4OHF


Conserved Protein Domain Family
5_nucleotid

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pfam05761: 5_nucleotid 
5' nucleotidase family
This family of eukaryotic proteins includes 5' nucleotidase enzymes, such as purine 5'-nucleotidase EC:3.1.3.5.
Statistics
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PSSM-Id: 461733
Aligned: 85 rows
Threshold Bit Score: 457.752
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4OHF_D             14 MRKIKLIGLDMDHTLIRYNsKNFESLVYDLVKERLAESFHYPEEIKKFKFNFDDAIRGLVIDSKNGNILKLSRYGAIR-- 91  Legionella...
EEB19928           81 LKEISVYGFDYDYTLACYK-PSLDLLIFNLGKEALVNKFMYPKDVLNLKYNPDFTIRGLHYDIEKGLFVKLDSFLQIQlg 159
FlyBase:CG1814-PC  22 LSEVQVYGFDYDYTLACYK-PILEDLLYNLAREMLVKRFRYPEDILQLEYEPNFAVRGLHYDVEKGLLVKLDSFLQLQlg 100
XP_002595182       28 MGDVEVYGFDYDYTLAHYT-DELYPLIYNLAKERLLMRNKYPESIMALEYIPGFAVRGLHYDIEKALLMKIDAFHHIQlg 106
XP_005796446      114 LRDIEIYGFDYDYTLAFYS-SHLHTLIFDIARDILINNHRYPEDLRKYEYIPDFAVRGLHYDVQKALLMKIDAFHYIQlg 192
XP_003269986       93 LSDIEIYGFDYDYTLVFYS-KHLHTLIFNAARDLLINEHRYPAEIRKYEYDPNFAIRGLHYDVQRAVLMKIDAFHYIQlg 171
XP_014348827      116 LSDIEVYGFDYDYTLAFYS-KDLHTMIFNIARNILIDQLRYPEELRTYEYSPNFAIRGLHYDVQTALLMKIDAFHYIQlg 194
XP_005801814      150 LEEVDIYGFDYDYTLAQYS-NALNALIYDTAKGFLIEHFKYPEEIAKYEYIPNFTVRGLHYDIQKGLLMKIDAFHYIEpg 228
XP_008102124      105 LNTIEVYGFDYDYTLALYS-PALHSRIYNTARDILVEQYKYPKGILEYEYWPTFAIRGLHYDIAKGLLMKIDAFHYIQlg 183
XP_014344299      130 LGDIEIYGFDYDYTLAQYS-NSLHTMIFNTARDILVDQYRYPEDIKKHKYAPGFAIRGLHYDIQKSLLMKIDAFHYVQsg 208 coelacanth
4OHF_D             92 LSYHGTKQISFSDQKKIYRSIyvdl-------------gdpNYMAIDTSFSIAFCILYGQLVDLKDTnpDKMPSYQAIAQ 158 Legionella...
EEB19928          160 TVYKGLRRVPDEEVIQLYKNKviplafvea--kdkigsgrtKLYQLADIFSRPEMSLLCCIVDYFDAk-GFDYHPEIVFR 236
FlyBase:CG1814-PC 101 SVYRGRTKVEADEVLKLYHNRllpiayvegpnnsyrhntnsKMVQLADLFSVPEMCLLCNVIEYFERn-RIDYNPEIVFH 179
XP_002595182      107 TVFRGHQQVSDAEVFSQYDGThvpvdymss--fhgrvsmgkQMVQLMDMFSLSEMALLCDITEFFLKn-GIEYDPEYLFY 183
XP_005796446      193 TVYRGLHPMPDEEVIAMYEGShvpleimsd--fygksihghTMKQFMDIFSLPEMTLLSCVNDFFMRh-NIDYEPVHLYK 269
XP_003269986      172 TVYRGLSVVPDEEVIEMYEGShvpleqmsd--fygksshgnTMKQFMDIFSLPEMTLLSCVNEYFLKn-nIDYEPVHLYK 248
XP_014348827      195 SVYRGLNTVPDEEVIAIYEGShvpleqmsd--fygksshgnTMKQFMDIFSLPEVTLLSCVNDYFITn-NIDYEPVHLYK 271
XP_005801814      229 TVYRGLSPVSDDEVLYLYGGTfhvplsqd----sgfygkgpKVKQFMDIFSIPEMTLLAVANDFFITn-DIEYDPVHLFK 303
XP_008102124      184 TVYRGLKPVPDDEVLEMYDGThhiplhqa----sgfygkgpAIKQFMDIFSLPEMTLLAVANDFFISn-DIDYDPIHLYK 258
XP_014344299      209 TAYRGLKPVPDEEVIEKYGGTqhiplyqm----sdfygkgpSLKQFMDIFSLPEMTLISCVNDYFINh-NIEFDPVHLYR 283 coelacanth
4OHF_D            159 DVQYCVDKVHSDGTLKNIIIKNLKKYVIREKEVVEGLKHFIRYGKKIFILTNSEYSYSKLLLDYALSpfldkgEHWQGLF 238 Legionella...
EEB19928          237 DVRSAIGSIH--PVMHSEVMENTNKYLEENTDITKLLIKLKNAGKKLFLITNSPFHFVNKGLNVILG------QGWKDFF 308
FlyBase:CG1814-PC 180 DTRTAMGSCH--PIMHGKVMRNTEKYIERNPKLVKFFEKLQQAGKNLFLVTNSPYSFVNCGMSFLVG------ANWRDFF 251
XP_002595182      184 DVKNAVISVHLSGDMHKAVAEDMDRYLERGEEIAQLLRRLAGAGKKLFLITNSPFWFVQRGMEYIAG------PSWMEMF 257
XP_005796446      270 DVKEAIRDVHVKGIMYRAVEADIGKYICYGEQSHAVLKKLSAHGKKMFLITNSPFDFVDRGMSYIVG------KDWRDLF 343
XP_003269986      249 DVKDSIRDVHIKGIMYRAIEADIEKYICYAEQTRAVLAKLADHGKKMFLITNSPSSFVDKGMSYIVG------KDWRDLF 322
XP_014348827      272 DVKEAIRDVHVKGMMYRAIEADIGRYICYGEQTCAVLRKLAEHGKKMFLITNSPISFVDRGMNYIVD------KDWKDLF 345
XP_005801814      304 DVSEAIGMVHLKGYMYKWIMQDLDKFILRKEETDAVLHRLVSQGKKLFLITNSPFSFVDKGMTHMVG------KNWRDFF 377
XP_008102124      259 DVTDAIRDVHIKGFMYKWIMQDLEKYILRGDETYAVLHRLAKSGKKLFLITNSPFSFVDKGMRYMVG------KDWRDFF 332
XP_014344299      284 DITDAIKDVHVKGMMYKWIEKDMENYILHGDETYAVLNRLVSNGKKLFLITNSPFSFVNKGMKHMVG------KDWQDLF 357 coelacanth
4OHF_D            239 EFVITLANKPRFFYD-NLRFLSVNPENG--TMTNVHgpIVPG--VYQGGNAKKFTEDLGVGGDEILYIGDHIYGDILRLK 313 Legionella...
EEB19928          309 DIVIVQARKPKFFTDeTTPIRIFDTKLKtqLWDRVT--KLEKgvIYCEGTMKQLKEITGWVGSEVLYFGDHPYSDLADVT 386
FlyBase:CG1814-PC 252 DVVIVQARKPKFFTDeSRPIRLFDERTQshLWDRVF--KLEKgkIYYEGSVRQLQELKGWRGHSVLYFGDHPYSDLADVT 329
XP_002595182      258 DVVIAESRKPKFFTDtKRPFREVSKTSGtcKFERVT--SLRKgqVYIQGNLQDFRQMTGWYGARVLYFGDHVYSDLADPF 335
XP_005796446      344 DVVIVQADKPSFFNDrRKPFRRVT-DKGvlLWDRIH--RLEKgeIYKQGNLYEFLRLTGWRGSKVLYFGDHIYSDLADLT 420
XP_003269986      323 DVVIVQAEKPNFFNDkRRPFRKMN-EKGvlLWDKIH--KLQKgqIYKQGNLYEFLKLTGWRGSRVLYFGDHIYSDLADLT 399
XP_014348827      346 DVIIVQADKPSFFNDrRKPFRRVN-QKGvlLWDKIH--QLEKgqIYKQGNLYEFLKLTGWRGSKVLYFGDHIYSDLADLT 422
XP_005801814      378 DVVIVQADKPHFFTDcIKPFRRLD-NNGdlRWEKIN--RLDKgqIYKQGNLFDFLRLTGWRGSKVLYFGDHLYSDLADLM 454
XP_008102124      333 DVVIVQADKPHFFNDcVKPFRRLD-NNGdlQWDKIN--RLEKgqVYKQGNLFDFLRLTGWRGSKVLYFGDHLYSDLADLM 409
XP_014344299      358 DVVIVQAHKPSFFTDkCKPFRRLD-ETGslQWDKIN--ELEKgkIYKQGNLFDFLRITGWRGSRVLYFGDHLYSDLADLM 434 coelacanth
4OHF_D            314 KDCNWRTALVVEELGEEIASQIRALPIeKKIGEAMAIKKELEQkyvdlctrsidEssqQyDQEIHDLQLQISTVDLQISR 393 Legionella...
