Conserved Protein Domain Family
NEMP

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pfam10225: NEMP 
NEMP family
This entry includes a group of nuclear envelope integral membrane proteins from animals and plants, including NEMP1 from Xenopus laevis. NEMP1 is a RanGTP-binding protein and is involved in eye development.
Statistics
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PSSM-Id: 463008
Aligned: 60 rows
Threshold Bit Score: 157.757
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003554045 152 TVAIEEDFQQWRLVCLAVGLILLLLAPTVSRWVPFYYSTSMAIGIFLVIIILLFQGMKLMPTgrKNIFYLTIYGSVvGAG 231
XP_009104989 140 TISVTEDFQQWRILCLVVGLVVILAAPVVSSWLPFYYTSSMAVGVFLVILIIIFQVMRLLPTgrKNVMYLAFYGSVvGAG 219
Q9SHQ6       138 TVNVTEEFHQWRIFCLVAGLIVILLAPVVSSWLPFYYTSSMAVGVFLVVLIIIFQVMRLLPTgrKNVMYLAFYGSVvGAG 217 thale cress
XP_009413876 150 AVSLEEELQQWRLVCLGFGFLLLLMAPTVSNWVPFYYSSSMALGVLLVVLIILFQGMKLLPTgrKSILYFTICGSIvGVG 229
RCV41632     177 TLSIQEEFQKWRLACLGIGFILLFLSPTVSKWAPFYYSSSMALGILLVVLIVLFQGMKLLPMgkKSLFYLTIYGSViGVG 256
Q84ST1       188 SISIQEEFQKWRLACLGIGFILLFLSPIVSKWAPFYYSSSMALGVLLVVLIVLFQGMKLLPMgrKSLFYLTIYGSVvGVG 267 Japanese rice
XP_006847949 123 TISAEEESHPWRLAFLAFGLVVLLLAPYVSKWVPFYYTSSMLLGIIVVILILLFQGMKLLPTgrKNAFYLALYGSLvGLG 202
ERN18605     132 EVSIEEEFKLYRLFFLTMGLLMMALAPAISECVTFYYGTAMAIGIMLVILIVLFQGMKLLPTgrKRSLAIFLYGSIvGVG 211
EEF37112     156 ELSIEEEFYLYRVIFLILGIVMLSVASALSKSLAFYYSSAMAIGIILVTLVVLFQGMKLLPTgrKNSLAIFVYSSLvGLG 235
XP_015690222  32 VVSTEEEFLLHRVVFLLLGMVLMVVAHTLSESVVFYYGGAMTIGIFLVILIILFQGMKLLPTgrKSSLAIFAYSSLvGMT 111
XP_003554045 232 SFLLHQFSLILNSIFQSLgmseemhnpvAVFVILGIILAGaalgyliVRRFVISkEDGSV-DAGVAQFVKWAMRIIGSTF 310
XP_009104989 220 SFILHQFSMMVDMILVNFglsedmyspvAILVLVGIAITGaafgfwtVRKFVVS-KDGGV-DASVAQFVKWAMRSVAATF 297
Q9SHQ6       218 SFILHQFSMMVNMILVNFglsedmynpvAILVLVGVVITGaafgfwtVRKFVVS-KDGGGvDASVAQFVKWAMRSVAATF 296 thale cress
XP_009413876 230 SFIAHYFSTFVNSVLVTFglseelhnpvSVFIVVGVILSGaalgywiVRKFVLS-EDGTV-DAGIAQFVKWAMRFTGVVF 307
RCV41632     257 SYVFHYFSTLVSSILENFglgeemynpvSLFLVVAIILTGagfgywmVRKFILS-KDGSV-DAGIAQFVKWAMRVVATFF 334
Q84ST1       268 SYAVHYFSTLVASILENFglseemhnpvSIFLLVAIVLTGagfgywmVRRFILS-KDGSV-DAGIAQFVKWAMRVVAICF 345 Japanese rice
XP_006847949 203 SYIAHYFSTVVNSILLSFgldeemhspvSIFLVVGILIAGawlgywgVRKFVLS-EDGSV-DIGVAQFVKWAMRIIGTVC 280
