7MEZ


Conserved Protein Domain Family
PI3K_1B_p101

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pfam10486: PI3K_1B_p101 
Phosphoinositide 3-kinase gamma adapter protein p101 subunit
Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.
Statistics
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PSSM-Id: 463109
Aligned: 16 rows
Threshold Bit Score: 1264.22
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7MEZ_B        10 TTCTEDRIQHALERCLHGLSLSRR--STSWSAGLCLNCWSLQELVSRDPGHFLILLEQILQKTREVQEKGTYDLLAPLAL 87 
XP_022530922  20 TSCTEDRIQHALDRCLDGLQASSTl-SQSWNTGWCMNRWSLEELLRRDPENFLILLQQILTKARQAQEENEYELVAPLAI 98 
XP_009300642   4 TSCTEDRIQHALDRCLDGLRPSENl-SQSWSAGWCMNRWSLEELIKRDPDNFLILLQQILRKAREVQQECHYELVAPLAL 82 
2_pfamImport   1 SSCTEDRIQHVLERCLSGLGLDTPn-KQLWNAGLCINRWCLEELVKRDAHNFLILLQKILRKTTEVIQQCRYELVVPLTL 79 
XP_019213753   7 SSCTEDRIQHVLERCLSHLGVDTPd-TQLWKAGLCINRWSLEELVKRDPHNFLILLQQILRKTKEVLEQCQYELVVPLSL 85 
XP_015212007   4 TSCTEDRIHHALERCLHRLSQSSS--ADTWSAGLCMNRWSLEELVNRDPENFLILLQQILKKTREVQEQCEYILVAPLAL 81 
XP_005256637   6 TTCTEDRIQHALERCLHGLSLSRR--STSWSAGLCLNCWSLQELVSRDPGHFLILLEQILQKTREVQEKGTYDLLTPLAL 83 
XP_001366777   6 TTCTEDRIQHALERCLHGLSVSRG--TTTWTAGLCLNCWSLQELVSRDPDNFLILLEQILQKTTEVQEKCSYDLLAPLAL 83 
Q5ZIB8         4 TTCTEDRIYHALERCLHGLSRDAV--SSRWAAGLCLNCWSLQELVSRDAGNYLILVEKILGKAREVQEKCDYDLVMPLAL 81  chicken
XP_016846777   4 TTCTEDRIHHALERCLHGLSKSGTisASTWTAGLCLNCWSLQELVSRDAGNYLILLEKILQKTQEVHDKCDYDLFAPLAL 83 
7MEZ_B        88 LFYSTVLCTPHFPPDSDLLLKAARTYHRFLTWPVPYCSICQELLTFIDAELKAPGISYQRLVRAEQGLSTRSHRSSTVTV 167
XP_022530922  99 MFESTLIQTPHCPLDSDLLAEACEVFHGFLTWPEPYSNVCCSLLSTIQQELRAPGISYHRLVREEQGLAAAVQSRRTITV 178
XP_009300642  83 MFESTLLQMPLCPSSEKVLTEACEVFHGFLAWPEPYCSVCRNLLSTLHQELRAPGISYHRLVREEQGLATSSQRSKIITV 162
2_pfamImport  80 LFSSTLLKAPHVAPDCGLLEEAYLLFHRFLAWPEPCSSASKTLLKIIQKERRAPGISFHQLVRTEQGICPEIQFSKTITV 159
XP_019213753  86 LFSSTLLRAPYLPADCGVLQDANLLFHGFLSWPEPCSSAAKRLLNVIQQELRAPGISFQRLVRTEQGISHEIHCSKTITV 165
XP_015212007  82 MFFSTALQTPYFPPHCDLLREACEVYHSFLTWPEPYCSVCRDLLTFIHQELKAPGISYHRLVREEQGLATDNQQSKTITV 161
XP_005256637  84 LFYSTVLCTPHFPPDSDLLLKAASTYHRFLTWPVPYCSICQELLTFIDAELKAPGISYQRLVRAEQGLPIRSHRSSTVTV 163
XP_001366777  84 LFYSTVLCTPHFPPDSDLLLKAARTYHRFLTWPIPYCSICQELLTFIDAELKVPGINYQRLVRAEQGLSIRSHRNSTVTV 163
Q5ZIB8        82 LFYYAVLYAPHIPPDSELLLKAASIYHSFLTWPVPYCDVFRELLTFISDELKAPGISFQRLVRTEQGLPVKNYQSSTVTV 161 chicken
XP_016846777  84 LFGAAVLSIPHFPSDSDLLPRALRIYRDFLTWPVPYCDICQELLTFINNELKAPGISFQRLVRAEQGLPAKTHETSIITV 163
7MEZ_B       168 LLLNPVE-VQAEFLDVADKLSTPGPSPHSAYITLLLHAFQATFGAHCDLSGLHRRLQSKTLAELEAIFTETAEAQELASg 246
XP_022530922 179 MLLNPAD-VPASFLSVLEQMSGAEVSRRDSSITLIKHAFQSTLGTKYPLPSIHTALQSLGEEEMEQAVLLVTELLESASa 257
XP_009300642 163 FLMNPTE-VPPEFLSVAEQLSSIEVSQRESCVTLIKHSYQSVLGTKYPLHTINSALQCLSDDELAQIMSSVSDLLESAAa 241
2_pfamImport 160 LLVNPDEcVPPEVRSISEKISGARRSGRDVAITLVLHSFQASLGATCDLRALHAALQTKRDDELDQLAEAVTDHMEAAAs 239
XP_019213753 166 LLVSPDDdVPTEVQSVSEQLSVSQHCSRDVTITLILHSFQAALGTKHDLQELHKALQSKQPEELDQILQSLTESMEMAAs 245
XP_015212007 162 LLMNPSD-IPPEFLAVSEQLSNVRHSQKDAYIILIKHAYQSAFGARYPLDCMQKVLESKKVEELSSIFSDITDILETAVs 240
XP_005256637 164 LLLNPVE-VQAEFLAVANKLSTPGHSPHSAYTTLLLHAFQATFGAHCDVPGLHCRLQAKTLAELEDIFTETAEAQELASg 242
XP_001366777 164 LLLNPLE-VQAEFLSVANKMSFPEPSPRSTYVTLLQHVYQATFGVCCDLARLHLMLQSKTVTELEAIFEETTEAQELASa 242
Q5ZIB8       162 LLLNRSE-VQSEFLSIAEKLSSTEPPRHATLVLLLEHLYQVTFGTRCDLGSLHHLLKAKTLEELSEIYTSAAEAQEIAAa 240 chicken
XP_016846777 164 LLLNPSE-VDGEFLSVAEKMSTTELSQQTLLVTLLEHIYQANFGTKCDLGKLHQILKLKTVEELMELFASTSEAQEIAAv 242
7MEZ_B       247 IG-DAAEARQWLRTKLQAVGEKAGFPG------VLDTAKPGKLRTIPIPVARCYTYSWNQDSFDILQEILLKEQELLQPE 319
XP_022530922 258 MP-DVNEARSHVAQGLEQLKEKLNIPG------CDSKKMDGMLQILRVPTAKCYTIRWDTDNFDVLNELLESEPELASIQ 330
XP_009300642 242 MV-DIAKARKHVEGGLEVLREKLGIPS------SNGKMSDGVLQTLGLPAAKCYTFHWDKDNFDVLNDILDIESELTLSQ 314
2_pfamImport 240 AA-DPETARRALLHVMEKLRDRVAGPAavctdaGMTDDVRGAVETFMLPFPKCHTCSWENDNFDFLKDILSCESDLDSPP 318
XP_019213753 246 AA-DLRSAREGILQSMERLKESLTVPAr-----ADEGTDMGAVDIFTLPFPKCHKCHWENDNFDVLKHILGAQNDMDL-S 318
XP_015212007 241 VE-DIDKAREHLLEDLERLREKIGLPA------PNSKKSEGMLQTLSLPIARCHTYHWDKDNFDILNEIFQAECDLAEAQ 313
XP_005256637 243 IG-DAAEARRWLRTKLQAVGEKAGFPG------VLDTAKPGKLHTIPIPVARCYTYSWSQDSFDILQEILLKEQELLQPG 315
