5HP5,5N0Y


Conserved Protein Domain Family
PAD

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pfam03068: PAD 
Protein-arginine deiminase (PAD)
Members of this family are found in mammals. In the presence of calcium ions, PAD enzymes EC:3.5.3.15 catalyze the post-translational modification reaction responsible for the formation of citrulline residues: Protein L-arginine + H2O <=> Protein L-citrulline + NH3. Several types are recognized (and included in the family) on the basis of molecular mass, substrate specificity, and tissue localization. The expression of type I PAD is known to be under the control of oestrogen.
Statistics
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PSSM-Id: 460794
Aligned: 53 rows
Threshold Bit Score: 350.37
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5HP5_B       302 TLFTDTVGFRMAPWIMTPNTQPPEELYVCRVMDTh-gSNEKFLEDMSYLTLKANCKLTICPQVENRnD---RWIQDEMEF 377 human
XP_018244738 196 MTTYDAVAMKQAPVLFHHHLQRVQEVLSVKGNETsspVQNKFVRGLEDALMNVVETPALHLLNGTD-E---IWAQDFMEP 271
EJP63553     206 RSGSDFVAMRQAPVLLHHHLQSMDAVVTMQTEESk--WQGAFVNSLRDAIHELAPAVTLLLLNSSR-G---IWAQDFMEP 279
XP_008602913 206 RSGSDFVAMRQAPVLLHHHRQSMEAVVTMQTVESk--WQGAFVNTLGAIIHKLKPAVPLITLNDSR-D---VWAQDLMEP 279
XP_003044046 193 TTASDTVAMKQAPVLIHHHLQAPEVVLSTDGSITtstWQTGFINSVQNALENLDQDIPLFLFNETD-D---IWAQDFLEP 268
ENH76503     261 VISTDDVMLRVAPVLTHHHLQDVETVLAANSRPGqnaLER-FNEHFERVLKWARIEEETFFVDEST-ErtsASVQDFVEP 338
EEH07995     188 KISADSVKLRVAPILTYHHSQSVQQIFATAGNDTsnfFQRKFVSALEASLAEMDVNYPLFKFNASD-D---IWAQDFFEP 263
XP_007798908  89 ESSHDIVRLRVAPILTFHHLMTVSEVLATNGNESmslYQAQFVSELRDILDAPSISKPLWLFNHSD-D---VWAQDIVEP 164
XP_013952202 189 ASDSDAVRLRVAPVITFHHLMPVSQVFVTNGNKSetpFQEQFVSDLRQILDRPDMRKPLFTFDHSD-D---IWAQDILEP 264
XP_003045412 207 DYVRDSVALKVAPVLTHHPLQRVETLVSTFANDSe-pIQQYFVQQLDDARSVAGIENPLWLFNQSS-D---IWAQDIVEP 281
5HP5_B       378 GYIEAPHK-S---FPVVFDSPR-----NRGlkdfPYKRILGPDFGYV--------TREIPLPGPSSLDSFGNLDVSPPV- 439 human
XP_018244738 272 GFASMPGPeGpisLRVLVRSAQstrvaGRQ----VFESFRGNRVGGHql-------sLGSGFGHEEIDSGGNIEIIPPYv 340
EJP63553     280 AFASMPGPhGpisIRVLLRSAQssrsnGRL----VFEKLRGAGVGGWqp-------gSGSGFGWEEINSGGNIETIPPYt 348
XP_008602913 280 AFASMPGRnGpisIRVLLRSPQstrpnGRL----VFEQLRGAGVGGWqp-------gPESGFGWEEINSGGNIETIPPYt 348
XP_003044046 269 GYASMPGPnGpisIRVLLRSPQsgraaGRQ----VFSLLRGPEIGGFqp-------gLGSGFGHEEINSGGNFETIPPYt 337
ENH76503     339 GYVSMPTGiGivsLRIMICSAQaarsdGVK----VFTEFRNTGIGAVqhr---gdRPAAESPFIEAINGAGNIETIPPY- 410
