Conserved Protein Domain Family
zf-LITAF-like
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pfam10601: zf-LITAF-like 
LITAF-like zinc ribbon domain
Members of this family display a conserved zinc ribbon structure with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS). The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure.
Links
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Statistics
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PSSM-Id: 463165
Aligned: 306 rows
Threshold Bit Score: 36.4264
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002115291         35 ESTQTMDCPFCNQQIQTVIRYEAGEGTCTTaalCcCFLFLTSIgpyirgiiglLIV-----FCC----NSFQDIKHYCPE 105
WGS:AAPP:GF13577-PA  25 TEPQELECPACQQTQVTRVAREAVTVTQKIvcsLnVLL---------------CCNp----IRW----EGRHDTNHYCSS 81 
Q4V6L7               49 REPVEIECPACGIKDLSVVQNDLKWWASELnriVgCLFVTFCC----------CCCfny------yvpCKQTDRSHYCGN 112 fruit fly
EDW31900             31 TAPQELQCPACRQWQTTRLEREAVTCLQKIactLnVLL---------------CCNp----IRW----EGRHDVNHYCGA 87 
Q22CA4               62 EEPAVIECPKCLKVCQTKIQVKSGKNTYLC---S-GLLFVLSIgi-------cCVLp----LLS----SGFKDKIHFCSA 122 Tetrahym...
CEF74384            144 DQADSVDCPFCQHQTETKVKKSPSGMTHVY---A-AALFFGTff--------gVMCp----YIC----HCASNVSHYCKN 203
XP_016756879         70 EQPEHIYCPRVGRVCLTKSESKDSEKTWFAvigIcLICPCVA-----------CIp-----LKGccgdGMLQDWDHYCTG 133
EME43456             66 ERPENVWCPTKGAIVQTRAESKDSDKTWFAvigIcLICPCIA-----------CFp-----LKGccgdGMLQDWDHYCSG 129
XP_015034257         37 PSTYRVLCPLCQQKARTETVQMSGALGQLS-----CLLSVLSC----------CFpifaltCVYsclqSRLKSKRVFCSS 101
XP_002039943        195 PSSYQVRCPLCQQNSKTETVEMTGALGQLS-----CLLSTLSC----------CFpifaltFVYsclqSRLKSKRVFCSR 259

XP_002115291        106 CQKLIKAYE 114
WGS:AAPP:GF13577-PA  82 CGCFIGRHI 90 
Q4V6L7              113 CGCYFGRSM 121 fruit fly
EDW31900             88 CGCFIGRHI 96 
Q22CA4              123 CGNQVGIHK 131 Tetrahymena thermophila SB210
CEF74384            204 CGRKVAMRE 212
XP_016756879        134 CGKQLTHRP 142
EME43456            130 CGKQITHRP 138
XP_015034257        102 CGGHLGFHW 110
XP_002039943        260 CGGHLGFHW 268
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