5UQ1


Conserved Protein Domain Family
Spy1

?
pfam11357: Spy1 
Cell cycle regulatory protein
Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27. Spy1 is also known as Ringo protein A.
Statistics
?
PSSM-Id: 463263
Aligned: 30 rows
Threshold Bit Score: 164.72
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
5UQ1_B        16 QDMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTISEHTRINFFIALYLANTV-EEDEEETKYEIFPW 94 
EHB09292      51 EHQAAFTRLLEDPIVKRFLAWDMNLRASDKYLLAMVITYFSRAGLFPWEYKRIHFFLALFLANEM-EEDSQLQKYDMFFF 129
EHB08993      84 EH-EAFTRLLKDPVIKRFLAWDINLKASDKNLLAMVIVYFGRAGLFPWKYQRIHFLLVLYLASDM--ENHQEPKLYTF-F 159
EHB15623      59 EHHEAFTKLLEDPVIQGFLAWDINLKASDKNLLATVITYFTQASLFPWQFQRIYFFLALYLANDMeEEDDREPKLHMFFF 138
XP_023615660  77 EHHQAFTRLLEDPVIKRFLAWDTNLRLSDKYLLSMVIAYFSRAGLFSWQYQRLHFFLALYLALDM-EENYHAPKQAILSF 155
XP_002723139 121 EHHAVFARLLEDPVVKRFLAWDKNLRVSDKYLLAMVVAYFSRAGLFSWQYQRLHFFIALYVASDM-EEDNQASKQAIFAF 199
XP_014585297  93 EHHEVFTTLLEDPVVKRFLAWDRDLLVSDKYLLSMVIAYFSRAGLFSWQYRRIHFFIALYLANDM-EEDNQAPKQAIFSF 171
XP_027817348  71 EHHMVFNKMLEDHVIKRFLAWDRNLKVSDKYLLAMVIAYFSRAGLFSWQYRRIHFFIALYLASKM-EEDNRAPKQIIFSF 149
XP_005582931 104 EHHEAFNRLLEDPVIQKFLAWDKDLRVSDKYLLAMVIAYFSRAGLFSWQYQRIHFFLALYLASDM-EEDNQAPKQDIFSF 182
XP_003758957  90 EDYKAFNRLLGDPVVQNFLAWDRKLRVSDKYLLAMIIAYFARAGRPSWQYQRLHFFLALYLANDM-EEDCQGPKHGMFVF 168
5UQ1_B        95 ALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRER 146
EHB09292     130 LYGRNL-AQIPKFQKLRYEFICCMGWNLRVTPEECEEIQAYDPGFWVWRRDR 180
EHB08993     160 ISGTNF-DKIPQFHKLRYQFICYISW----TREGCEEIQAYDPTLWEWA--- 203
EHB15623     139 LYGMNF-NKIPQFQKLRYQFIRCMDWNLRVTREKCEEIQAYNPTLWVW---G 186
XP_023615660 156 LYGENNCSQRPLFHKLRFQFFRSMGWRARVTREECEEIQAFDPELWVWKRDR 207
XP_002723139 200 LYGQSR-AQRPLFHKLRLQFIRSMGWQTRVTREECEEIQAYDPELWVWRRDR 250
XP_014585297 172 LYGKNR-AERPLFHKLRLQFVRSMDWRMRVTREECEEIQAFDPDLWVWGRDR 222
XP_027817348 150 LYGRNH-SQRHLFHKLVFQFICSMNWKMRVTQEECEKIQAFHPRLWVWDRDR 200
XP_005582931 183 LYGKDY-SQRPLFHKLRYQLICSMRWRTWVSPEEMEEIQAYDPEHWVWARDR 233
XP_003758957 169 LYGQDR-TQRAKFQWLRAQLFRAIGWKAWVTREECEEIQAYQPGHWVWKRDR 219
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap