4GBY,4GC0,4JA3,4QIQ,4LDS


Conserved Protein Domain Family
MFS_XylE_like
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cd17359: MFS_XylE_like 
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D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily
This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Links
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Statistics
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PSSM-Id: 340917
Aligned: 36 rows
Threshold Bit Score: 392.701
Created: 24-Oct-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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chemical
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:chemical substrate binding pocket [chemical binding site]
Evidence:
  • Structure:4GBY; Escherichia coli Proton:xylose symporter XylE binds D-xylose; contacts at 5A
  • Structure:4GC0; Escherichia coli Proton:xylose symporter XylE binds 6-bromo-6-deoxy-D-glucose; contacts at 5A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #                                                                   
4GBY_A     12 SITLVATLGGLLFGYDTAVISGTVESLNtvfvapqnlsesaANSLLGFCVASALIGCIIGGALGGYCSNRFGRrdSLKIA 91  Escherichia coli K-12
P0AGF4     12 SITLVATLGGLLFGYDTAVISGTVESLNtvfvapqnlsesaANSLLGFCVASALIGCIIGGALGGYCSNRFGRrdSLKIA 91  Escherichia coli K12
4JA3_A     12 SITLVATLGGLLFGYDTAVISGTVESLNtvfvapqnlsesaANSLLGFCVASALIGCIIGGALGGYCSNRFGRrdSLKIA 91  Escherichia coli K-12
4QIQ_A     11 SITLVATLGGLLFGYDTAVISGTVESLNtvfvapqnlsesaANSLLGFCVASALIGCIIGGALGGYCSNRFGRrdSLKIA 90  Escherichia coli K-12
NP_463279  15 RICAIAALGGILFGYDTAVISGAIGSLTsyf--------hlSPAETGWAVSCVVVGCVIGSFSAGYLSKRFGRkkSLMVS 86  Salmonella enterica
NP_809707  15 SITSVAILGGLLFGYDTAVISGAEKGLEafflsa--sdfqyNKVMHGITSSSALIGCVLGGALSGVFASRLGRrnSLRLA 92  Bacteroides thetai...
P96710     25 LISCAAGLGGLLYGYDTAVISGAIGFLKdly--------slSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRrkILMTA 96  Bacillus subtilis
NP_347967  16 LISCAAGLGGLLYGYDTAVISGAIGFLKkly--------nlSPAMQGFVISSIMVGGVLGVGFSGFLGDAIGRrkVLMLA 87  Clostridium acetob...
NP_463280  14 VLCCIAALAGLMFGYSTAVITGVVLPLQqyy--------qlTPTETGWAVSSIVIGCIIGALVGGKIADKLGRkpALLII 85  Salmonella enterica
P21906     12 RLALIAAIGGLLFGYDSAVIAAIGTPVDihfiaprhlsataAASLSGMVVVAVLVGCVTGSLLSGWIGIRFGRrgGLLMS 91  Zymomonas mobilis

Feature 1                                                                                 #  #
4GBY_A     92 AVLFFISGVGSAWpelgftsinpdntvpvylagyvpeFVIYRIIGGIGVGLASMLSPMYIAELApahirGKLVSFNQFAI 171 Escherichia coli K-12
P0AGF4     92 AVLFFISGVGSAWpelgftsinpdntvpvylagyvpeFVIYRIIGGIGVGLASMLSPMYIAELApahirGKLVSFNQFAI 171 Escherichia coli K12
4JA3_A     92 AVLFFISGVGSAWpelgftsinpdntvpvylagyvpeFVIYRIIGGIGVGLASMLSPMYIAELApahirGKLVSFNQFAI 171 Escherichia coli K-12
4QIQ_A     91 AVLFFISGVGSAWpelgftsinpdntvpvylagyvpeFVIYRIIGGIGVGLASMLSPMYIAELApahirGKLVSFNQFAI 170 Escherichia coli K-12
NP_463279  87 ALLFTISAVGTSLsyt------------------fthFVIYRIIGGLAVGLAATVSPMYMSEVSpknmrGRALSMQQFAI 148 Salmonella enterica
NP_809707  93 AVLFFLSALGSYYpevlffeyg------kpnmdlliaFNLYRVLGGIGVGLASAVCPMYIAEIApsnirGTLVSCNQFAI 166 Bacteroides thetai...
P96710     97 ALLFAISAIVSALsqd------------------vstLIIARIIGGLGIGMGSSLSVTYITEAAppairGSLSSLYQLFT 158 Bacillus subtilis
NP_347967  88 AALFAISAVISSIsts------------------afmLIFARIVGGLGIGMASALSVTYITECAppsirGRLSSLYQLFT 149 Clostridium acetob...
NP_463280  86 AIIFIASSLGAAMses------------------fmiFSLSRIVCGFAVGMAGTASTMYMSELApaeirGKALGIYNISV 147 Salmonella enterica
P21906     92 SICFVAAGFGAALteklfgt----------ggsalqiFCFFRFLAGLGIGVVSTLTPTYIAEIAppdkrGQMVSGQQMAI 161 Zymomonas mobilis

