3IYL,1EJ6


Conserved Protein Domain Family
Reovirus_L2

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pfam06016: Reovirus_L2 
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Reovirus core-spike protein lambda-2 (L2)
This family consists of several Reovirus core-spike protein lambda-2 (L2) sequences. The reovirus L2 genome segment encodes the core spike protein lambda-2, which mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts.
Statistics
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PSSM-Id: 283634
Aligned: 5 rows
Threshold Bit Score: 2085.72
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3IYL_W    1 MAAVFGIQLVPKLNTSTtrrtflplrfdllldrLQSTNLHGVLYra---lDF-----------------NP--------- 51  
Q91RA6    1 MANVWGVRLADSLSSPT----------------IETRTRHYTLR------DFcsdldavagkepwrplrNQ--------- 49   Mammalian orthoreov...
B2BND9    1 MAAVYGIQLVNKLNTATvrrtylpnrydilidrLTNHTQHNVLHra---lDF-----------------NA--------- 51   American grass carp...
Q8JU62    1 MAAVFGIQLVPKLNTSTtrrtflplrfdllldrLQSTNLHGVLYra---lDF-----------------NP--------- 51   Golden shiner reovirus
1EJ6_A    1 MANVWGVRLADSLSSPT----------------IETRTRQYTLHdlcsdlDA-----------------NPgrepwkplr 47  
3IYL_W   52 --VDRSATVIQTYPPLNAWSPHHAFIENPLDYRDWTEFIHDRALAFVGVLTQRYPLTQNAQRYTNPLVLGAAFGDFLNar 129 
Q91RA6   50 --RTNDIVAVQLFRPLQGLVLDTQFYGFPGIFSEWEQFIKEKLRVLKYEVLRIYPISNYNHERVNVFVANALVGAFLS-- 125  Mammalian orthoreov...
B2BND9   52 --TTREATVVQLYPPLNAWTPSSATNVTDYTYLEWVDFIQERSTTFSEVLRQRYPITTYANRFVNPLVVGAAFSDFLNad 129  American grass carp...
Q8JU62   52 --VDRSATVIQTYPPLNAWSPHPAFIENPLDYRDWTEFIHDRALAFVGVLTQRYPLTQNAQRYTNPLVLGAAFGDFLNar 129  Golden shiner reovirus
1EJ6_A   48 nqRTNNIVAVQLFRPLQGLVLDTQLYGFPGAFDDWERFMREKLRVLKYEVLRIYPISNYSNEHVNVFVANALVGAFLS-- 125 
3IYL_W  130 sidiflDRLFYD--PTQ---DSPITAITKFPYQWTIDSNVTTDSVRTSAGCKYITLYGYdPSRPSTPAT------YGKHR 198 
Q91RA6  126 ------NQAFYDllPLLvinDTMINDLLGTGAALSQFFQSHGEVLEVAAGRKYLQMKNY-SNDDDDPPL------FAKDL 192  Mammalian orthoreov...
B2BND9  130 disvylEHLFYD--PRV---ESPVQAILSFPYQWTPRFHVFQEFIRTGAGCKYAR-----SSRDMTPPTparlprYGKHR 199  American grass carp...
Q8JU62  130 sidiflDRLFYG--PTQ---ESPITSITKFPYQWTIDFNVTADSVRTPAGCKYITLYGYdPSRPSTPAT------YGKHR 198  Golden shiner reovirus
1EJ6_A  126 ------NQAFYDllPLLiinDTMIGDLLGTGASLSQFFQSHGDVLEVAAGRKYLQMENY-SNDDDDPPL------FAKDL 192 
3IYL_W  199 PTYATVFYYSTLPARSRLLANLAAGPTVLEHFDSPTYGPHLLLPQTGDVLGYSSSLISQAALLMVESVMDALRDNANASA 278 
Q91RA6  193 SDYAKAFYSDTFETLDRFFWTHDSSAGVLVHYDKPTNGNHYILGTLTQMVSAPPHIINATDALLLESCLEQFAANVRARP 272  Mammalian orthoreov...
