Conserved Protein Domain Family
DBB
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pfam14545: DBB 
Dof, BCAP, and BANK (DBB) motif,
The DBB domain is named from the Drosophila (Downstream of FGFR - Dof, also known as Heartbroken or Stumps) protein, the BANKS and BCAP, both signalling in B-cell pathway, proteins. This domain defines a minimal region required for mediating Dof dimerization. Since this domain can interact both with itself and with a region in the C-terminal part of the molecule, it may mediate either intermolecular or intramolecular interactions. Mutants lacking this domain disrupt FGFR signal transduction and fibroblast growth-factor signalling. The DBB domain of BCAP mediates BCAP TIR dimerization and negatively regulates TLR signalling.
Links
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Statistics
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PSSM-Id: 464205
Aligned: 28 rows
Threshold Bit Score: 146.201
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFX77290      429 KIAPKKLRSGEERVTMILmetTENIKHMATVQVGVDLNNqLNKSVHIERLcwvNPYVITFNVPkKFLelDVVVKVQLKVG 508 
EEB19499      137 MLMPKKVNKSQNKVLILL---NEPITKEDVMTVTMIRNNeVFEIPSVKKR---NPYTLIFRMPeEFLtvSLLVTIRVERN 210 
XP_028173099  359 SIVPKKVKIGQSRVIALL---NDPIREEDSIKIMVDKKGeVIQIPTFKKR---NPYTLQFDIPdSCLevSMLVWVRVSKN 432 
EFN67200      471 SVHPKKVKLGQNKIIVLL---NDPLNSEDNVSVIVDRCGdAIDISNVKRR---NPYALQFSIPeRCLevSMLVGVRISKN 544 
XP_003244802  335 SITPKKIKIGQNKLIVLL---SEPLVSEDNVVITVDKNGhKIEVTNVTRR---NPYTLQFKMPlSCLqvSVLVNVIVEKN 408 
2_pfamImport    1 SIVPKKIKVGQNKVLILL---NEPIGSHDKVSITVDRSGnKLDITSIKRR---NPYTLQFTMPsSCLqtSMLVTVNVDKN 74  
Q9VFH9        215 TVLPKKVKLGQNKVVALL---AEPLEKNDTLKLQVEKSGeLIELRNFKCR---NPYTLQFNIPeACMeiSTMIEIRIEKN 288  fruit fly
EDS41712       88 TLFPRKVKVGQNKIIIIL---VEHLMKDDWIKIKIEMSNeTIEITNVKRR---NPYTIQFNIPdACLeiSMMIGVRVEKN 161 
ETN63912      451 VLFPRKVKVGQSKILVIL---NEPLTKEDWIKIKVEKADrTIEITNIKRR---NPYTIQFNVPeVCMeiSMMIKIRLEKN 524 
EEC09131      165 RLCPRKVHQGNNKVFVML---NQPVQQDQNIQLSLENSG--LKEVQVKWK---NPYVLQFVVPdCFLqvSKVINVHLRCD 236 

EFX77290      509 NHSWGVRDLKCQSKLGEIGVLLskcQLMGSPAEVMCQALKISPVDTEKLDQVLTRSLDKaKISLSAFGLEQ 579 
EEB19499      211 GVDLGTKLLKCESQLYAMAQIL---KSCDSPIEFMCQALNIVPCDKEKLDDILMSSFQR-NVPPN-FNILQ 276 
XP_028173099  433 GQSLGRRQIKCESRLRELDQLL---RASDHPLEFMCQTLGFKTTSKEQLDSWMLNAFQK-NIPPH-FNLLS 498 
EFN67200      545 GFSLGVRQVKCESRLRELDQIL---RAHDNPLEFMCQTFGFSSTDREQLDNWMVHAFQK-NIPPY-FNLLS 610 
XP_003244802  409 GQVLGQRSVKCESRMRELDQLI---RSLDNPLNFLCQTFGLNPVDREQLDLFLVTAYVK-NVPPN-FHLLQ 474 
2_pfamImport   75 GRSLGQRLVKCECRMRELDQLL---RSVDNPLLFMCQALGLTSGEKEQLDACLVAALQK-NMPPN-FNILN 140 
Q9VFH9        289 NKSLGARPIKCESRLRELEQLL---RIEDSPIEFMCHALGIGPVERDALDQHLLQCFQR-NMPPN-FHLLS 354  fruit fly
EDS41712      162 NIDLGCRPLKCESRLRELEQIL---KSQTSPVEFLCQSVGIASADRDRLDSLLLQSFQK-NVPTN-FHLLN 227 
ETN63912      525 SVDLGCRPLKCESQMRELEQIL---SSKDAPMELICQSLGLSTNDREKLDMLLLKAFLR-NVPPN-YNLLS 590 
EEC09131      237 AALLGVRQLKCESQLSQLHALL---QTVSSPYEMLCLTLGLATL--HEVDVALAQNFRR-NLPAQRFHLLG 301
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