2H2N


Conserved Protein Domain Family
Apyrase

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pfam06079: Apyrase 
Apyrase
This family consists of several eukaryotic apyrase proteins (EC:3.6.1.5). The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes implicated in the inhibition of host platelet aggregation through the hydrolysis of extracellular adenosine diphosphate..
Statistics
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PSSM-Id: 461822
Aligned: 45 rows
Threshold Bit Score: 343.756
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2H2N_A                    51 LDTESR--AQEENTWFSYLKKGYLTLSd-------SGDKVAVEWDKDh---gVLESHLAEKGRGMELSDLIVFNGKLYSV 118
XP_002895412             143 LDKKSKddNSKKPQFLSYIMHATLKVTpgsssathKRDAYSVTFGEEt----KFSTHMNEAGRGFELSELAWFDGKLLAF 218
XP_002181909              11 LDELSRveWEKKPTFRSVLVPGTLTA---------TQGRYHIKFENAr----ELLTLHNEAGRGAEFSELTVYNDRLLTF 77 
CBJ27122                  89 LDKKSKv-DDKGKQYRSVLQAAALTRDp-------ATKKFSVEMGEAt----DLFSGHNEAGRGMELSELINYRGSLLTV 156
EAK89829                  54 LDMNSKp-GNGEKNYKSLFQKGSIIQD--------KRGNYRVDWGEIl----ELKSGYNEYGRGMELSELISYNGMMLAG 120
XP_002140694              54 LDLKSRpsNPGEKDFRSILQKGRIYFDt-------KEEQYKVTWDAAl----VLLSGHNEYGRGMELSELVIYDGKLLAG 122
XP_648646                 36 LDKASK----EGQMWRSVVIVGII-----------FRQGNSYDFQEQee--fNISLPINENGRGMELSELLSFNGSLYGF 98 
XP_654244                 67 LDKASK----LNKKWRSSMIIGTI-----------FKQGNTYEFQQQee--fNLTLGINENGRGMELSELLNFNGELYGF 129
WGS:AAFB:cds.EHI_103690A  50 LDSTKK-------QHICKVHFGML-----------FKEKDEWKFNESvskgfDVVSNYLYKTRGNEMSEIISFYDKLFVF 111
EED95937                   8 LDKLSVvtDSKKPLFRSTLLPGTLTRDd-------KTNRYSIKFEQHr----TLVSQHNEAGRGMELSELTIYNNRLLSF 76 
2H2N_A                   119 DDRTGVVYQI-EGSK--------AVPWVILSDGDGTVEKGFKAEWLAVKDERLYVGGLGKEWTTTTGDVVNENPEWVKVV 189
XP_002895412             219 DDRTGIVFRLkHFEGisrtkplqAIPEHIIMEGDGFNGKGQKHEWATVKDGELYMGSVGKEFTDNDGNVIGDGNLWVAVM 298
XP_002181909              78 DDRTGDVFELlNNAEatk---sfVVPRFVITEGNGDTDKGMKWEWSTVKNGELYMGSMGKEYTRPDGTIQNRNNLWIGIL 154
CBJ27122                 157 DDRTGIVFEIlEEQGer-----hMAPRYILPEGDGNLDKGMKLEWATEKDGSLVVGSFGKEYTDNDGRIVNTNNNWIITI 231
EAK89829                 121 DDRTGIIFEItDDGKg-------VAPRYILSEGNGRTAKGMKIEWFAVRDGILWVGSFGKEFVS-NGIIEKRDNMWVATI 192
XP_002140694             123 DDRSGIMFEIiDDGKv-------IAPRYILSEGDGNKGKGMKIEWATVRDDVLWVGSFGKEFVQ-NGIISKQDNMWVASV 194
XP_648646                 99 DDRTGLVCAIdIEKKk-------AYPRLILRDGDSFSDKGMKIEWATVYKDSMYVGSIGKEFTTPTGEYLNDNPLYVKQI 171
XP_654244                130 DDRTGVVMAIdLEKKk-------TYPRYILMDGDLNSDKGMKIEWATVYKDSMYIGSIGKEFTTPTGEYLNDNPLYIKKI 202
WGS:AAFB:cds.EHI_103690A 112 DDKTGIGHQLdIKNKk-------FYARVIMADGNGTSDSAFKPEWATIVDDTLYLGSQGLDSLNVDGVIGRSNKYYIQKV 184
EED95937                  77 DDRTGTVFEIlSTPDgsd---syVVPRFVITEGDGDTDKGMKWEWATVKNNELVLGSMGKEFTRPDGSIENTNNLWVAML 153
