3AL8,1SHY,3OL2


Conserved Protein Domain Family
Sema_plexin_like

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cd11236: Sema_plexin_like 
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The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases
Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Statistics
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PSSM-Id: 200497
Aligned: 31 rows
Threshold Bit Score: 257.644
Created: 26-May-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3AL8_B         19 TFNHLTVHrrt-gaVYVGAINRVYKLTGnlt-------------iqVAHKTGPeednkacyppl-------ivqpcsevl 77   house mouse
NP_005752      45 AIGAIAASqe--dgVFVASGSCLDQLDYslehslsrlyrdqagnctEPVSLAPpar-----------------------p 99   human
Q9Y4D7         58 PTNNFALDgaa-gtVYLAAVNRLYQLSGanl------------sleAEAAVGPvpdsplchapql------pqascehpr 118  human
3OL2_B         18 YLQHLARDpts-gtLYLGATNFLFQLSPglq-------------leATVSTGPvldsrdclppv--------mpdecpqa 75   human
XP_002732530    1 MTRTLWVCvivngiICTFCGNAKQMVNFtsstle-------fthltVNDNTGDvyvgggnyvyrldsdlqliynittkpd 73   Saccoglossus ...
XP_001197635 2269 PFNHIAINnit-gdVYIGARERLYQLDSkln-------------lkHTVDTGLcpsp----------------------n 2312 purple urchin
XP_001195685   95 TLNRFVVHnrt-gsIYVAAEKFLFRLGSdl---------------qSLEGTGTssca---------------------ed 137  purple urchin
XP_002738392   45 EFQHLIVHnnt-geVYVGATNNIYHLTPelq-------------mkLEHVTGPaidnprclpe----------gqcdyyk 100  Saccoglossus ...
XP_002112670   44 NIQHVVIHqvn-gdVYVGATNTIVKLTAnlt-------------wqSNSTTGPqmdnplclpd----------tncnhpr 99   Trichoplax ad...
ADY40164       27 PINAIAFTdn---kIYVGSVNRLSILDVstl------------epiSEVITGPqldstlcnydt-------saclkdakl 84   pig roundworm
3AL8_B         78 tlTNNVNKLLIIDys-----enRLLACGSLyqGVCKLLRld-dLFILVEPshk------------keHYLSSVnktgTMY 139  house mouse
NP_005752     100 rpGSSFSKLLLPYregaaglggLLLTGWTFdrGACEVRPlg-nLSRNSLRn---------------gTEVVSChpqgSTA 163  human
Q9Y4D7        119 rlTDNYNKILQLDpg-----qgLVVVCGSIyqGFCQLRRrg-nISAVAVRfppaappaepvtvfpsmLNVAANhpnaSTV 192  human
3OL2_B         76 qpTNNPNQLLLVSp-------gALVVCGSVhqGVCEQRRlgqlEQLLLRPerp-----------gdtQYVAANdpavSTV 137  human
XP_002732530   74 dgTDNYNKILSINyd-----ynNLITCGSYr-GVCQIRDls-dLSVLNDSv----------------TWVAAPtkedSTV 130  Saccoglossus ...
XP_001197635 2313 deNVNDNKLLAVVitp---knyLLITCGGCd-GYCESRSlt-nISHDVIRynp-----------adsQRVVTT----NDV 2372 purple urchin
XP_001195685  138 dnCEDITKILAISqgd----aeSLIICMSAe-GKCEVRDls-dIEQVVHSsn-------------imVPGESAe--lTAA 196  purple urchin
XP_002738392  101 gqIHNNNKILLIDyq-----inKLLTCGDAyqGTCELHNin-rISPSEGRiy--------------dSSNVNNdfvaTTG 160  Saccoglossus ...
XP_002112670  100 klTDNINKLLLINyq-----gnSLITCGSVflGRCQLRDlk-tLANRQEPt----------------ISVASNdpnaTTY 157  Trichoplax ad...
ADY40164       85 spTDYVTKILHLRg-------eTLLVCGSLhqGVCQVRSad-tLSILINGs----------------VPVAPNdansSCV 140  pig roundworm
3AL8_B        140 GVIVrseg------------edgKLFIGTAvdgk---------------qdyFPTLSSRKlprdpessamldyelhsdfv 192  house mouse
NP_005752     164 GVVYragr-----------nnrwYLAVAATyv------------------lpEPETASRCnpaa-------------sdh 201  human
Q9Y4D7        193 GLVLppaag----------aggsRLLVGATytgygssffprnrsledhrfenTPEIAIRSldtrg-----------dlak 251  human
3OL2_B        138 GLVAqgla------------gepLLFVGRGytsrg-------------vgggIPPITTRAlwppdpqa------afsyee 186  human
XP_002732530  131 GFVApgyd------------nkpNLYVGTPrrgn--------------aypgDQAVSGRQldel--------------lf 170  Saccoglossus ...
