5DJ4


Conserved Protein Domain Family
PA26

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pfam04636: PA26 
PA26 p53-induced protein (sestrin)
PA26 is a p53-inducible protein. Its function is unknown. It has similarity to pfam04636 in its N-terminus.
Statistics
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PSSM-Id: 461375
Aligned: 32 rows
Threshold Bit Score: 540.692
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5DJ4_A               43 GPSAFIPVEEVL--REGae---slEQHLGLEALMssGRVDNLAVVMGLHPDYFTSFWRLHYLLLHTDGPLASSWRHYIAI 117
KMY96100              4 AVDYYADMGQIS--QDCfaa-tqtGASDFDMDEL--DDLDQVTQVIGYHPQFHDHFLATQNFIMKGDGPLPNDYRYYLAI 78 
WGS:AAQB:GK23074-PA   4 AIDYYAGMGQIA--QDC-------SSTDTDIVDMdpDDLDQVTQVIGYHPRYKDHFLHTQNFIMKGDGPLPYHYRYYLAI 74 
EDO38575            102 GPSSFIPSKELP--SMDtdd--eqTHSLLVDSFLfnGRVPNVTCIIGVHPQYLDWNARTEYFLMRGEGPLPYDWRHYIAI 177
XP_003386260        119 GPSSFMSVKDVAgyHESskpvtheLQQLYENAFLrdARLSNIVQCLSDHPQYLDLFIQTMDFIMNGDGPLNQDVRCYIAI 198
XP_004348274        294 APSRFIPTPKLM--PMNeepgaeaSYQVMVDSFLhdCRVSHFVRALSYHPTYLAAFLHTHHFILRGDGPLPAHWRNYIAI 371
XP_004354715        150 KTTSFINETQLP--PLNsnd--qlTKRLFQEAFLqsGRVNHIIRLLGWHPQYLERFLASYNKVMRDQGPLPLPWRNYIGI 225
Q54WU6              138 RTTVFTSESQLP--PLNtdd--elTRKLFQDVFLqhGRVNHLTRILGWHPQYLEKFLLAYNTIMRDPGPLPLHWRNYIGI 213 Dictyost...
XP_002059309          4 AVDYYAEMGQIS--QDC-------SSTDFDMDDL--DECDQVTQVIGYHPLYRDHFLRTQNFIMKGDGPLPYAYRYYLAI 72 
XP_001688028          4 MVEYYSDMGQIG--QDYgsknsptDSSN----------LDHVTKVIAYHPRYLDHFLNTQKFVMQCDGPLPYDYRNYIAI 71  Anophele...
5DJ4_A              118 MAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQALLKTgEHTWSLAELIQA 197
KMY96100             79 IAAARHQCPYLVKRYEKEFINQGGDSAWLGGLDFIPAKLRAIYDINKILAHRPWLLRKEHIERLTKG-KNSWSLSEVVHA 157
WGS:AAQB:GK23074-PA  75 IAAARHQCPYLVKRYEKEFINQGGSSDWLNGLEYIPPKLRAIYDINKILAHRPWLLRKEHIERLTKG-KNSWSLSEVVHA 153
EDO38575            178 MAASRHQCSYLVSIYEREFLRYHGDKQWLKGIQHIPKKLHALLDMNKYLAHQPWLVSTQLIEKLLKG-EDNWSLSELVHA 256
XP_003386260        199 LASSRHRCSYLVTYLEMEFRAKGGNVLWLKGISHIPTKISNLLILNKMLCHQPWYISQTHFQELLVG-PDSWSVAELVHA 277
XP_004348274        372 MAAARCGVKYVVSVQQSTFLVNGGDTTWLKGLEFAPVKLQNLDELNMLLAYQPWRVTAEHIRTLLRG-QDSWSLAELVQA 450
XP_004354715        226 LASARYNCGYLVALLEHEYLHSGGDPKWLQGVDHIPQKLKNLLKIVEMMAHQPWLLPNVDIEYLVKG-QDAWSIAELVHA 304
Q54WU6              214 LAAARYKCSYIIALQEHEFLMNNGDARWLQGIDHIPAKLKNLLKVIELLAHQPWLLPKLDIEYLVKG-TDAWSIAELVHA 292 Dictyost...
XP_002059309         73 IAAARHQCPYLVKRYEKEFINQGGNSEWLNGLDYIPAKLRAIYDINKILAHRPWLLRKEHIERLTKG-RSSWSLSEVVHA 151
XP_001688028         72 MAAARHKCTYLVNLYEEIFLANGGDPNWLNGLEHIPPKLRAISDINKILAHRPWLLNKEHVERLTKG-QNSWSLSEVVHA 150 Anophele...
