Conserved Protein Domain Family
AKAP_110

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smart00807: AKAP_110 
A-kinase anchor protein 110 kDa
This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.
Statistics
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PSSM-Id: 214827
Aligned: 5 rows
Threshold Bit Score: 1087.36
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAC63370       1 VDWLQSQNGVCKVDVYSPGDSQPQDWKMsdesl----------------------------------------------- 33  cattle
NP_001005557   5 VDWLQSQSGVCKVGVYSPGDNQHQDWKM---------------------------------------------------- 32  Norway rat
AAH47535       5 VDWLQSQNGVCKVDVYSPGDNQAQDWKM---------------------------------------------------- 32  human
AAC83697       5 IDWLHSRRGVCKVDLYSPKGQQDQDRKVicfvdvstlnvedfnskgaagprsegelnlenleekeiivikdtekqdqskt 84  house mouse
CAA75494      13 IDWLRSHRGVCKVDLYNPEGQQDQDRKVicfvdvstlnvedkdykdaassssegnlnlgsleekeiivikdtekkdqskt 92  human
AAC63370      34 ----sifkEASHDPIRVLSWLRRDLEKSTAGFQDIRFKPGESSLGREMVS-SGDPRKGFCVDYYNTTSR--------GSP 100 cattle
NP_001005557  33 --------DSSTDPVRVLSWLRKDLEKSTAGFQDSRFKPGESSFGEEVAY-PGDQRKGFCVDYYNTTNK--------GNP 95  Norway rat
AAH47535      33 --------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPGES-FGGETSN-SGDPHKGFSVDYYNTTTK--------GTP 94  human
AAC83697      85 egsvclfkQAPSDPISVLNWLLNDLQKYASGFQQA-LSPSASSCKHKVGDlEGDYHKIPSEECYSVYADqvnldylnKGP 163 house mouse
CAA75494      93 egsvclfkQAPSDPVSVLNWLLSDLQKYALGFQHA-LSPSTSTCKHKVGDtEGEYHRASSENCYSVYADqvnidylmNRP 171 human
AAC63370     101 GRLHFEMSHREN---------------PH---------------QGPTC---NGSSVDEVSFYANRLTNLVIAMARKEIN 147 cattle
NP_001005557  96 GRLHFEMSHKET---------------PP---------------QGLIAhvgNGGSIDEVSFYANRLTNLVIAMARKEIN 145 Norway rat
AAH47535      95 ERLHFEMTHKEI---------------PC---------------QGPRAqlgNESSVDEVSFYANRLTNLVIAMARKEIN 144 human
AAC83697     164 QNLRLEMAASKNtnnnqspsnpatkspSN---------------QRSVAtpdGECSMDDLSYYVNRLSSLVIQMARKEIK 228 house mouse
CAA75494     172 QNLRLEMTAAKN---------------TNnnqspsappakppstQRAVIspdGECSIDDLSFYVNRLSSLVIQMAHKEIK 236 human
AAC63370     148 EKIDGSENRCVHQSVYMG----DE---PPPNKSLSKVASELVNETVTACSKNTPSDKAPGSGDRASGTLQSPpNLKYKST 220 cattle
NP_001005557 146 EKIHGTENKCVHQSLYMG----DD---PTPHKSLSTVASELVNETVSACSKNITGDKAPGSGDRALASSQSP-GLRFTST 217 Norway rat
AAH47535     145 EKIDGSENKCVYQSLYMG----NE---PTPTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRVSGSSQSPpNLKYKST 217 human
AAC83697     229 DKLEG-GNKCLHHSMYTS----GEkgkTSPRSAVSKIASEMAHEAV---------------------------------- 269 house mouse
