Conserved Protein Domain Family
COPIIcoated_ERV

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pfam07970: COPIIcoated_ERV 
Endoplasmic reticulum vesicle transporter
This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localization. All proteins identified biochemically as Erv41p-Erv46p interactors are localized to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi.
Statistics
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PSSM-Id: 462327
Aligned: 159 rows
Threshold Bit Score: 151.991
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFX05200     141 CYGATPPQhaikTGCCNTCDEVREAYASSSWAFGkGENVEQCQr--eHYAERIDEQRH--EGCRIEGGLRVNKVVGNFHI 216
EAX93843     131 CLGANVSK------CCLTCTDIANSFRQMEEFIPnLQNVEQCNr--------dKKAIEdkETCRIVAKLNTHFTKGKLTI 196
EAY02613     131 CYGHKYQE------CCYTCLDVVYGHIATYRAPPsLEGISQCKr--------dLNFYNngSKCLLMGSTRTPYAYGQLII 196
EAY21037     138 CYLSTDKK------CCNTCREVMDVFKAKGLTYYaSFRWEQCIr--eGVLDFGN------ETCRIKGKLKVKKQSGNFHI 203
XP_001299739 123 CYGAESSQ----RKCCQTCEDVVAAYQEKGWGIGnLSSWAQCRa--------eGVMFDgkERCQAYGNLHVNAIEGGFHL 190
XP_001580938 129 CHGLKPEG-----ECCNTCDEVKAIFEARGEDFN-PLPFDQCM-------GNVNFKKDmsESCLIEGTIHTFKSPGQFHI 195
XP_001324018 130 CYGLLPEG-----SCCNSCEQTLLLHIMNGKAAN-TKDWPQCQ-------GKNPGKVYenEKCRIKGKVCLNKAQGNFHI 196
XP_001295947 103 CYDFYDNR-----FCCNGCEKLKEIYHSNNKTAT-PENWTQCK-------PENKQKFDpnEKCHVKGKISVNRVPGSFHL 169
XP_001307985 130 CYNLSTNP----DECCNSCLKVQLLSLMQNKPVD-FSKYRVCN----NYEKKPNVSLS--EKCLVKGKLTVNRIPGSFHI 198
XP_002140035 120 CYNPSKKN-----HCCNTCSEVIRSYQEDNIKLPqKINFEQCKfdprERLEKAISAPLniSGCKIKVDINIPKVKGRIEI 194
EFX05200     217 APGRSFSN--GN------MHVHDL--KNYWdmptpnLHSFTHTVHSLRFGpqlpeslqktlagg---gakgqpwtnhhin 283
EAX93843     197 MAGGIVPT--PVnykfdlSHFg-------------dNVNLTHTIHTLRFGrdfeg----------------------lkn 239
EAY02613     197 SMNSQNQVpkKTlidntlVTK---------------YLNLSHTIGHFFFGkeskf----------------------ikn 239
EAY21037     204 ALGANTNDnyKG-------HSHDL--SSVDa-----SHKLNHVIHSLTFGepvdyykpql------------tdvemqlp 257
XP_001299739 191 APGINVFSr--------fGHVHdfsp-------lvdTLNLTHEIEHISFGapid------------------------ks 231
XP_001580938 196 APGRNTKFrrTG-------HQHDTglSP--------EASCPHTIHEFYVGqkydn----------------------vrs 238
XP_001324018 197 APGTNMKEr-YG-------HVHdlsg-------qlpNFDLSHVIQGMRVGpkipl----------------------tyn 239
XP_001295947 170 AIGQSIED--YG-------HQHilld-------dyqTITFDHDIIDLRFGanipm----------------------tsh 211
XP_001307985 199 APGTNVPQs---------AYLHdlss-------mqmFHDMTHSIQRLRFGphipr----------------------tsn 240
XP_002140035 195 SHKRWMNYneMTnldiseAHL----------------YNFSYIVKYLHYGddlpginniwnnqeyiqtakfthnkesdnl 258
EFX05200     284 pLDGVm--QQTSDPNFNYMYFIKIVPTSYLAL-GWektfrgfvddhdsAdvgsyglladgsvethqYSVTSHKRSLQGGD 360
EAX93843     240 pLDNYt-nNQLKKSQFMYNYKIDLVPTITNDVeNQipa--------------------------hqYSASSSSKEITKMI 292
EAY02613     240 pLDSYi-qIQNDTKYHQYIYRLSLIQTSIYYPdQifa--------------------------ttqYSAHFSDKILEKKS 292
EAY21037     258 eLNGS--------NYWMVTYYLHAAPERISTT-DKids--------------------------yrYSAFPSRRKVTNKt 302
XP_001299739 232 pLDNTr-vVQKKPGQIHYRYNLKAVPTVKEVNgKvhr--------------------------ffrFTVNYAEIPVTARG 284
XP_001580938 239 pIRGKi-fRDRDSLPRIYLYDLFITKVLHTFNdALqyt-------------------------syeYSYNLGAKIFNPGS 292
XP_001324018 240 pLRYVq-qIQNPNQPVVYRYDLVVTPAVYKSGnRIlgk-------------------------gydYTAMINRFFVGNSG 293
XP_001295947 212 pLRGTh--IKSTGEPLATEYNLIITPIVFYADgQYiekgf---------------------eyvyfYSMTYHL------- 261
XP_001307985 241 pLDNFksfQQIPTHDRTYFYNLLITPVIFYRDgVEylk-------------------------gyeYTAFSEAIDTFQLF 295
XP_002140035 259 fLEDA-----------HLDIDMHCIPTQFNSInSK-------------Ktki-----------ghqFSVRKQSKQVNV-L 302
EFX05200     361 daaeghqerlharggIPGVFFSYDISPMKVVNREERAkTFAGFLAGLCAIIGGTLTVAAAVD 422
EAX93843     293 tk------------kHPGITFDFDTAPVAARFIVEKQ-SLSSFLTQLCAILGGGFTLGGFID 341
EAY02613     293 e-------------eRPGIIFKFSIYPINSKITVTKT-KLHFLLLSVCSIIGGGFMISSLIh 340
EAY21037     303 k------------kgFPGIVFYYDFAPMIVVYQPTHG-SIRSIIVDICGIVGGAFSFAAIID 351
XP_001299739 285 r-------------yGPGIFFVYSFAPVAITSTYDRP-NITVLLARLISIFGGSFMLARLID 332
XP_001580938 293 f-------------yQPGIYFKYMFSPMTIVERSISK-NPMRFLVTSVGVLAGIFAFLNAVg 340
XP_001324018 294 g--------------APGIYFHYSFTPYGVTVNATYL-TIAQIFTSIFGFMSGAYAIFSIID 340
XP_001295947 262 ---------------VPGIYFYYSFTPYTIAVTWQSR-SFRSFLISTGGLLSGIYAIFSMVs 307
XP_001307985 296 g-------------iSPGLFFQYQFTPYTIVVSANRQ-NFLQFISNTFGVISGIYACLSILD 343
XP_002140035 303 nngrf-----vpetsLPGIYINYDFTPFIVKITESRR-SFLSFLTECCAIIGGIFAFSSMID 358
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