extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 3 (TRPML3)
TRPML3, also called mucolipin-3 (ML3), acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. It mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. The model corresponds to extracytosolic/lumenal domain (ELD), a linker located between the first two transmembrane segments (S1 and S2) of TRPML3. It forms a tight tetramer that is crucial for full-length TRPML3 assembly and localization.
Structure:6AYE; Homo sapiens TRPML3 extracytosolic/lumenal domain (ELD, also called TRPML I-II linker) forms a tetramer with a four-fold rotational symmetry, contacts at 4A.
Jiyao W et al.(2023). "The conserved domain database in 2023.",