Conserved Protein Domain Family
L6_membrane
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pfam05805: L6_membrane 
L6 membrane protein
This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family. Several members of this family have been implicated in human cancer.
Links
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Statistics
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PSSM-Id: 461745
Aligned: 90 rows
Threshold Bit Score: 119.209
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003766182   2 TCTEGFTSCNGFSLMVLALLAVVLNTIPLISYKLQSDelSKNPISCFEWWYPGIIGAGVLVIPATIMSLAARKRaCCNNR 81 
XP_006638044   2 TCCEGFTSCNGFFLISLCILAIAFNLLPLFADYSMDGrlFQKPVSCFEWWLPGVLGGGILVLPAVAMTFAAKKRgSCNSR 81 
XP_001507415   2 TCCEGLTSCNGFSLLILVLISVGLNMVPLISDYAQDGllLHNSISCYEWWLPGIMGAGFLGLPAVAVSLAARKRgSCNSR 81 
XP_004005030   2 TCCEGWTACNGFSLLVLLLLGVTLNVIPLIVNLVDEDqfLKNPISCFEWWFPGIIGAGVMAIPATTMSLAARKRaCCNSK 81 
XP_003474663   2 TCCEGWTSCNGFSLLALLLVGVVLNAVPLGINLVEQDriFQNPISCYEWWFPGIIGAGLMVIPATTMSLAARKRgCCNNK 81 
EHB18162       2 TCCEGWTSCNGFSLLALLLAGVILNAIPLGINLVEADkvFQNPISCFEWWFPGIIGAGLMVIPATTMSLAARKRaCCNNK 81 
Q9CQY8         2 TCCEGWTSCNGFSLLILILLGVVINCIPLGISLVEADstSQNPISCYEWWFPGIIGAGLMAIPATTMSLAARKRaCCNNK 81  house mouse
XP_005326520   2 TCCEGWTSCNGICLLILLVIGVVLNAIPLGIDLVEQDkdFQNPISCYEWWFPGIIGAGLMVIPATTMSLAARKRgCCNNR 81 
XP_006142007   2 TCCEGWTSCNGFGLLVLLLFGIVLNAVPLIVNLVEEDklFESPISCFEWWFPGIVGAGVMVIPATTMSLAARKRgCCNNK 81 
XP_003785119   2 TCCEGWTSCNGFGLLVLLLLGVILNAIPLVMNLLEQDqfFQNPISCFEGWFPGIIGAGLM-------------------- 61  small-eared galago

XP_003766182  82 LGMILSSFLSLVTIGGAVYCILVSALALSEGPLiCNYNGNSTfnceFSMKNlsdihdqlqqpitLRWFFSPTC-EPEipn 160
XP_006638044  82 TGMLLSAFFCIISIVGAIYCVLISLIALASGPLiCQDPDAGLssctFSLGNissls---tlnfdIGWYLQFDGcHNStgg 158
XP_001507415  82 TGMLFSSFLSSVSIIGASYCLVVSLHALSEGPLiCNPNGNDLsncvFSLKNlsnfq---eqafqLDWFFKGNCgLTIpdn 158
XP_004005030  82 TGMFLSSLLNAITVIGAAYCLLVSIQALAEGPLiCNSQSNTTssceFSLENltasy---yesfdLQWFFEDSCvSRMdsn 158
XP_003474663  82 TGMFLSSLLNVITIIGAVYCVLVSVQALSEGPLiCNSQVNGTvkceFSLKNlsnih---sksfnLQWFLNDSCvSPTghk 158
EHB18162      82 TGMFLSSLLNVITVIGAAYCMLVSIQALSEGPLvCNSQVNGTanckFSWKNltdih---lqplfLQWFWNDSCvSPTgst 158
Q9CQY8        82 TGMFLSSLFSVITVVGAVYCMLVSLQALLEGPLiCNTQANSTvtceFSLKNlskfd---pesfnLLWFFNGTCvSPTdfk 158 house mouse
XP_005326520  82 TGMLLSSLLNAITVIGAVYCLLVSIQALSEGPLiCNSPSNSTttceFSLKNltdfh---pksfnLQWFFNDSCvPPTgfp 158
XP_006142007  82 TGMFLSSLLNVITIIGAVYCMLVSIQALAKGPLiCNTPGNTnc--eFSLKNlsdiq---pesfnLHWFFNDTCvPPGnsn 156
XP_003785119  62 --MFLSSLFSVITILGAVYCMVVSLQALSEGPLvCSLPANSSaqceFSFKNltnih---pesftLQWFYNNSClLPVlnn 136 small-eared galago

XP_003766182 161 nsvpdnstnlfqrtntltvsseenRYKIIHLTVFVGLFLVGILEILFSISQIVIGLFGCLCGVSK 225
XP_006638044 159 egngtwvp-----lghsftnldesQIVNLHLITFSGLSVVALLEIIFSLLQIVAGICGCLCGTSK 218
XP_001507415 159 fitnndimglhrskssrsfgsdenEPKILHLSVFIGLFTTGVLEILFSISQIMVGIFGCICGTSA 223
XP_004005030 159 nppitnttasnwrvynlhfnsienKHRIIHFSVFLGLLLVGILEMLFGLSQIIIGFLGCLCGGVS 223
XP_003474663 159 nsnpsdnmga--swkipssgseedRYRIVHFAVFLGLLLVGALEILCGLSQIVIGLFGCMCGVSK 221
EHB18162     159 klntnnnmst--swkipssnseedRYRIFHFSVFLGLLLVGILEALFGLSQIVIGFLGCLCGVSE 221
Q9CQY8       159 nptinnmvs---nwkipnsnseedRHRIFHFSVFMSLLLVGILELLFGLSQILIGFLGCLCGVSQ 220 house mouse
XP_005326520 159 nsainnmhs---nwripnsnseedRQRIFHFSVFLSLFLVGVLELLFGLSQIVIGFLGCLCGVSG 220
XP_006142007 157 ipntnntwpsnwtaysldfsseedKRRIIHFATFLGLLLVGILEVLFGLSQIVIGFLGCLCGVSR 221
XP_003785119 137 ptf----------------sdttsQHTVIHFSVFLGLLLVGILEVLFGLSQIVIGFLGCLCGVSK 185 small-eared galago
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