XP_001197635 2373 PTVGavvlgadfvddvegtnenfYLFTGVSd--------------------gQSSFISKRnvlyln----------fvqg 2422 purple urchin
XP_001195685  197 GVITevaqg---------snlveKFYVANTlsaeats---------finpirRWTVSGSFdlade-----------lnhy 247  purple urchin
XP_002738392  161 STVAffapgp--------pnnatALYVGATynsgrp-----------eslatQYAVSTKRfe-----------------f 204  Saccoglossus ...
XP_002112670  158 GFIGagpd------------henVLYVGAThtqhgg----------gdwykvVLAVSTRRlkhisvtev---alsvydnt 212  Trichoplax ad...
ADY40164      141 SVMDsd----------------eVLFVASAytnds------------pyresFPAVSSREppyyniin------sgsieg 186  pig roundworm
3AL8_B        193 sSLIKIPsdtla------------lvshfDIFYIYGFASG--------GFVYFLTVQPetpdgmainsagdlfYTSRIVR 252  house mouse
NP_005752     202 dTAIALKdtegrslatqelgrlklcegagSLHFVDAFLWNgs-----iYFPYYPYNYTsga----------atGWPSMAR 266  human
Q9Y4D7        252 lFTFDLNpsddnilki-----kqgakeqhKLGFVSAFLHPsdpppgaqSYAYLALNSEaragd------kesqARSLLAR 320  human
3OL2_B        187 tAKLAVGrls-----------------eySHHFVSAFARG--------ASAYFLFLRRdlqa-------qsraFRAYVSR 234  human
XP_002732530  171 hSARSWEwecavdm---------ywfyenSVIYVTGFSYH--------RFSYFLTVQRlsrn--------dntYISRIVR 225  Saccoglossus ...
XP_001197635 2423 iQRFSSLt--------------------eNVFKHLIAYRD--------YLYYFISRRTs-------------mYIGRLCR 2461 purple urchin
XP_001195685  248 aLGVSVNs--------------------fPISYKETFTHN--------GFVYFVMNQV---------------GNVKLGR 284  purple urchin
XP_002738392  205 lFGTSTDs--------------------yKVKYIYGFSSG--------GFSYFVTVQRinvd--------vasYHTRLIR 248  Saccoglossus ...
XP_002112670  213 nSQFNYDdp------------------nyYIDYHYGFISG--------SYSYFLTVQKgvvingf-nsvidqrYESRVVR 265  Trichoplax ad...
ADY40164      187 eAAVHIRteyr---------------trfRLRYVGAFLHD--------DYVYFVSVQSkrlssn----vlanlLISKLVR 239  pig roundworm
3AL8_B        253 LCkddp-------kfhSYVSLPFGCtra---gvEYRLLQAAYLAKpgealaqafnissdeDVLFAIFSKgqkqy------ 316  house mouse
NP_005752     267 IAqst--------evlFQGQASLDCghg--hpdGRRLLLSSSLVEa-------------lDVWAGVFSAaagegq----- 318  human
Q9Y4D7        321 IClphgaggdakklteSYIQLGLQCaggagrgdLYSRLVSVFPAR---------------ERLFAVFERpqgsp------ 379  human
3OL2_B        235 VClrdq-------hyySYVELPLACeg-----gRYGLIQAAAVATsrev--------ahgEVLFAAFSSaapptvgrpps 294  human
XP_002732530  226 VCqernd-----yyydSYTEVTLQCegs--dstLYNLLQAADVMRpasdlatslsleddeHVLFAVFGKgrtpws----- 293  Saccoglossus ...
XP_001197635 2462 NSldq--------yfeSYTEIELQCg-------SHNMIQSAHIGPagpqladaltmnstdALLYAVFSNe---------- 2516 purple urchin
XP_001195685  285 VCeta--------rmeYYSEITLRCdsrkrpdaSYNLVQAARVGKagptlqm-smgsgsgSILYGAFSEsds-------- 347  purple urchin
XP_002738392  249 ICnqdk-------gyySYTELPLRCtnd--mgmEYNLAQDAYVSKvgedlsetmgigskdDVLFVVFAKsnrds------ 313  Saccoglossus ...
XP_002112670  266 LCsada-------tytSYVETPLKClgr--nniNYNLLQAAYTIKpgsslatslgittreDIIIGVFAAsttpss----- 331  Trichoplax ad...
ADY40164      240 VCrgdh-------ryvSYSEIEVQCrga--dnrNYNLVTSISLVD---------------DILLAAFTDqy--------- 286  pig roundworm
3AL8_B        317 --hhppdDSALCAFPIRAINLQIKErlqscyhgegnlelnwllgkdvq-----------ctkapvpiddnfcgldinqpl 383  house mouse
NP_005752     319 -errsptTTALCLFRMSEIQARAKRvswdfkta-----------------------------------------eshcke 356  human
Q9Y4D7        380 --aaraaPAALCAFRFADVRAAIRAartacfvepapdvvavldsvvqgt---------gpacerklniqlqpeqldcgaa 448  human
3OL2_B        295 aaagasgASALCAFPLDEVDRLANRtrdacytregraedgtevayieydvns----dcaqlpvdtldaypcgsdhtpspm 370  human
XP_002732530  294 --ltplqHSVICIYKMTDIEQAFIDaisgcitqggdeyql---------------------------dhifesrcytwdn 344  Saccoglossus ...