5DJ4_A              198 LVLLTHCHSLSSFVFGCGILPEGDADGSPAPQAPTPPse----------------------------------------- 236
KMY96100            158 MVLLSHFHSLSSFVFSCGLTQKLDGLSSPKLKSPPAAvgalaptilitptspteaq-----------kgkpvlaeislnn 226
WGS:AAQB:GK23074-PA 154 MVLLSHFHSLSSFVFSCGLTQKLDGLSSPKLKSAPAEiapngngvadgsrqtttspihqqq--------------lqlqq 219
EDO38575            257 IVIMAHIHALSSFVYGCGVVPEIDSENGHTFKPPTLT------------------------------------------- 293
XP_003386260        278 VVIMAFFHALAGFCLGCGLNPEIDTELGHTVSDQSEIvpshft------------------------------------- 320
XP_004348274        451 IVVLTHFHSVSAIAAGAGLTPEVDLEGGHLFATESERae----------------------------------------- 489
XP_004354715        305 MILICTFLSLAGFVFSCGILPEYGLASTTTLDERTSFsl----------------------------------------- 343
Q54WU6              293 MVLICTFLSLSGFVFCCGISPECGLSESNNLSSSFsl------------------------------------------- 329 Dictyost...
XP_002059309        152 MVLLSHFHSLSSFVFSCGLTQKLDGLSSPKLKGAPVSmppqspplppvddarqpttspinqqqqqqqqknvlgeislnss 231
XP_001688028        151 IVLLAHYHSLSSFVFSCGLTQELDGASHKIENNNVLTqkta--------------------------------------- 191 Anophele...
5DJ4_A              237 -----qSSPP-----SRDPLNNSGgf----------------------esARDV---------------------EALME 263
KMY96100            227 anpdynSQTAas--snGGAPPDSAnaaadgpdatalngylataqqlpqqhGISV---------------------ETLME 283
WGS:AAQB:GK23074-PA 220 qqqqktvlgeislngssanPIDNSgvgateaaalng--ylataqqqpqqhGICV---------------------EALME 276
EDO38575            294 ------ETNQasfdsGNATTGSESvr----------------------ssTMTR---------------------DELMA 324
XP_003386260        321 -npalgVGGTgsdsePSSEAMSPAcs----------------------ppNEQVskylvehyietskltdtrkldDTIKE 377
XP_004348274        490 -------------laEQLNSSQDAvgd--------------------atdSSWT---------------------AAMLQ 515
XP_004354715        344 -------------neSDCEVEDLTas----------------------enTIKV---------------------MELLK 367
Q54WU6              330 -------------ndSDCEIEDTAat----------------------enTAKV---------------------MELLK 353 Dictyost...
XP_002059309        232 sagggnNTKQdynntMDNNNSRSTgannnfgqhyl----ataelqpqhqcAISV---------------------EALME 286
XP_001688028        192 --fnrlNDLYnsqhpENLPNGDDAni----------------------rpEVTV---------------------DALMQ 226 Anophele...
5DJ4_A              264 RMQQLQESLLRd-eGtSQEEMESRF------ELEKS--------ESLLVTPSa---------dILEPSPH---------- 309
KMY96100            284 RMKVLSQKQDE---C-SEAELSSRF------QKVEQ--------QTAELAAV-----------TPEAAVGv--------- 325
WGS:AAQB:GK23074-PA 277 RMKVLSQKQDE---C-SEAELSNRF------KNVEM--------QTAELPAV-----------TPEAAVVl--------- 318
EDO38575            325 RMREVRAEQDTlmeA-SQEELFQHF------EKLESgelahfkdEAASTPTEsl-------------------------- 371
XP_003386260        378 KLAAVSQEEDEteeI-DNDRQFAESvssfglEKIHS--------RSVPTP------------------------------ 418
XP_004348274        516 RLNAVAGEAD----V-TEEENVKNF------EKSET--------Efnt-------------ghIHHAASA---------- 553
XP_004354715        368 KKKEEQEEDDFedgG-PEIDRQQEFhnagniDADNS--------SSSSSGSSs---------lATTSSSTyg-------- 421
Q54WU6              354 NRRSQQQDDDDdd---qLHDRQQDFhnagddSQSSN--------NNTTTTTTtttttttttntNTTSNSAgggdsssstl 422 Dictyost...
XP_002059309        287 RMKVLSQNQDE---C-SEAELSNRF------KSVEL--------QTAELAAA-----------SPEVAVAl--------- 328
XP_001688028        227 RMKRLSEKNDE---C-SETELSNRF------KHVEQ--------QAAELPPV-----------VREAPADv--------- 268 Anophele...
