1F60,1B64,1IJE,1GH8


Conserved Protein Domain Family
EF1B
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cd00292: EF1B 
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Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl tRNA to the ribosome. The guanine nucleotide exchange domain of EF1B, which is the alpha subunit in yeast, is responsible for the catalysis of this exchange reaction.
Links
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Statistics
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PSSM-Id: 238181
Aligned: 31 rows
Threshold Bit Score: 64.1548
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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EF1A
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:EF1A interaction surface [polypeptide binding site]
Evidence:
  • Structure:1F60; yeast elongation factor complex
  • Structure:1IJE; insertion of lysine into the Mg binding site
  • Comment:GDP/GTP exchange is induced by disruption of Mg binding site of EF1A by insertion of N terminal lysine
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #   #   ###                         ##    #  #       # #   #  #   ##          
1F60_B       6 AAKSIVTLDVKPWDDETNLEEMVANVKAIEME--GLTWGAHQFIPIGFGIKKLQINCVV-EDDKVSl-DDLQQSIEedeD 81  baker's yeast
Q9HKN1       1 MGDVLVTLKILPKDTDADIKSIEDQVKRNIEG--LCSINRMDEVDIGFGLKYIKLEIIV-QDKEGEi-DRVENSISs-iE 75  Thermoplasma acid...
Q64214       1 MTDVLVVLKVFPDSDEVNLDNLYTDISSKLPK--EYKIIRKETEPIAFGLNALILYVQMpEQTEGGt-DNLEEVVNn-iQ 76  Sulfolobus solfat...
Q9Y904       1 MARVAVVVKVYPDDVSIDPKTLAERIKSKLPS--GYEVLAEGEEPIAFGLKALKLVIAMnEDTEGGt-EEVEQLLKn-iE 76  Aeropyrum pernix
Q9HQG6       1 MSKVAAVLKVMPDSPDIDLDGLEADLSESLPD--GAEINGTDTEEVAFGLTALLTTVIV-PDDSGGt-EAVEDAFGa-vD 75  Halobacterium sp....
Q8TYN8       4 VSKVLVDLKVLPESADVDYEELKEAIREKLESmdVVDIEGMEEEPIAFGLKAIRVKVVV-PDAEGGt-DALEDALKe-vD 80  Methanopyrus kand...
Q9V2P6       3 DFNIVGVIKVMPSDPEVNLDELEEKLKAVIPE--KYGLAKVEREPIAFGLVALKFYVLG-KDEEGYsfDEVAEKFKe-vE 78  Pyrococcus abyssi
Q57901       1 MATVLAKIKIMPTSPEVNKEKLKEKIKEVLEKq-DVAIRGLFDEPLAFGLYAIYTVIEM-EEREGGt-EPIENALAe-iD 76  Methanocaldococcu...
ZP_00001569  1 MGDVMVQLRILPESVDVNLKDLRVAITASIEK--LCTINEVKEEEIGFGLSALLFSVIV-PDEEGKi-DSVENAISs-vK 75  Ferroplasma acida...
Q8ZYN5       2 SAEVALVYRVLPDSAEVNIEKLKNDVINKLAP--KYKVDKVEVEEIGFGIKALRLYIRMpESDEYSs-DEIEELLRs-vE 77  Pyrobaculum aerop...

Feature 1           #    ## 
1F60_B      82 HVQSTDIAAMQKL 94  baker's yeast
Q9HKN1      76 GVGEISTENVSLI 88  Thermoplasma acidophilum
Q64214      77 GVSHAEVVGITRL 89  Sulfolobus solfataricus
Q9Y904      77 GVQEVEVENVSRM 89  Aeropyrum pernix
Q9HQG6      76 DVESVSVEEVGRL 88  Halobacterium sp. NRC-1
Q8TYN8      81 EVNQVEVVSASRT 93  Methanopyrus kandleri
Q9V2P6      79 NVESAEVETVSRI 91  Pyrococcus abyssi
Q57901      77 EVESVETVEVSLA 89  Methanocaldococcus jannaschii
ZP_00001569 76 NVSQVDTRDVTLI 88  Ferroplasma acidarmanus
Q8ZYN5      78 GVGGYELEYFSRL 90  Pyrobaculum aerophilum

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