XP_001366777 243 IR-DPLEARQWLKAKLKAVGERAGFPY------ISETAQSCKLYTIPIPVARCYTCSWNQDSFDILNEILLKERELFQPE 315
Q5ZIB8       241 SS-DPVLARERLQSALRDIAGAAALPT------IAGDAQPRRLQPIPIPTSRCYTYSWDQDNFDVLNDVLSKECSVVEPV 313 chicken
XP_016846777 243 SSdDPSIAREQLESALWEIAKAAELPI------ITDEALPSKLRLIPIPVARCYTYRWDTDNFDILNEVLDKEGYYPKPV 316
7MEZ_B       320 ILDDEEDE--De--------eDEEEDLDADGHCAERDSVlstgsaASHASTLSLASSQ-----------------ASG-- 370
XP_022530922 331 ASEVPAEEdeVde------dvDEEEDLEEMEEFGTLSYM------DPRASMFSTVSSLstas---------kdsmFST-- 387
XP_009300642 315 TSE-SMEEddVdnvdveddeyDDLEDVCTD----------------YRASTFSTVSSLstas---------kdsmFST-- 366
2_pfamImport 319 DCFLENETdnVikd----tsvDGEDGAEGNKEDHE-----------LHSHRVSTASSSsrd------------ssYSLss 371
XP_019213753 319 DCFLKTGLddDdnnd---tsfDEEDELEGNKDDPE-----------FQSHRISTASSSsrd------------------s 366
XP_015212007 314 PQPDEGEDdeEe-----------EEDVEEEEVAVNGCVD-------HRASTFSTVSILstas---------kdsmLSNns 366
XP_005256637 316 ILGDDEEEeeEe--------eEVEEDLETDGHCAERDSLlstsslASHDSTLSLASSQ-----------------ASG-- 368
XP_001366777 316 TLEDEEE----------------EEDLEADGCFAERDSLfstssmAFRDLTRSTASLP-----------------ASV-- 360
Q5ZIB8       314 ASENEEDEeeE------------EEDVETDGCSPERDSLlspissISKDSVYSALSEDgpkhscvslfssskdsiSEL-- 379 chicken
XP_016846777 317 LLEDE----------------------EADNCFSERDSL---------------LSEDgpcnsrv----sivskdSAL-- 353
7MEZ_B       371 -PTLSRQLLTS----FVSGLSDgVDS---GYMEDIEESAYERP-RRPgGHERRGhRRPGQKF--NRIYKLF-KSTSQMVl 438
XP_022530922 388 -YSVASSECSPlstlSSSSQASgTDS---DFCEEAEEDSPVPP----------TsGKPKSSSgfKRLSRLF-KAKSSHS- 451
XP_009300642 367 -LSVASSECSPlstlSSSSQASgTDS---DFCEDLEDDSSSTV--------SPSkTKNSGRLs-KRISRFF-KPRSSNS- 431
2_pfamImport 372 sHSLSSSWSAV----STPSGSSgVES---DFSEDTDGGPDSRP-----KLRKKPkKKSRSILgvERFSLLFkGPRSPGT- 438
XP_019213753 367 gYSLSSSW-------SVPSGSSgVESgeeTTQEDIEERQDSQT-----KPRKKPkKKSRSLLg---FSLLFkPPRSPRV- 430
XP_015212007 367 fSSISSSSSGP----SRLSVASgMDS---DFCEDTEEESSTDKt-----------PKARARLg-KRISMLF-KSKSSNS- 425
XP_005256637 369 -PALSRHLLTS----FVSGLSDgMDS---GYVEDSEESSSEWPwRRG-SQERRGhRRPGQKF--IRIYKLF-KSTSQLVl 436
XP_001366777 361 -PGFSSHLLTS----FVSGLSDcMDS---GYMEDSDESSPDRPrKAE-SQEEQEsQRPRRKL--NRIYKLL-KSKSHLVl 428