2H2N_A                   190 GYKGSVDHENWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPRRASQERYSEKDDERKGA-NLLLSASPDFGDI 268
XP_002895412             299 NRAGEVRHEDWTANFAAVRKALGCEWPGYVVHEAIEWSPVRRQWFILPRRVSTEPYNDMEDERRGS-NKIIIASEDFSSI 377
XP_002181909             155 NAEGELRREDWTDQYNVVRKALKALSPGYLIIEAVNWSDHLQKWVFLPRRISETAYDENEDERRGG-RQLVLVSPDFSST 233
CBJ27122                 232 DPHGVISRQDWTKQYNTLRDKVGATFPGYMIHESAAWSDALNKWVFLPRRISSEKYDDVRDEKMGS-NTILIVDEDFRKV 310
EAK89829                 193 DKRGHVSRFNWSFVYEKIRNSLGAQYPGYCIHEAVIWSHLMRKWIFLPRRVSFDEYDEEKDEKRGS-NKMIIMTDDFEIL 271
XP_002140694             195 DKFGNIRYYNWSKVYNSIRSALDADFPGYCIHEAVGWSPYMRKWIFLPRRVSNEPYDEFLDEMKGS-NKMVILSDDLEIL 273
XP_648646                172 NVDGKVSVLNWKNKFNAIKNAVRIYGEGYMIHEAVAYSVSDNKWYFAPRKCSNERYDDIKDEVRGC-PYIIS-TKDFIHF 249
XP_654244                203 DQNGKITAINWKNKYNNLKNAVGIYGDGYMINEAVTYSASANKWYFAPRKCSKEKYDDSKDETRGC-PYIIS-TEDFTNF 280
WGS:AAFB:cds.EHI_103690A 185 KKNGVYETVDFSFVYKTIDNLLGVSSPGYTSMEAVVFSNVNRKWYFAPRKISNIAYNETYDNLYASgKYVVEFDENFQNP 264
EED95937                 154 NDRGELRREDWEDKFNFVRKLVGAAPPGYIIMEAILWSDKLKRWVFLPRRISSTAYDEVADEKMGA-TKVVLVNESFTDG 232
2H2N_A                   269 AVSHV--GAVV--PTHGFSSFKFIPNTDDQIIVALKSEED------SGR-VASYIMAFTL-DGRFLLPETKI-GSVKYEG 335
XP_002895412             378 QVREV--GKVT--PLRGFSSFKFVPRSDDSVIVAIKSVEVe-----DEErQTSYITVFSV-DGNVLMEETEIpGAKKYEG 447
XP_002181909             234 QVVDI--NLQKd-PLKGFSTFAFVPNTNDRHAFAIRSVEEdcvgglETCkQRSYFIVFDVlSGETLSEEVKYpEDLKFEG 310
CBJ27122                 311 DVRHV--GDIV--ETHGFSSFKFVPGTGDQVVVALKSEEIe-----ELQtQTTFVMVFTL-DGEVLLEENEIpGGFKFEG 380
EAK89829                 272 EIIDV--GLII--PERGFSSLKFLPGSFDQIIVATKSVEEs-----ISDtQKSFLTIFTI-NGKILMEDLEVpGDYKYEG 341
XP_002140694             274 DVKAI--GDII--PERGFSSFKFLPGSKDQIIVALKTVENs-----RIDfQSTYVSMFTI-DGDLLIDDIKVpGEFKFEG 343
XP_648646                250 NIINDpqHDFN----KGFSSIKILPHDEN-KLIYLKSVEV------GKR-SETYMGMIST-TGEVIMKEKLI-TKMKMEG 315
XP_654244                281 DIINDpqHDLN----KGFSSIKVLPNDEN-KLVYLKSVEV------GER-SETYIGMIST-SGEVLMQDKLV-AKMKMEG 346
WGS:AAFB:cds.EHI_103690A 265 RVFTD--SQFN--KSHGFSSIKLIPYQED-VILYLKTFEN------EDK-LETFIGMMNL-EGKSLMKEKSL-GANKFEG 330
EED95937                 233 TVVDI--NMKTvdPLHGFSTFAFVPGTNDHHALAVRSVEEdctgelELCkQRSYLMVFDIlTGEVLMDEVQIdLAEKFEG 310
2H2N_A                   336 IEFI 339
XP_002895412             448 VAFA 451
XP_002181909             311 LEFV 314
CBJ27122                 381 LEIF 384
EAK89829                 342 IEFI 345
XP_002140694             344 IEFT 347
XP_648646                316 IEFI 319
XP_654244                347 IEFI 350
WGS:AAFB:cds.EHI_103690A 331 IEII 334
EED95937                 311 IEFV 314
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