B2BND9  200 PAYATVFYYNTLAARSTILAGISAGPTALEHFDSPTYGPHIILPQAGDVLGYHSRPVSQADLLMTESVMDCLRENSQASA 279  American grass carp...
Q8JU62  199 PTYATVFYYSTLPARSRLLANLAAGPTVLEHFDSPTYGPHLLLPQTGDVLGYSSSLISQAALLMVESVMDALRDNANASA 278  Golden shiner reovirus
1EJ6_A  193 SDYAKAFYSDTYEVLDRFFWTHDSSAGVLVHYDKPTNGHHYLLGTLTQMVSAPPYIINATDAMLLESCLEQFSANVRARP 272 
3IYL_W  279 STAVTRLDQSYHPVTSFDPSTFNTLLQRATNLALLAVQGVQSESAIPAIPTMSDVRSFVARLMAEGDPQQ--WFPYRVDQ 356 
Q91RA6  273 AQPVARLDQCYHLRWGAQYVGEDSLTYRLGVLSLLATNGYQLARPIPKQLTNRWLSSFVSQVMSDGVNETplWPQERYVQ 352  Mammalian orthoreov...
B2BND9  280 STAVARLDQTYHPVANFDPTNEDSMMSRLTNLALLVVQGAQAELAIPTVPTNDDVRGFVARLMSEGQRQR--WFPYRTDR 357  American grass carp...
Q8JU62  279 STAVTRLDQSYHPVTSFDPSTFNTLLQRATNLALLAVQGVQSESAIPAIPTMSDVRSFVARLMAEGDPQQ--WFPYRVDQ 356  Golden shiner reovirus
1EJ6_A  273 AQPVTRLDQCYHLRWGAQYVGEDSLTYRLGVLSLLATNGYQLARPIPRQLTNRWLSSFVSQIMSDGVNETplWPQERYVQ 352 
3IYL_W  357 ILYwpESPFVPPIGPFYAPFR--PVNFPFTTGSYTVVPDASRPLRLLPQYrnatiTVQQADDAYEDTALS-----PLITT 429 
Q91RA6  353 IAY--DSPSVVDGATHYGYVRrnQLRLGMRVSALQSLSDTPAPIQWLPQY-----TIEQAAVDEGDLMVSrltqlPLRPD 425  Mammalian orthoreov...
B2BND9  358 VLIhpDSPFVLPPGDFYAAYR--VANFPFTSGTYTSVPNATKPLRVLPQYraatiLPAQATQAYEDHVIA-----PININ 430  American grass carp...
Q8JU62  357 ILYwpESPFVPPIGPFYAPFR--PVNFPFTTGSYTVVPDASRPLRLLPQYrnatiTVQQADDAYEDTALS-----PLITT 429  Golden shiner reovirus
1EJ6_A  353 IAY--DSPSVVDGATQYGYVRknQLRLGMRISALQSLSDTPSPVQWLPQY-----TIDQAAMDEGDLMVSrltqlPLRPD 425 
3IYL_W  430 HGFCVTGGVFTSIYDISGDPTAYPPAQLVDAPNDYFDRERMARRDLFRRLRAPADRSAIKDRAVFDFLASLVNPTTANPV 509 
Q91RA6  426 YGSIWVGDALSYYVDYNRSHRVVLSSELPQLPDTYFDGDEQYGRSLFSLARKIGDRSLIKDTAVLKHAYQAIDPNTGKEY 505  Mammalian orthoreov...
B2BND9  431 HGYCISGGVYFTADDISIDPTPFPARDLAQLPQNYFDPNRMARRELLRRLRVPSDRSYLKDNAVFTFLASLVNPATALPA 510  American grass carp...