XP_001197635 2517 ------gSSALCVYEMSDVQQSFDVavlgcihgtsngttnrylrgsmcsdyplwlsppdsvqctayfrdgdvwntlhrya 2590 purple urchin
XP_001195685  348 ----vssNAALCMYSMTDVEAAFLQavkdclsgtqgarlsyl-----------------------ngatcdgskysftya 400  purple urchin
XP_002738392  314 --tvptnESALCFYTLKKIIRKFTSgiqqcfngvgtqglrfmsdd-----------------lpcsyinyreiqddfcgs 374  Saccoglossus ...
XP_002112670  332 --kipstSSAVCIFTIAQVNKVLRDtirnclaggisrglpwdtkgag--------------skkctkvdlntvpecsrry 395  Trichoplax ad...
ADY40164      287 -----ggRSAICIYPMQKIRLTFWYnidrcrvgtdtvglphi-----------------------grdtkclnkshlpls 338  pig roundworm
3AL8_B        384 ggSTPVEg--------lTLYTTs-------rDRLTSVASYVyn------gYSVVFVGTKSGKLKKIRadgpp-----hgg 437  house mouse
NP_005752     357 gdQPERVq---------PIASStl-----ihSDLTSVYGTVvm------nRTVLFLGTGDGQLLKVIlgenlt--sncpe 414  human
Q9Y4D7        449 hlQHPLSil-------qPLKATpvf----raPGLTSVAVASvn------nYTAVFLGTVNGRLLKIN------------- 498  human
3OL2_B        371 asRVPLEa--------tPILEWp-------gIQLTAVAVTMed------gHTIAFLGDSQGQLHRVYlgpg------sdg 423  human
XP_002732530  345 ggNIPVHf--------hSYYCNqyd----nvILPDPVRVYNdtkfdaysrYLYVLVEYNVYKLEVQNc------------ 400  Saccoglossus ...
XP_001197635 2591 sgTVPLSa--------sPIITMp-------dVIPTSIVTTTer------qHTVAFIGDTQGELHKLNivns------scg 2643 purple urchin
XP_001195685  401 ngIHPLVss-------aAVEMSs--------HVPTSIVSAVvr------nHTVVFIGTQEGDLLKLYrlav------anc 453  purple urchin
XP_002738392  375 giLHPIQiq-------rSLTAQdflwysghgSIFTSVLVNIyd------rHTIVLIGTDAGVLMKVIvnaegensphelr 441  Saccoglossus ...
XP_002112670  396 lsNPRIGgn-------iSVTTTavre--ysnRLLTSIVAFSad------sTTLAFIGTSDGDIVKLSinsk------sia 454  Trichoplax ad...
ADY40164      339 edTCAMGvggniecdqiAVYHSd--------SNIRSLASTRid------nITVIAAGTDEGKLLQLRvkgs-------sv 397  pig roundworm
3AL8_B        438 vQYEMVSVFkd-------gSPILrDMAFSInq-lyLYVMSe-rQVTRVPVE 479  house mouse
NP_005752     415 vIYEIKEET----------PVFY-KLVPDPvkniyIYLTAg-kEVRRIRVA 453  human
Q9Y4D7        499 -LNESMQVVsrrvvtvaygEPVHhVMQFDPadsgyLYLMTs-hQMARVKVA 547  human
3OL2_B        424 hPYSTQSIQq--------gSAVSrDLTFDGtf-ehLYVMTq-sTLLKVPVA 464  human
XP_002732530  401 kQYTTCRECfe-------aMDPYcGWCTLErr-csLYNECp-fSNIRSRWL 442  Saccoglossus kowalevskii
XP_001197635 2644 yVYEDVFLGg---------GSVLqKMFLDEst-elLTLATssdEGSKVLTL 2684 purple urchin
XP_001195685  454 gQYSTCGECig-------vGGAEdGDPYCGwc--tLQATCtqyRECVNPEE 495  purple urchin
XP_002738392  442 kPYQNITLTn--------nSPIKqDMVMDNsn-qyIFVMSd-qQVFKVPVH 482  Saccoglossus kowalevskii
XP_002112670  455 tQYFEEHVAq---------LPIN-SLAFAKds-gkYYAATs-kTVHRLPLE 493  Trichoplax adhaerens
ADY40164      398 eQYEELQLSv---------DPIT-TIRFINn---gSYVAIt--NHKILRLS 433  pig roundworm
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