1HU3,3RK6,1UW4,3FEX,6N7P,4LUN,2VSX,4IUL


Conserved Protein Domain Family
MIF4G

?
pfam02854: MIF4G 
Click on image for an interactive view with Cn3D
MIF4G domain
MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
Statistics
?
PSSM-Id: 397130
Aligned: 34 rows
Threshold Bit Score: 79.7144
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1HU3_A   12 FRKVRSILNKLT---PQXFNQLXKQVSGLTVDT------EERLKGVIDLVFEKAIDEP--SFSVAYANXCRCLVTLKVpx 80   human
1UW4_B    9 RKLLYKDLSKVT------TEKVLRQMRKLPWQD------QEVKDYVICCMINIWNVKY--NSIHCVANLLAGLVLYQE-- 72   human
F4IUX6  671 QYVRKLLFSDLD---KDSIANVLKQLRKLPWSE--------CEQYILKCFMKVHKGKY--GQIHLIASLTSGLSRHHD-- 735  thale cress
O13824  649 EFLYDLIQIRLK---DDNVFPTLLLLRKFDWKD--------DYQILYNTIMEVWNIKY--NSLNALARLLSALYKFHP-- 713  Schizosaccharomyces...
O14253   34 AARIKKDITFLAd--PRGNSVAADDINYVAMSLsreandPETISTILDCIQTTAFIIP--VKIPHLATLIIRASLRVP-- 107  Schizosaccharomyces...
Q9SIU2    8 LLRIGEKGPEYGt--SSDYKDHIETCFGVIRREi-----ERSGDQVLPFLLQCAEQLP--HKIPLYGTLIGLLNLENE-- 76   thale cress
O01763   28 EKKLQGVIGKVGentGSSIECNLDKLTAFLHDDle-----kYRASIIDIIAGCAIYLP--NRVTVYTTLVGLLNSKNF-- 98   Caenorhabditis elegans
3FEX_A   28 EDHLESLICKVGeksACSLESNLEGLAGVLEADl-----PNYKSKILRLLCTVARLLP--EKLTIYTTLVGLLNARNY-- 98   human
6N7P_X   36 CKEMMPDIRTIGe-sVKAFEDDIKFLSEAIMNEygh--edYFNNALLSTLNAVVVEQP--QKQAAIALLTMVVNSKNN-- 108  Saccharomyces cerev...
Q9W3L1  104 LKKNTAFVKKLK----LFTATQLDGLLREISAL-------NLSKYISEICAALVEAKLkmTDVPAVVTLASRLHCTYA-- 170  fruit fly
1HU3_A   81 adkpgntvNFRKLLLNRCQKEFEKDkadddvfekkqkeleaasapeertrlhDELEEAKDKARRRSIGNIKFIGELFKLK 160  human
1UW4_B   73 --------DVGIHVVDGVLEDIRL-----------------------------GMEVNQPKFNQRRISSAKFLGELYNYR 115  human
F4IUX6  736 --------EFVVAVVDEVLEEIRV-----------------------------GLELNEYGAQQKRLAHMRFLGELYNYE 778  thale cress
O13824  714 --------EFCIHVIDDTLESLFS-----------------------------AVNNSDHVEKQKRLAQARFISELCVIH 756  Schizosaccharomyces...
O14253  108 --------LILEKAAAYFCLQYFT-------------------------------NLNSFLYYEAKVDLRMLICMSFALQ 148  Schizosaccharomyces...
Q9SIU2   77 --------DFVQKLVESVHANFQV--------------------------------ALDSGNCNSIRILLRFMTSLLCSK 116  thale cress
O01763   99 --------NFGGDVVEKLISEQQD--------------------------------LLSKQKYQEAQNLAIFLCDLGNSG 138  Caenorhabditis elegans
3FEX_A   99 --------NFGGEFVEAMIRQLKE--------------------------------SLKANNYNEAVYLVRFLSDLVNCH 138  human
6N7P_X  109 --------VAGKSIINYFFEELQKWckqt-------------------yndeFKSTSNETGPWNKIKLILRFLSILSPMF 161  Saccharomyces cerev...
Q9W3L1  171 --------DFDVHFLEAWQKALNI------------------------------KATEKIGNPSKLRVDLRLFAELVSSG 212  fruit fly
1HU3_A  161 XLTEA-IXHDCVVKLLKNHDE------------------ESLECLCRLLTTIGKDLD----FEKAKPRXDQYFNQXEKIV 217  human
1UW4_B  116 MVESA-VIFRTLYSFTSFGVNpdgspss----ldppehlFRIRLVCTILDTCGQYFD----RGSSKRKLDCFLVYFQRYV 186  human
F4IUX6  779 HVDSS-VIFETLYLTLLYGHDtseqevl-----dppedfFRVRMVIILLETCGHYFD----RGSSKKRLDQFLIHFQRYI 848  thale cress
O13824  757 MLDVR-AITNFLFHLLPLEKFesfltmkastltninndmFRLRLIVVVLQTCGPSII----RSKTKKTMLTYLLAYQCYF 831  Schizosaccharomyces...
O14253  149 PGTLK-PLFSLLADAISKETKpsv------------wgdNFLRIILINLPYFIAANN----DLGKKDFANEILDQCEIYV 211  Schizosaccharomyces...
Q9SIU2  117 VIQPA-SLIVVFETLLSSAATtvdeekgn--pswqpqadFYVICILSSLPWGGSELA-----EQVPDEIERVLVGIQAYL 188  thale cress
O01763  139 VLTA--QSIGEYLESFIAAAFeenmp--------qvrndYYIQTVLRCLPWIGKELT-----EKAPEQMENIGEAIGKYL 203  Caenorhabditis elegans
3FEX_A  139 VIAA--PSMVAMFENFVSVTQeedvp--------qvrrdWYVYAFLSSLPWVGKELY-----EKKDAEMDRIFANTESYL 203  human
6N7P_X  162 LVDELiNIYKSLFELSIELNNldpg----------nrvpLSEAIYTNTLLNIPYLFFfnrnNDGLRTKVEELLAYVEQNY 231  Saccharomyces cerev...
Q9W3L1  213 VIQMK-PGLAQLGVVLVHLIAldk------------ddhSNFSIILSFCRHCGEEYA-----GLVPQKMQQLATKYGVEV 274  fruit fly
1HU3_A  218 KE-----------------RKTSSRIRFXLQDVIDLRLCN 240  human
1UW4_B  187 Wwkksle-------vwtkdHPFPIDIDYMISDTLELLRPK 219  human
F4IUX6  849 LSk----------------GHLPLDIEFDLQDLFANLRPN 872  thale cress
O13824  832 LIq----------------PEMPLDMLYEFEDVIGYVRPS 855  Schizosaccharomyces pombe 972h-
O14253  212 RHrkssitls--nplsihdNLSEEELDLLYKQLILSREND 249  Schizosaccharomyces pombe 972h-
Q9SIU2  189 SIrknsstsglnffhngefESSLAEKDFVEDLLDRIQSLA 228  thale cress
O01763  204 ELrnknhval--lqvwregSTDQKQEDYLESLSAQIEALR 241  Caenorhabditis elegans
3FEX_A  204 KRrqkthvp---mlqvwtaDKPHPQEEYLDCLWAQIQKLK 240  human
6N7P_X  232 LVkttdi-------nllreYNGEPPYEMVELVRVVLPNVK 264  Saccharomyces cerevisiae S288C
Q9W3L1  275 PKsd--------------fLTADKQLNLRTMLKGYFKALC 300  fruit fly
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap