3TMP,3PFY,3TMO


Conserved Protein Domain Family
OTU_OTUD5-like

?
cd22752: OTU_OTUD5-like 
Click on image for an interactive view with Cn3D
OTU (ovarian tumor) domain of OTU domain-containing protein 5 and similar proteins
OTU domain-containing protein 5 (OTUD5), also called deubiquitinating enzyme A (DUBA), is a phosphorylation-dependent deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that can hydrolyze 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, and may function as negative regulator of the innate immune system. It limits type I interferon production in macrophages and suppresses interleukin-17A production in T cells. OTUD5 also functions in an apoptotic signaling cascade by mediating the sequential activation of PDCD5 (programmed cell death 5) and p53 in response to genotoxic stress. In Drosophila, OTUD5/DUBA is essential for spermatogenesis. This subfamily also includes Arabidopsis thaliana OTU domain-containing protein 6, also called deubiquitinating enzyme OTU6 or otubain-like deubiquitinase 1 (OTLD1), which binds chromatin and has enzymatic histone deubiquitinase activity specific for the H2B histone. This subfamily belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad. It also includes plant OTU6.
Statistics
?
PSSM-Id: 438589
Aligned: 43 rows
Threshold Bit Score: 159.251
Created: 22-Sep-2020
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
 
polypeptideactive site
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Structure:3TMP: Human deubiquitinase DUBA/OTUD5 binds ubiquitin; contacts at 4A

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                ##  #                                #  ##                              
3TMP_A        45 GFIIKQMKEDGACLFRAVADQVYGDqdMHEVVRKHCMDYLMKNADYFSNYv----------------------------- 95   Homo sapiens
OQR91922     181 QLQLVEVPGDGNCLFRAISHQLYGDdrFHAVVRAACMDYMEAEKTYFEPYvv---------------------------- 232  Achlya hypogyna
OII76157      10 EVYIRDIIGDGNCLFRAISDQLYGNseNHEIIRSYCMDYIEINKDKFSDFih---------------------------- 61   Cryptosporidiu...
XP_001434899 214 GMLIREVQGDGNCMFRAISDQLYGNeiYHKELRKFAMQYILQEKDYFQDYi----------------------------- 264  Paramecium tet...
CEM35289     537 RFAIRVMASDGNCLFRSVADQMYGNpdLHRLVRTKCMEYMEAEREYFQQFv----------------------------- 587  Vitrella brass...
KRX01602     178 DFEIYEVEGDGNCLFRAISHQIYGTekYHQEIRNICLDYIMINKNYFKDFii---------------------------- 229  Pseudocohnilem...
OMJ85331     178 NLKIFPVEGDGNCLFRSFSHQLYGDtgFHDIIRASAMKYISIEREYYSQYiv---------------------------- 229  Stentor coeruleus
XP_001016136  24 GLVLREMESDGNCLFRSVADQLYGDqsLHSDIRKYVIEYLKIEKPYFINFiaemeenskkgkrkkqkikqkqekqqkene 103  Tetrahymena th...
TRY50970      10 EVRVKNIEGDGNCLFRSIGSQLYGEseHHEIIRSACMDYVDLNKESFSGFvh---------------------------- 61   Cryptosporidiu...
OLP92159       7 QYASYGQARDGNCLFRSFSDQVYGCpdYHALLRDRCTKYIASERSYFEQFv----------------------------- 57   Symbiodinium m...
Feature 1                      #               ####  ##                                          
3TMP_A        96 --------------TEDFTTYINRKRKnNCHGNHIEMQAMAEMYNRPVEVYQYStgts---------------------- 139  Homo sapiens
OQR91922     233 ------------gdMPAFLRYVAHKRQdAVWGDDPELQALSELYDRPLQVFVSDast----------------------- 277  Achlya hypogyna
OII76157      62 -------------eYPNIDSYINNKRClGVWGDNIELQALCELYNVPIHIFQIVddmklitnkqnyiknnkdtkcnsmny 128  Cryptosporidiu...
XP_001434899 265 -------------iNGNVEEYVEYKSKdGVWGDNIELQAFRELYDIPIEIYVCSk------------------------- 306  Paramecium tet...
CEM35289     588 --------------TDRFEEHVHRMKQdGEWGDDVEIEAMSEMYDCRIEIYGYSn------------------------- 628  Vitrella brass...
KRX01602     230 ------------ggVRNFEDYIQWKRSdKVWGDNLEIQALREIYERPIQIYAYSn------------------------- 272  Pseudocohnilem...
OMJ85331     230 ------------ggLDKVDEYLEHQSRnGAWGDDIEIQALSEIYNKPVEIFAYSn------------------------- 272  Stentor coeruleus
XP_001016136 104 qiekqveiepknelDLLFDKYVQEMSEnGTWGDNIEIQIISEIYQRSVEIYVAFqe------------------------ 159  Tetrahymena th...
TRY50970      62 -------------eYSSIEKYIQEKRKlGVWADNIEIQALSDLYRIPIYIFEKVrnsklnaslle--------------- 113  Cryptosporidiu...
OLP92159      58 --------------AEPFEEFLARIQReGEWGDDVEIEALSEIYDCRVEIYASYgh------------------------ 99   Symbiodinium m...
Feature 1                      # #                                      #  ####     
3TMP_A       140 ---------avePINTFHGIHqn------------------------edEPIRVSYHrNIHYNSVVN 173  Homo sapiens
OQR91922     278 ---------gaaCLRTFHEASag------------------------rgPPLRLSFYgGGHYDSIIP 311  Achlya hypogyna
OII76157     129 iiqsrscflqriAIVTSSNANdrdsy-------------------vkglWPLRLLYYgDTHYDSLYF 176  Cryptosporidium andersoni
XP_001434899 307 -----------ePLKTGLEANpf------------------------nkEPIRLSYHgRSHYNSIKL 338  Paramecium tetraurelia stra...
CEM35289     629 -----------eALRTFHETCnac-----------------------npHPMRLSYRgGSHYNSIVL 661  Vitrella brassicaformis CCM...
KRX01602     273 -----------ePMRTFSEIGesq-----------------------qhEPIRLSYHgQCHYNSIVT 305  Pseudocohnilembus persalinus
OMJ85331     273 -----------iPMRTFHEDSgi-------------------------gIPIKVAYHgQSHYNSIVS 303  Stentor coeruleus
XP_001016136 160 -----------tPMRTFHENQdkf----------------------kvnEPIRLSYHgECHYNSIKS 193  Tetrahymena thermophila SB210
TRY50970     114 -khrlegssgamSENIFYENKefvykllckieprhssfldqiknyysnsRPIRLLYYnDLHYDSLFY 179  Cryptosporidium tyzzeri
OLP92159     100 -----------sLMRTFHEACdak-----------------------wsQPVRLLYEgHAHYNSLAP 132  Symbiodinium microadriaticum

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap