 1076
NP_001324637  1004 ------------R--MSCrSLRQD--ILIW-KVDslgEW---Nd--Cq-SIVLNY-SGvFNQRLTLKp------------ 1047
10_pfamImport   46 ------------R--NRCrAIHQQ--ARLW-VLH---DLvkrEn--Kc-DIVLNY-CSlLIQRIVLNi------------ 89  
28_pfamImport   46 ------------R--SQCrIIHQQ--AWLW-ELN---DL---VkreNkcDIVLNYcSL-LFQRITLN------------- 88  
XP_004965919   832 ------------R--NQC-HFIHQ--QAGLcELT---GIv-kRd--NkrDLILNY-HNlLFQRIILNm------------ 875 
ELA46738       590 ------------K--KRY-LLSAT--FYQC-EVL---KV---E---Ne-RIEFNF-LQ-FGVVYGVK------------- 626 
EAZ01623       678 ------------R--NQCrIINQQ--ARLW-KLN---DLvkrEn--Kr-DIVLNY-CSlLFQRIVLNi------------ 721  long-grained...
XP_020173424   806 ------------R--NQCrIINQQ--ASLW-ELK---DIvkrEn--Kr-DVILNY-RNlLLQRIILNl------------ 849  Aegilops tau...
KFP19470       293 RKIVSLNFESLLDEEKAPPSS---CLVQRLIFQFIESQGCWQGK------CPtLYYLPQVLHDLSSVVSQCKILG 358 
ESQ37036       895 gHASCVMISNSLSDAFT-KHFpdmNVSVAFNSLFNAEYPPKYVGs---------NTLLEITQKTSLVLHNMLDVA 959 
XP_006299822  1077 gHPSCVLVSNSLSDTLV-KHFpetNVSIALNSLFKAEDSQKCIGc--------SNILLEITQKTSLLLHNLLDVA 1142
NP_001324637  1048 GHPSCVLVSNSLSDTFVKHFPe-mNVSIAFNSMFNAEDSRRYIGg--------SNTLLEITQTSEVFLILLRGYR 1113
10_pfamImport   90 sDMSGIFVNNSLSGTKIDQKFpnlNAPVAFNFVFKAEENQKVSD---------LRSLQKKTTETSLLLGNLIDVL 155 
28_pfamImport   89 INDMSLFVNNSLSGSIIGQKFp--NLNAPMAFNFVLKAEVNQR-------VSdLRSLQKKTMETSLLLSNLIDVL 154 
XP_004965919   876 SDMSSIFVNNSLNGTKIGQIFpnlDASMAFNFLFKAEENQRVHDl---------QSLQQMTMETSLLLGNLIDVL 941 
ELA46738       627 GAVVRATV------------------KNEFINFYVRVVNERIGKvvacydNEkDSNCDSGTDSSTDVLHPSFVIN 683 
EAZ01623       722 SDMSGIFVSNSLNGTKIGQAFpnlNASVAFNFVFKAEGTQRVSDl---------RSLQKMTTETSLLLGNLIDVL 787  long-grained rice
XP_020173424   850 sDMSTLFVSNSLMGTKIEKAFpnlKATVAFSFLFKAEENQRLSD---------LRSLQKKTMETSLLLGNLIDVL 915  Aegilops tauschii...
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