CAA75494     237 EKLEG-KSKCLHHSICPSpgnkER---ISPRTPASKIASEMAYEAV---------------------------------- 278 human
AAC63370     221 LKIKESNKGGRGPDDRPSSKKSLFYKEVFESRNAGDAKEGGRTLPAERKMFRGYERPDDFTASISQGIMTYANSVVSDMM 300 cattle
NP_001005557 218 LKIKESTKEGKCPDNKPGSKKSFFYKEVFESRNAGDAKEGGRSLPGDRKLFRCPDRPDDFSNSISQGIMTYANSVVSDMM 297 Norway rat
AAH47535     218 LKIKESTKERQGPDDKPPSKKSFFYKEVFESRNGDYAREGGRFFPRERKRFRGQERPDDFTASVSEGIMTYANSVVSDMM 297 human
AAC83697     270 -ELTSSEMRGNGEEGRDG-RKTFLYSELSNKNKCGEKQQ------------MCPKDSKEFADSISKGLMVYANQVASDMM 335 house mouse
CAA75494     279 -ELTAAEMRGTGEESREGGQKSFLYSELSNKSKSGDKQ-------------MSQRESKEFADSISKGLMVYANQVASDMM 344 human
AAC63370     301 VSIMKTLKIQVKDTTI-ATIVLKKVLIKHAKEVVSDLIDSFMKNLHNVTGTLMTDTDFVSAVKRSFFSHGSQKA-TDIMD 378 cattle
NP_001005557 298 VSIMKTLKIQVKDTTI-ATILLKKVLMKHAKEVVSDLIDSFMKNLHSVTGSLMTDTDFVSAVKRSFFSHGSQKA-TDIMD 375 Norway rat
AAH47535     298 VSIMKTLKIQVKDTTI-ATILLKKVLLKHAKEVVSDLIDSFLRNLHSVTGTLMTDTQFVSAVKRTVFSHGSQKA-TDIMD 375 human
AAC83697     336 VSVMKTLKVHSCGKPIpACVVLKRVLLKHTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNHGKQNA-ADIME 414 house mouse
CAA75494     345 VSLMKTLKVHSSGKPIpASVVLKWVLLRHTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNQWKQNAyRHHRR 424 human
AAC63370     379 AMLGKLYSVIFAKKPPETVRKTKDKSESYSLVSMK-GMGDPKHRN--VNFAsMKSEGKVRE---RVCT--PTP-KpEKSC 449 cattle
NP_001005557 376 AMLGKLYNVMCAKKYPENIRKARDKSESYSLISMKsRPGDPKLSN--LNFA-MKSESKLKEn--LFSA--CISeK-EKTC 447 Norway rat
AAH47535     376 AMLRKLYNVMFAKKVPEHVRKAQDKAESYSLISMK-GMGDPKNRN--VNFA-MKSETKLREk--MYSE--PKS-E-EETC 445 human
AAC83697     415 AMLKRLVSALLGE-------KKETKSQSLAYATLKaGTHDPKCKNqsLEFSaMKAEMKGKDk--GKTKgdPCC-K-SLTS 483 house mouse
CAA75494     425 PMLKRLVSALIGE-------EKETKSQSLSYASLKaGSHDPKCRNqsLEFStMKAEMKERDkgkMKSD--PC--K-SLTS 492 human
AAC63370     450 VETLGEHIIKEGLTLWHNSQQKEgisaclqgSPFVTPKRQYKPVPDFPLGFPfDPCNFS--LPMQCPEKPEN-FMCDSDS 526 cattle
NP_001005557 448 AETLGEHIIKEGLNMWHKSQQNS--------PGLERATKQGAVPQEVSFECP-DPCEVNplQQPQPPENFEN-FMCESDS 517 Norway rat
AAH47535     446 AKTLGEHIIKEGLTLWHKSQQKEckslgfqhAAFEAPNTQRKPASDISFEYPeDIGNLS--LPPYPPEKPEN-FMYDSDS 522 human
AAC83697     484 AERVSEHILKESLTMWNNQKQG-------------------------------TQGRVPnkVCPSKDEKREK-ISPSTDS 531 house mouse
CAA75494     493 AEKVGEHILKEGLTIWNQKQG--------------------------------NSCKVAtkACSQIKMSKENrSMLPQIH 540 human
AAC63370     527 WAKDLLVSALLLIQYHLAQGGNMDAQSFLEAAGTSNLY--------------PTKSPAVSHESSLRSPQV-GADPE---- 587 cattle
NP_001005557 518 WAKDLIVSALLLIQYHLAQGGRMDAQSFLEAAASTNFP--------------TKSSPVVHDEGKVKSPPLkICEQE---- 579 Norway rat