Q5ZIB8       380 -TVVSKKSLRS----FVSSLKDcMDS---GYAEDSDESSLDTLgRPE-LKVEKThHKYRHTLt-NKIYKLF-KSKSQLVl 448 chicken
XP_016846777 354 -SLVSKKSLKS----FVSSLKDcVDS---GYMEDSDESSPELAgRLD-PKEEKMsSRHRHRLs-NKLYKLF-KSKSQLIl 422
7MEZ_B       439 rrdsrsle-gspdsgppLRRAGSLC---SPLDSPtLPP-SRAQRSRSLPQPKLSPQLPG---WLLAPASRHQ----RRRP 506
XP_022530922 452 -----------------LCRAKSLG---NAEAKD-ILPsVRSKRSNSVPQQALLRSSEVgltESLLMQQALGcvryRRRP 510
XP_009300642 432 -----------------LCRAKSLG---SPEAKE-LVVaVRSKRSNSLPQQVHLRSSDFg--FPVIPLSQLQyvcyRRRP 488
2_pfamImport 439 -----------------CRRVQSMGhrqDFPRDV-PTAgL---NSLSLCRQVRPLHACA---ATRDPLSPRKhmcvRRRP 494
XP_019213753 431 -----------------CRRVQSMAyhkDFQRTQ-----SQLKHSK-----VHPLHESP---PPLDPLSPQKhlcvRRRP 480
XP_015212007 426 -----------------LNRAKSLG---NTEAKD-YVT-IRSKRSNSLPQQVHLQSPEN---------MFLRnvcyRRRP 474
XP_005256637 437 rrdsrsle-gssdtalpLRRAGSLC---SPLDEP-VSPpSRAQRSRSLPQPKLGTQLPS---WLLAPASRPq----RRRP 504
XP_001366777 429 rrdsqspvkgassvelpLRRTGSLC---SPLNIP-SPPsSCSQRSHSLPQHMLESQLSS---WLHPTATHHr----HRRP 497
Q5ZIB8       449 rrdlkdc---vdtgslpLRRAESLC---HPQAKP-RIP-ARSRRAHSLPQHGLGQKLQT----PQTPQLLSl----PRRP 512 chicken
XP_016846777 423 gkelrdis-evtslslpLRRAESLC---NPVAKD-RIP-ARSRRAQSLPQHVLSATLFQ----NHVPQNTCv----QRRP 488
7MEZ_B       507 FLSGDED---PKASTLRVVVFGSDRISGKVARAYSNLRRLENNRPLLTRFFKLQFFYVPVKRSRGT-GTPTSPAPRSQTP 582
XP_022530922 511 ILSSAETe-ePGATLLRVLVFGADHVAGRVARAYSSLRRKERDCPRLSKAFRLRFFFVPVRRD-----PPGNGAVTQFSA 584
XP_009300642 489 ILSTDDEegpTGATLLRVVVFGADHVAGRLARAYSSLRKRERDCPHLTKAFRMKFFFVPVRRD-TA-PVNSRRSSLQLSA 566
2_pfamImport 495 IMSCDEGdaqEAPTLVKVVVFGGDKEAGRLARAYSDLQQKESKCPRLTKTCKLRFYLVPTKRRATG-SSGGHASPVVKSK 573
XP_019213753 481 ILSCNEEdlvEAPTLVKVVVFGGDREAGRLARAYSDLHQKESKCPQLTKVCKLQFYFVPTKRR-SG-SPGGGHTPTEERI 558
XP_015212007 475 ILSCDED---TKTTTLRVVVFGADQITGKVARAYSNLRLQESRCPRLTRLFKLQFFFIPVKRNSSS-PAVGVSSPGSLSD 550
XP_005256637 505 FLSGDED---PKASTLRVVVFGSDRISGKVARAYSNLRRLENNRPLLTRFFKLQFFYVPVKRSHGT-SPGACPPPRSQTP 580
XP_001366777 498 FLSGDED---SKASTLRVVVFGSDRISGKVARAYSNLRKLESNCPLLTRYFKLQFFYVPVKRSYQP-ISGTSSAPSNQSH 573
