Conserved Protein Domain Family
Reticulon

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pfam02453: Reticulon 
Reticulon
Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.
Statistics
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PSSM-Id: 460562
Aligned: 212 rows
Threshold Bit Score: 72.9026
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPB88465     156 VLNILNWKNPVRSGSIFALIVGSIILTRWY-----SLLQIGSSLLTIAIGVNLIYVNFIMQGQKLvSSnqdashpynnvi 230
EFC39794     116 LADILMWRNIFVTVPVFLAIQALFLLLCKYe---fTLVNLIGKVVFIQVLISVGYMVVFKIIQNNpNHt----------- 181
XP_006852583 157 VVDLIMWKDVSKSSLWFGLGCLCFLSTCYTreiniSSVSVVSNLGLLLLAVSFLFNSFSGIREKK-ND------------ 223
EER88893     213 IVELVMWRNVAKSALWFGSGSM-FFSCSFSrdvtfSPISALCHLGVMILGLAFFKNSVPQRPQVE--------------- 276
XP_003539539 142 VSDLIMWKNSSKSTFWFGFGSLCLVSSCFTqglnfSIFSALSQLGILLSGVSFFSNSICQRNEVE--------------- 206
XP_006582310 177 ISDLIMWKDVSKSTLWFGLGCLCFLSSCFTkgvnfSIFSAISRLAILLLGVSFFSNSVCQRNQVE--------------- 241
EEF44385     191 IYDLIMWKDVAKSSLWFGFGCLCFLSSCFAkgisfSIFSAISQLGLLFLGASFISNSICQRNNVE--------------- 255
XP_010656999 185 VTDLIMWKDASKSSFWFGFGSVCFLSSCFTrgisfSIFSAISQLGLLFLGLSFFSNSLYQRDNVE--------------- 249
VDC63656     180 ISDLVMWRDVAKSTLWFGFGCLSFLSSCFAkglnfSLFSAVSNLGLVLLCGSFLSNTLSQRNKED--------------- 244
XP_009129630 186 INDLIMWRDVAKSSLWFGFGCLCFLSSCFAkgfsfSVFSAVSHVGLLYLGVSFLSHSLRQRLTEEt-------------- 251
EPB88465     231 hNDKHTMIDKQSVRHYSTVMTEVSETLIRALTRIVFVENTATSIKWMSIFFVIWKVSAHVSTMDIVLAVVISAFIFPRLY 310
EFC39794     182 fPFQNVEISQELVNKIVTGIVANVNSGLKYYLDILSCKELGKTLAFGVVVLIVSWLGKKMAGETFLYLALNVLFTLPLIY 261
XP_006852583 224 -LRRRYELNEDDVKRVVRVVLPLANEAFAKIRELFSG-EPLMTLRMAPLLLLAAEFGPLLSIWRLAAAGFLVSFTVPKLY 301
EER88893     277 -NKRSFQLTEEDVLRASQAVLPIANSMISMAQVIFSG-EPSMTLKVLPVLLFGAKYGGLVTVWRLVAAGFFTSFTVPKLY 354
XP_003539539 207 -EKREIKLKEDDISRLAKLILPALNFALSRMRALFSG-EPSMTLKVVPFLLLGAEYGHLITIWRLCAIGFLVSFSVPKLY 284
XP_006582310 242 -KRSFAKLKEDDILHLAKLILPALNFAISKTRELFSG-EPCMTLKVAPFLLLGAEYGHLITIWRLCAIGFFVSFSVPRLY 319
EEF44385     256 -SRCNFKLKEEDILKLGRLILPPANLAISMARELFSG-EPSMTLKVIPFLLVGAEYGHLITMWRLCAIGFFIGFTIPKLY 333
XP_010656999 250 -KRREFKLKEDDILRVARAILPATNLAISKTIQLFSG-EPSMTLKVAPFFLVGAEYGHLLTVRRLCALGFFISFTIPKLY 327
VDC63656     245 -AKREFHVSEDDVLRLARRFLPAANLIISKTSELFSG-EPSMTLKVTPFLLIGAEYGHLITLWRLSAFGFFLSFTVPKLY 322
XP_009129630 252 -EQREVKVSEEDVLRVARRMLPITNLAISKMSQLFSG-EPAMTLKVAPFVLIGAEYGYLITLWRLFALGFFLSFTLPKLY 329
EPB88465     311 ISNKDVVDAQIQKG 324
EFC39794     262 EWKQDEIDSVLKIA 275
XP_006852583 302 SSYSDQIQRQVKCT 315
EER88893     355 SCYSSQIHRRVEIL 368
XP_003539539 285 SCYTAQINQRAEGL 298
XP_006582310 320 SCYSAQINLRVECL 333
EEF44385     334 SCYSSQINQKVDYA 347
XP_010656999 328 SCYSAQINTRVEYL 341
VDC63656     323 SCYTHQISQKVERV 336
XP_009129630 330 SCYANQINQKVENA 343
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