EEB19928          387 LKHGWRTGAIIHELTHEIQTLNKQSFK-MDSNWLQVLTQLIEE-----------Ne--Y-LAEDESSEKEVKQWIDERNY 451
FlyBase:CG1814-PC 330 LKHSWRTGAIISELAHEIKTLNRKDFK-MSANWLQMLTQLIED-----------T---Q-DDDSEAAQICLKEWMEERDQ 393
XP_002595182      336 LKHGWRTGAIIPELEDEIKISNSTSYK-DTISWLLALQGLIES-----------Qq--K-SRHDEAVQAVVQEWMKEMRE 400
XP_005796446      421 LKHGWRTGAIIPELRKEIKIMNTPQYV-HMMTWLQALTVLIEQ-----------M---Q-AHRDPATQAVVEEWIKEREA 484
XP_003269986      400 LKHGWRTGAIIPELRSELKIMNTEQYI-QTMTWLQTLTGLLEQ---------------MqVHRDAESQLVLQEWKKERKE 463
XP_014348827      423 LKHGWRTGAIIPELRSEIKTMNTEEYT-RVMAFLQTLTGLLEK-----------M---Q-VYRDTESQMLLQEWIKERQD 486
XP_005801814      455 LRHGWRTAAIVPELEHETKIVSAHRYA-VTLTWLQALTGLMERl---------------qTHRDPASKKVFLEWQKEREE 518
XP_008102124      410 LRHGWRTGAIVPELETETKMVNTEQYS-QALTWLQALTGLLER-----------M---Q-MFQDQESQQVLQDWMKERQE 473
XP_014344299      435 LRHGWRTGAIVPELEAEIRIINTEQYM-HSLTWLQAITGLLER-----------M---Q-MHQDAESKQVLSEWWKERQE 498 coelacanth
4OHF_D            394 LLQEQNSFYNPKWERVFRAGAEESYFAYQVDRFACIYMEKLSDLLEHSPMTYFRANRRLLAHDID 458 Legionella pneumophila su...
EEB19928          452 LLQSTKNVFNPQFGSVFRTYNNPTYFSRRLFRFADIYTSNLGNLLNYSLNHTFFPRRGALPHEYA 516
FlyBase:CG1814-PC 394 LRNKTKNVFNEQFGSVFRTYHNPTYFSRRLFRFADIYTSDITNLLKFSTTHTFYPRRGVMPHEYA 458
XP_002595182      401 LRHYTKDIFNPQFGSLFRTHHNPTYFSRRLMRFADIYTSSVANLLHFPIDYTFYPRRSALPHEIN 465
XP_005796446      485 MKPQTKDIFNAQFGSLFRTYHNPTYFSRRLSRFADIYMASISCMLNYDLQHTFFPRRTPLQHEAP 549
XP_003269986      464 MREMTKSFFNAQFGSLFRTDQNPTYFLRRLSRFADIYMASLSCLLNYDVSHTFYPRRTPLQHELP 528
XP_014348827      487 TRELAKKVFNPQFGSIFRTNQNPTYFSRRLSRFADIYMASLSCLLNYDLHHTFYPRRTPLQHEAP 551
XP_005801814      519 LRVMTKNLFNPQFGSIFRTCHNPTYFSRRLSRFSDIYMASLSCLLNYDPSYTFYPRRTPLQHEAP 583
XP_008102124      474 LRALTKNLFNPQFGSIFRTCHNPTYFSRRLCRFSDIYMASLSCLLNYDLNYTFYPRRTPLQHEAP 538
XP_014344299      499 LRSRTKNLFNPQFGSIFRTYHNPTYFSRRLCRFSDIYMSSISCLLNYDLNFTFYPRRTPLQHEAP 563 coelacanth
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