EEH07995     264 GYTSMPGPsGpvtLQVMIRSAQddrvaGRQ----VFEYLRGSGTGAVqd----------rGGSRDEINSMGNLETIPPH- 328
XP_007798908 165 GYTSIPGSsEpitLEVMIRSSQgsrvaGRQ----VFEYLRKTGRGAVys----------tGGTRDEIDSMGNLETIPPY- 229
XP_013952202 265 AYTSMPSPqGpiiLEIMIRSPQgsrvaGRQ----VFEYLRNGTRGAIyt----------tGGIRDEIDSTGNVETIPPY- 329
XP_003045412 282 AYASMPGPnGpiaIRIMLRSAQstrtgGRQ----VFEQLRGPGIGGFqpadgpgiGFSSSGFGYHTINSYGNLETIPPHr 357
5HP5_B       440 TVGGTEYPLGRILIG---SSFPksgGRQMAravrNFLKAQQVQAPVELYSDWLSVGHVDEFLTFVPTSDQ-KGFRLLLAS 515 human
XP_018244738 341 SKNGTSYKHGRVIMGkhfDKHP---AKSMT----SLIEAQIYQSPLILEAGWLVIGHVDEFVQFLPYQND-LGWTIAIAD 412
EJP63553     349 SRSGVSYKNGRVVLGkhyDKYP---AASLT----KFLEAQREQTPLYLEAGWLVAGHVDEFVQFLPYNNT-IGFRVAVPD 420
XP_008602913 349 SRSGVSYKNGRVVLGkhyDKYP---AASLT----KFLEAQREQTPLYLEAGWLVAGHVDEFVQFLPSNNT-IGFRVAVPD 420
XP_003044046 338 SRAGVEYKSGRVITGkhfDKYP---AESMI----KFLEAQGVQKPLVLETGWLAVGHVDELVQFVPYDNE-LGFTIAVVD 409
ENH76503     411 THKRESYPAGRIVIGghgSHVP-----DLF----HLLLAQETQQPILLETDWLQVSQVDQFLQFLPANNS-RGWAMQVDD 480
EEH07995     329 NFNGKNYTAGRIVLGthgARKP-----YIL----KYMLAQEIQDPLLLDTNWLAVGHVDEMLQFLPANNS-LGWAMLVPD 398
XP_007798908 230 EYGGKSFPAGRVIEGshaESYPp--FPHVY----DYMRAQETQDPLILDTDWLAVGHVDEMVQFLPANGTlHGWALYIAD 303
XP_013952202 330 SYGEKSYPAGRIIQGshgKSLP-----HLY----DYLKAQEIQSPIILDVDWLAVGHVDEIVQFIPFESSpYGWALYIAD 400
XP_003045412 358 SKDGTLYKAGRVIQGkhfEEFP---AQAVR----NLIFGNGVQSALFLETGWLVVGHVDEFVQFLPFDND-LGFTIGIAS 429
5HP5_B       516 PSACLKLF---------------------------------QEKKEEGYGEAAQFDGL---------------------- 540 human
XP_018244738 413 TQAPLALL---------------------------------KKAKDSGHGSTLVTSYPdlrqpe--------------gf 445
EJP63553     421 TRSAMRIL---------------------------------NRINETGHGAVPFLTYTgditsdp-------------wa 454
XP_008602913 421 TRSAMRIL---------------------------------KHVNETGHGTVPFLSFKgnltddn-------------wp 454
XP_003044046 410 TASAFSLL---------------------------------QEAWKDGHGDTKVISYDgdmtpdn-------------et 443
ENH76503     481 PREGIELLtmiqtlaelyrsemdvselevaiqrwdtvsgacNQTKQACHR------------------------------ 530
EEH07995     399 PQAGLAIL---------------------------------RKTQSAGYGNIRAFSRQndtegnpsd---------lfgi 436
XP_007798908 304 PMGGIEIL---------------------------------QKAQQEGHGYDPAFSRPngti------------------ 332
XP_013952202 401 PIGGINIL---------------------------------EQAKKDGYGHLPAFSRPsgvlmerllgdnygklrsysrs 447
XP_003045412 430 PDVGIKIL---------------------------------SDAQAAGHGNASAISFDaqpqme--------------rf 462
