1XAG


Conserved Protein Domain Family
aroB
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TIGR01357: aroB 
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3-dehydroquinate synthase
This model represents 3-dehydroquinate synthase, the enzyme catalyzing the second of seven steps in the shikimate pathway of chorismate biosynthesis. Chorismate is the last common intermediate in the biosynthesis of all three aromatic amino acids. [Amino acid biosynthesis, Aromatic amino acid family]
Links
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Statistics
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PSSM-Id: 273575
Aligned: 21 rows
Threshold Bit Score: 365.417
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1XAG_A        12 YPIYVEHGAIK-YIGTYLNQ---F--DQSFLLIDEYVNQYFANKFDDILSY--ENVHKVIIPAGEKTKTFEQYQETLEYI 83  Staphylococcus ...
Q9WYI3       172 HLVKIILGGFKrVRNEE------------LVFTTERVEKIYGRYLPENR---------LLFPDGEEVKTLEHVSRAYYEL 230 Thermotoga mari...
Q9Z6M3        11 HVVKLISNFFQkKLFSSISt---A--YPLVIITDVSVQQHLLGPILDHIKMlgYQVIVLTFPPGEPNKTWETFISLQYQL 85  Chlamydia pneum...
WP_000702172  12 YDIQIEKGCMA-QAGQWLRElwqP--QKVVIVTDNHVASLYAEKVKLSLEDagFQVAVFDFLEGEERKNLTTVQKVYEFL 88  Streptococcus p...
WP_005874788   1 -MVIVGTDIIGrKLVPALSG---MacDRLFVLCDEAVATLHAERI-AAIRAltAADDWYLLSGGETIKQWGNCLPLWRWL 75  Porphyromonas g...
WP_010231103  10 HPMHLVDSLCDpQLFATLAK---T--SPLIFITNSTLEILVLPPLLETARSlgFSVEILIIPEGEQAKTETTFLYLHKQL 84  Chlamydia murid...
WP_014635596  14 YDILFTDHVLK-TLADCLGEr-kQ--RKLLFITDQTVYHLYQTLFEEFAQQ--YNAFVHVCPPGGQSKSLERVSAIYDQL 87  Streptococcus p...
WP_010900714  15 isVVIGEDITG-HISEEVGH---Y--DSLVFMISRNVEEMFGSKIPP-LENygSSTIKITLNDGESLKTLRNYQRIIKVL 87  Thermoplasma ac...
WP_010887423  12 YAVEVGPGLL-----TRLAV---P--ETPSALIHP--ADLPAAWVEQAQASl-QPHLTVTVPARDECKTLEVFADVLSQL 78  Deinococcus rad...
WP_010865843  11 FRLSVDEETVVaAGVGALSEaprAagGTAYIVHEEALSAEA-ARLARILEArgVEVLGAVAGGGERVKSLDWVTRLWDLM 89  Aeropyrum pernix