5DJ4_A              310 -------PDMLCFVEDPTFGYEDFTRRGAQ-APPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQAAYSLTYNTIAMH 381
KMY96100            326 ------pTNLSHYVDDANFIYQDFARRGTE-SINTFRIQDYSWEDHGYSLVDGLYNDVGIFLDAKFRAAYNLTYCTMGGI 398
WGS:AAQB:GK23074-PA 319 ------pPIISQYVDDPNFTYQDFARRGAE-NINTFRIQDYSWEDHGYSLVDGLYNEVGTFLDEKFRAAYNLTYFTMGGI 391
EDO38575            372 ------tTDLARYLEDPNFRYQDFASRPQQ-DISTFRIQDCSWEEHGFSLFNRLYPDIGTLLDEKFSSTLGLTYFTLGDR 444
XP_003386260        419 -------VNLLRYITDPSYEHEDFTLASAC----TLRAREYSWEDHGFSFLNSLYPLLSELLDEKFKVASEMTYRHVGAT 487
XP_004348274        554 -------SDINRFIRRPDFAHEDFDIKSRE--YSVFRYQDYSWEDHGFSLVDRFYESCAQLLDQQFSIAKTMTYATMGGQ 624
XP_004354715        422 -----giVDMSRYNCNNQLTHTDFDVSSKD--YTIFSVQDYSWKEHGYELVSRIFPDAAPLLDEEFSFVYTMTYYRFNNS 494
Q54WU6              423 sqssdrmSDFSRYIGNNTMTHTDFDVSSKL--YNIFSAQEYSWREHGYELVSRYFPDAAPLLDEEFSFVYTMTYYKFNNN 500 Dictyost...
XP_002059309        329 ------pPIISHYVDDASFTYQDFARRGAE-NINTFRIQDYSWEDHGYSLVDGLYNDVGTFLDEKFRAAYNLTYFTMGGI 401
XP_001688028        269 ------pQQLGRYVDDPGFTYQDFARRGAEnIPQTFRIQDYSWDDHGYSLVNRLYNDVGFYLDDKFRAAYNLTYYTIAGR 342 Anophele...
5DJ4_A              382 SGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKTTRRMYNLFWRHFRHSEKVHVNLLLLE 461
KMY96100            399 KNVDTSKFRRAIWNYIQCIYGIRHDDYDYGEVNQLLVRPLKMFIKTACCFPERITTKDYDSVLVELQDSEKVHVNLMIME 478
WGS:AAQB:GK23074-PA 392 KNVDTSKFRRAIWNYIQCIYGIRHDDYDYGEVNQLLVRPLKMFIKTACCFPERITTKDYDSVLVELQDSEKVHVNLMIME 471
EDO38575            445 TNVDTTVFRMATWNYIHLIFGIYHDDYLYTEVNKLMERSYKRYIKKVACVPEKATQEDYLEFMPELTHSEKVHINLLLLE 524
XP_003386260        488 KDIDTKPFREATWYYIQSIKGIRHDDYNYGKVNKVLSIEYKTYIRMVACFPEKVSLYDFRECMDGLQFSEKVHVNVLVME 567
XP_004348274        625 GGIDTQKLRYAVWYYITRVNGILHDDFNYGTVNELLEREVKLYIKRLACSPAEITQAEYVAASRGLLPSEKIHIAILATE 704
XP_004354715        495 TDIDTLPFRRAVWYYVQRVKGMCHDDYNYQEVNMFLSRNLKYYVKKAVCFPDNISKIDYSKLGYDLKPDEKCHLALLAVC 574
Q54WU6              501 TDIDTLPFRRAVWYYVQRVKGMLHDDYNYQEVNMFLSRSLKNFVKKAVCFPETIKRDDYSKLGYSLKPDEKCHLSLLAVC 580 Dictyost...
XP_002059309        402 KNVDTSKFRRAIWNYIQCIFGIRHDDYDYGEVNQLLVRPLKMFIKTACCFPERITTKDYDSVLVELQDSEKVHVNLMIME 481
XP_001688028        343 TNVDTSKFRRAIWNYIQCIYGIRHDDYDYGEVNQLLDRSLKMFIKTACCFPERITKLDYDSVLVELQHSEKVHINLMILE 422 Anophele...
5DJ4_A              462 ARMQAALLYALRAITRYM 479
KMY96100            479 ARNQAELLYALREIMRYM 496
WGS:AAQB:GK23074-PA 472 ARNQAELLYALREIMRYM 489
EDO38575            525 ARLQAELLYATRAIMKYM 542
XP_003386260        568 ARLQAELIYSLKALMSHM 585
XP_004348274        705 ANKQAGLMYALHAVMKYM 722
XP_004354715        575 SHKQAALLYGLYTVMSYQ 592
Q54WU6              581 SHKQASLLYGLYSVMNYQ 598 Dictyostelium discoideum
XP_002059309        482 ARNQAELLYALREIMRYM 499
XP_001688028        423 ARNQAELLYALREVMRYM 440 Anopheles gambiae str. PEST
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