Q5ZIB8       513 FLSYDED---AKVATMRVVVFGSDRISGKVARAYSNLRLKESTCPTLTRYFKLQFFYVPVKRSCLLpAALLMHPP----P 585 chicken
XP_016846777 489 FLSCDEN---TKVSTLRVVVFGSDRISGKVARAYSHLKSQESSCPRLTRYFKMHFYYVPVKRSGPT-SSVLTHPP----P 560
7MEZ_B       583 PLPTdapRH---PGPaELGAAPWEESTNDISHYLGMLDPWYERNVLGLMHLPPEVLC-QSLKAEPRPLEGS-PAQLPILA 657
XP_022530922 585 SPLK---ASq------DVNMDAPEHSTNDIATLLGMLDPWYERNTLCLLDLPLHIVCkQTSKPEPELLEDSaEDGLPILA 655
XP_009300642 567 SPLK---TA---ISTtDLCVNRMEDSTNDIANLLGMLDPWYERNTLSLMELPVNVVCqQTSKIDSDLSEGTgEERLPIFA 640
2_pfamImport 574 AVLL---SC---FAGrESNGSVLEDGTQDIAQMLGMMDPWYERNVLSLLSLSSDVLFqTACKDDAESVSG--EERLPLLA 645
XP_019213753 559 GGLT---KT---TTSaDSNGLAVDDCTTDIAHMLGIMDPWYERNVLSLLSLSSDVLSqAASKDDSVSHSNGgTEQLPLLA 632
XP_015212007 551 SPGR---GS---MAV-DPSLPCLEDSTNDIAQYLGMLDPWYKRNMLSLLNLPVEVLCqQTSKTEPDVSSST-RERLPILA 622
XP_005256637 581 SPPT---DSprhASPgELGTTPWEESTNDISHYLGMLDPWYERNVLGLMHLPPEVLC-QSLKAEAQALEGS-PTQLPILA 655
XP_001366777 574 LMST---ESlrhLTPmDITLSSWEDSTNDISHYLGMLDPWYERNVLGLMHLPTDVLCqQTLKTETGPLESA-QEQLPILA 649
Q5ZIB8       586 SPSD---LQlraLAQaEPTLAGAESSTNDISHYIGMLDPWYERNVLGLMNLPMDVLC-QSAKPEAEPQEDS-REQLPILA 660 chicken
XP_016846777 561 SPGN---SHsrtPGAtVLNLAGMESSTNDISLYLGMQDPWYERNVLGLMNLPIHVLCqQSIKPEGEPLEET-SEQLPILA 636
7MEZ_B       658 DMLLYYCRFAARPVLLQVYQTELTFITGEKTTEIFIHSLELGHSAATRAIKASGPGSKRLGIDGDREAVPLTLQIIYSKG 737
XP_022530922 656 DLLLYYCRNATRPALVQLYQAELTLAGGEIRTEVFVHSLELGHTAGTRAIKAMGAASKRFGIDGDREAVPLSLEVVYNQV 735
XP_009300642 641 DLVLYYCRHAARPALIQLYQAEFTLAGGVRRTEVFIHSLELGHTAGTRAIKAMGAASKRFGIDGDREAVPLSLEITYNRI 720
2_pfamImport 646 DMVLYYCRHADQPVLVQLYQAELTLAGGERRKEVFIHSLELGHTAGTRAVKAMGSASKRFGIDEEREAVPLTLSVAYNKV 725
XP_019213753 633 DLVLYYCRHADQPVLVQLYQVELTLVGGERRREVFIQSLELGHTAGTRAVKAMGAASKRFGIDEEREAVPLTLSLAYNKV 712
XP_015212007 623 DMVLYYCRHAARPVLVQLYQAELMLAGGMKRTEVFIHSLELGHTAGTRAVKASGPVCKRFGIDGDREAVPLTLEIVYNKV 702
XP_005256637 656 DMLLYYCRFAARPVLLQVYQTELTFITGEKTTEIFIHSLELGHSAATRAIKASGPGSKRLGIDGDREAVPLTLQIIYSKG 735
XP_001366777 650 DMLLYYCRFATRPVLLQVYQTELTFISGEKMTEIFIHSLELGHSAAVRAIKASGPGSKRLGIDGDREAIPLTLQIIYSKG 729
Q5ZIB8       661 DMILYYCRFATRPVLLQLYQTELTFIGGEKMTEVFIHSLELGHSAATRAIKASGPGSKRLGIDGDREAIPLTLQIAYSKT 740 chicken
