4HQJ,2MKV,4HYT,4XE5


Conserved Protein Domain Family
FXYD2
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cd20318: FXYD2 
FXYD domain-containing ion transport regulator 2
FXYD domain-containing ion transport regulator 2 (FXYD2), also known as sodium/potassium-transporting ATPase subunit gamma, or Na(+)/K(+) ATPase subunit gamma, or sodium pump gamma chain, is the regulatory subunit of the sodium/potassium-transporting ATPase (Na,K-ATPase). Na+,K+-ATPase is a heteromeric complex consisting of a large alpha-subunit, which is responsible for ATP hydrolysis, ion transport, and CTS binding, and a beta-subunit, acting as a chaperone. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Mutations in this gene have been associated with renal hypomagnesaemia.
Links
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Statistics
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PSSM-Id: 410557
Aligned: 53 rows
Threshold Bit Score: 68.2875
Created: 9-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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trimer
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:trimer interface [polypeptide binding site]
Evidence:
  • Structure:4HQJ: Sus scrofa Na+/K+ ATPase gamma subunit forms a heterotrimer with the alpha and beta subunits; contacts at 4A
  • Structure:4XE5: Bos taurus sodium/potassium-transporting ATPase subunit gamma forms a heterotrimer with the alpha and beta subunits; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   # # #  ##  ## ##  #  ### ## #     
4HQJ_G        10 GSPKGDv--DPFYYDYETVRNGGLIFAALAFIVGLIILLSKRLRC 52  pig
XP_007884229   6 GFPENG---GDFTYDYETIRKAGLIFAAVAFCIGVFIIMSKKLRC 47  elephant shark
O13001         6 DDMSQMq--DKFTYDYETIRKGGLIFAAIAFVVGMLIIFSGRFRC 48  African clawed frog
XP_030077584 299 QDDETS---TGFFYDYEVIRRGGLIFAAIAFVIGLLVIFSGRFRC 340 Microcaecilia unicolor
XP_026884423   4 ETPLYSd--DDFTYDYEVIRRGGLIFAAVLFCLGIAIIFSKRLTC 46  electric eel
GCF49760      27 KQTERSa-dGTMAGDYETIRQGGLIFAAAAFLVGLLVVLSRRFRC 70  Paroedura picta
XP_026777623   4 ETPDYLnndSDFFYDYELIRRGGLIFSAVLFCLGIAIIFSKRLTC 48  striped catfish
XP_007261048   4 VTPDHSd--ADFTYNYEVIRKGGLIFAAVLFCFGIAIIMGKRLTC 46  Mexican tetra
CDQ82300      11 TSHDISd--YDFNYDYPLLRRGGLIFAAVFFCLGIAIIFSKKLSC 53  rainbow trout
AAI61260       6 DDMSQMq--DKFTYDYETVRKGGLIFAAIAFVVGMLIIFSGRFRC 48  tropical clawed frog

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