Feature 1        #                                                                            
4GBY_A    172 IFGQLLVYCVNYFIArsgdas------------------wlntdgWRYMFASECIPALLFLMLLYTVPESPRWLMSRGKq 233 Escherichia coli K-12
P0AGF4    172 IFGQLLVYCVNYFIArsgdas------------------wlntdgWRYMFASECIPALLFLMLLYTVPESPRWLMSRGKq 233 Escherichia coli K12
4JA3_A    172 IFGQLLVYCVNYFIArsgdas------------------wlntdgWRYMFASECIPALLFLMLLYTVPESPRWLMSRGKq 233 Escherichia coli K-12
4QIQ_A    171 IFGQLLVYCVNYFIArsgdas------------------wlntdgWRYMFASECIPALLFLMLLYTVPESPRWLMSRGKq 232 Escherichia coli K-12
NP_463279 149 VFGQILIFYVNYKIAsiaadt------------------wlielgWRYMFAAGIIPCILFCILVFLIPESPRWMMMIGRe 210 Salmonella enterica
NP_809707 167 IFGMLVVYFVNYLIMgdhqnpiilkdaagvlsvsaesdmwtvqegWRYMFGSEAFPAAFFGLLLFFVPKTPRYLVLVQQe 246 Bacteroides thetai...
P96710    159 ILGISATYFINLAVQrsgtye------------------wgvhtgWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAGKt 220 Bacillus subtilis
NP_347967 150 ILGISITFFVNLGIVnmgset------------------wrvstgWRYMLACGTVPAIVFLITLFFVPESPRFLVKSGNi 211 Clostridium acetob...
NP_463280 148 VSGQVIVFIVNYLIAkgmpad------------------vlvsqgWKTMLFAQVVPSIAMLAITLFLPESPAWCARNNRs 209 Salmonella enterica
P21906    162 VTGALTGYIFTWLLAhfgsid------------------wvnasgWCWSPASEGLIGIAFLLLLLTAPDTPHWLVMKGRh 223 Zymomonas mobilis

Feature 1                                                                     ##   ##  ##     
4GBY_A    234 eqaegilrkimgntlatqavq----------eikhsldhgrktggrllmfgvGVIVIGVMLSIFQQFVGINVVLYYAPEV 303 Escherichia coli K-12
P0AGF4    234 eqaegilrkimgntlatqavq----------eikhsldhgrktggrllmfgvGVIVIGVMLSIFQQFVGINVVLYYAPEV 303 Escherichia coli K12
4JA3_A    234 eqaegilrkimgntlatqavq----------eikhsldhgrktggrllmfgvGVIVIGVMLSIFQQFVGINVVLYYAPEV 303 Escherichia coli K-12
4QIQ_A    233 eqaegilrkimgntlatqavq----------eikhsldhgrktggrllmfgvGVIVIGVMLSIFQQFVGINVVLYYAPEV 302 Escherichia coli K-12
NP_463279 211 eetlkiltkisneeharhlladi------ktslqndqlnahqklnyrdgnvrFILILGCMIAMLQQVTGVNVMMYYAPIV 284 Salmonella enterica
NP_809707 247 ekaytilekingkkkaqei-------------lndikataqekteklftygvTVIVIGILLSVFQQAIGINAVLYYAPRI 313 Bacteroides thetai...
P96710    221 nealkiltringetvakeelkn--------ienslkieqmgslsqlfkpglrKALVIGILLALFNQVIGMNAITYYGPEI 292 Bacillus subtilis
NP_347967 212 kkaaavltkingaeiakqelds--------iskslatendsslgqllqpglrRALLIGIFLAIFNQAIGMNSITYYGPEI 283 Clostridium acetob...
NP_463280 210 earsikvltriysgltatdvaaifdsmketvrsqdnvaggertnlksspvlrYILLVGCCIAVLQQFTGVNVMNYYAPLV 289 Salmonella enterica
P21906    224 seaskilarlepqadpnltiq---------kikagfdkamdkssaglfafgiTVVFAGVSVAAFQQLVGINAVLYYAPQM 294 Zymomonas mobilis

