Conserved Protein Domain Family
CXCR4_N
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pfam12109: CXCR4_N 
CXCR4 Chemokine receptor N terminal
CXCR4 and its ligand stromal cell-derived factor-1 (a.k.a. CXCL12) are essential for proper fetal development. CXCR4 is also the major coreceptor for T-tropic strains of human immunodeficiency virus 1 (HIV-1), and SDF-1 inhibits HIV-1 infection. Additionally, SDF-1 and CXCR4 mediate cancer cell migration and metastasis. The N terminal domain of most chemokine receptors is the ligand binding domain and so the N terminal domain of CXCR4 is the binding site for SDF-1.
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Statistics
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PSSM-Id: 432337
Aligned: 6 rows
Threshold Bit Score: 63.2638
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002712170   6 IYTSDNYTE-ELGSGDYDSIKEPCFREENAHFNR 38 
Q07FZ4        10 INIFDSNST-ENGSGDFEDFSEPCFMHDNSDFNR 42  tropical clawed frog
XP_007494171  16 IEFHDNNTVeGFGSGDYEG-KEPCYPNENEDFNR 48 
XP_010712326  16 IEFADNGSE-EIGSADYGDYGEPCFQHENADFNR 48 
XP_003215140   9 IFMTENSTD-EPGSGDDGDYQEVCLQQENADFNR 41 
XP_002198314  20 IELSENGTD-EIGSGDYGDYKEPCYQNENADFNR 52
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