Q8JU62  430 HGFCVTGGVSTSIYDISGDPTAYPPAQLVDTPNDYFDRERMARRDLFRRLRAPADRSAIKDRAVFDFLASLVNPTTANPV 509  Golden shiner reovirus
1EJ6_A  426 YGNIWVGDALSYYVDYNRSHRVVLSSELPQLPDTYFDGDEQYGRSLFSLARKIGDRSLVKDTAVLKHAYQAIDPNTGKEY 505 
3IYL_W  510 LDTSFSMAYLGASSAHANADEPVILADIRSGSIPGLPIPRRIVQFGYDVVHGSLLDLSRAVPTGTFGLVYADLDQVEDAG 589 
Q91RA6  506 LRAGQSVAYFGASAGHSGADQPLVIEPWTQGKISGVPPPSSVRQFGYDVAKGAIVDLARPFPSGDYQFVYSDVDQVVDGH 585  Mammalian orthoreov...
B2BND9  511 LQPGFSLAYLGASAAHAKSDEPTILADLRNGSIPGLPIPSRIAQFGYDVVHGSLLDLTRAVPTGTFGLVYADLDQVEDAG 590  American grass carp...
Q8JU62  510 LDTSFSMAYLGASSAHANADEPVILADIRSGSIPGLPIPRRIVQFGYDVVHGSLLDLSRAVPTGTFGLVYADLDQVEDAG 589  Golden shiner reovirus
1EJ6_A  506 LRSRQSVAYFGASAGHSGADQPLVIEPWIQGKISGVPPPSSVRQFGYDVARGAIVDLARPFPSGDYQFVYSDVDQVVDGH 585 
3IYL_W  590 TDMPAANRAAIAMLGTALQMTTAGGVSVLKVNFPTRAFWTQVFNLYATHATTLHLVKPTIVNSSEVFLVFGGRQSNGALR 669 
Q91RA6  586 DDLSISSGLVESLLDSCMHATSPGGSFVMKINFPTRTVWHYIEQKILPNITSYMLIKPFVTNNVELFFVAFGVHQQSALT 665  Mammalian orthoreov...
B2BND9  591 TDLPAANRAALAMLGTTLQMCTAGGVAVLKVNFPTVEFWTQLFNQYATFATTLHVVKPIVVNSSEVFVVMSGRQSAGNLT 670  American grass carp...
Q8JU62  590 TDMPAANRAAIAMLGTALQMTTAGGVSVLKVNFPTRAFWTQVFNLYATHATTLHLVKPTIVNSSEVFLVFGGRQSNGALR 669  Golden shiner reovirus
1EJ6_A  586 DDLSISSGLVESLLSSCMHATAPGGSFVVKINFPTRPVWHYIEQKILPNITSYMLIKPFVTNNVELFFVAFGVHQHSSLT 665 
3IYL_W  670 STTALQRALLSLYARNAAIDRAVTHIPFFGVPDDGTSDLGIDAVRLFDPMFSDaVANLPSNALASLVSRVVPSSIMFTRV 749 
Q91RA6  666 WTSGVYFFLVDHFYRYETLSTISRQLPSFGYVDDGSSVTGIEMISLENPGFSN-MTQAARVGISGLCANVGNARKLISIH 744  Mammalian orthoreov...
B2BND9  671 CTTSLQRALLAMYARNAAIDQTMTHVPMLGQADDGTSALGMEAIRLFDPLFVEgNPNAATSALATLMANVVPSSIHMSRL 750  American grass carp...
Q8JU62  670 STTALQRALLSLYARNAAIDRAVTHIPFFGVPDDGTSDLGIDAVRLFDPMFSDaVANLPSNALASLVSRVVPSSIMFTRV 749  Golden shiner reovirus
1EJ6_A  666 WTSGVYFFLVDHFYRYETLSTISRQLPSFGYVDDGSSVTGIETISIENPGFSN-MTQAARIGISGLCANVGNARKSIAIY 744 
3IYL_W  750 PSNGPVSTTIYGKRTFLSNRRRARLRDVPMLITTTLVHQRRFTTPPTFTLF-----SSEAVPVTTLvaagYNSFISEQTR 824 
Q91RA6  745 ESHGARVLTITSRRSPASARRKARLRYLPLVDPRSLEVQARTILPSNPVLFdnvngASPHVCLTMM----YNFEVSSAVY 820  Mammalian orthoreov...