Feature 1                                                                                     
4GBY_A    304 FKTLGAstdiALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLgtafyt-qapgiVALLSMLFYVAA 382 Escherichia coli K-12
P0AGF4    304 FKTLGAstdiALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLgtafyt-qapgiVALLSMLFYVAA 382 Escherichia coli K12
4JA3_A    304 FKTLGAstdiALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLgtafyt-qapgiVALLSMLFYVAA 382 Escherichia coli K-12
4QIQ_A    303 FKTLGAstdiALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLgtafyt-qapgiVALLSMLFYVAA 381 Escherichia coli K-12
NP_463279 285 LKDVTGsaqeALFQTIWIGVIQLIGSIIGAMIMDKMGRLSLMRKGTIGSIIGLLLTswalys-qatgyFALFGMLFFMIF 363 Salmonella enterica
NP_809707 314 FENAGAeg-gGMMQTVIMGIVNIIFTLVAIFTVDRFGRKPLLIIGSIGMAVGAFAVamcdsm-aikgvLPVLSIIVYAAF 391 Bacteroides thetai...
P96710    293 FKMMGFgqnaGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLMSIGSAFMAIFMILIgtsfyfeltsgiMMIVLILGFVAA 372 Bacillus subtilis
NP_347967 284 FQMIGFknnsSFLATSVIGVVEVFSTILAMFLIDKLGRKKLMEIGSAAMAVFMLLIgtsfyiklsngfVILIFIICFVVS 363 Clostridium acetob...
NP_463280 290 LQNSSTe--vVMFQTIFIAVCNVVGSFIGMILFDRYGRIPIMKIGTIGSIVGLLIAsyglyt-hdtgyITIFGILFFMLL 366 Salmonella enterica
P21906    295 FQNLGFgadtALLQTISIGVVNFIFTMIASRVVDRFGRKPLLIWGALGMAAMMAVLgccfwf-kvggvLPLASVLLYIAV 373 Zymomonas mobilis

Feature 1     #   ##   #                      ##  #                                           
4GBY_A    383 FAMSWGPVCWVLLSeifpnaIRGKALAIAVAAQWLANYFVSWTFPMmdknswlvaHFHNGFSYWIYGCMGVLAALFMWKF 462 Escherichia coli K-12
P0AGF4    383 FAMSWGPVCWVLLSeifpnaIRGKALAIAVAAQWLANYFVSWTFPMmdknswlvaHFHNGFSYWIYGCMGVLAALFMWKF 462 Escherichia coli K12
4JA3_A    383 FAMSWGPVCWVLLSeifpnaIRGKALAIAVAAQWLANYFVSWTFPMmdknswlvaHFHNGFSYWIYGCMGVLAALFMWKF 462 Escherichia coli K-12
4QIQ_A    382 FAMSWGPVCWVLLSeifpnaIRGKALAIAVAAQWLANYFVSWTFPMmdknswlvaHFHNGFSYWIYGCMGVLAALFMWKF 461 Escherichia coli K-12
NP_463279 364 YALSWGVGAWVLISeifpnrMRSQGMSISVGFMWMANFLVSQFFPMinenpyllsHFHGAFPMWIFAICCIFSYFFICRY 443 Salmonella enterica
NP_809707 392 FMMSWGPICWVLISeifpntIRGKAVAIAVAFQWIFNYIVSSTFPAl-------yDFSPMFAYSLYGIICVAAAIFVWRW 464 Bacteroides thetai...
P96710    373 FCVSVGPITWIMISeifpnhLRARAAGIATIFLWGANWAIGQFVPMmi------dSFGLAYTFWIFAVINILCFLFVVTI 446 Bacillus subtilis
NP_347967 364 FCISMGPIPWIMIPeifpnhLRARATGIATIFLWGANWAIGQFTPMll------nGIGGAYTFWIFCGINVICFLVVTTK 437 Clostridium acetob...
NP_463280 367 FAVSWSVGAWVLISevfpekIKGFGMGLAVSLMWIANFLISLLFPVindnawlqeTFGGAFSMWIFVVFNLVCYVFISRY 446 Salmonella enterica
P21906    374 FGMSWGPVCWVVLSemfpssIKGAAMPIAVTGQWLANILVNFLFKVadgspalnqTFNHGFSYLVFAALSILGGLIVARF 453 Zymomonas mobilis

Feature 1        
4GBY_A    463 VPE 465 Escherichia coli K-12
P0AGF4    463 VPE 465 Escherichia coli K12
4JA3_A    463 VPE 465 Escherichia coli K-12
4QIQ_A    462 VPE 464 Escherichia coli K-12
NP_463279 444 LPE 446 Salmonella enterica
NP_809707 465 VPE 467 Bacteroides thetaiotaomicron
P96710    447 CPE 449 Bacillus subtilis
NP_347967 438 VPE 440 Clostridium acetobutylicum
NP_463280 447 VPE 449 Salmonella enterica
P21906    454 VPE 456 Zymomonas mobilis

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