1AON,1G31,1SX4,1WNR,1HX5,1WF4,1LEP


Conserved Protein Domain Family
cpn10
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cd00320: cpn10 
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Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It forms heptameric rings with a dome-like structure, forming a lid to the large cavity of the tetradecameric cpn60 cylinder and thereby tightly regulating release and binding of proteins to the cpn60 surface.
Links
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Statistics
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PSSM-Id: 238197
Aligned: 97 rows
Threshold Bit Score: 39.0275
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomerisation interface [polypeptide binding site]
Evidence:
  • Comment:members form heptameric rings
  • Structure:1AON; E.coli GroEL/GroES chaperonin
  • Structure:1G31; bacteriophage T4 chaperonin
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       # # #  #                                   ##                     #         #   
1AON_O        2 NIRPLHDRVIVKRKe----vETKSAGGIVLTGSAa-----aKSTRGEVLAVGNgrile-ngevkPLDVKVGDIVIFNDGy 71  Escherichia coli
1G31_A        8 PIRAVGEYVILVSEpaqagdEEVTESGLIIGKRVqg----eVPELCVVHSVGPdv--------pEGFCEVGDLTSLPVGq 75  coliphage T4
AAM28886      7 PIRAVGEYVILVSEpaqagdEEVTESGLVIGKRVqg----eVPELCVVHSVGPdv--------pEGFVEVGDLTPLPVGq 74  Bacteriophage RB69
ZP_00380409   7 PIRMLHDRILVDPGee--agERKSSAGIVIPATAsm---gkRLVWGKVVAAGPh----------VRQANLGDTVLYDPEe 71  Brevibacterium l...
NP_705233    60 PLTPLNEYILIQKDe----aGDTTDSGVFIGDTLk-----kNQYIGKVLSVGAgaintkngeriPIDIQVGDVVIFNPNd 130 Plasmodium falci...
EAN32594    104 SVVPLSDYVLIVKSd----aVDVTQSGVYLGTKKt------RDFIGRVLAVGPgrlnkttgvttPLSVSVGDTVLFDSPy 173 Theileria parva
CAH04520     11 PIKPLRGMVLLERRe----aVEKSAGGVYLPIESk-----aKQVIAKVIEVGPgevnretgariPVDVAIGDWTIISRHt 81  Toxoplasma gondii
EAN32594    212 KVVPLFDRMLVRVLe----sPKRTESGLVISSSNtr----dEVVKAKIVSLGPgsytesgklvpIVGLSVGDTVLYRHNe 283 Theileria parva
CAH04520    117 DILPLGDTILVKLVk----qAQRTASGLYLQPTGserdrgqGVKRAQVVAVGLgrynr-ngervPNDVVPGDEVLFPAYs 191 Toxoplasma gondii
NP_705233   163 NITPLYDRVLIKLIn----pNVNSDSLIIIPESKnn----dKVTDGQVVAIGNgiyde-nnqkvPIDLRIDDYIKFSPFs 233 Plasmodium falci...

Feature 1          # #                           ### 
1AON_O       72 -gVKSEKi------------dNEEVLIMSESDILAIV 95  Escherichia coli
1G31_A       76 --IRNVPhpfvalglkqpkeiKQKFVTCHYKAIPCLY 110 coliphage T4
AAM28886     75 --IRNVPhpfvalglkqpkeiKQKFVTCHYKAIPCLY 109 Bacteriophage RB69
ZP_00380409  72 --LAEVEl------------eGSAYVLLRERDVHAIS 94  Brevibacterium linens BL2
NP_705233   131 --GNKVKy------------nDKECLLISNEEVLGKI 153 Plasmodium falciparum 3D7
EAN32594    174 -eSIDLKy------------nDKPCALVREEQIFARL 197 Theileria parva
CAH04520     82 --YESFKy------------nGKDCVLVEARDIIAKV 104 Toxoplasma gondii
EAN32594    284 ydSGEFTs------------nNVNYAFVRRDAVLGKL 308 Theileria parva
CAH04520    192 qdEPEMKy------------gGESYAFVRAADLLAKW 216 Toxoplasma gondii
NP_705233   234 neSCEFTy------------qNAKYTFVKARYVMAKY 258 Plasmodium falciparum 3D7

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