Conserved Protein Domain Family
Maf1

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pfam09174: Maf1 
Maf1 regulator
Maf1 is a negative regulator of RNA polymerase III. It targets the initiation factor TFIIIB.
Statistics
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PSSM-Id: 462704
Aligned: 87 rows
Threshold Bit Score: 104.629
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006695441  44 VTGSCDLYTTKAAGSDKKLYKNITQSLeaqaqaQQQNNGQgtragsassppqhpqp------------------------ 99 
EGT40167      25 idfkletysskmVTSEKKQWKTNDKSVmwgerqPLGSYE----------------------------------------- 63 
Q9TZN2        25 idfkletysskmVTSEKKQWKSNDKSViwgerqPLGSYE----------------------------------------- 63  Caenorhabditis ...
Q57YV3        26 MTVRLEAFTCRCTRKKKLLAASIAEYAnkttpplrplcsanapv------------------------------------ 69  Trypanosoma brucei
CAM70669      26 ITMRLEAYTCRHTKEERQIANSIACYQnnvqltppisplptigayagft------------------------------- 74 
XP_002489362  25 VRGGCDLFTTKPVGSDKKLYKTIDKHLd----dILQESLNwnmshspptasritdnvdfqtrfsrrassssivkptlkrk 100
XP_001645936 136 eylssssieSSSNHGEK---SRRSSSVavngssSNNKFKVskisknr--------------------------------- 179
CCE64277     188 NNNSNNNNNNNNNNNDLKSDDSKVNTFndttlqNNNKFKVtkthpnr--------------------------------- 234
Q6FIZ7       158 sSSSVESLTHKNKE------RRTSSLSstggkvDKLRADSstandit--------------------------------- 198 [Candida] glabr...
XP_003668051 177 skssssLYNSMNKRNDSNRDESTTNGInn---dNNSTEDGekkkkir--------------------------------- 220
XP_006695441 100 ------rrdsstlsvsstsrrLSSSATDsa---------------------------fgSLEDVSSRRVFAYLIATLNAS 146
EGT40167      64 ----------------------EMVISAspsvghnhrlrhlserscsggsdndfdtnefHI-DSISRKRLYDLTQVLNSS 120
Q9TZN2        64 ----------------------EMVMSAspsvghnhrlrhlserscsggsdndfdvndyLIKDSISRKKLYDLTQVLNCS 121 Caenorhabditis ...
Q57YV3        70 ------------------------------------------ppllnlsddsvhvvptePVEPSDIDDRLVFLVAALNSI 107 Trypanosoma brucei
CAM70669      75 --------------------------------------qealpplvlggsaenvtasysLVSPNEIDDRLVYFVAALNTV 116
XP_002489362 101 sfnhhqattlskslenidineSALYDEEtp---------------------------fgPITSTHSRKIFSYLIGILNAS 153
XP_001645936 180 --------------rrssanhDPSNINIgp---------------------------fgPINETASRRIFAYLIAILNAS 218
CCE64277     235 --------------rrssiqdAPPNISIgp---------------------------fgPISETASRRTFAYLIAILNAS 273
Q6FIZ7       199 --------------arsvlndTSRTLNLgp---------------------------fgPINEPSSRRTFAYLIAILNAS 237 [Candida] glabr...
XP_003668051 221 --------------rrsslndTSSNITIgp---------------------------fgPIKEPASRRTFAYLIAILNAS 259
XP_006695441 147 H-PD-YDFSQvLRPADFKRERVLRRVMAHIDST-LSS-------VRPqkgddaetaalrassytsptqlildgrgggggd 216
EGT40167     121 F-PD-HDFTN-ASSEAFALV-NYTDLSRLVDMK-LETivrdyhvRRE--------------------------------- 162
Q9TZN2       122 F-PD-HDFSN-ANSEAFALV-NYSDLSRLVDMK-LETivrdyhvRRE--------------------------------- 163 Caenorhabditis ...
Q57YV3       108 YgEDgYDFSV-LTEEDFVPC-DEAHVRAEVNNT-LRS-------FPSscgp----------------------------- 148 Trypanosoma brucei
CAM70669     117 YeSDgYDFSV-LRENDFVRY-TEPQFRTEVSST-LQS-------LPEqcrp----------------------------- 157
XP_002489362 154 Y-PD-HDFSS-LTPDYFTAVDSANSMMNRFNSIvLSLgyk--dqIDDgdk------------------------------ 198
XP_001645936 219 Y-PD-HDFSS-LEPTDFVK-SSLKELISKFENS-LYSlg---kqPEE--------------------------------- 257
CCE64277     274 Y-PD-HDFSS-LEPTNFVK-STIKQMVSKIENS-LYSlg---kkPDE--------------------------------- 312
Q6FIZ7       238 Y-PD-HDFSL-LEPTDFKR-SSIKSFIAKFENS-MYSlg---rkPEE--------------------------------- 276 [Candida] glabr...
XP_003668051 260 Y-PD-HDFST-LEPTDFTR-SSLKSFISKFESS-LYSlg---kqSEE--------------------------------- 298
XP_006695441 217 ginpapywgpQMWALIDKQMALEE--CAVYSYA-PEEG--AFd-EEEGAIWALHYFFFNKALKRVCYLY 279
EGT40167     163 ----------ELWGLIDDAIVPSD--CQIYSFK-SQFEddPF--TEDGCIWALAFIFYNKGLKRFVLLt 216
Q9TZN2       164 ----------ELWGIIDEAIVPGD--CQIYSFK-SQFEddPF--TEDGCIWALAFIFYNKGLKRFVLLt 217 Caenorhabditis elegans
Q57YV3       149 -------avgQFWVRVTEHASDASqgCEYFRFAsPSCd--PMa---sRALFSQHYFLYNKRTRLLVSLl 205 Trypanosoma brucei
CAM70669     158 -------avqRFWPTIEEVVENAEsgCEYYEFRcPSCd--PLa---dTTVYARHYFVYNRRKKVLVLLv 214
XP_002489362 199 -------dinWIWETINSHMDIQD--CSIYALE-PKd--gVLadLEPNTLWCLMWFIFNKKRKRVAFLh 255
XP_001645936 258 ----------WMWEIINSHMDLSD--CVIYRYD-PNK---SFldDEPGHLWSLNWFIFNKKRKRVAYLY 310
CCE64277     313 ----------SMWEIINSHMDFSD--SVIYEYD-PSK---LLldDEPGYLWSLNWFIFNKKRKRVAYIY 365
Q6FIZ7       277 ----------WIWEVINSHMTLSD--CVLYQYC-PTQ---SFldDEPGHLWSLIGFFFNKKRKRVAYVY 329 [Candida] glabrata CBS 138
XP_003668051 299 ----------WIWDIINPHMTLAD--CVVYLYS-PAK---SFleDEPGYLWSLMGFLFNKKRKRVAFLY 351
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