B2BND9  751 PVNGPVSTTIFGKRTFLSTRRRDRLLEYPLPMVTAINHQRRFTAPPSFSIY-----PTEPVNVTTLvaagYNAYVHTVIT 825  American grass carp...
Q8JU62  750 PSNGPVSTTIYGKRTFLSNRRRARLRDVPMLITTTLVHQRRFTTPPTFTLF-----SSEAVPVTTLvaagYNSFISEQTR 824  Golden shiner reovirus
1EJ6_A  745 ESHGARVLTITSRRSPASARRKSRLRYLPLIDPRSLEVQARTILPADPVLFenvsgASPHVCLTMM----YNFEVSSAVY 820 
3IYL_W  825 NPNLahLLDLGTGPECRILSLIPPTLQVTMSDSRPCAELMASFDPALTaYVQGDYSTAAFWNGIRCDSATAIFTIGAAAA 904 
Q91RA6  821 DGDV--VLDLGTGPEAKILELIPPTSPVTCVDIRPTAQPSGCWNVRTT-FLELDYLSDGWITGIRGDIVTCMLSLGAAAA 897  Mammalian orthoreov...
B2BND9  826 SAQPahLFDLGTGPECRILSLVPQNTRVTMVDSRPCAELMQAYDPNTTaYEQADYTLAAFWNGRQCDAVSAIFTLGAAAA 905  American grass carp...
Q8JU62  825 NPNLahLLDLGTGPECRILSLIPPTLQVTMSDARPCAELMASFDPALTaYVQGDYSTAAFWNGIRCDSATAIFTLGAAAA 904  Golden shiner reovirus
1EJ6_A  821 DGDV--VLDLGTGPEAKILELIPATSPVTCVDIRPTAQPSGCWNVRTT-FLELDYLSDGWITGVRGDIVTCMLSLGAAAA 897 
3IYL_W  905 AAGTDLIAFVQQLIPRIVAAGGTRMWLQLNTPLYEVSSLPDLIEIDLRDHVYRFNGGERVEPYADPVPLQQAIAALLPAA 984 
Q91RA6  898 GKSMTFDAAFQQLVKVLTKSTANVLLIQVNCPTDVIRTIKGYLEIDQTNKRYRFPKFGRDEPYSDMDSLERICRAAWPNC 977  Mammalian orthoreov...
B2BND9  906 SNAVTIDALLANLLPSIANAGTTRLWLQVNAPLAGPTPIPGLIDIDTRAGTYTFNNGERTEPYIDPQVMQATVLAHFPNA 985  American grass carp...
Q8JU62  905 AAGTDLIAFVQQLIPRIVAAGGTRMWLQLNTPLYEVSSLPDLIDIDLRDRVYRFNGGERVEPYADPVPLQQAIAALLPAA 984  Golden shiner reovirus
1EJ6_A  898 GKSMTFDAAFQQLIKVLSKSTANVVLVQVNCPTDVVRSIKGYLEIDSTNKRYRFPKFGRDEPYSDMDALEKICRTAWPNC 977 
3IYL_W  985 ALSWHTLSPTCDWLPYIIGVGSPLNLSDINTAISYSRLTPILHIDTTTPPLRV--NPVptpLNQQCAIRITSLDPAAVLS 1062
Q91RA6  978 SITWVPLSYDLRWTKLALLESTTLSSASVRIAELMYKYMPVMRIDIHGLPMEKqgNFI---VGQNCSLTIPGFNAQDVFN 1054 Mammalian orthoreov...
B2BND9  986 TLSWYTLPPTCEWLDYIIGAGSSLDLSTIPTALQYSQLTPILSIDTNVAPLRV--NPIptpLGQQCAIRIPTNDPAAVLD 1063 American grass carp...
Q8JU62  985 ALSWHTLSPTCDWLPYIIGVGSPLNLSDINTAISYSRLTPILHIDTTTPPLRV--NPVptpLNQQCAIRITSLDPAAVLS 1062 Golden shiner reovirus
1EJ6_A  978 SITWVPLSYDLRWTRLALLESTTLSSASIRIAELMYKYMPIMRIDIHGLPMEKrgNFI---VGQNCSLVIPGFNAQDVFN 1054
3IYL_W 1063 VQHNGVEVIGgTPGNVISVAGAAALQYILANQEFLLQFTPTLPGIFDV-FLTTLGQPPVPRGSFTITPPptTVALNMPPP 1141
Q91RA6 1055 CYFNSALAFS-TEDVNSAMIPQVTAQFDANKGEWSLDMVFSDAGIYTMqALVGSNANPVSLGSFVVDSP--DVDITDAWP 1131 Mammalian orthoreov...
B2BND9 1064 AKHRGVPVITgTPAALTSLMGNAALQYIQANNEFLLQLTPTLAGIFDV-TLTSAGQPPIPRGSFTITAPppTAAVTM--P 1140 American grass carp...
Q8JU62 1063 VQHNGVEVIGgTPGNVISVAGAAALQYILANQEFLLQFTPTLPGIFDV-FLTTLGQPPVPRGSFTITPPptTVVLNMPPP 1141 Golden shiner reovirus
1EJ6_A 1055 CYFNSALAFS-TEDVNAAMIPQVSAQFDATKGEWTLDMVFSDAGIYTMqALVGSNANPVSLGSFVVDSP--DVDITDAWP 1131
3IYL_W 1142 RQLDFTDVGNDARITCDPYYQLAVCIFKDGQYVRVNPEKASVVTNAPNR-DLHFVLDLADNHVLLYLCDVTPSGLGDRIA 1220
Q91RA6 1132 AQLDFTIAGTDVDITVNPYYRLMAFVRIDGQWQIANPDKFQFFSSSTGTlVMNVKLDIADRYLLYYIRDVQSRDVGFYIQ 1211 Mammalian orthoreov...
B2BND9 1141 ANIDYTDAGNDGPIACDPYYNLAVCIMRNGQYVRVNPEKARVETVAAGR-ALHFVLDLADNHVLMYLCDVTPAAIGAIIA 1219 American grass carp...
Q8JU62 1142 GQLDFTDVGNDARITCDPYYQLAVCIFKDGQYVRVNPEKASVVTNAPNR-DLHFVLDLADNHVLLYLCDVTPSGLGDRIA 1220 Golden shiner reovirus
1EJ6_A 1132 AQLDFTIAGTDVDITVNPYYRLMTFVRIDGQWQIANPDKFQFFSSASGTlVMNVKLDIADKYLLYYIRDVQSRDVGFYIQ 1211
3IYL_W 1221 FPIVDIYRIAFPRNTPVRASLPYTGGGAhLTSGGNPFMSLTTPPAVLPAGVALAALSTSVATQYPTYTLPAGVYEYVI 1298
Q91RA6 1212 HPLQLLNTITLPTNEDLFLSAPDMREWA-VKESGNTICILNSQGFVPPQDWDVLTDTISWSPSLPTYVVPPGDYTLTP 1288 Mammalian orthoreovir...
B2BND9 1220 HPLADIYQLVFPNNTPLRASLPYIGGGArVELNNQPYLSLTNPPPVLPAGTALAALATAASVGQPTYTLPAGAYRYVL 1297 American grass carp r...
Q8JU62 1221 FPIVDIYRIAFPRNTPVRASLPYTGGGAhLTSGGNPFMSLTTPPAVLPAGVALAALSTSVATQYPTYTLPAGVYEYVI 1298 Golden shiner reovirus
1EJ6_A 1212 HPLQLLNTITLPTNEDLFLSAPDMREWA-VKESGNTICILNSQGFVLPQDWDVLTDTISWSPSIPTYIVPPGDYTLTP 1288
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