AAH47535     523 WAKDLIVSALLLIQYHLAQGGRRDARSFVEAAGTTNFP--------------ANEPPVAPDESCLKSAPI-VGDQE---- 583 human
AAC83697     532 LAKDLIVSALMLIQYHLTQQAKGKDPCEEECPGSSMGYmsqsaqyeksgggqSSKSLSMKHFESRGAPGPsTCAKEnq-l 610 house mouse
CAA75494     541 WPKDLIVSALKLIQYHLTQQIKGKDTCEEDCPGSTMGYmaqstqyekcgggqSAKALSVKQLESHRAPGPsTCQKEnqhl 620 human
AAC63370     588 EVEKKDLMSVFFNFIRNLLSETIFKSDHSCDPKATKE---D---------NSPQ--CERPVTPSPAKLNECDE-TGGAFA 652 cattle
NP_001005557 580 QTEKKDLMSVIFNFIRNLLSETIFKGSRNCESKAHEQ---IikeeeinlcERPLspCERPMSPPVPKFCEDEEaTGGALS 656 Norway rat
AAH47535     584 QAEKKDLRSVFFNFIRNLLSETIFKRDQSPEPKVPEQpvkE---------DRKL--CERPLASSPPRLYEDDE-TPGALS 651 human
AAC83697     611 ESQKMDMSNMVLSLIQKLLSESPFSCDELSES------------------ENKR--CCDSRSKQAAPVAKRPE---DQSQ 667 house mouse
CAA75494     621 DSQKMDMSNIVLMLIQKLLNENPFKCEDPCEG------------------ENK---CSEPRASKAASMSNRSDkAEEQCQ 679 human
AAC63370     653 GLTKMVANKLDGHMNGQMVDHLMDSVMKLCLIIAKSCD--SPLAELGDDKSGDASRPTSAFPESLYECLSTKGTGTAETF 730 cattle
NP_001005557 657 GLTKMVANQLDGCMNGQMVEHLMDSVMKLCLIIAKSCD--SPLSELGDEKCGDASRPSSAFPDNLYECLPVKGTGTAEAL 734 Norway rat
AAH47535     652 GLTKMAVSQIDGHMSGQMVEHLMNSVMKLCVIIAKSCD--ASLAELGDDKSGDASRLTSAFPDSLYECLPAKGTGSAEAV 729 human
AAC83697     668 DSTEMDFISGMKQMNRQFIDQLVESVMKLCLIMAKYSNngAALAEL-EEQAALASN----GPRCGR-----------EAV 731 house mouse
CAA75494     680 EHQELDCTSGMKQANGQFIDKLVESVMKLCLIMAKYSNdgAALAEL-EEQAASANKPNFRGTRCIH-----------SGA 747 human
AAC63370     731 LQNAYQAIHNELRSLSAQPPEGCTAPKVIVSNHNLTDTVQNKQLQAVLQWVAASELN-VPILYFAGDDEGIQEKLLQLSA 809 cattle
NP_001005557 735 LQNAYLAIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQAVLQWVAASELN-VPILYFAGDDEGIQEKLLQLSA 813 Norway rat
AAH47535     730 LQNAYQAIHNEMRGTSGQPPEGCAAPTVIVSNHNLTDTVQNKQLQAVLQWVAASELN-VPILYFAGDDEGIQEKLLQLSA 808 human
AAC83697     732 MSQSYPE---------------TPGPEVIVNNQCSTSNLQ-KQLQAVLQWIAASQFN-VPMLYFMGDDDGQLEKLPEVSA 794 house mouse
CAA75494     748 MPQNYQD---------------SLGHEVIVNNQCSTNSLQ-KSAPGCPAVDCSLQFNrCPCSTSWEIRMDNWKSLAQVSA 811 human
AAC63370     810 AAVEKGRSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMVNL 854 cattle
NP_001005557 814 TAVEKGRSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMANL 858 Norway rat
AAH47535     809 AAVDKGCSVGEVLQSVLRYEKERQLNEAVGNVTPLQLLDWLMVNL 853 human
AAC83697     795 KAAEKGYSVGDLLQEVMKFAKETQLDEAVGNMARKQLLDWLLANL 839 house mouse
CAA75494     812 KAAEKGYSVGGLLQEVMKFAKERQPDEVWERWPGNSC--WTGCSL 854 human
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