1XAG_A        84 LSHHVTRNTAIIAVGGGATGDFAGFVAATLLRGVHFIQVPTTILAH-DSSVGGKVGINSKQGKNLIGAFYRPTAVIYDLD 162 Staphylococcus ...
Q9WYI3       231 IRMDFPRGKTIAGVGGGALTDFTGFVASTFKRGVGLSFYPTTLLAQvDASVGGKNAIDFAGVKNVVGTFRMPDYVIIDPT 310 Thermotoga mari...
Q9Z6M3        86 VDQNISPKSSIIGIGGGTVLDMTGFLAATYCRGLPLYLIPTTITAMvDTSIGGKNGINLRGIKNRLGTFYLPKEVWMCPQ 165 Chlamydia pneum...
WP_000702172  89 VKQGLTRSDGIVALGGGVVGDLAGFVASTYMRGIHFVQIPTSLTAQvDSSIGGKTGVNTPFAKNMVGTFAQPDGVLIDPL 168 Streptococcus p...
WP_005874788  76 SERGASRHSLLLNIGGGTITDLGGFVASVYKRGIRTVNLSTTLMGMvDASVGGKTGIDFEGVKNEIGTFHLPKAVFCDCA 155 Porphyromonas g...
WP_010231103  85 ATLTIPRQATLIGVGGGVVLDIVGFVASTHCRGMPFIAVPTTLVAMiDASIGGKNGINLDHIKNRIGSFYLPKDVWICPS 164 Chlamydia murid...
WP_014635596  88 IAENFSKKDMIVTIGGGVVGDLGGFVAATYYRGIPYIQIPTTLLSQvDSSIGGKVGVHFKGLTNMIGSIYPPEAIIISTT 167 Streptococcus p...
WP_010900714  88 VEKKVSRNSLLVYVGGGTVGDLAGFVAATYKRGLRMIAVPTTLLAQvDSSIGGKNGLDFSDVKNVIGTFYNPYLIIDDLQ 167 Thermoplasma ac...
WP_010887423  79 AQAGLPRSGAVVGLGGGAATDLAGFVAASYLRGVAFYTAPTTLLGMvDAAVGGKTGVNLPEGKNLVGAFWPPRAVWCDTA 158 Deinococcus rad...
WP_010865843  90 LQAGVERSTTVYIIGGGALLDAAGFAASTLMRGLSTVNIPSTTLAAfDAAAGGKTGVNLR-GKNMVGTFHNPRMVLVEPG 168 Aeropyrum pernix

1XAG_A       163 FLKTLPFKQILSGYAEVYKHALLNGE--SATQDIEQHFKD--REILQSLNGMDKYIAKGIETKLDIVVADEKEQ-GVRKF 237 Staphylococcus ...
Q9WYI3       311 VTLSMDEGRFEEGVVEAFKMTILSGRgvELFDEPEKIEK----R---NLRVLSEMVKISVEEKARIVMEDPYDM-GLRHA 382 Thermotoga mari...
Q9Z6M3       166 FLSTLPREEWYHGIAEAIKHGFIADA--YLWEFLNSHSK---MLFSSS-QILHEFIKRNCQIKAAIVAEDPYDR-SLRKI 238 Chlamydia pneum...
WP_000702172 169 VLETLGKRELIEGMGEVIKYGLIEDP--ELWALLTGLNGS--VESI--LEHAETLIEHSCQVKRKMVVEDELDN-GIRLY 241 Streptococcus p...
WP_005874788 156 FLSTLTDRELLSGHAELVKHALLMGA--DEWKEVISFDPF--GNN---MEAWEEIVRHSVTFKESIVNRDLHES-GLRSM 227 Porphyromonas g...
WP_010231103 165 VLSSLPEQEFYHGIAECIKHAYIADA--SILPILQNPASL--RS----TKQLSLLIKRNCLCKASIVGKDIRDH-GIRQI 235 Chlamydia murid...
WP_014635596 168 FLETLPQREFSCGISEMLKIGFIHDR--PLFQQLRDFQKE------TDKQGLERLIYQSISNKKRIVEQDEFEN-GLRMS 238 Streptococcus p...
WP_010900714 168 FLKSTPD-LIREGMGEVIKYSIIAGG--DMFRKVSEC------SLSNFHDHSADIVKMSIKIKADIVNRDYYDRnGVRSI 238 Thermoplasma ac...
WP_010887423 159 TLTTLPDAVFREGAAEAFKHGLMADP--SLLDRVVSPD------FRPGGALLEDTLADAIAVKAGVVTRDLTEQ-GERAF 229 Deinococcus rad...
WP_010865843 169 IVAGQPDEGYRDGFAELVKHVALSGD--REPAASLLPQALarRP-----APLARLAFWSLGYKMQVVAGDPRER-GLRRI 240 Aeropyrum pernix