5HP5_B       541 ----KHQAKRSINEMLADRHLQRDNLHAQKCIDWNRNVLKRELGLAESDIVDIPQLFFL----------------KNFY- 599 human
XP_018244738 446 sfydSSLENLTINALLSDDDFLQTQKYAQKYIDHNLKLLLEEVPLPHNQVLRVPALFKNvtypwps---nldgipPRLHr 522
EJP63553     455 ifadHDLPNKTVEMLLAEKDFANTNEYAQKFIDRNVELLREELPISDADVLRVPALWRDvtydwva---dpdglpARLHh 531
XP_008602913 455 ifadHDLPNKTVEALLAEESFVKTNAYAQKFIDRNVEILLEELPISDADVLRVPALWRDqtydwla---dpdgfpARLHh 531
XP_003044046 444 ifidPEVRNLTIKDLLSDKDFVAINAYAQSFINDTLDLLLEEVPLTESDILRVPTLWKDvtypwpk---tpdghpLRLNr 520
ENH76503     531 ------VDNTSVAELLADDALIKANLQAADKIERNIVTIKEATGLSEKEIIRVPAFYKFadk-----------shDASK- 592
EEH07995     437 pwglHGVPSYTIDDLLSQSQIIEANANFARSIRGTVNLLKRETGITNADIHGVPAVFRTgltfppnggirpernnNSEL- 515
XP_007798908 333 pgiaGDVPGLTINEILTDK-LIEDNKRFAQHVDGVQAVLQSETGITEGDIHQVPMIFTTgvcwgpdegvspdrncSTTH- 410
XP_013952202 448 nipmRSIPDVTINDILTDR-LIEENKEFAMSISKVQKILERETGIPKEYIHHVPMVFETgfcfppdegvlperncSSEH- 525
XP_003045412 463 daeePPFLNLSVSNLLDNKTFIEVNRYAQKWIDYNLDILLSEIPLDREDVIHVPALYRDqsgygpw--irpdgldYYWPp 540
5HP5_B       600 -------AEAFFPDMVNMVVL--GKYLgIPKPYGPIINGRCCLEEKVQSLLEPLGLHCIFIDDYLSYHELQGEIHCGTNV 670 human
XP_018244738 523 vapgqrqLIAFLPAVINGVVIg-SDYL-AAKPWGPIVDGQDIFEEAVRDVYGQAGMKVHFVDDFMSHHVNGGEVHCGTNT 600
EJP63553     532 tipgerqLQGFFPLAVNGLLLd-QHYI-APKPFGPQVDGVDVFEREIRKVYTDAGLNVVFIDDYMSHHVRGGEVHCGTNS 609
XP_008602913 532 tipgerqLQGFFPLAVNGLVLd-QHYI-CPKPFGPRVDGVDVLEREIGKVYTEAGFNVVFIDDYMSHHVRGGEVHCGTNS 609
XP_003044046 521 appgerqVKSFFPQSINGLVLg-HDCL-APKPWGPVINGRDILEDAVKDVYARANMTVWLIDDYMSHHVRGGEVHCGTNT 598
ENH76503     593 -------LTSFFPGVVNSLVLsgSDVLvAPEPW------NSALAEIMEDLYKKIGLDVLYIDDWRSHHVNGREVHSGTNT 659
EEH07995     516 -------AGSLYPASINGQVLssTQYL-APNPWGPVVDGRDIMADAVSEVYGRLGFKVNFVDNWNSHHTWGGEVHCATNT 587
XP_007798908 411 -------AAALYPGVLNGVVLndRSYL-CPKPWGPVINNKDIMVEATDQVYGEVGMEVIYIDDWYSHHKGGGEVHCGTNT 482
XP_013952202 526 -------AVALYPGVLNGVVLsdSQYL-SPNPWGPVIDGIDIMAQATDKVYGKAGMDVIYIDDWYSHHEGGGEVHCGTNT 597
XP_003045412 541 vhkdeyqLGAFIPAPINGIVIg-NHYL-SPNPFGPIINGVDVIARAVTEAYARAGMNVTFVDDYYSHHMRGGEIHCGSNT 618
5HP5_B       671 RRKPfPFKWWN 681 human
XP_018244738 601 LRDA-TVEWWS 610
EJP63553     610 LRRT-DIEWWK 619
XP_008602913 610 LRHT-NVEWWK 619
XP_003044046 599 LREK-DVAWWE 608
ENH76503     660 VRDM-SDPWWK 669
EEH07995     588 IRNG-NYRWW- 596
XP_007798908 483 IRIP-KQPWWD 492
XP_013952202 598 VRLP-AYGWWE 607
XP_003045412 619 LRET-AVEWWQ 628
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