ERN18605     212 SVILRHVSVLLRSMLEEMgisndmynpvAIFVMISLGLAGawlgfwgVRKLVLS-EDGSV-DASTATFIKWSIRIVSAVM 289
EEF37112     236 SFLLRYVPGLLRSLLVEIgisedmyyplAIFLVAFVVLAGawmgfwaVRKLVLT-EEGSV-DISTSYFVAWSIRILGVIM 313
XP_015690222 112 TYFLHYLSGLLRSVLVEIgiaedmhnplGVFLLVTVILAGawfgywgVRKLVLT-EEGAV-DAGVAYFVEWAILIISAVM 189
XP_003554045 311 ILQSTLDPLLAIGALISCGAACKLISAIKwlcgWYETSnddyslqwmRGRR---------------------GRAEFLSK 369
XP_009104989 298 IFQSTMDTPLAMGAFLSASLLGYLISRTIhr----rKSvvtqrqwlvPAGKgrp----------------mhGRAEFLSR 357
Q9SHQ6       297 ILQSSLDTPMAMGAFVLASLFGFLVSKT--------KSfvgkshwlvSAGErrp---------------imhGRAEFLSR 353 thale cress
XP_009413876 308 ILQSTLDVPLALAALAVCWNFSSLINSKKwr----qAPvknhslwqqKARQsp-----------------ynRQAEFLSP 366
RCV41632     335 VMQSTLDPRLAMVALASCWSVCALLTGKKvqkkTTQKQkqskvssqlMLTQgsp----------------ssPQVQFLSP 398
Q84ST1       346 VMQSTLDPLLALFALAASWWICSVFTAYRapksMTLKQkqskastqpMYNKgsp----------------npRQIQFLSP 409 Japanese rice
XP_006847949 281 ILQSSKDALLATGSLAACWCLCSLMSCMRw-----rPRsgkrnmwhpPGNR---------------------TKAEFFRR 334
ERN18605     290 ILQSSLDALLATGILIFEVIISLTARNFFmprfILDLFrylfkmlkrFVKSamaislpayffgtehsrkvakHRAEFRHH 369
EEF37112     314 ILQSSLDPLLAAEALISGIVVSSILRRIFrlrfLRRMCksavysvrsSLHQ----------------------------- 364
XP_015690222 190 ILQSSLDYLFAFSALAFCTVVKAVSRIEGtsrfLLCLSrgiskgitiFPTSy-------------------eDFGEEYSS 250
XP_003554045 370 STPKGKHWSSPKGKLWN--SPRRS-AWSDSPVRGVVSpssgissqs---sgtqagqnyYSTFHKTR 429
XP_009104989 358 PGG---------GGLWN--SARTVpSSTGSPSNGLRNvmsrssfnr---ripierkdyYSTYHRTP 409
Q9SHQ6       354 PGG---------GGLWK--SAKSVpSYSGSPSYDVIVsspssvnrr----ipignqdyYSTFHTTP 404 thale cress
XP_009413876 367 ISKK---------------EPGRAfWGSSSPFSMSLSpyqagksysssrqgrqqnkdyYSTYHNLP 417
RCV41632     399 SSKVGFGRTASR-------SSATQyGWSNLANGGRVSsaltnqvvp----kqdkdedyYSTFHNIE 453
Q84ST1       410 SKRDIGRTTSN--------SSATQyGWSNLANGGLVSptltkrvv-----pdnqdedhYSTFHNIQ 462 Japanese rice
XP_006847949 335 TPPKMGAQKALIKASHNrqSPSNQySWSGSPTRGLVLtpsrst---------sqsqnyYSTVHKDP 391
ERN18605     370 NSP----------------IPGTYsSTARTLPSNPKTpd-----------------tyYSTFHTTP 402
EEF37112     365 -------------------LSVTPsGLSRTPQHQLSDsd-----------------vyPSTFHATP 394
XP_015690222 251 MNGSHEDGFTKLGGEYQrcTPKRNsLRSRKTLSQGHDtd-----------------syYSTFHTTP 299
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