1XAG_A       238 LNLGHTFGHAVEY---YHk-----IPHGHAVMVGIIYQFIVANALFD-S-KHDISHYIQYLIQLGYPLDMI--------T 299 Staphylococcus ...
Q9WYI3       383 LNLGHTLGHVYEMle--------gVPHGIAVAWGIEKETMYLYRKGIvP--KETMRWIVEKVKQIVPIPVP--------S 444 Thermotoga mari...
Q9Z6M3       239 LNFGHSIAHAIETlakGT------VNHGQAVSVGMMIETRISLAEGVmKtPQLIDQLERLLKRFNLPSTLK--------D 304 Chlamydia pneum...
WP_000702172 242 LNFGHTIGHAIEAtagYGk-----VMHGEAVAMGMVQISKVAEEKGLmP-AGITQSITEMCQKFGLPVDYE--------N 307 Streptococcus p...
WP_005874788 228 LNLGHTVGHAMESf-sYTlpgnvgLSHGHAVIIGLICELYYSVVAHGfP-REILYSLVAWSKEYYSPFFFT--------C 297 Porphyromonas g...
WP_010231103 236 LNFGHTLGHALEMlf-tGk-----ISHGFAISVGMVLETKLSLAMGVaRnPNILHFLVQDLLRYQLPTSLKdlyaqaqiP 309 Chlamydia murid...
WP_014635596 239 LNFGHTLGHAIESlchHDf-----YHHGEAIAIGMVVDAKLAVSKGLlP-KEDLDSLLQVFERYQLPTTLE--------R 304 Streptococcus p...
WP_010900714 239 LNLGHTIAHGIEGas-kGq-----ISHGRAVATGLMVEAHIGEKYGNtR-PEVIDEIMKLADNYGIERVRI--------S 303 Thermoplasma ac...
WP_010887423 230 LNFGHTLAHALEAvt-hQa-----IPHGEAVAYGMHYAARLSHALGGaD---LTAHTRAFLRW-QRPRRLP--------P 291 Deinococcus rad...
WP_010865843 241 LNLGHTIGHALEAassYT------LSHGRSVSIGLAGELELSRRLAGlP-RGEAEDVLDMLSTAGLPLEPP--------P 305 Aeropyrum pernix

1XAG_A       300 d------------LDFETLYQYMLSD-KK-NDKQGVQMVLMRQFGDIVVQH---VDQLTLQhAC 346 Staphylococcus aureus
Q9WYI3       445 -------------VDVEKARNLILND-KKiLKGSRVRLPYVKEIGKIEFLe--vDPLELLEvVD 492 Thermotoga maritima MSB8
Q9Z6M3       305 lqsivpehlhnslYSPENIIYTLGYD-KKnLSQHELKMIMIEHLGRAAPFNgtyCASPNME-IL 366 Chlamydia pneumoniae
WP_000702172 308 -------------WEVGKLYQALTHD-KK-ARGNTLKLVLVPELGSATIHPv-sLEEMKDYlVk 355 Streptococcus pneumoniae
WP_005874788 298 -------------KQYPSLTAFCMKD-KK-NLGSKIRLIPLKGIGLPAEPCe-iTEKMLHEcFD 345 Porphyromonas gingivalis
WP_010231103 310 i------------HSCSQILSALSYDkKK-QNASLPPFVMIEEIGLAASCNgsfCQPASNHfLt 360 Chlamydia muridarum
WP_014635596 305 a-----------dVSATSLFDVFKTD-KK-NSEQHIIFILPTETGFTTLAIn-kDDHQFVEkLD 354 Streptococcus pyogenes
WP_010900714 304 d------------IGVNSILRYISND-KK-MSEGYINMPVPADIGNIITMKv--TERMISDgLN 351 Thermoplasma acidophilum
WP_010887423 292 -------------LTFDALAPFIARD-KK-ADSAGVRFVLLRDLAQPYLAr--vPDDVLRReFD 338 Deinococcus radiodurans
WP_010865843 306 -------------GLAGEAAGLVGLD-KK-REGGSIVMPLLERLGRPRLSr--vPVETVSRlMV 352 Aeropyrum pernix
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