Conserved Protein Domain Family
LINES_N

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pfam14694: LINES_N 
Lines N-terminus
This family represents the N-terminus of protein lines. In Drosophila this protein is involved in embryonic segmentation and may function as a transcriptional regulator.
Statistics
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PSSM-Id: 464266
Aligned: 22 rows
Threshold Bit Score: 304.623
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_016156514 194 TLASIIKETLKDALVPRAGVLKKLLAPLDAVLEGFFNAILLHHFDSHHYTSpy-sE----ATNNLISFVDLLEALLASRV 268
XP_002939313 168 TLICVFKGLLRDENLQQGDILSVLLQPLDPTFERFCSSLLSDVGTTHCQTSaldpE----SSCCLSCLLDLMELLIALRI 243
XP_022525247 164 SLTEVIKGILRGECANKPEILRKLLAGFEEVLTSLFFKMLLHDAFENSQVAenitD----LDVTVSTFMDLLEALCAARP 239
XP_015198441 184 SLTFVIKGLLRGVFQQKMEILGKLLTSLDLVFPALHSMMF-SFADFSQELSts-sKyefgFETSLASFIDLIEVLIAART 261
XP_005990207 229 SLTAVIKAILKDKTFKKTEVLKNLFTNLDTVFENLYNHMFPQCSKDSKQIMsn-tKsqfeTVNNLISFIDLLEVLVACRT 307
EFN64138     202 NTHIISDTESFDSTAIKEMCVKALESKWTILVSKFKIILRTYTPQHASV---------------VITFLHLWETIISVKA 266
NP_001127865 203 NVITISDPESLDSTPVKAMCVKALESKWTVLVTKFDAILGSYTPQHESA---------------VITFLNLWESIISVKA 267
XP_014248050 213 HVLSVSDPDSLDSSQIKCLCIKALEAKWPAIVSRFDRLLATSPAQNDST---------------VITFLGLWEAIISVKA 277
EEB19719     210 NATSLMDTESPDSSEVKCICIKVLEVKWPDLVKKVDDMISTYTSENECA---------------IVTFLGLWESIISVKA 274
XP_002005702 448 HVVALTDSESFDTTHLKCVTIQKLEHKWPTLVKHMSELM-APVHQDSAEHC-------------VLNFLQLWENIISVKA 513
XP_016156514 269 ELELPL-RCQRILFLKVSYVLNVISSSIPYVIKKKFILLLKKCVLYKSREDAKSGS---LFLETPSLCEDMLALSNAVLQ 344
XP_002939313 244 KYKRSLpLCHTVLSVTIPQAFTLVSSPVAYYVKRQFILVLKRSLLKKAGEDFYPVLhsmSQPGDPVLEQEITMLVLALLN 323
XP_022525247 240 RYGVCS-TVQRLMFLHSSVLLRLMDSCLGYFVKKRVLLLLKRTVVQRPGEDWALGDrhsALQEDEFLAGDMLVLADAVLQ 318
XP_015198441 262 KLKTLA-SSQRLLFIQASLALQLVGSPVHCSVKKKMLLLLKRCLLQKAGEDFSIGQvkgSLLRDDILDSDMLMLATAVLQ 340
XP_005990207 308 QLSLHY-LCQRLLFLQASQPLEFMTSLGDYMIKKKLILLLKKCVLHKAGEDFISGSlhaVSQQLPCLNEDVLVLANAIFH 386
EFN64138     267 NLSV---IDTKPFYSKLNDLVWLLNSNLPSVVWRHLLSLFNEVLCYGS-----------TLALQDMLPDEPCSLATLIVR 332
NP_001127865 268 NLSV---IDTKLFYSQLDNLVMLLNANVPGIIWRHLIGLFNEVLCYGS-----------TLSLQGILPEEPCLLAHVVVR 333
XP_014248050 278 NLSI---VDTKPFYAHLANFVALLNSGVSPIVWKHMLDLFNEVLCYGS-----------TLALQDILAEEPCSLAHLIVR 343
EEB19719     275 NLSV---IDTKPFYSNLYSFIVVLNSSVPSTVWKHLLNLFNEVLCYGS-----------TLALQECLAEEPCALAHHVMR 340
XP_002005702 514 NLSI---DETRPFYAQLDKFELLLNHNLSCTVYKQMLCLFNEALCYGS-----------TLALQDMLPEETCRLAHQIVC 579
XP_016156514 345 VV-NLTWLNQIPVSGKSSSFG---------------------------SSEAAHGHDSRGGSDQTVLRALSLVVLKALEF 396
XP_002939313 324 SV-DQGWLLQVPIRDRISSFG---------------------------GSYMASES----SPDLVVLGAVCLSVLKALEI 371
XP_022525247 319 EV-AAGWFRRVWVKPQPSFLG---------------------------GNRQKFPEGE--GKDVVMLRATSLILIKSLQI 368
XP_015198441 341 SP-FSGWLQSVSVSSNPSYFG---------------------------GTSIV-GENVLGSADCVMLRAAILTLIKSLEY 391
XP_005990207 387 AV-MSGWLQQVPVSPKGSLFG---------------------------GSELLSEDITR-RPDLTMLRAISLMVIKALEI 437