XP_016846777 637 DMILYYCRFATHPVLLQVYQTQLTFTGGETRTEIFIHSLELGHSATTRAIKASGPGCKRLGIDGDREAIPLTLQIAYSKR 716
7MEZ_B       738 AISGRSRWSNMEKLCTSVNLSKACRQQEELDSSTEALTLNLTEVVKRQTPKSKKGFNQ-ISTSQIKVDKVQIIGSN-SCP 815
XP_022530922 736 VISGRNQKTRAEKVCTSVNLIKACRNAEELDPKIECLQLTMTEVLKRQNSKSKKSFNQqLSTTRAKVDKVRVCGSG-NTT 814
XP_009300642 721 HISGRSQKTRTEKSCTSINLQKACRNSEELDSKMECLRLTMTEVLKRQNSKSKKGYNQqLTTTEVKVDKVQVSGTC-NTT 799
2_pfamImport 726 VVSGRSQWIQKEVVCTSINLHKACRNPEQLDTRIESLQLTMTEVVKRQSSKSKKGYNQqIYISEVKVDKVQVHGGAdGAT 805
XP_019213753 713 AISGRSQWINKEIMCTSINLHKQWRTPQQLDS-AESLQLTMTEVLKRQCSKSKKGYKQhISVSEVKVDKMQVNGRDpGTT 791
XP_015212007 703 SVSGRNQWSKVNKICTSVNLTKACKKPEELDSKMECLQLTMTEVLKRQNSKSKKGYNQqLNTTQVKVDKVQVSGAC-NTT 781
XP_005256637 736 AISGRSRWSNLEKVCTSVNLNKACRKQEELDSSMEALTLNLTEVVKRQNSKSKKGFNQ-ISTSQIKVDKVQIIGSN-SCP 813
XP_001366777 730 AISGRSRWNNLEKVCTSVNLNKACRKLEELDSNIEALTLTLTEVVKRQNSKSKKSYNQ-ISTSQIKVDKIQIIGSN-NCS 807
Q5ZIB8       741 AISGRSQWNDVEKVCTSVNLSKACKKYEELASKTECLNLTMTEVVKRQNSKSKKSFNQ-LSVSQIKVDKVQIIGV--QSS 817 chicken
XP_016846777 717 SVSGRSRWNNTEKVCTSVNLRKACKRQEELGPKTECLTLTATEVIKRQSSKSKKSFNQ-ISVSQIKVDKIQIIGV--NCS 793
7MEZ_B       816 FAVCLDQDERKILQSVIRCEVSPCYKPEKSSLCPPPQRPSYPPA-PATPDLCSLLCLPIMTFSGALP 881
XP_022530922 815 FAVCLDQDEKKILQSVTRCEVSVCYKPDSSANWPRFRTLT-TQVqPLQPTFCSLLCLPISTFSGPQP 880
XP_009300642 800 FAVCLDQDEKKILQSVMRCEVSVCYKPDSSTDWTRGRVFS-SQTqLLQPTFCSLLCLPVATFSGPQP 865
2_pfamImport 806 FAVCLDQDEKKFIQSVTRCEVSLCSKQGSSSDWKAYKPSP-GQVqPLHPSYCSLLCLPITSFSASCP 871
XP_019213753 792 FAVCLDQDEKKFIQSVTRCEVSPCCKPGSGLDWRTYKPLL-GQVqPLHPSYCSMLCLPITSFSSSYP 857
XP_015212007 782 FAVCLDQDERKIFQSVTRCEISVCYKPESGMHWRIRKALSSq---PLCPEFCSLLCLPISTFSGAHS 845
XP_005256637 814 FAVCLDQDERKILQSVVRCEVSPCYKPEKSDLSSPPQTPPDLPAqA-APDLCSLLCLPIMTFSGALP 879
XP_001366777 808 FAVCLDQDERKILQSVVRCEVSPCYKSENNSLCPQPQRLSFLPPqN-SPDLCSFLCLPIMTFSGALP 873
Q5ZIB8       818 FAVCLDQDEQKILQSVTRCEISVCYRPRDSDPLALRR--SSLTPqD-PSEFHSLLCLPISTFSGALP 881 chicken
XP_016846777 794 FAVCLDQDERKIMQSVVRCEVSACYKPKISKSSIGGKVMPSFPPqE-PSDFCSLLCLPIATFSGALP 859
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