EFN64138     333 VVkDHRLLDALPYRHGSGRFG-----------------------------------GGTGDGDRPLLQKMVLLVLKSAAV 377
NP_001127865 334 AVkDWRLLDSLPYRHGSGRFG-----------------------------------GGSGDGDHPLLQKVVLLVLKSVAV 378
XP_014248050 344 SVkDWRLLEAIPFRGGSGRFG-----------------------------------GGSGDGDKPLLQKAVLLVLKAVAV 388
EEB19719     341 SVkDWRLLDLLPFRNGSGRFG-----------------------------------GGRGDGDRPLLQKMALLVLKSVAV 385
XP_002005702 580 HVrSLRILESLPRRQPQNIVGligyngapvnyvpgtllahnslpahegTEAAAAGSVGLIEMDKTLLQKMVLLVLKSIAV 659
XP_016156514 397 KINNSAT-EAE-----------------IKGDFESSMSQLLMFWRSHVKPs-pQSHpvvHHCEWLSLVFMEQDDDMWEAA 457
XP_002939313 372 QLLEVTL-SSI-----------------IAEKLQSVMDQLLAFLRHHLG-----WQkpwHPCEWVSLVFIEQDDDMLEVA 428
XP_022525247 369 RTQHAGTeESE-----------------RALHVQEYLLELLAFLQQRVAQ----FKgepHSCSWILMVFAEQDDDMMEAL 427
XP_015198441 392 KVLH--A-GSV-----------------PGFEIQGYLPSLMLFLKKHLNAteqQLC---HPCSWVSVVFLDQDDDMMEAA 448
XP_005990207 438 KILNLAA-GDD-----------------PRAELLGFMPQLMTFVGKHLKSpqeFL----HPCTWVSLVFLEHDEDMLEAA 495
EFN64138     378 TVRETRS-DSSdssldseaedldedmavIDRSIREVLRQLDQCVKALMP-----FHpemPLSQWVVQMFHDQDDFLIEGM 451
NP_001127865 379 TMRETRSdSSSdsslasdtedldadmviIERSIRGVLRQLDQCVKQLMP-----FHpemPLSQWVVRMFNDQDDFLIEGM 453
XP_014248050 389 TVKETRCeSSSdssvcsesedadadmavIERSIREVLRQLDNCVKTLLP-----FHpetPLAQWVVQLFSDQDDALIEGM 463
EEB19719     386 TVKETRYeSSSdssvgseaddvdadmavIERSIREVLRQLDNCVKQLLP-----FHpetPLAQWVVQLFADQDDSLIEAM 460
XP_002005702 660 TVKEIRS-DSSdssidstdydafqdiqlIERSIRDVLSKLETFIKQTLE-----FHpecHFSKILIHLFDDQDDHLIEAM 733
XP_016156514 458 KALLLIYLKFDRLrCDAADTLSq-KEEESWKFLVHEGGYN---PHCIFLFFLEKIAFDSTVLLDFLISSETCFLEYLVRY 533
XP_002939313 429 NILLKMYLRCQNFwSQVPVCVNpgNEMGIWDGISHQFGCD---PNCIFVLLLNSVAFDTSVLLDFLISSETCFLEYFVRY 505
XP_022525247 428 KTLTSLYL-FQRS----TSSSG--CDACSW-------GCN---PHCHFILLLQSLCFDHTVLLDFLISTETCFLEYCVLY 490
XP_015198441 449 KAMLTLYLHFRRV-----SNTEv-CDAELFVQLTHEYGCN---PHCHFLFFLNSVAFDHTVLLDFLISTETCFLEYFVGY 519
XP_005990207 496 KALLTIYVHFDRF-----KTKSd-HKNEMWSHVTHRQGYN---PHCIFLLLLKNILFDHRVLLDFLISTETCFLEYFVRY 566
EFN64138     452 VCCLDVAVGLFYRgSPNGPVSR--------------SVLSplrPTLTFVQFIHVVAHDPDVLLDLLVSNETCFLLYLLRF 517
NP_001127865 454 VCCLDVANGLFYRgPPQNTDLA--------------NMLS---PTLTFVQFIKAVSNHHEVLLDFLISNETCFLLYLLKF 516
XP_014248050 464 VCCLDVSVGLFHR-ENASQDLR--------------RALS---PAISLAQFLRTVSHGSDVLLDFLVSNETCFLLYLLRL 525
EEB19719     461 VCCLDVRVGLYYS-PTMTPNLS----------------LS---PTNTLIAFLHVVSHDPDVLLDLLVSNETCFLLYLLRI 520
XP_002005702 734 VCTLDVTSGISFR-NNAFPELV--------------AMLN---PVYTFLEFLKMASNSSDLLLDLLVSNETCFLLYLLRF 795
XP_016156514 534 LKLLGKEWHQFVDVC 548
XP_002939313 506 LKLLKEDWPRFCLTC 520
XP_022525247 491 LKLLRDNWRDFSDSC 505
XP_015198441 520 LKILRENWQDFCYIC 534
XP_005990207 567 LKFLREDWDQFCSTC 581
EFN64138     518 LKYIRRNWGEFVECC 532
NP_001127865 517 LKYIKRSWPEFVSCC 531
XP_014248050 526 LKYIRRNWHEFASTC 540
EEB19719     521 LKFMRRNWSEFVSCC 535
XP_002005702 796 LKYIRMNWTMFVHSC 810
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